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Richard Koche
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Journal Articles

Isogenic MDS-RS Patient-Derived iPSCs Define the Mis-Spliced Transcript Repertoire and Chromatin Landscape of SF3B1-Mutant Hematopoietic Stem/Progenitor Cells

George Asimomitis, André G. Deslauriers, Andriana G. Kotini, Elsa Bernard, Davide Esposito, Malgorzata Olszewska, Nikolaos Spyrou, Juan Arango Ossa, Teresa Mortera-Blanco, Richard Koche, Stuart Aaronson, Eva Hellström-Lindberg, Elli Papaemmanuil, Eirini P. Papapetrou
Journal: Blood
Blood (2021) 138 (Supplement 1): 147.
DOI: https://doi.org/10.1182/blood-2021-149830
Published: 2021
Journal Articles

HMGA1 Chromatin Regulators Drive Progression in Myeloproliferative Neoplasms through Epigenetic Rewiring to Induce Networks Involved in GATA2 and Proliferation

Liping Li, Jung-Hyun Kim, Wenyan Lu, Leslie Cope, Donna M Williams, Joseph Kim, Raajit Rampal, Richard Koche, Lingling Xian, Li Luo, Marija Vasiljevic, Daniel R Matson, Zhizhuang Joe Zhao, Ophelia Rogers, Matthew C. Stubbs, Karen Reddy, Jerry L. Spivak, Alison R. Moliterno, Linda Resar
Journal: Blood
Blood (2021) 138 (Supplement 1): 625.
DOI: https://doi.org/10.1182/blood-2021-144712
Published: 2021
Journal Articles

The BMP/SMAD Pathway Is a Key Mediator of Leukemic Transformation of TP53-Mutant Post-MPN AML

Bing Li, Wenbin An, Hua Wang, Aishwarya Krishnan, Shoron Mowla, Timour Baslan, Richard Koche, Wenbin Xiao, Scott Lowe, Ross L. Levine, Raajit Rampal
Journal: Blood
Blood (2021) 138 (Supplement 1): 626.
DOI: https://doi.org/10.1182/blood-2021-152036
Published: 2021
Journal Articles

Single Cell ATAC Lineage Deconvolution Reveals Overlapping Subclones in Epigenetically Distinct AML Samples

Deepika Dilip, Richard Koche, Kamal Menghrajani, Ari Melnick, Olivier Elemento, Ross L. Levine, Jacob L Glass
Journal: Blood
Blood (2021) 138 (Supplement 1): 2381.
DOI: https://doi.org/10.1182/blood-2021-154517
Published: 2021
Journal Articles

The High Mobility Group A1 Chromatin Regulator Drives Immune Evasion during MPN Progression By Repressing Genes Involved in Antigen Presentation and Immune Attack

Joseph Kim, Jung-Hyun Kim, Leslie Cope, Liping Li, Raajit Rampal, Richard Koche, Donna M Williams, Jerry L. Spivak, Alison R. Moliterno, Linda Resar
Journal: Blood
Blood (2021) 138 (Supplement 1): 2546.
DOI: https://doi.org/10.1182/blood-2021-151139
Published: 2021
Journal Articles

Stag2 Regulates Hematopoietic Differentiation and Self-Renewal through Alterations in Gene Expression and Topological Control

Aaron D Viny, MDMS, Robert L Bowman, PhD, Yu Liu, PhD, Vincent-Philippe Lavallee, MD, Shira Eisman, Wenbin Xiao, MD PhD, Benjamin H Durham, MD, Anastasia Navitski, Jane Park, Stephanie Braunstein, Besmira Alija, Abdul Karzai, Isabelle S. Csete, Matthew Witkin, Elham Azizi, PhD, Timour Baslan, Christopher J. Ott, PhD, Dana Pe'er, PhD, Job Dekker, Richard Koche, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 279.
DOI: https://doi.org/10.1182/blood-2019-123464
Published: 2019
Journal Articles

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Sheng F Cai, MD PhD, S Haihua Chu, PhD, Aaron D Goldberg, MD PhD, Salma Parvin, PhD, Richard Koche, PhD, Jacob L Glass, MD PhD, Eytan M. Stein, MD, Martin S. Tallman, MD, Filiz Sen, MD, Christopher Famulare, MS, Monica Cusan, MD, Chun-Hao Huang, PhD, Chun-Wei David Chen, PhD, Lihua Zou, PhD, Keith B Cordner, BS, Vidushi Durani, MS, Mitali Kini, BS, Madison Rex, Johannes Zuber, Timour Baslan, PhD, Scott W. Lowe, PhD, Hugh Young Rienhoff, Jr., MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 109.
DOI: https://doi.org/10.1182/blood-2019-122483
Published: 2019
Journal Articles

The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination

S. Haihua Chu, PhD, Jonathan Chabon, BS, Janna Minehart, BS, Chloe N Matovina, BS, Jian Zhang, Bo-Ruei Chen, PhD, Elsa Callen-Moreu, PhD, Putzer J Hung, Zhaohui Feng, BM, BS, Richard Koche, PhD, X. Shirley Liu, Jayanta Chaudhuri, Andre Nussenzweig, PhD, Barry Sleckman, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 511.
DOI: https://doi.org/10.1182/blood-2018-99-111952
Published: 2018
Journal Articles

AML with Mutations in IDH1 and DNMT3A Exhibits a Distinct Epigenetic Signature with Poorer Overall Survival

Katya Ahr, BA, Christopher Famulare, MS, Richard Koche, PhD, Barbara Spitzer, MD, Ross L. Levine, MD, Martin S. Tallman, MD, Aaron D Goldberg, MD PhD, Eytan M. Stein, MD, Jacob L Glass, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1471.
DOI: https://doi.org/10.1182/blood-2018-99-118407
Published: 2018
Journal Articles

Functional Profiling of Patient AML Stem Cells Reveals Mechanisms of Epigenetic Plasticity Controlling Therapy Resistance

Sumiko Takao, MD PhD, Richard Koche, PhD, Paolo Cifani, PhD, Zheng Ser, Alex Kentsis, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1318.
DOI: https://doi.org/10.1182/blood-2018-99-114433
Published: 2018
Journal Articles

SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia

Brenton G. Mar, S. Haihua Chu, Josephine D. Kahn, Andrei V. Krivtsov, Richard Koche, Cecilia A. Castellano, Jacob L. Kotlier, Rebecca L. Zon, Marie E. McConkey, Jonathan Chabon, Ryan Chappell, Peter V. Grauman, James J. Hsieh, Scott A. Armstrong, Benjamin L. Ebert
Journal: Blood
Blood (2017) 130 (24): 2631–2641.
DOI: https://doi.org/10.1182/blood-2017-03-775569
Published: 2017
Includes: Supplemental data
Journal Articles

Targeting the DNA Damage Response Pathway in MLL- rearranged B-Acute Lymphoblastic Leukemias

S. Haihua Chu, PhD, Evelyn Junyao Song, BS, Jonathan Chabon, BS, Janna Minehart, BS, Zhaohui Feng, BM, BS, Kenneth Ross, PhD, Richard Koche, PhD, Andrei V. Krivtsov, PhD, Scott Armstrong, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3880.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3880.3880
Published: 2017
Journal Articles

LSD1 Inhibition Exerts Its Anti-Leukemic Effect By Recommissioning PU.1- and C/Ebpα-Dependent Enhancers in AML

Monica Cusan, MD, Sheng Cai, MD PhD, Helai P Mohammad, PhD, Andrei V. Krivtsov, PhD, Alan Chramiec, Evangelia Loizou, Daniel G. Tenen, MD, Min Ye, PhD, Britta Will, PhD, Ulrich G. Steidl, MDPhD, Ryan G. Kruger, PhD, Richard Koche, PhD, Scott Armstrong, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 242.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.242.242
Published: 2017
Journal Articles

Lineage Deconvolution Using Chromatin Accessibility and DNA Methylation Shows a Spectrum of Lineage Characteristics and Differentiation States across Acute Leukemias

Jacob L Glass, MDPhD, Alyson J Palia, Francine E. Garrett-Bakelman, MDPhD, Richard Koche, PhD, Ross L. Levine, MD, Martin S. Tallman, MD, Richard James Dillon, MA, PhD MRCP, FRCPath, David Grimwade, Adolfo A. Ferrando, MD PhD, Peter J.M. Valk, PhD, Ruud Delwel, PhD, Maria E. Figueroa, MD, Ari Melnick, MD, Olivier Elemento, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1208.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1208.1208
Published: 2017
Journal Articles

Inhibition of MEK and DDR Pathways Induces Synergistic Killing of Novel Mll-Af4 B-ALL Model Harboring Activated Ras Mutations

Evelyn J Song, BS, S. Haihua Chu, PhD, Janna Minehart, BS, Jonathan Chabon, BS, Richard Koche, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1511.
DOI: https://doi.org/10.1182/blood.V128.22.1511.1511
Published: 2016
Journal Articles

An Epigenetic Regulator Screen Identifies Novel Targets That Sensitize MLL -Rearranged Leukemia to DOT1L Inhibition

Chun-Wei David Chen, PhD, Christopher Delaney, BS, Haiming Xu, PhD, Richard Koche, PhD, Amaya Lujambio Goizueta, PhD, Takayuki Hoshii, PhD, Monica Cusan, MD PhD, Jonathan Chabon, BS, Daria Gianina Valerio, MD, Michael Kuehn, MD, Xi Wang, BS, Sheng Cai, MD PhD, S. Haihua Chu, PhD, Yining Kevin Chen, Justin He, Chun-Hao Huang, PhD, Zhaohui Feng, BM, BS, Andrei Krivtsov, PhD, Jun Qi, PhD, James E. Bradner, MD, Scott W. Lowe, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 571.
DOI: https://doi.org/10.1182/blood.V128.22.571.571
Published: 2016
Journal Articles

Aberrant Phosphorylation of MEF2C Is Dispensable for Hematopoiesis, and Induces Chemotherapy Resistance and Susceptibility to MARK Kinase Inhibition Therapy in Acute Myeloid Leukemia

Fiona C Brown, PhD, Eric Still, Paolo Cifani, PhD, Casie Reed, Scott Ficarro, PhD, Jie He, PhD, Richard Koche, PhD, Patrick Bhola, PhD, Peter Romanienko, PhD, Willie Mark, PhD, Andrei V. Krivtsov, PhD, Anthony Letai, MD PhD, Nathanael Gray, PhD, Jarrod Marto, PhD, Scott A. Armstrong, MD PhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 436.
DOI: https://doi.org/10.1182/blood.V128.22.436.436
Published: 2016
Journal Articles

Non-Catalytic Role of SETD1A Regulates DNA Repair in Leukemia

Takayuki Hoshii, PhD, Paolo Cifani, PhD, Tomoyoshi Nakadai, PhD, Zhaohui Feng, BM, BS, Chun-Hao Huang, PhD, Richard Koche, PhD, Christopher D Delaney, Chun-Wei David Chen, PhD, Scott W. Lowe, PhD, Robert Roeder, PhD, Alex Kentsis, MD PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 434.
DOI: https://doi.org/10.1182/blood.V128.22.434.434
Published: 2016
Journal Articles

Loss of Lysine Histone Methyltransferase Setd2 Disrupts Normal Hematopoiesis, Lineage Commitment and Reveals a Novel Role for H3K36me3 in Immunoglobulin VDJ Recombination

S. Haihua Chu, PhD, Jonathan R Chabon, BS, Janna Minehart, BS, Richard Koche, PhD, Katie Li, BS, Matthew Witkin, BS, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2016) 128 (22): 423.
DOI: https://doi.org/10.1182/blood.V128.22.423.423
Published: 2016
Journal Articles

Peptidomimetic Blockade of MYB in Acute Myeloid Leukemia

Kavitha Ramaswamy, MD, Lauren Forbes, Fiona C Brown, PhD, Richard Koche, PhD, Tatyana Gindin, MDPhD, Gerard Minuesa, PhD, Michael G. Kharas, PhD, Andrei Krivtsov, PhD, Scott A. Armstrong, MD PhD, Eric Still, Elisa de Stanchina, PhD, Randi Isenhart, Guangwu Guo, Birgit Knoechel, MDPhD, Alex Kentsis, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3945.
DOI: https://doi.org/10.1182/blood.V128.22.3945.3945
Published: 2016