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Journal Articles

Bioengineered iPSC-derived megakaryocytes for the detection of platelet-specific patient alloantibodies

e-blood
Nanyan Zhang, Sentot Santoso, Richard H. Aster, Brian R. Curtis, Peter J. Newman
Blood (2019) 134 (22): e1–e8.
DOI: https://doi.org/10.1182/blood.2019002225
Published: 2019
Includes: Supplemental data
Journal Articles

Cross-Reactivity of Drug-Dependent Antibodies in Patients with Immune Thrombocytopenia Induced By Beta-Lactam Antibiotics

Matthew John Slaught, BS, Daniel W. Bougie, PhD, Richard H. Aster, MD
Blood (2019) 134 (Supplement_1): 2350.
DOI: https://doi.org/10.1182/blood-2019-131375
Published: 2019
Journal Articles

Cross-Strain Platelet Immunization in Selected Mouse Strains Recapitulates Clinical and Serologic Findings Typical of Post-Transfusion Purpura (PTP)

Daniel W. Bougie, PhD, Jessica Sutton, Richard H. Aster, MD
Blood (2019) 134 (Supplement_1): 2349.
DOI: https://doi.org/10.1182/blood-2019-126815
Published: 2019
Journal Articles

The First Case Report of Tazobactam Induced Thrombocytopenia

Minh-Tri H. Nguyen, MD, Pavneet Kaur, MD, Richard H. Aster, MD, Vidya Krishnan, MD MHS
Blood (2019) 134 (Supplement_1): 4897.
DOI: https://doi.org/10.1182/blood-2019-126227
Published: 2019
Journal Articles

Antibody Cloning Identifies Pathogenic and Non-Pathogenic Antibodies in Heparin-Induced Thrombocytopenia and Defines the Molecular Signatures That Differentiate the Two Types of Antibodies

Wen Zhu, Yongwei Zheng, PhD, Mei Yu, PhD, Yaling Wu, Jianhui Wei, Nicholas Schneider, Anand Padmanabhan, MD PhD, Richard H. Aster, MD, Demin Wang, PhD, Renren Wen, PhD
Blood (2019) 134 (Supplement_1): 439.
DOI: https://doi.org/10.1182/blood-2019-126097
Published: 2019
Journal Articles

Serologic Characterization of Antibodies in Patients Experiencing Piperacillin-Induced Immune Thrombocytopenia

Mark Rasmussen, Daniel W. Bougie, PhD, Gregory H. Denomme, Richard H. Aster, MD
Blood (2019) 134 (Supplement_1): 1078.
DOI: https://doi.org/10.1182/blood-2019-130966
Published: 2019
Journal Articles

New Monoclonal Antibodies Reveal Distinct Specificities for Platelet Factor 4 Bound to Heparin Vs. Platelets: Implications for HIT Pathogenesis

Anand Padmanabhan, MD PhD, Shannon Pechauer, Curtis Jones, BS, Daniel Bougie, PhD, Richard H. Aster, MD
Blood (2019) 134 (Supplement_1): 1144.
DOI: https://doi.org/10.1182/blood-2019-127169
Published: 2019
Journal Articles

Regulatory T Cells Control PF4/Heparin Antibody Production in Mice

Yongwei Zheng, Wen Zhu, Dipica Haribhai, PhD, Calvin B. Williams, PhD, Richard H. Aster, MD, Renren Wen, PhD, Demin Wang, PhD
Blood (2018) 132 (Supplement 1): 2542.
DOI: https://doi.org/10.1182/blood-2018-99-113049
Published: 2018
Journal Articles

Use of Intravenous Immunoglobulin G in HIT: Impact on Thrombosis and Mortality in a Population-Based Study

Binod Dhakal, MBBS, Rein Lisa, Aniko Szabo, PhD, Richard H. Aster, MD, Anand Padmanabhan, MD PhD
Blood (2018) 132 (Supplement 1): 2512.
DOI: https://doi.org/10.1182/blood-2018-99-117190
Published: 2018
Journal Articles

The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study

Deepti M. Warad, MD, Bethany T Samuelson Bannow, MD, Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhD, Daniel W. Bougie, PhD, Parisa R Khalighi, BS, Diane E. Grill, MS, Rachel Leger, BAE, Ruchika Sharma, MD, Dong Chen, MD PhD, Richard H. Aster, MD, David A. Garcia, MD, Anand Padmanabhan, MD PhD
Blood (2018) 132 (Supplement 1): 416.
DOI: https://doi.org/10.1182/blood-2018-99-112475
Published: 2018
Journal Articles

Patients treated with oxaliplatin are at risk for thrombocytopenia caused by multiple drug-dependent antibodies

Clinical Trials & Observations
Brian R. Curtis, Yen-Michael S. Hsu, Nikolai Podoltsev, Jill Lacy, Susanna Curtis, Michael S. Samuel, Kristin Zutavern, Robert A. DeSimone, Daniel W. Bougie, Richard H. Aster
Blood (2018) 131 (13): 1486–1489.
DOI: https://doi.org/10.1182/blood-2017-10-812461
Published: 2018
Includes: Supplemental data
Journal Articles

Normal plasma IgG inhibits HIT antibody–mediated platelet activation: implications for therapeutic plasma exchange

Curtis G. Jones, Shannon M. Pechauer, Brian R. Curtis, Daniel W. Bougie, Richard H. Aster, Anand Padmanabhan
Blood (2018) 131 (6): 703–706.
DOI: https://doi.org/10.1182/blood-2017-08-803031
Published: 2018
Includes: Supplemental data
Journal Articles

Drug-Induced Immune Thrombocytopenia (DITP) Caused By Multiple Drug-Dependent Platelet-Reactive Antibodies (DDAbs) in Patients Undergoing Oxaliplatin-Containing Combination Chemotherapy for Metastatic Colon Cancer

Brian R. Curtis, PhDMT(ASCP), Yen-Michael S. Hsu, MD PhD, Nikolai A. Podoltsev, MD PhD, Jill Lacy, MD, Susanna A Curtis, MD, Robert Andrew Desimone, MD, Michael Samuel, MD, Kristin Zutavern, BS, Daniel Bougie, PhD, Richard H. Aster, MD
Blood (2017) 130 (Supplement 1): 3625.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3625.3625
Published: 2017
Journal Articles

Immunoglobulin G in Normal Plasma Inhibits HIT Antibody-Mediated Platelet Activation: Implications for Therapeutic Plasma Exchange Treatment in HIT

Curtis Jones, BS, Shannon Pechauer, Brian R. Curtis, PhDMT(ASCP), Daniel W. Bougie, PhD, Richard H. Aster, MD, Anand Padmanabhan, MD PhD
Blood (2017) 130 (Supplement 1): 2402.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2402.2402
Published: 2017
Journal Articles

A New Assay for Platelet-Activating HIT Antibodies, the PEA, Is Specific, Reproducible and Relatively Independent of the Choice of Platelet Donor

Shannon Pechauer, Curtis Jones, BS, Daniel W. Bougie, PhD, Brian R. Curtis, PhDMT(ASCP), Richard H. Aster, MD, Anand Padmanabhan, MD PhD
Blood (2017) 130 (Supplement 1): 458.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.458.458
Published: 2017
Journal Articles

Autoimmune Thrombocytopenia in Mice Immunized with Allogeneic Platelets: A Model for Post-Transfusion Purpura (PTP)?

Daniel W. Bougie, PhD, Jessica Sutton, Richard H. Aster, MD
Blood (2016) 128 (22): 168.
DOI: https://doi.org/10.1182/blood.V128.22.168.168
Published: 2016
Journal Articles

A Novel PF4-Dependent P-Selectin Expression Assay (PEA) Facilitates Early Detection of Pathogenic HIT Antibodies: Implications for Diagnosis and Treatment of HIT

Anand Padmanabhan, MBBS, MA, PhD, Curtis G Jones, Shannon M Pechauer, Brian R Curtis, PhD D(ABMLI) MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia J Sullivan, Mehraboon S. Irani, MBBChir, Binod Dhakal, MDMS, Lisa M. Baumann Kreuziger, MD MS, Brenda M. Pierce, MD, Richard H. Aster, MD
Blood (2016) 128 (22): 2599.
DOI: https://doi.org/10.1182/blood.V128.22.2599.2599
Published: 2016
Journal Articles

Intravenous Immunoglobulin (IVIg) Is a Highly Effective Treatment for HIT: Critical Role of the IgG Fc Domain in Inhibiting HIT Antibody-Mediated Platelet Activation

Anand Padmanabhan, MBBS, MA, PhD, Curtis G Jones, Shannon M Pechauer, Barbara J. Bryant, MD, Jack B. Alperin, MD, Mehraboon S. Irani, MBBChir, Binod Dhakal, MDMS, Brian R Curtis, PhD D(ABMLI) MT(ASCP)SBB, Daniel W. Bougie, PhD, Mia J Sullivan, Renren Wen, PhD, Demin Wang, PhD, Richard H. Aster, MD
Blood (2016) 128 (22): 2600.
DOI: https://doi.org/10.1182/blood.V128.22.2600.2600
Published: 2016
Journal Articles

Structural Basis for Quinine-Dependent Antibody Binding to Platelet Integrin alphaIIbbeta3

Jianghai Zhu, PhD, Jieqing Zhu, PhD, Daniel W. Bougie, PhD, Richard H. Aster, MD, Timothy A. Springer, PhD
Blood (2015) 126 (23): 1063.
DOI: https://doi.org/10.1182/blood.V126.23.1063.1063
Published: 2015
Journal Articles

Binding of Quinine-Dependent Monoclonal Antibodies to Gpiib/Iiia Appears to Involve Drug-Induced Modulation of Antibody Affinity

Daniel W. Bougie, PhD, Julie A. Peterson, PhD, Mark Rasmussen, Richard H. Aster, MD
Blood (2015) 126 (23): 2246.
DOI: https://doi.org/10.1182/blood.V126.23.2246.2246
Published: 2015