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Journal Articles

Revisiting coexisting chromosomal abnormalities in NPM1 -mutated AML in light of the revised ELN 2022 classification

Clinical Trials & Observations
Linus Angenendt, Christoph Röllig, Pau Montesinos, Farhad Ravandi, Gunnar Juliusson, Christian Récher, Raphaël Itzykson, Zdeněk Ráčil, Andrew H. Wei, Christoph Schliemann
Journal: Blood
Blood (2023) 141 (4): 433–435.
https://doi.org/10.1182/blood.2022018582
Published: 2023
Journal Articles

Azithromycin promotes relapse by disrupting immune and metabolic networks after allogeneic stem cell transplantation

Nicolas Vallet, Sophie Le Grand, Louise Bondeelle, Bénédicte Hoareau, Aurélien Corneau, Delphine Bouteiller, Simon Tournier, Lucille Derivry, Armelle Bohineust, Marie Tourret, Delphine Gibert, Ethan Mayeur, Raphael Itzykson, Kim Pacchiardi, Brian Ingram, Stéphane Cassonnet, Patricia Lepage, Régis Peffault de Latour, Gérard Socié, Anne Bergeron, David Michonneau
Journal: Blood
Blood (2022) 140 (23): 2500–2513.
https://doi.org/10.1182/blood.2022016926
Published: 2022
Includes: Supplemental data
Journal Articles

Persistence of Mutations in Complete Remission Including DNMT3A , TET2 and ASXL1 Mutations Is Associated with Worse Prognosis in Patients with Acute Myeloid Leukemia Treated in ALFA 0702 Study

Pierre Hirsch, Jérôme Lambert, Maxime Bucci, Caroline Deswarte, Juliette Lambert, Laurène Fenwarth, Herve Dombret, Nicolas Duployez, Claude Preudhomme, Raphael Itzykson, Francois Delhommeau
Journal: Blood
Blood (2022) 140 (Supplement 1): 549–550.
https://doi.org/10.1182/blood-2022-166713
Published: 2022
Journal Articles

LSC17 Score Is Complementary with Minimal Residual Disease to Stratify NPM1 -Mutated Acute Myeloid Leukemia: An ALFA Study

Loïc Vasseur, Laurène Fenwarth, Xavier Thomas, Jérôme Lambert, Stéphane de Botton, Martin Figeac, Céline Villenet, Pierre-Yves Dumas, Christian Recher, Céline Berthon, Emilie Lemasle, Delphine Lebon, Juliette Lambert, Christine Terré, Karine Celli-Lebras, Hervé Dombret, Claude Preudhomme, Meyling Cheok, Raphael Itzykson, Nicolas Duployez
Journal: Blood
Blood (2022) 140 (Supplement 1): 6303–6305.
https://doi.org/10.1182/blood-2022-163348
Published: 2022
Journal Articles

Characteristics of Germline CHEK2 Mutated Patients in a Large Cohort of 2322 Myeloid Malignancies

Lucie Freiman, Lise Larcher, Giulia Tueur, Nadia Vasquez, Mélanie Da Costa, Emmanuel Raffoux, Lionel Ades, Pierre Fenaux, Jean Soulier, Emmanuelle Clappier, Raphael Itzykson
Journal: Blood
Blood (2022) 140 (Supplement 1): 4082–4083.
https://doi.org/10.1182/blood-2022-158799
Published: 2022
Journal Articles

Prognostic Impact of Monoallelic Versus Biallelic TP53 Alterations in Intensively-Treated Adults AML Patients: A Retrospective Study from the ALFA Group

Laurène Fenwarth, Loïc Vasseur, Nicolas Duployez, Claude Gardin, Christine Terré, Juliette Lambert, Stéphane de Botton, Karine Celli-Lebras, Pascal Turlure, Thomas Cluzeau, Thorsten Braun, Xavier Thomas, Christian Recher, Sylvain Chantepie, Cécile Pautas, Hervé Dombret, Claude Preudhomme, Raphael Itzykson
Journal: Blood
Blood (2022) 140 (Supplement 1): 737–738.
https://doi.org/10.1182/blood-2022-163044
Published: 2022
Journal Articles

Management of MDS with Isolated Del(5q) Patients in the European MDS (EUMDS) Registry: A Report on 197 Cases

Inga Mandac Smoljanovic, Adele Taylor, Pierre Fenaux, Agnès Guerci-Bresler, Raphael Itzykson, Argiris Symeonidis, Ioannis Kotsianidis, Moshe Mittelman, Guillermo Sanz, Dominic J. Culligan, Jaroslav Cermak, Reinhard Stauder, Eva Hellström-Lindberg, Luca Malcovati, Saskia M.C. Langemeijer, Ulrich Germing, Krzysztof Madry, Howard S. Oster, Alexandra Smith, Corine van Marrewijk, Theo M de Witte, David Bowen
Journal: Blood
Blood (2022) 140 (Supplement 1): 9802–9803.
https://doi.org/10.1182/blood-2022-167716
Published: 2022
Journal Articles

AML MRD By Multiparameter Flow Cytometry Using Laip/Dfn and LSC: Methodological Aspects in a Multicentric Study of the French-Flow MRD AML ALFA Network

Adriana Plesa, Florent Dumezy, Stéphanie Mathis, Anne-Catherine Lhoumeau, Valerie Bardet, Véronique Saada, Isabelle Arnoux, Bouchra Badaoui, Edouard Cornet, Jennifer Osman, Estelle Guerin, Nicolas Chapuis, Franck Genevieve, Rémi Letestu, Delphine Manzoni, Anne Roggy, Mikael Roussel, Véronique Harrivel, Elsa Bera, Caroline Mayeur-Rousse, Hélène Lapillonne, Richard Veyrat-Masson, Lydia Campos, Magali Le Garff-Tavernier, Tatiana Raskovalova, Francois Vergez, Julien Guy, Agnes Charpentier, Claire Hemar, Valerie Goncalves Monteiro, Frederic Fegier, Karine Celli-Lebras, Raphael Itzykson, Herve Dombret, Claude Preudhomme, Christophe Roumier
Journal: Blood
Blood (2022) 140 (Supplement 1): 6279–6281.
https://doi.org/10.1182/blood-2022-169696
Published: 2022
Journal Articles

Role of allogeneic transplantation in chronic myelomonocytic leukemia: an international collaborative analysis

CME Clinical Trials & Observations
Marie Robin, Liesbeth C. de Wreede, Eric Padron, Katerina Bakunina, Pierre Fenaux, Linda Koster, Aziz Nazha, Dietrich W. Beelen, Raajit K. Rampal, Katja Sockel, Rami S. Komrokji, Nico Gagelmann, Dirk-Jan Eikema, Aleksandar Radujkovic, Jürgen Finke, Victoria Potter, Sally B. Killick, Faezeh Legrand, Eric Solary, Angus Broom, Guillermo Garcia-Manero, Vittorio Rizzoli, Patrick Hayden, Mrinal M. Patnaik, Francesco Onida, Ibrahim Yakoub-Agha, Raphael Itzykson
Journal: Blood
Blood (2022) 140 (12): 1408–1418.
https://doi.org/10.1182/blood.2021015173
Published: 2022
Includes: Supplemental data
Journal Articles

Prognostic impact of DDX41 germline mutations in intensively treated acute myeloid leukemia patients: an ALFA-FILO study

Clinical Trials & Observations
Nicolas Duployez, Laëtitia Largeaud, Matthieu Duchmann, Rathana Kim, Julie Rieunier, Juliette Lambert, Audrey Bidet, Lise Larcher, Jean Lemoine, François Delhommeau, Pierre Hirsch, Laurène Fenwarth, Olivier Kosmider, Justine Decroocq, Anne Bouvier, Yannick Le Bris, Marlène Ochmann, Alberto Santagostino, Lionel Adès, Pierre Fenaux, Xavier Thomas, Jean-Baptiste Micol, Claude Gardin, Raphael Itzykson, Jean Soulier, Emmanuelle Clappier, Christian Recher, Claude Preudhomme, Arnaud Pigneux, Hervé Dombret, Eric Delabesse, Marie Sébert
Journal: Blood
Blood (2022) 140 (7): 756–768.
https://doi.org/10.1182/blood.2021015328
Published: 2022
Includes: Supplemental data
Journal Articles

Prognostic Significance of DDX41 Germline Mutations in Intensively Treated AML Patients: An ALFA-Filo Study

Nicolas Duployez, Matthieu Duchmann, Laetitia Largeaud, Juliette Lambert, Audrey Bidet, Emmanuelle Clappier, Xavier Thomas, Stephane de Botton, Claude Gardin, Christian Recher, Arnaud Pigneux, Raphael Itzykson, Claude Preudhomme, Hervé Dombret, Eric Delabesse, Marie Sebert
Journal: Blood
Blood (2021) 138 (Supplement 1): 612.
https://doi.org/10.1182/blood-2021-148465
Published: 2021
Journal Articles

Ivosidenib Monotherapy Is Effective in Patients with IDH1 Mutated Myelodysplastic Syndrome (MDS): The Idiome Phase 2 Study By the GFM Group

Marie Sebert, Thomas Cluzeau, Odile Beyne Rauzy, Aspasia Stamatoulas Bastard, Sophie Dimicoli-Salazar, Sylvain Thepot, Pierre Peterlin, Sophie Park, Marie-Pierre Gourin, Oana Brehar, Cécile Bally, Sébastien Maury, Gaelle Fossard, Lamya Ait Si Selmi, Cendrine Chaffaut, Emmanuelle Clappier, Raphael Itzykson, Fatiha Chermat, Sylvie Chevret, Pierre Fenaux, Lionel Ades
Journal: Blood
Blood (2021) 138 (Supplement 1): 62.
https://doi.org/10.1182/blood-2021-146932
Published: 2021
Journal Articles

Enasidenib (ENA) Is Effective in Patients with IDH2 Mutated Myelodysplastic Syndrome (MDS) : The Ideal Phase 2 Study By the GFM Group

Lionel Ades, Sophie Dimicoli-Salazar, Marie Sebert, Thomas Cluzeau, Aspasia Stamatoulas Bastard, Kamel Laribi, Gaelle Fossard, Raphael Itzykson, Odile Beyne Rauzy, Alice Garnier, Silke Gloaguen, Norbert Vey, Caroline Le Jeune, Aristoteles Giagounidis, Emmanuel Gyan, Baptiste Perard, Sylvain Thepot, Mario Ojeda, Fatiha Chermat, Kristell Desseaux, Emmanuelle Clappier, Sylvie Chevret, Uwe Platzbecker, Pierre Fenaux
Journal: Blood
Blood (2021) 138 (Supplement 1): 63.
https://doi.org/10.1182/blood-2021-147898
Published: 2021
Journal Articles

Management of MDS with Isolated Del(5q) Patients in the European MDS (EUMDS) Registry, a Unique Prospective Real-World Dataset

David Bowen, Adele Taylor, Pierre Fenaux, Agnes Guerci-Bresler, Raphael Itzykson, Argiris Symeonidis, Ioannis Kotsianidis, Moshe Mittelman, Guillermo Sanz, Dominic J. Culligan, Jaroslav Cermak, Reinhard Stauder, Eva Hellstrom Lindberg, Luca Malcovati, Saskia M. C. Langemeijer, Ulrich Germing, Howard S. Oster, Krzysztof Madry, Mette Skov Holm, Alexandra Smith, Corine van Marrewijk, Theo M de Witte
Journal: Blood
Blood (2021) 138 (Supplement 1): 4671.
https://doi.org/10.1182/blood-2021-150322
Published: 2021
Journal Articles

Genetic identification of patients with AML older than 60 years achieving long-term survival with intensive chemotherapy

CME Clinical Trials & Observations
Raphael Itzykson, Elise Fournier, Céline Berthon, Christoph Röllig, Thorsten Braun, Alice Marceau-Renaut, Cécile Pautas, Olivier Nibourel, Emilie Lemasle, Jean-Baptiste Micol, Lionel Adès, Delphine Lebon, Jean-Valère Malfuson, Lauris Gastaud, Laure Goursaud, Emmanuel Raffoux, Kevin-James Wattebled, Philippe Rousselot, Xavier Thomas, Sylvain Chantepie, Thomas Cluzeau, Hubert Serve, Nicolas Boissel, Christine Terré, Karine Celli-Lebras, Claude Preudhomme, Christian Thiede, Hervé Dombret, Claude Gardin, Nicolas Duployez
Journal: Blood
Blood (2021) 138 (7): 507–519.
https://doi.org/10.1182/blood.2021011103
Published: 2021
Includes: Supplemental data
Journal Articles

Cytokine-like protein 1–induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML

Margaux Sevin, Franck Debeurme, Lucie Laplane, Séverine Badel, Margot Morabito, Hanna L. Newman, Miguel Torres-Martin, Qin Yang, Bouchra Badaoui, Orianne Wagner-Ballon, Véronique Saada, Dorothée Sélimoglu-Buet, Laurence Kraus-Berthier, Sébastien Banquet, Alix Derreal, Pierre Fenaux, Raphael Itzykson, Thorsten Braun, Gabriel Etienne, Celine Berthon, Sylvain Thépot, Oliver Kepp, Guido Kroemer, Eric Padron, Maria E. Figueroa, Nathalie Droin, Eric Solary
Journal: Blood
Blood (2021) 137 (24): 3390–3402.
https://doi.org/10.1182/blood.2020008729
Published: 2021
Includes: Supplemental data
Journal Articles

Prognostic significance of concurrent gene mutations in intensively treated patients with IDH -mutated AML: an ALFA study

CME Clinical Trials & Observations
Matthieu Duchmann, Jean-Baptiste Micol, Nicolas Duployez, Emmanuel Raffoux, Xavier Thomas, Jean-Pierre Marolleau, Thorsten Braun, Lionel Adès, Sylvain Chantepie, Emilie Lemasle, Céline Berthon, Jean-Valère Malfuson, Cécile Pautas, Juliette Lambert, Nicolas Boissel, Karine Celli-Lebras, Denis Caillot, Pascal Turlure, Norbert Vey, Arnaud Pigneux, Christian Recher, Christine Terré, Claude Gardin, Raphaël Itzykson, Claude Preudhomme, Hervé Dombret, Stéphane de Botton
Journal: Blood
Blood (2021) 137 (20): 2827–2837.
https://doi.org/10.1182/blood.2020010165
Published: 2021
Includes: Supplemental data
Journal Articles

A personalized approach to guide allogeneic stem cell transplantation in younger adults with acute myeloid leukemia

Clinical Trials & Observations
Laurène Fenwarth, Xavier Thomas, Stéphane de Botton, Nicolas Duployez, Jean-Henri Bourhis, Auriane Lesieur, Gael Fortin, Paul-Arthur Meslin, Ibrahim Yakoub-Agha, Pierre Sujobert, Pierre-Yves Dumas, Christian Récher, Delphine Lebon, Céline Berthon, Mauricette Michallet, Arnaud Pigneux, Stéphanie Nguyen, Sylvain Chantepie, Norbert Vey, Emmanuel Raffoux, Karine Celli-Lebras, Claude Gardin, Juliette Lambert, Jean-Valère Malfuson, Denis Caillot, Sébastien Maury, Benoît Ducourneau, Pascal Turlure, Emilie Lemasle, Cécile Pautas, Sylvie Chevret, Christine Terré, Nicolas Boissel, Gérard Socié, Hervé Dombret, Claude Preudhomme, Raphael Itzykson
Journal: Blood
Blood (2021) 137 (4): 524–532.
https://doi.org/10.1182/blood.2020005524
Published: 2021
Includes: Supplemental data
Journal Articles

Niche-like Ex Vivo High Throughput (NEXT) Drug Screening Platform in Acute Myeloid Leukemia

Reinaldo Dal Bello Figueiras, MD, Justine Pasanisi, Romane Joudinaud, Matthieu Duchmann, Gaetano Sodaro, Clementine Chauvel, Loic Vasseur, MD, Bryann Pardieu, Frank Ling, Kim Pacchiardi, Camille Vaganay, Lionel Faivre, Chaïma Benaksas, Claude Preudhomme, MD PhD, Emmanuel Raffoux, MD, Emmanuelle Clappier, PhD PharmD, Lionel Ades, MDPhD, Alexandre Puissant, PhD, Raphael Itzykson, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-137048
Published: 2020
Journal Articles

Decitabine Versus Hydroxyurea for Advanced Proliferative CMML: Results of the Emsco Randomized Phase 3 Dacota Trial

Raphael Itzykson, MD PhD, Valeria Santini, Cendrine Chaffaut, Ades Lionel, Sylvain Thepot, MD, Aristoteles Giagounidis, Margot Morabito, Nathalie Droin, Michael Luebbert, Rosa Sapena, Stanislas Nimubona, MD, Jean E. Goasguen, MD PhD, Eric Wattel, MD PhD, Gina Zini, MDPhD, Jose Miguel Torregrosa Diaz, Ulrich Germing, Anna Maria Pelizzari, Sophie Park, MD PhD, Nadja Jaekel, Georgia Metzgeroth, Francesco Onida, MD, Robert Navarro, Andrea Patriarca, MD, Aspasia Stamatoulas Bastard, MD, Martin Puttrich, Sandra Mossuto, Eric Solary, MD PhD, Silke Gloaguen, Msc, Sylvie Chevret, MD PhD, Fatiha Chermat, Uwe Platzbecker, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53–54.
https://doi.org/10.1182/blood-2020-138680
Published: 2020