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Philipp Lohneis
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Journal Articles

A Novel Autochthonous Mouse Model Serves As a Preclinical Evaluation Platform and Explores Dual BTK and BCL2 Inhibition for Activated B Cell-like Diffuse Large B Cell Lymphoma

Ruth Flümann, Pascal Nieper, Tim Lohmann, Ilmars Kisis, Martin Peifer, Nima Abedpour, Roman Thomas, Moritz Kochanek, Benedikt Pelzer, Filippo Beleggia, Reinhard Buettner, Philipp Lohneis, Thorsten Persigehl, Michael Hallek, Dinis Pedro Calado, Laura Pasqualucci, Bastian von Tresckow, Björn Chapuy, Ron Jachimowicz, Christian Reinhardt, Gero Knittel
Journal: Blood
Blood (2021) 138 (Supplement 1): 712.
https://doi.org/10.1182/blood-2021-146871
Published: 2021
Journal Articles

Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas

Maurice Reimann, Jens Schrezenmeier, Paulina Richter-Pechanska, Anna Dolnik, Timon Pablo Hick, Kolja Schleich, Xiurong Cai, Dorothy N. Y. Fan, Philipp Lohneis, Sven Maßwig, Sophy Denker, Antonia Busse, Gero Knittel, Ruth Flümann, Dorothee Childs, Liam Childs, Ana-Maria Gätjens-Sanchez, Lars Bullinger, Andreas Rosenwald, Hans Christian Reinhardt, Clemens A. Schmitt
Journal: Blood
Blood (2021) 137 (20): 2785–2799.
https://doi.org/10.1182/blood.2020005244
Published: 2021
Includes: Supplemental data
Journal Articles

Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1

Vivien Kohlhaas, Stuart James Blakemore, Mona Al-Maarri, Nadine Nickel, Martin Pal, Andreas Roth, Nadine Hövelmeyer, Stephan C. Schäfer, Gero Knittel, Philipp Lohneis, Milos Nikolic, Janica L. Wiederstein, Marek Franitza, Theodoros Georgomonolis, Nina Reinart, Marco Herling, Carmen Herling, Elena M. Hartmann, Andreas Rosenwald, Wolfram Klapper, Reinhard Büttner, Riccardo Moia, Davide Rossi, Renzo Boldorini, Gianluca Gaidano, Lukas P. Frenzel, Hans Christian Reinhardt, Jens C. Brüning, Michael Hallek, Marcus Krüger, Martin Peifer, Christian P. Pallasch, F. Thomas Wunderlich
Journal: Blood
Blood (2021) 137 (5): 646–660.
https://doi.org/10.1182/blood.2020005734
Published: 2021
Includes: Supplemental data
Journal Articles

Senescence Markers from a DLBCL-Reminiscent Mouse Lymphoma Model Predict Patient Outcome

Kolja Schleich, Julia Kase, MD, Jan R. Dörr, Saskia Trescher, Animesh Battacharya, Yong Yu, Philipp Lohneis, MD, Dido Lenze, Dorothy Ngo-Yin Fan, Michael Hummel, PhD, Ulf Leser, Clemens A. Schmitt
Journal: Blood
Blood (2018) 132 (Supplement 1): 2850.
https://doi.org/10.1182/blood-2018-99-118002
Published: 2018
Journal Articles

Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice

Dana Hoser, Christian Schön, Christoph Loddenkemper, Philipp Lohneis, Anja A. Kühl, Thomas Sommermann, Thomas Blankenstein, Gerald Willimsky
Journal: Blood
Blood (2018) 132 (9): 924–934.
https://doi.org/10.1182/blood-2018-02-834036
Published: 2018
Includes: Supplemental data
Journal Articles

DLBCL-Derived NF-κb Mutations Exploit Senescence and Immune Evasion Mechanisms to Promote Myc-Driven Lymphomagenesis

Jens F. Schrezenmeier, Maurice Reimann, Sven Masswig, Liam Childs, PhD, Dorothee Childs, PhD, Philipp Lohneis, MD, Clemens A. Schmitt
Journal: Blood
Blood (2017) 130 (Supplement 1): 2491.
https://doi.org/10.1182/blood.V130.Suppl_1.2491.2491
Published: 2017
Journal Articles

Mouse Lymphoma Model-Based Senescence Exploitation to Predict Treatment Outcome of DLBCL Patients

Kolja Schleich, PhD, Julia Kase, MD, Jan R. Dörr, Saskia Trescher, Animesh Battacharya, Yong Yu, Philipp Lohneis, MD, Dido Lenze, Dorothy Ngo-Yin Fan, Michael Hummel, PhD, Ulf Leser, Clemens A. Schmitt
Journal: Blood
Blood (2017) 130 (Supplement 1): 5133.
https://doi.org/10.1182/blood.V130.Suppl_1.5133.5133
Published: 2017
Journal Articles

Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma

Jing Du, Martin Neuenschwander, Yong Yu, J. Henry M. Däbritz, Nina-Rosa Neuendorff, Kolja Schleich, Aitomi Bittner, Maja Milanovic, Gregor Beuster, Silke Radetzki, Edgar Specker, Maurice Reimann, Frank Rosenbauer, Stephan Mathas, Philipp Lohneis, Michael Hummel, Bernd Dörken, Jens Peter von Kries, Soyoung Lee, Clemens A. Schmitt
Journal: Blood
Blood (2017) 129 (1): 71–81.
https://doi.org/10.1182/blood-2016-02-700773
Published: 2017
Includes: Supplemental data
Journal Articles

B-cell–specific conditional expression of Myd88 p.L252P leads to the development of diffuse large B-cell lymphoma in mice

Gero Knittel, Paul Liedgens, Darya Korovkina, Jens M. Seeger, Yussor Al-Baldawi, Mona Al-Maarri, Christian Fritz, Katerina Vlantis, Svetlana Bezhanova, Andreas H. Scheel, Olaf-Oliver Wolz, Maurice Reimann, Peter Möller, Cristina López, Matthias Schlesner, Philipp Lohneis, Alexander N. R. Weber, Lorenz Trümper, German International Cancer Genome Consortium Molecular Mechanisms in Malignant Lymphoma by Sequencing Project Consortium, Louis M. Staudt, Monika Ortmann, Manolis Pasparakis, Reiner Siebert, Clemens A. Schmitt, Andreas R. Klatt, F. Thomas Wunderlich, Stephan C. Schäfer, Thorsten Persigehl, Manuel Montesinos-Rongen, Margarete Odenthal, Reinhard Büttner, Lukas P. Frenzel, Hamid Kashkar, H. Christian Reinhardt
Journal: Blood
Blood (2016) 127 (22): 2732–2741.
https://doi.org/10.1182/blood-2015-11-684183
Published: 2016
Includes: Supplemental data
Journal Articles

Modeling the CNS Tropism of Diffuse Large B-Cell Lymphomas in Vivo

Maurice Reimann, Dr., Sven Masswig, Kolja Schleich, Dr., Andrea Herrmann, Philipp Lohneis, MD, Jens Schrezenmeier, Bernd Dörken, Prof., Clemens Schmitt
Journal: Blood
Blood (2015) 126 (23): 576.
https://doi.org/10.1182/blood.V126.23.576.576
Published: 2015
Journal Articles

H3K9me3-Governed Senescence In Tumor Development and Lymphoma Treatment

Julia Kase, MD, Jan Dörr, Yong Yu, Maja Milanovic, PhD, Sujuan Ji, PhD, Sandra Spiesicke-Wegener, Philipp Lohneis, MD, Bernd Dörken, Soyoung Lee, PhD, Clemens A. Schmitt, MD
Journal: Blood
Blood (2013) 122 (21): 345.
https://doi.org/10.1182/blood.V122.21.345.345
Published: 2013