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Peter J. M. Valk
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Journal Articles

RUNX1 germline variants in RUNX1 -mutant AML: how frequent?

Martijn P. T. Ernst, François G. Kavelaars, Bob Löwenberg, Peter J. M. Valk, Marc H. G. P. Raaijmakers
Journal: Blood
Blood (2021) 137 (10): 1428–1431.
DOI: https://doi.org/10.1182/blood.2020008478
Published: 2021
Includes: Supplemental data
Journal Articles

Atypical 3q26/ MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia

Sophie Ottema, Roger Mulet-Lazaro, H. Berna Beverloo, Claudia Erpelinck, Stanley van Herk, Robert van der Helm, Marije Havermans, Tim Grob, Peter J. M. Valk, Eric Bindels, Torsten Haferlach, Claudia Haferlach, Leonie Smeenk, Ruud Delwel
Journal: Blood
Blood (2020) 136 (2): 224–234.
DOI: https://doi.org/10.1182/blood.2019003701
Published: 2020
Includes: Supplemental data
Journal Articles

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

Jonas Samuel Jutzi, Titiksha Basu, Maximilian Pellmann, Sandra Kaiser, Doris Steinemann, Mathijs A. Sanders, Adil S. A. Hinai, Annelieke Zeilemaker, Sarolta Bojtine Kovacs, Christoph Koellerer, Jenny Ostendorp, Konrad Aumann, Wei Wang, Emmanuel Raffoux, Bruno Cassinat, Lars Bullinger, Brigitte Schlegelberger, Peter J. M. Valk, Heike Luise Pahl
Journal: Blood
Blood (2019) 133 (16): 1766–1777.
DOI: https://doi.org/10.1182/blood-2018-09-875047
Published: 2019
Includes: Supplemental data
Journal Articles

Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients

Friederike Christen, Kaja Hoyer, Kenichi Yoshida, Hsin-An Hou, Nils Waldhueter, Michael Heuser, Robert K. Hills, Willy Chan, Raphael Hablesreiter, Olga Blau, Yotaro Ochi, Piroska Klement, Wen-Chien Chou, Igor-Wolfgang Blau, Jih-Luh Tang, Tomasz Zemojtel, Yuichi Shiraishi, Yusuke Shiozawa, Felicitas Thol, Arnold Ganser, Bob Löwenberg, David C. Linch, Lars Bullinger, Peter J. M. Valk, Hwei-Fang Tien, Rosemary E. Gale, Seishi Ogawa, Frederik Damm
Journal: Blood
Blood (2019) 133 (10): 1140–1151.
DOI: https://doi.org/10.1182/blood-2018-05-852822
Published: 2019
Includes: Supplemental data
Journal Articles

MBD4 guards against methylation damage and germ line deficiency predisposes to clonal hematopoiesis and early-onset AML

Mathijs A. Sanders, Edward Chew, Christoffer Flensburg, Annelieke Zeilemaker, Sarah E. Miller, Adil S. al Hinai, Ashish Bajel, Bram Luiken, Melissa Rijken, Tamara Mclennan, Remco M. Hoogenboezem, François G. Kavelaars, Stefan Fröhling, Marnie E. Blewitt, Eric M. Bindels, Warren S. Alexander, Bob Löwenberg, Andrew W. Roberts, Peter J. M. Valk, Ian J. Majewski
Journal: Blood
Blood (2018) 132 (14): 1526–1534.
DOI: https://doi.org/10.1182/blood-2018-05-852566
Published: 2018
Includes: Supplemental data
Journal Articles

Therapeutic value of clofarabine in younger and middle-aged (18-65 years) adults with newly diagnosed AML

Clinical Trials & Observations
Bob Löwenberg, Thomas Pabst, Johan Maertens, Yvette van Norden, Bart J. Biemond, Harry C. Schouten, Olivier Spertini, Edo Vellenga, Carlos Graux, Violaine Havelange, Georgine E. de Greef, Okke de Weerdt, Marie-Cecile J. C. Legdeur, Juergen Kuball, Marinus van Marwijk Kooy, Bjorn T. Gjertsen, Mojca Jongen-Lavrencic, Arjan A. van de Loosdrecht, Daniëlle van Lammeren-Venema, Beata Hodossy, Dimitri A. Breems, Yves Chalandon, Jakob Passweg, Peter J. M. Valk, Markus G. Manz, Gert J. Ossenkoppele
Journal: Blood
Blood (2017) 129 (12): 1636–1645.
DOI: https://doi.org/10.1182/blood-2016-10-740613
Published: 2017
Includes: Supplemental data
Journal Articles

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

Brief Report
Philipp J. Rauch, Jana M. Ellegast, Corinne C. Widmer, Kristin Fritsch, Jeroen S. Goede, Peter J. M. Valk, Bob Löwenberg, Hitoshi Takizawa, Markus G. Manz
Journal: Blood
Blood (2016) 128 (18): 2253–2257.
DOI: https://doi.org/10.1182/blood-2016-04-711986
Published: 2016
Includes: Supplemental data
Journal Articles

Mpl Expression on AML Blasts Predicts Cytopenia

Philipp J Rauch, MD, Corinne Widmer, MD, Kristin Fritsch, MS, Jana M Ellegast, MD, Jeroen S Goede, MD, Peter J M Valk, PhD, Hitoshi Takizawa, PhD, Markus G Manz, MD
Journal: Blood
Blood (2015) 126 (23): 1387.
DOI: https://doi.org/10.1182/blood.V126.23.1387.1387
Published: 2015
Journal Articles

Divergent Dynamics of Epigenetic and Genetic Heterogeneity in Relapsed Acute Myeloid Leukemia

Francine E. Garrett-Bakelman, MD PhD, Sheng Li, PhD, Stephen S. Chung, MD, Todd Hricik, Rapaport Franck, Jay Patel, Richard Dillon, MA, MRCP, FRCPath, Priyanka Vijay, Anna L Brown, PhD, Alexander E. Perl, MD, B. Joy Cannon, Mathijs A. Sanders, PhD, Peter J M Valk, PhD, Lars Bullinger, MD, Selina Luger, MD, Michael W. Becker, MD, Ian D. Lewis, MBBS PhDFRACP FRCPA, L. Bik To, MD, Richard J D'Andrea, PhD, David Grimwade, MD PhD, Ruud Delwel, PhD, Bob Lowenberg, MD PhD, Hartmut Dohner, MD, Konstanze Dohner, MD, Duane C Hassane, PhD, Monica L. Guzman, PhD, Gail J Roboz, MD, Martin Carroll, MD, Christopher Y. Park, MD, PhD, Donna S. Neuberg, Sc.D., Ross L. Levine, MD, Christopher Mason, PhD, Ari Melnick, MD
Journal: Blood
Blood (2015) 126 (23): 306.
DOI: https://doi.org/10.1182/blood.V126.23.306.306
Published: 2015
Journal Articles

Downregulation of the Wnt inhibitor CXXC5 predicts a better prognosis in acute myeloid leukemia

Clinical Trials & Observations
Andrea Kühnl, Peter J. M. Valk, Mathijs A. Sanders, Adam Ivey, Robert K. Hills, Ken I. Mills, Rosemary E. Gale, Martin F. Kaiser, Richard Dillon, Melanie Joannides, Amanda Gilkes, Torsten Haferlach, Susanne Schnittger, Estelle Duprez, David C. Linch, Ruud Delwel, Bob Löwenberg, Claudia D. Baldus, Ellen Solomon, Alan K. Burnett, David Grimwade
Journal: Blood
Blood (2015) 125 (19): 2985–2994.
DOI: https://doi.org/10.1182/blood-2014-12-613703
Published: 2015
Includes: Supplemental data
Journal Articles

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways

Stefan Gröschel, Mathijs A. Sanders, Remco Hoogenboezem, Annelieke Zeilemaker, Marije Havermans, Claudia Erpelinck, Eric M. J. Bindels, H. Berna Beverloo, Hartmut Döhner, Bob Löwenberg, Konstanze Döhner, Ruud Delwel, Peter J. M. Valk
Journal: Blood
Blood (2015) 125 (1): 133–139.
DOI: https://doi.org/10.1182/blood-2014-07-591461
Published: 2015
Includes: Supplemental data
Journal Articles

Nras G12D oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis

Liting Xue, John A. Pulikkan, Peter J. M. Valk, Lucio H. Castilla
Journal: Blood
Blood (2014) 124 (3): 426–436.
DOI: https://doi.org/10.1182/blood-2013-12-541730
Published: 2014
Includes: Supplemental data
Journal Articles

Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling

Erdogan Taskesen, Marije Havermans, Kirsten van Lom, Mathijs A. Sanders, Yvette van Norden, Eric Bindels, Remco Hoogenboezem, Marcel J. T. Reinders, Maria E. Figueroa, Peter J. M. Valk, Bob Löwenberg, Ari Melnick, Ruud Delwel
Journal: Blood
Blood (2014) 123 (21): 3327–3335.
DOI: https://doi.org/10.1182/blood-2013-07-512855
Published: 2014
Includes: Supplemental data
Journal Articles

Gfi1 As a Novel Prognostic Marker and Tumor Suppressor In Acute Myeloid Leukemia

Judith Hönes, M.Sc., Lacramioara Botezatu, Phd, Amos Zeller, Lars C. Michel, Christian Thiede, MD, Renata Köster, Andre Görgens, Phd, Bert A. van der Reijden, Bertram Opalka, PhD, Klaus Lennartz, Peter J. M. Valk, Bernd Giebel, Karen Fischer, Basri Adiprasito, Michael Heuser, MD, Bob Löwenberg, MD, PhD, Joop H. Jansen, PhD, Gerhard Ehninger, MD, Ulrich Dührsen, MD, Cyrus Khandanpour, M.D.
Journal: Blood
Blood (2013) 122 (21): 2516.
DOI: https://doi.org/10.1182/blood.V122.21.2516.2516
Published: 2013
Journal Articles

Downregulation Of The Wnt Inhibitor CXXC5 Predicts a Better Prognosis In Acute Myeloid Leukemia

Andrea Kühnl, Peter J. M. Valk, Mathijs A. Sanders, Robert K. Hills, MA, MSc, DPhil, Ken I. Mills, PhD, Rosemary E Gale, PhD, Martin Kaiser, MD, Richard Dillon, Melanie Joannides, Adam Ivey, Amanda F Gilkes, MSc, Torsten Haferlach, MD, Susanne Schnittger, PhD, Estelle Duprez, David Linch, FMedSci, Ruud Delwel, Bob Löwenberg, MD, PhD, Claudia D. Baldus, MD, PhD, Ellen Solomon, Alan K Burnett, MD, David Grimwade, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 52.
DOI: https://doi.org/10.1182/blood.V122.21.52.52
Published: 2013
Journal Articles

PBX3 is an important cofactor of HOXA9 in leukemogenesis

Zejuan Li, Zhiyu Zhang, Yuanyuan Li, Stephen Arnovitz, Ping Chen, Hao Huang, Xi Jiang, Gia-Ming Hong, Rejani B. Kunjamma, Haomin Ren, Chunjiang He, Chong-Zhi Wang, Abdel G. Elkahloun, Peter J. M. Valk, Konstanze Döhner, Mary Beth Neilly, Lars Bullinger, Ruud Delwel, Bob Löwenberg, Paul P. Liu, Richard Morgan, Janet D. Rowley, Chun-Su Yuan, Jianjun Chen
Journal: Blood
Blood (2013) 121 (8): 1422–1431.
DOI: https://doi.org/10.1182/blood-2012-07-442004
Published: 2013
Includes: Supplemental data
Journal Articles

Prognostic and Functional Relevance of Aberrant Microrna-9/9* Expression in Acute Myeloid Leukemia.

Su Ming Sun, Katarzyna Nowek, Lars Bullinger, MD, PhD, Menno Dijkstra, Peter J. M. Valk, PhD, Hartmut Dohner, MD, Stefan J. Erkeland, PhD, Bob Lowenberg, MD, PhD, Mojca Jongen-Lavrencic, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2542.
DOI: https://doi.org/10.1182/blood.V120.21.2542.2542
Published: 2012
Journal Articles

BAALC and EVI1 Prognostic Gene Expression in Adult Acute Myeloid Leukemia Using the Amlprofiler Custom Microarray

Erik H van Beers, PhD, Jaap Brand, PhD, Martin H. van Vliet, PhD, Henk E Vietor, MD, PhD, Peter J. M. Valk, PhD, Bob Lowenberg, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 1420.
DOI: https://doi.org/10.1182/blood.V120.21.1420.1420
Published: 2012
Journal Articles

Identification of Sox4 As Key Oncogene in Leukemias with Mutated or Silenced C/EBPα

Hong Zhang, PhD, Min Ye, PhD, Meritxell Alberich-Jordà, PhD, Giovanni Amabile, PhD, Philipp B. Staber, M.D., Peter J. M. Valk, PhD, Ruud Delwel, PhD, Véronique Lefebvre, PhD, Constanze Bonifer, PhD, Daniel G. Tenen, MD
Journal: Blood
Blood (2012) 120 (21): 114.
DOI: https://doi.org/10.1182/blood.V120.21.114.114
Published: 2012
Journal Articles

The Gene Encoding Nuclear Erythroid Factor 2 (NFE2) Is Recurrently Mutated in Acute Myeloid Leukemia

Mathijs A. Sanders, Annelieke Zeilemakers, Jasper Koenders, Remco Hoogenboezem, François Kavelaars, Rob Henderson, Bob Lowenberg, MD, PhD, Peter J. M. Valk, PhD
Journal: Blood
Blood (2012) 120 (21): 1392.
DOI: https://doi.org/10.1182/blood.V120.21.1392.1392
Published: 2012