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Journal Articles

Inhibition of MAPK-ERK Signaling Pathway Overcomes Microrna-Mediated Ibrutinib Resistance in Mantle Cell Lymphoma

Olga Kersy, Mali Salmon-Divon, Maria Gomes da Silva, Ana Filipa Moita, Jose Cabecadas, Pavel Klener, Jr., Marek Trněný, May Basood, Ofer Shpilberg, Oshrat Hershkovitz-Rokah
Journal: Blood
Blood (2022) 140 (Supplement 1): 3109–3110.
DOI: https://doi.org/10.1182/blood-2022-169574
Published: 2022
Journal Articles

BCL-XL Blockage with A1155463 Significantly Increases Efficacy of Venetoclax in Mantle Cell Lymphoma in Vitro and In Vivo

Alexandra Dolníková, Dmitry Kazantsev, Diana Malarikova, Eva Pokorna, Dana Sovilj, Cristina Daniela Kelemen, Ladislav Andera, Marek Trněný, Pavel Klener, Jr.
Journal: Blood
Blood (2022) 140 (Supplement 1): 6383–6384.
DOI: https://doi.org/10.1182/blood-2022-170109
Published: 2022
Journal Articles

Sequencing-Based Analysis of Clonal Evolution of 25 Mantle Cell Lymphoma Patients at Diagnosis and after Failure of Standard Immunochemotherapy

Jana Karolova, Dmitry Kazantsev, Michael Svaton, Liliana Tušková, Kristina Forsterova, Diana Malarikova, Katerina Benesova, Tomáš Heizer, Alexandra Dolníková, Magdalena Klanova, Eva Fronkova, Marek Trněný, Pavel Klener, Jr.
Journal: Blood
Blood (2022) 140 (Supplement 1): 6409–6410.
DOI: https://doi.org/10.1182/blood-2022-166069
Published: 2022
Journal Articles

Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib Synergizes with BH3-Mimetics in Experimental Models of Relapsed/Refractory Mantle Cell Lymphoma

Diana Malarikova, Radek Jorda, Alexandra Dolníková, Ondrej Havranek, Eva Pokorna, Dmitry Kazantsev, Dana Sovilj, Karel Helman, Magdalena Klanova, Ladislav Andera, Miroslav Strnad, David Chiron, Marek Trneny, Pavel Klener, Jr.
Journal: Blood
Blood (2022) 140 (Supplement 1): 5996–5997.
DOI: https://doi.org/10.1182/blood-2022-168617
Published: 2022
Journal Articles

How Relevant Are the Control Cohorts of Clinical Trials in Patients with Newly Diagnosed DLBCL in a Daily Practice?

Prokop Vodicka, Katerina Benesova, Andrea Janikova, David Belada, Heidi Mocikova, Jan Pirnos, Vit Prochazka, Juraj Duras, Katerina Kopeckova, Katerina Steinerova, Petra Blahovcova, Vit Campr, Pavel Klener, Jr., Alice Sykorova, Marek Trneny
Journal: Blood
Blood (2022) 140 (Supplement 1): 3775–3776.
DOI: https://doi.org/10.1182/blood-2022-159408
Published: 2022
Journal Articles

Ibrutinib improves survival compared with chemotherapy in mantle cell lymphoma with central nervous system relapse

Clinical Trials & Observations
Chiara Rusconi, Chan Y. Cheah, Toby A. Eyre, David Tucker, Pavel Klener, Eva Giné, Lara Crucitti, Cristina Muzi, Sara Iadecola, Gabriele Infante, Sophie Bernard, Rebecca L. Auer, Chiara Pagani, Monika Duglosz-Danecka, Heidi Mocikova, Tom van Meerten, Emanuele Cencini, Ana Marin-Niebla, Michael E. Williams, Piera Angelillo, Paolo Nicoli, Annalisa Arcari, Lucia Morello, Donato Mannina, Orsola Vitagliano, Roberto Sartori, Annalisa Chiappella, Roberta Sciarra, Piero M. Stefani, Martin Dreyling, John F. Seymour, Carlo Visco
Journal: Blood
Blood (2022) 140 (17): 1907–1916.
DOI: https://doi.org/10.1182/blood.2022015560
Published: 2022
Includes: Supplemental data
Journal Articles

Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib Synergizes with BCL2 Inhibitor Venetoclax in Experimental Models of Chemotherapy Refractory Mantle Cell Lymphoma

Diana Malarikova, Radek Jorda, Alexandra Dolnikova, Eva Pokorna, Dmitry Kazantsev, Ondrej Havranek, Karel Helman, Magdalena Klanova, Miroslav Strnad, Marek Trneny, Pavel Klener, Jr.
Journal: Blood
Blood (2021) 138 (Supplement 1): 1203.
DOI: https://doi.org/10.1182/blood-2021-150517
Published: 2021
Journal Articles

Combination Benefit of Capivasertib and Venetoclax in Preclinical Models of Diffuse Large B-Cell Lymphoma

Brandon Willis, India Neveras, Hannah Dry, Wendan Xu, Yang Li, Kevin Mongeon, Justine Roderick, Alan Rosen, Pavel Klener, Jr., Georg Lenz, Jerome Mettetal, Simon Barry
Journal: Blood
Blood (2021) 138 (Supplement 1): 1870.
DOI: https://doi.org/10.1182/blood-2021-153711
Published: 2021
Journal Articles

Ibrutinib in Mantle Cell Lymphoma Patients: Analysis of the Czech Lymphoma Study Group

Aleš Obr, Pavel Klener, Jr., Andrea Janíková, Heidi Mocikova, David Belada, David Šálek, Alice Sýkorová, Andrea Jirkuvová, Tomáš Papajík, Marek Trněný
Journal: Blood
Blood (2021) 138 (Supplement 1): 4526.
DOI: https://doi.org/10.1182/blood-2021-146589
Published: 2021
Journal Articles

Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL

Anja Schmitt, Wendan Xu, Philip Bucher, Melanie Grimm, Martina Konantz, Heike Horn, Myroslav Zapukhlyak, Philipp Berning, Marc Brändle, Mohamed-Ali Jarboui, Caroline Schönfeld, Karsten Boldt, Andreas Rosenwald, German Ott, Michael Grau, Pavel Klener, Petra Vockova, Claudia Lengerke, Georg Lenz, Klaus Schulze-Osthoff, Stephan Hailfinger
Journal: Blood
Blood (2021) 138 (10): 871–884.
DOI: https://doi.org/10.1182/blood.2020009404
Published: 2021
Includes: Supplemental data
Journal Articles

Targeting chronic NFAT activation with calcineurin inhibitors in diffuse large B-cell lymphoma

Philip Bucher, Tabea Erdmann, Paula Grondona, Wendan Xu, Anja Schmitt, Christoph Schürch, Myroslav Zapukhlyak, Caroline Schönfeld, Edgar Serfling, Daniela Kramer, Michael Grau, Pavel Klener, Claudia Lengerke, Klaus Schulze-Osthoff, Georg Lenz, Stephan Hailfinger
Journal: Blood
Blood (2020) 135 (2): 121–132.
DOI: https://doi.org/10.1182/blood.2019001866
Published: 2020
Includes: Supplemental data
Journal Articles

High TP53 Mutation Load Predicts Primary Refractory Mantle Cell Lymphoma

Aleš Obr, MD PhD, Pavel Klener, Jr., Eva Kriegova, Dr, assoc prof, Zuzana Zemanova, PhD, Helena Urbankova, MSc, PhD, Andrea Jirkuvova, MD, Anna Petrackova, MSc, Barbora Cudova, Lenka Sedlarikova, MSc, VIT K Prochazka, MD, Tomas Papajik, MD prof, Marek Trneny, MD prof
Journal: Blood
Blood (2019) 134 (Supplement_1): 3995.
DOI: https://doi.org/10.1182/blood-2019-123812
Published: 2019
Journal Articles

Role of Angiogenesis and Anti-Angiogenic Treatment Strategies in Mantle Cell Lymphoma

Petra Vockova, MD, Magdalena Klanova, MD PhD, Jan Molinsky, MD PhD, Diana Tuskova, MD, Bokang Calvin Maswabi, MD PhD, Radek Jaksa, MD, Marek Trneny, MD CSc, Pavel Klener, Jr.
Journal: Blood
Blood (2018) 132 (Supplement 1): 1672.
DOI: https://doi.org/10.1182/blood-2018-99-116874
Published: 2018
Journal Articles

Co-Targeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Refractory Mantle Cell Lymphoma with Complex Karyotype Changes

Pavel Klener, Jr., Marek Trněný, Ladislav Andera, MSc, PhD, Zuzana Nahacka, MSc, Magdalena Klanova, MD PhD, Jana Karolova, MD, Michael Svaton, MD, Ondrej Havranek, MDPhD, Jan Soukup, MD, Zuzana Zemanova, PhD, Diana Tuskova, MD, Eva Pokorna, Kristina Forsterova, MSc, PhD, Petra Vockova, MD, Eva Fronkova, MD PhD, Dana Prukova, Ing, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 42.
DOI: https://doi.org/10.1182/blood-2018-99-112437
Published: 2018
Journal Articles

Rituximab Maintenance Failure in Mantle Cell Lymphoma Is Associated with High Risk of Death: Analysis of the Czech Lymphoma Study Group (CLSG)

Aleš Obr, MD, Vit Prochazka, MD PhD Assoc Prof, Tomas Papajik, MD PhD prof., Pavel Klener, Jr., MD PhD Assoc Prof, Andrea Janikova, MD PhD Assoc Prof, David Salek, MD PhD, David Belada, MD PhD, Robert Pytlik, Alice Sýkorová, MD PhD, Heidi Mocikova, MD PhD, Martin Simkovic, MD PhD, Vit Campr, MD PhD, Jitka Dlouha, Tomas Fuerst, MSc, PhD, Marek Trněný, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1498.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1498.1498
Published: 2017
Journal Articles

Destiny of Elderly Patients with Lymphoma Indicated for Autologous Stem Cell Transplantation (ASCT)

Robert Pytlik, Kamila Polgarova, MD, Marie Trnkova, Mgr, Pavel Klener, Jr., MD PhD Assoc Prof, Petra Blahovcova, Mgr, Blanka Vackova, MD, Eva Konířová, MD, Benešová Kateřina, MD PhD, Marek Trněný, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3289.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3289.3289
Published: 2017
Journal Articles

Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL

Tabea Erdmann, Pavel Klener, James T. Lynch, Michael Grau, Petra Vočková, Jan Molinsky, Diana Tuskova, Kevin Hudson, Urszula M. Polanska, Michael Grondine, Michele Mayo, Beiying Dai, Matthias Pfeifer, Kristian Erdmann, Daniela Schwammbach, Myroslav Zapukhlyak, Annette M. Staiger, German Ott, Wolfgang E. Berdel, Barry R. Davies, Francisco Cruzalegui, Marek Trneny, Peter Lenz, Simon T. Barry, Georg Lenz
Journal: Blood
Blood (2017) 130 (3): 310–322.
DOI: https://doi.org/10.1182/blood-2016-12-758599
Published: 2017
Includes: Supplemental data
Journal Articles

B-cell receptor–driven MALT1 activity regulates MYC signaling in mantle cell lymphoma

Beiying Dai, Michael Grau, Mélanie Juilland, Pavel Klener, Elisabeth Höring, Jan Molinsky, Gisela Schimmack, Sietse M. Aukema, Eva Hoster, Niklas Vogt, Annette M. Staiger, Tabea Erdmann, Wendan Xu, Kristian Erdmann, Nicole Dzyuba, Hannelore Madle, Wolfgang E. Berdel, Marek Trneny, Martin Dreyling, Korinna Jöhrens, Peter Lenz, Andreas Rosenwald, Reiner Siebert, Alexandar Tzankov, Wolfram Klapper, Ioannis Anagnostopoulos, Daniel Krappmann, German Ott, Margot Thome, Georg Lenz
Journal: Blood
Blood (2017) 129 (3): 333–346.
DOI: https://doi.org/10.1182/blood-2016-05-718775
Published: 2017
Includes: Supplemental data
Journal Articles

Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Is a New Biomarker for Mantle Cell Lymphoma: Expression, Localization, and Phosphorylation Study

Tomas Stopka, MD PhD, Jarmila Vargova, MSc, Karina Vargova, PhD, Nina Dusilkova, MD, Vojtech Kulvait, MSc, Vit Pospisil, PhD, Jiri Zavadil, PhD, Marek Trneny, Pavel Klener, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1767.
DOI: https://doi.org/10.1182/blood.V128.22.1767.1767
Published: 2016
Journal Articles

Population-Based Analysis of Elderly Patients (>70 YEARS) with Peripheral T-CELL Lymphoma: A Results from Czech Lymphoma Study Group (CLSG) Registry

Andrea Janikova, MD PhD, Assoc Prof, Robert Pytlik, MD, Pavel Klener, MD PhD, Zbynek Bortlicek, PhD, Vit Campr, MD PhD, Natasa Kopalova, Mgr, Katerina Benesova, MD PhD, Michaela Hamouzova, David Belada, MDPhD, Vit Prochazka, MD PhD ass. prof., Jan Pirnos, MD, Juraj Duras, MD, Heidi Mocikova, MD, PhD, Jiri Mayer, MD, Marek Trneny
Journal: Blood
Blood (2016) 128 (22): 3000.
DOI: https://doi.org/10.1182/blood.V128.22.3000.3000
Published: 2016