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Patricia Arreba-Tutusaus
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Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

Single-Cell Transcriptomic Profiling of De Novo and Relapsed Acute Myeloid Leukemia Identifies a Leukemic Stemness Program Shared across Diverse Phenotypes

Samantha Worme, BSc, Selin Jessa, BSc, William Poon, BSc, Maja Jankovic, MSc, Gabriela Galicia Vazquez, PhD, Alexandre Bazinet, MD, Katharine Fooks, BSc, Isabella Iasenza, BSc, Patricia Arreba-Tutusaus, PhD, Kolja Eppert, PhD, Ioannis Ragoussis, PhD, Yu Chang Wang, PhD, Nathalie A Johnson, MD PhD, Sarit E Assouline, MD MSc, Claudia L Kleinman, PhD, François E Mercier, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-143221
Published: 2020
Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Tina M. Schnoeder, PhD, Adrian Schwarzer, MD PhD, Florian Perner, MD, Joanna Kirkpatrick, Anna Dolnik, Konstanze Döhner, Patricia Arreba-Tutusaus, PhD, Salam A. Assi, PhD, Claudia Bruedigam, PhD, Carolin Kathner, Theresa Eifert, Marcus Buschbeck, PhD, Monica Nafria I Fedi, Anetta Ptasinska, PhD, Andrew Elefanty, Elizabeth Ng, Holger Bierhoff, PhD, Florian Gras, MD, Georg Matziolis, MD, Klaus-Dieter Fischer, Olaf Heidenreich, Steven W. Lane, MD PhD, Lars Bullinger, Björn von Eyss, PhD, Alessandro Ori, PhD, Constanze Bonifer, PhD, Florian H. Heidel
Journal: Blood
Blood (2019) 134 (Supplement_1): 531.
https://doi.org/10.1182/blood-2019-121996
Published: 2019
Journal Articles

Functional Impact of MacroH2A Histone Variants in Acute Myeloid Leukemia

Chen Jen Hsu, MSc, Tina M. Schnoeder, PhD, Patricia Arreba-Tutusaus, PhD, Maximilian Lassi, Raffaele Teperino, Stefan Dimitrov, Marcus Buschbeck, PhD, Florian H. Heidel, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1250.
https://doi.org/10.1182/blood-2019-122099
Published: 2019
Journal Articles

Myeloid Leukemia Stem Cells Depend on Phospholipase C Gamma 1 (Plcg1) Signaling

Tina M. Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, BS, Juliane Mohr, PhD, Soenke Weinert, PhD, Stephanie Frey, Anja Sammt, Lars Bullinger, MD, Florian H. Heidel, MD
Journal: Blood
Blood (2016) 128 (22): 1202.
https://doi.org/10.1182/blood.V128.22.1202.1202
Published: 2016
Journal Articles

Distinct Biological and Transcriptional Features Of FLT3-ITD Variants In Vitro and In Vivo

Patricia Arreba-Tutusaus, M.Sc, Lars Bullinger, MD, PhD, Anja Polanetzki, Tina M Schnoeder, PhD, Raghavan V. Thangapandi, M.Sc., Konstanze Döhner, MD, Thomas Fischer, M.D. Ph.D., Florian H Heidel, MD
Journal: Blood
Blood (2013) 122 (21): 481.
https://doi.org/10.1182/blood.V122.21.481.481
Published: 2013
Journal Articles

Epo-Induced Erythroid Maturation Is Dependent On Plcγ1 Signalling

Tina M Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, Inga Griehl, cand. med., Lars Bullinger, MD, PhD, Konstanze Doehner, MD, Christoph Plass, PhD, Daniel B Lipka, MD, Florian H Heidel, MD, Thomas Fischer, M.D. Ph.D.
Journal: Blood
Blood (2013) 122 (21): 1182.
https://doi.org/10.1182/blood.V122.21.1182.1182
Published: 2013
Journal Articles

Identification of Phospholipase C Gamma 1 As a Key Regulator of Erythropoiesis

Tina M Schnoeder, PhD, Patricia Arreba-Tutusaus, MSc, Inga Griehl, cand. med., Daniel B Lipka, MD, Florian H Heidel, MD, Thomas Fischer, MD
Journal: Blood
Blood (2012) 120 (21): 4744.
https://doi.org/10.1182/blood.V120.21.4744.4744
Published: 2012
Journal Articles

Inactivation of the Cell Fate Determinate Llgl1 (Lethal Giant Larvae Homolog 1) Leads to Enhanced HSC Fitness and Predicts a Poor Prognosis in AML.

Florian H Heidel, MD, Lars Bullinger, MD, PhD, Zhu Wang, Patricia Arreba-Tutusaus, MSc, Carsten Hirt, MD, Dietger Niederwieser, MD, Konstanze Dohner, MD, PhD, Thomas Fischer, MD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2293.
https://doi.org/10.1182/blood.V120.21.2293.2293
Published: 2012
Journal Articles

Location of FLT3 -ITDs within the beta1-Sheet of FLT3 Kinase Confers Resistance to Tyrosine Kinase Inhibitors (TKI) in Vitro .

Thomas S. Mack, MSc, Patricia Arreba-Tutusaus, MSc, Tina M Schnoeder, PhD, Florian H Heidel, MD, Thomas Fischer, MD
Journal: Blood
Blood (2012) 120 (21): 2440.
https://doi.org/10.1182/blood.V120.21.2440.2440
Published: 2012