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Olaf Heidenreich
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Journal Articles

Inhibition of the Menin-MLL1 Interaction in MLL -Rearranged Primary Mixed-Phenotype Acute Leukemia Samples Promotes Leukemic Differentiation

Katarzyna Szoltysek, Rachel L. Cameron, Anja Krippner-Heidenreich, Milad Rasouli, Jayne Y. Hehir-Kwa, Elizabeth K. Schweighart, Minoo Ashtiani, Janine Stutterheim, Josef Vormoor, Olaf Heidenreich
Journal: Blood
Blood (2022) 140 (Supplement 1): 9191.
DOI: https://doi.org/10.1182/blood-2022-166326
Published: 2022
Journal Articles

Dual Targeting of MDM2 and BCL2/Bclxl Demonstrates Potent Synergistic Activity in High-Risk Adult Acute Lymphoblastic Leukemia

Hayden L Bell, Mankaran Singh, Helen J Blair, Olaf Heidenreich, Frederik W. van Delft, Anthony V. Moorman, John Lunec, Julie Irving
Journal: Blood
Blood (2022) 140 (Supplement 1): 9181–9182.
DOI: https://doi.org/10.1182/blood-2022-159573
Published: 2022
Journal Articles

Epigenetic regulator genes direct lineage switching in  MLL/AF4 leukemia

Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
Journal: Blood
Blood (2022) 140 (17): 1875–1890.
DOI: https://doi.org/10.1182/blood.2021015036
Published: 2022
Includes: Supplemental data
Journal Articles

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M. Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Döhner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A. Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G. Kellaway, Anetta Ptasinska, Elizabeth S. Ng, Edouard G. Stanley, Andrew G. Elefanty, Marcus Buschbeck, Holger Bierhoff, Steffen Brodt, Georg Matziolis, Klaus-Dieter Fischer, Andreas Hochhaus, Chun-Wei Chen, Olaf Heidenreich, Matthias Mann, Steven W. Lane, Lars Bullinger, Alessandro Ori, Björn von Eyss, Constanze Bonifer, Florian H. Heidel
Journal: Blood
Blood (2022) 139 (7): 1080–1097.
DOI: https://doi.org/10.1182/blood.2021012778
Published: 2022
Includes: Supplemental data
Journal Articles

To switch or not to switch: PU.1 expression is the question

Julie A. I. Thoms, John E. Pimanda, Olaf Heidenreich
Journal: Blood
Blood (2021) 138 (15): 1289–1291.
DOI: https://doi.org/10.1182/blood.2021012112
Published: 2021
Journal Articles

Venetoclax and dexamethasone synergize with inotuzumab ozogamicin–induced DNA damage signaling in B-lineage ALL

Brief Report
Hanna Kirchhoff, Uemran Karsli, Caroline Schoenherr, Karin Battmer, Sergej Erschow, Steven R. Talbot, Doris Steinemann, Michael Heuser, Olaf Heidenreich, Denise Hilfiker-Kleiner, Arnold Ganser, Matthias Eder, Michaela Scherr
Journal: Blood
Blood (2021) 137 (19): 2657–2661.
DOI: https://doi.org/10.1182/blood.2020008544
Published: 2021
Includes: Supplemental data
Journal Articles

Loss of Phospholipase C Gamma 1 (PLCG1) Impairs AML1-ETO Induced Leukemia Stem Cell Self-Renewal

Tina M. Schnoeder, PhD, Adrian Schwarzer, MD PhD, Florian Perner, MD, Joanna Kirkpatrick, Anna Dolnik, Konstanze Döhner, Patricia Arreba-Tutusaus, PhD, Salam A. Assi, PhD, Claudia Bruedigam, PhD, Carolin Kathner, Theresa Eifert, Marcus Buschbeck, PhD, Monica Nafria I Fedi, Anetta Ptasinska, PhD, Andrew Elefanty, Elizabeth Ng, Holger Bierhoff, PhD, Florian Gras, MD, Georg Matziolis, MD, Klaus-Dieter Fischer, Olaf Heidenreich, Steven W. Lane, MD PhD, Lars Bullinger, Björn von Eyss, PhD, Alessandro Ori, PhD, Constanze Bonifer, PhD, Florian H. Heidel
Journal: Blood
Blood (2019) 134 (Supplement_1): 531.
DOI: https://doi.org/10.1182/blood-2019-121996
Published: 2019
Journal Articles

The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia

Shalini Sankar, Miriam Guillen Navarro, Frida Ponthan, PhD, Simon Bomken, MD, Sirintra Nakjang, Vasily Grinev, PhD, Hesta McNeill, Michel C Zwaan, MD PhD, Josef Vormoor, MD PhD, Ronald W. Stam, PhD, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 1237.
DOI: https://doi.org/10.1182/blood-2019-124787
Published: 2019
Journal Articles

Mutant TET2 Allele Dosage Affects Response to 5-Azacitidine in Acute Myeloid Leukemia

Friedrich Stoelzel, MD, Sarah Elizabeth Fordham, PhD BSc, Wei Yu Lin, PhD, Helen Blair, PhD, Leo Ruhnke, MD, Desireé Kunadt, MD, Brigitte Mohr, PhD, Claire Elstob, PhD, Daniel Allsop, MD, Devi Nandana, BSc, Emmanouela-Niki Soura, MPhil, Catherine Park, PhD, Mohd Fadly, PhD, Thahira Rahman, PhD, Olaf Heidenreich, Heidi Altmann, PhD, Gail Jones, MD, Tobias Menne, MD PhD, Manja Wobus, PhD, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Helen Marr, PhD, Kenan Onel, MD PhD, Manja Meggendorfer, PhD, Torsten Haferlach, MD, Martin Bornhäuser, MD, James M. Allan
Journal: Blood
Blood (2019) 134 (Supplement_1): 113.
DOI: https://doi.org/10.1182/blood-2019-123047
Published: 2019
Journal Articles

Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

Katarzyna Szoltysek, PhD, Helen Blair, Sirintra Nakjang, Ricky Tirtakusuma, Mankaran Singh, Ryan Nelson, Hesta McNeill, Catherine Dodd, Melanie Beckett, Lynsey McKenzie, Edward Law, Josef Vormoor, MD PhD, Deepali Pal, Olaf Heidenreich
Journal: Blood
Blood (2019) 134 (Supplement_1): 3952.
DOI: https://doi.org/10.1182/blood-2019-124818
Published: 2019
Journal Articles

Optimized Induction of Mitochondrial Apoptosis By Combination Therapies with Venetoclax for Chemotherapy-Free Treatment of BCR-ABL + Acute Lymphoblastic Leukemia in Preclinical Models

Matthias Eder, MD, Hanna Kirchhoff, Karin Battmer, Katharina Wohlan, Melanie Ricke-Hoch, PhD, Sergej Erschow, Edward Law, PhD, Arnold Kloos, Michael Heuser, MD, Arnold Ganser, MD, Denise Hilfiker-Kleiner, PhD, Olaf Heidenreich, PhD, Michaela Scherr, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4025.
DOI: https://doi.org/10.1182/blood-2018-99-114463
Published: 2018
Journal Articles

Inhibition of ATR in Combination with Nucleoside Analogues Eradicates Acute Myeloid Leukaemia in an Orthotopic Murine Xenograft Model

Sarah E Fordham, PhD, Helen J Blair, PhD, Claire J Elstob, PhD, Deepali Pal, PhD, Nicola Curtin, PhD, Paul Milne, PhD, Matthew Collin, MD PhD, Graham H Jackson, MD MBBS, Helen J Marr, MD PhD, Olaf Heidenreich, PhD, Ruth Plummer, John Pollard, PhD, Tobias F. Menne, MD PhD FRCPath, Gail L Jones, MD BMBS, James M Allan, DPhil
Journal: Blood
Blood (2016) 128 (22): 4031.
DOI: https://doi.org/10.1182/blood.V128.22.4031.4031
Published: 2016
Journal Articles

Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

Lynsey McKenzie, PhD, Natalia Martinez-Soria, PhD, Julia Draper, DPhil, Sirintra Nakjang, PhD, Helen J Blair, PhD, Christian Wichmann, MD, Josef Vormoor, MD FRCPCH, Constanze Bonifer, PhD, Georges Lacaud, PhD, Olaf Heidenreich, PhD
Journal: Blood
Blood (2016) 128 (22): 835.
DOI: https://doi.org/10.1182/blood.V128.22.835.835
Published: 2016
Journal Articles

The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Mark T. S. Williams, Yasar M. Yousafzai, Alex Elder, Klaus Rehe, Simon Bomken, Liron Frishman-Levy, Sigal Tavor, Paul Sinclair, Katie Dormon, Dino Masic, Tracey Perry, Victoria J. Weston, Pamela Kearns, Helen Blair, Lisa J. Russell, Olaf Heidenreich, Julie A. E. Irving, Shai Izraeli, Josef Vormoor, Gerard J. Graham, Christina Halsey
Journal: Blood
Blood (2016) 127 (16): 1998–2006.
DOI: https://doi.org/10.1182/blood-2015-08-665034
Published: 2016
Includes: Supplemental data
Journal Articles

High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity

Alex Elder, PhD, Helen Blair, PhD, Katherine Dormon, Simon Bomken, PhD MBBS, Simon J Cockell, PhD, Olaf Heidenreich, PhD, Josef Vormoor, MD FRCPCH
Journal: Blood
Blood (2015) 126 (23): 844.
DOI: https://doi.org/10.1182/blood.V126.23.844.844
Published: 2015
Journal Articles

A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

Katherine Dormon, MSci, Elda S Latif, PhD, Matthew Bashton, PhD, Deepali Pal, PhD, Matthew Selby, MSci, Helen Blair, PhD, Vikki Rand, PhD, Andrew G Hall, PhD, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD
Journal: Blood
Blood (2015) 126 (23): 2619.
DOI: https://doi.org/10.1182/blood.V126.23.2619.2619
Published: 2015
Journal Articles

A Targeted Functional Clone Tracking Assay for the Identification of Tumour Suppressor Genes in BCP- ALL Implicates the Transcription Factors FOXO3 and PRDM1

Paul Sinclair, PhD, Joanna Cheng, Prahlad Raninga, Rebecca Hanna, Shaun Hollern, Amir Enshaei, PhD, Helen Blair, PhD, Sirintra Nakjang, Sarra Ryan, PhD, Jeyanthy Eswaran, PhD, Lars Buechler, Olaf Heidenreich, PhD, Christine Harrison, PhDFRCPath FMedSci
Journal: Blood
Blood (2015) 126 (23): 2449.
DOI: https://doi.org/10.1182/blood.V126.23.2449.2449
Published: 2015
Journal Articles

Identification of a Dynamic Core Transcriptional Network in t(8;21) AML Regulating Differentiation Block and Self-Renewal

Anetta Ptasinska, PhD, Salam Assi, PhD, Natalia Martinez-Soria, PhD, Maria Rosaria Imperato, PhD, Jason Piper, PhD, Pierre Cauchy, PhD, Anna Pickin, Sally James, PhD, Maarten Hoogenkamp, PhD, Daniel G Tenen, MD, Sascha Ott, PhD, David R Westhead, PhD, Peter N Cockerill, PhD, Olaf Heidenreich, PhD, Constanze Bonifer, PhD
Journal: Blood
Blood (2014) 124 (21): 1061.
DOI: https://doi.org/10.1182/blood.V124.21.1061.1061
Published: 2014
Journal Articles

Development of in Vivo Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing

Natalie Bell, PhD, Helen J Blair, PhD, Josef Vormoor, MD FRCPCH, Chris Bacon, MBChB, PhD, Vikki Rand, PhD, Olaf Heidenreich, PhD, Simon Bomken, PhD MBBS
Journal: Blood
Blood (2014) 124 (21): 5501.
DOI: https://doi.org/10.1182/blood.V124.21.5501.5501
Published: 2014
Journal Articles

A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL

Frida Ponthan, PhD, Simon Bomken, PhD MBBS, Deepali Pal, PhD, Alex Elder, PhD, Hesta McNeill, Josef Vormoor, MD FRCPCH, Olaf Heidenreich, PhD
Journal: Blood
Blood (2014) 124 (21): 2390.
DOI: https://doi.org/10.1182/blood.V124.21.2390.2390
Published: 2014