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Nobutaka Kiyokawa
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Journal Articles

Safety and Efficacy of Arsenic Trioxide in the Treatment of Newly Diagnosed Pediatric Acute Promyelocytic Leukemia: Results from the JPLSG AML-P13 Study

Hiroyuki Takahashi, Shiro Tanaka, Yuki Yuza, Yuka Iijima-Yamashita, Daisuke Hasegawa, Hiroshi Moritake, Kiminori Terui, Shotaro Iwamoto, Akira Shimada, Jun Matsubayashi, Takao Deguchi, Yoshiko Hashii, Nobutaka Kiyokawa, Hayato Miyachi, Akiko Moriya Saito, Takashi Taga, Souichi Adachi, Daisuke Tomizawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 6160–6161.
DOI: https://doi.org/10.1182/blood-2022-162177
Published: 2022
Journal Articles

Prognosis of Pediatric Acute Myeloid Leukemia with KMT2A-MLLT3 According to DNA Methylation Patterns: Jccg JPLSG AML-05 Study

Genki Yamato, Tomoko Kawai, Norio Shiba, Yusuke Hara, Kentaro Ohki, Taeko Kaburagi, Etsuko Ishikita, Hirohide Kawasaki, Kenichi Yoshida, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Akira Shimada, Manabu Sotomatsu, Takumi Takizawa, Souichi Adachi, Takashi Taga, Keizo Horibe, Seishi Ogawa, Kenichiro Hata, Yasuhide Hayashi
Journal: Blood
Blood (2022) 140 (Supplement 1): 9134–9135.
DOI: https://doi.org/10.1182/blood-2022-163226
Published: 2022
Journal Articles

Evaluation of High-Dose Cytarabine Induction Therapy and Flow Cytometric Measurable Residual Disease Monitoring for Children with De Novo Acute Myeloid Leukemia: A Report from the JPLSG-AML-12 Trial

Daisuke Tomizawa, Shiro Tanaka, Shotaro Iwamoto, Hidefumi Hiramatsu, Jun Matsubayashi, Daisuke Hasegawa, Hiroshi Moritake, Daiichiro Hasegawa, Kiminori Terui, Asahito Hama, Shin-ichi Tsujimoto, Nobutaka Kiyokawa, Hayato Miyachi, Takao Deguchi, Yoshiko Hashii, Yuka Iijima-Yamashita, Tomohiko Taki, Yasushi Noguchi, Kazutoshi Koike, Katsuyoshi Koh, Yuki Yuza, Akiko Moriya Saito, Keizo Horibe, Takashi Taga, Souichi Adachi
Journal: Blood
Blood (2022) 140 (Supplement 1): 1450–1452.
DOI: https://doi.org/10.1182/blood-2022-158664
Published: 2022
Journal Articles

Chemotherapy with the Use of TKIs Based on MRD Has the Potential to Avoid Hematopoietic Stem Cell Transplantation in Treatment for Children with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL). Results of the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Study ALL-Ph13

Atsushi Sato, Hirohide Kawasaki, Takao Deguchi, Yoshiko Hashii, Yuka Iijima-Yamashita, Sachiko Yonezawa, Chiyo K Imamura, Haruko Shima, Hirotoshi Sakaguchi, Yuichi Kodama, Keisuke Kato, Motohiro Kato, Hidefumi Hiramatsu, Nobutaka Kiyokawa, Akiko Kada, Akiko M Saito, Keizo Horibe, Atsushi Manabe, Hiroyuki Shimada
Journal: Blood
Blood (2021) 138 (Supplement 1): 3394.
DOI: https://doi.org/10.1182/blood-2021-148264
Published: 2021
Journal Articles

Impact of Nelarabine, Intensive L-Asparaginase, and Protracted Intrathecal Therapy on Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia: Results from the Japanese Pediatric Leukemia/Lymphoma Study Group and the Japan Adult Leukemia Study Group

Atsushi Sato, Yoshihiro Hatta, Chihaya Imai, Koichi Oshima, Yasuhiro Okamoto, Takao Deguchi, Yoshiko Hashii, Takashi Fukushima, Toshinori Hori, Nobutaka Kiyokawa, Motohiro Kato, Shoji Saito, Kenichi Anami, Tatsuhiro Sakamoto, Akiko Kada, Akiko M Saito, Atsushi Manabe, Hitoshi Kiyoi, Itaru Matsumura, Keizo Horibe, Katsuyoshi Koh, Yasushi Miyazaki, Arata Watanabe
Journal: Blood
Blood (2021) 138 (Supplement 1): 3393.
DOI: https://doi.org/10.1182/blood-2021-149110
Published: 2021
Journal Articles

Clonal Evolution Pattern and Prognostic Significance of Clonal Architecture in KMT2A -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, Kenichi Yoshida, Yasuhito Nannya, Yuri Ito, Shoji Saito, Yuhki Koga, Hiroshi Moritake, Kiminori Terui, Koji Kawaguchi, Yasuhiro Okamoto, Hideki Nakayama, Kanno Miyako, Moeko Hino, Yusuke Akane, Akiko Inoue, Akira Shimada, Hiroaki Goto, Hiroo Ueno, Junko Takita, Genki Yamato, Norio Shiba, Yasuhide Hayashi, Yuichi Shiraishi, Satoru Miyano, Nobutaka Kiyokawa, Daisuke Tomizawa, Takashi Taga, Akio Tawa, Seishi Ogawa, Souichi Adachi
Journal: Blood
Blood (2021) 138 (Supplement 1): 2358.
DOI: https://doi.org/10.1182/blood-2021-146699
Published: 2021
Journal Articles

Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL

Atsushi Watanabe, Kunio Miyake, Jessica Nordlund, Ann-Christine Syvänen, Louise van der Weyden, Hiroaki Honda, Norimasa Yamasaki, Akiko Nagamachi, Toshiya Inaba, Tomokatsu Ikawa, Kevin Y. Urayama, Nobutaka Kiyokawa, Akira Ohara, Shunsuke Kimura, Yasuo Kubota, Junko Takita, Hiroaki Goto, Kimiyoshi Sakaguchi, Masayoshi Minegishi, Shotaro Iwamoto, Tamao Shinohara, Keiko Kagami, Masako Abe, Koshi Akahane, Kumiko Goi, Kanji Sugita, Takeshi Inukai
Journal: Blood
Blood (2020) 136 (20): 2319–2333.
DOI: https://doi.org/10.1182/blood.2019004090
Published: 2020
Includes: Supplemental data
Journal Articles

KRAS mutations Frequently Coexist with High-Risk MLL Fusions and Are Independent Adverse Prognostic Factors in MLL -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, Kenichi Yoshida, MDPhD, Kana Nakatani, Yutarou Harata, Moe Higashitani, Yuri Ito, Yasuhiko Kamikubo, Yusuke Shiozawa, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, Hiroko Tanaka, BA, Ai Okada, Yasuhito Nannya, MD PhD, June Takeda, MD, Hiroo Ueno, MD PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Satoru Miyano, PhD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Seishi Ogawa, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
DOI: https://doi.org/10.1182/blood-2020-134648
Published: 2020
Journal Articles

Coexistence and Prognostic Significance of EVI1 Expression and Driver Mutations in KMT2A -Rearranged Acute Myeloid Leukemia

Hidemasa Matsuo, PhD, Kenichi Yoshida, MD PhD, Kana Nakatani, Yasuhiko Kamikubo, MD, PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Nobutaka Kiyokawa, MD PhD, Seishi Ogawa, MD PhD, Manja Meggendorfer, PhD, Claudia Haferlach, MD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1409.
DOI: https://doi.org/10.1182/blood-2019-124652
Published: 2019
Journal Articles

Acute Lymphoblastic Leukemia with Zinc-Finger Protein 384 (ZNF384)-Related Rearrangements: A Retrospective Analysis from the Ponte Di Legno Childhood ALL Working Group

Shinsuke Hirabayashi, Ellie Butler, Kentaro Ohki, MD PhD, Nobutaka Kiyokawa, MD PhD, Anke K. Bergmann, Judith M. Boer, PhD, Hélène Cavé, PharmD, PhD, Giovanni Cazzaniga, Allen Eng Juh Yeoh, Toshihiko Imamura, MD PhD, Hiroto Inaba, MD, Mignon L. Loh, MD, Ulrika Norén-Nyström, MD PhD, Agata Pastorczak, Lee-Yung Shih, MD, Marketa Zaliova, MD PhD, Oskar A Haas, Christine J. Harrison, PhD FRCPath, Anthony V. Moorman, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 652.
DOI: https://doi.org/10.1182/blood-2019-123236
Published: 2019
Journal Articles

Recurrent Gene Mutations in Pediatric Patients with AML By Targeted Sequencing ―the Jccg Study, JPLSG AML-05―

Taeko Kaburagi, MD, Genki Yamato, MD PhD, Norio Shiba, Kenichi Yoshida, MD PhD, Yusuke Hara, Yuichi Shiraishi, PhD, Kentaro Ohki, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Hidemasa Matsuo, PhD, Akira Shimada, MD PhD, Tomohiko Taki, MD PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Keizo Horibe, MD PhD, Satoru Miyano, PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Seishi Ogawa, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2697.
DOI: https://doi.org/10.1182/blood-2019-126545
Published: 2019
Journal Articles

Clinical Features of Pediatric Acute Myeloid Leukemia with TP53 and CDKN2A / 2B copy Number Alterations

Yusuke Hara, Tomohiko Taki, MD PhD, Genki Yamato, Kenichi Yoshida, MD PhD, Yusuke Shiozawa, MD PhD, Norio Shiba, MD PhD, Taeko Kaburagi, MD, Yuichi Shiraishi, PhD, Kentaro Ohki, MD PhD, Machiko Kawamura, MD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Hidemasa Matsuo, PhD, Akira Shimada, MD PhD, Tsutomu Toki, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Etsuro Ito, MD PhD, Keizo Horibe, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Souichi Adachi, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2727.
DOI: https://doi.org/10.1182/blood-2019-126263
Published: 2019
Journal Articles

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Masanori Yoshida, MD, Kazuhiko Nakabayashi, PhD, Aiko Sato-Otsubo, PhD, Shinichi Tsujimoto, MD PhD, Kaoru Yoshida, MD, Ryota Shirai, MD, Tomoo Osumi, MD, Yuki Yuza, MD PhD, Masatoshi Takagi, MD PhD, Hiroyuki Takahashi, MD PhD, Katsuyoshi Koh, MD, Akitoshi Kinoshita, MD PhD, Moeko Hino, MD, Toshihiko Imamura, MD PhD, Yozo Nakazawa, MD PhD, Okuya Mayuko, MD PhD, Harumi Kakuda, MD PhD, Masashi Sanada, MD, Kimikazu Matsumoto, MD, PhD, Daisuke Tomizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Akira Ohara, MD PhD, Atsushi Manabe, MD PhD, Kenichiro Hata, MD PhD, Jun J. Yang, PhD, Motohiro Kato, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2751.
DOI: https://doi.org/10.1182/blood-2019-125713
Published: 2019
Journal Articles

Significant Features of DNA Methylation at Bivalent Promotor and Repressed Polycomb Regions in Pediatric AML-the Jccg Study, JPLSG AML-05-

Genki Yamato, Tomoko Kawai, PhD, Norio Shiba, Yusuke Hara, Kentaro Ohki, MD PhD, Taeko Kaburagi, MD, Kenichi Yoshida, MD PhD, Yuichi Shiraishi, PhD, Satoru Miyano, PhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Akira Shimada, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Souichi Adachi, MD PhD, Takashi Taga, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Kenichiro Hata, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2739.
DOI: https://doi.org/10.1182/blood-2019-125025
Published: 2019
Journal Articles

A Novel PAX5-KIDINS220 Fusion Protein Activates Multiple Signals Associated with Therapeutic Resistance

Takuyo Kanayama, MD, Toshihiko Imamura, MD PhD, Kenichi Sakamoto, MD PhD, Fumihiko Hayakawa, MD, PhD, Akihiko Tanizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Hajime Hosoi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3928.
DOI: https://doi.org/10.1182/blood-2018-99-116022
Published: 2018
Journal Articles

The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yusuke Shiozawa, MD, PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, PhD, Nobutaka Kiyokawa, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Tomoya Isobe, MD, Masafumi Seki, MD,PhD, Shunsuke Kimura, MD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD PhD, Hiroyuki Tsukamoto, MD PhD, Dai Nishijima, PhD, Takao Deguchi, MD PhD, Kentaro Ohki, MD PhD, Atsushi Sato, MD, Hiroyuki Takahashi, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Takeshi Inukai, MD, Junko Takita, MD, PhD, Toshihiko Imamura, MD PhD, Satoru Miyano, PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4077.
DOI: https://doi.org/10.1182/blood-2018-99-115617
Published: 2018
Journal Articles

Effect of Age on the Prognosis of Molecular Abnormalities in Pediatric Acute Myeloid Leukemia

Yusuke Hara, MD PhD, Norio Shiba, MD PhD, Genki Yamato, MD PhD, Kentaro Ohki, MD PhD, Manabu Sotomatsu, MD PhD, Ken Tabuchi, MD, Daisuke Tomizawa, MD PhD, Tomohiko Taki, MD PhD, Akitoshi Kinoshita, MD PhD, Nobutaka Kiyokawa, MD PhD, Hirokazu Arakawa, MD PhD, Masabumi Shibuya, MD PhD, Takashi Taga, MD PhD, Akio Tawa, MD PhD, Keizo Horibe, MD PhD, Souichi Adachi, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1506.
DOI: https://doi.org/10.1182/blood-2018-99-118097
Published: 2018
Journal Articles

Leukemic Cell Expressing a Novel Kinase Fusion Protein NCOR1-LYN Exhibits High Sensitivity to Dasatinib and Rapamycin

Toshihiro Tomii, MD, Toshihiko Imamura, MD PhD, Mio Yano, MD, Kenichi Sakamoto, MD PhD, Itaru Kato, Kuniaki Tanaka, MD, Takashi Mikami, MD, Makiko Morita, PhD, Souichi Adachi, MD PhD, Junko Takita, MD, PhD, Nobutaka Kiyokawa, MD PhD, Keizo Horibe, MD PhD, Hajime Hosoi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1557.
DOI: https://doi.org/10.1182/blood-2018-99-111612
Published: 2018
Journal Articles

Comprehensive Analysis of 343 Genes Using Targeted Sequencing Panel By Next-Generation Sequencer in 77 Pediatric AML Patients with Normal and Complex Karyotypes: Jccg Study, JPLSG AML-05

Taeko Kaburagi, Genki Yamato, MD PhD, Norio Shiba, MD, Kenichi Yoshida, MD PhD, Yusuke Hara, MD PhD, Yuichi Shiraishi, PhD, Kentaro Ohki, MD PhD, Manabu Sotomatsu, MD PhD, Hirokazu Arakawa, MD PhD, Hidemasa Matsuo, PhD, Akira Shimada, MDPhD, Nobutaka Kiyokawa, MD PhD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Keizo Horibe, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Souichi Adachi, MD PhD, Yasuhide Hayashi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1530.
DOI: https://doi.org/10.1182/blood-2018-99-114632
Published: 2018
Journal Articles

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, MD, Masafumi Seki, MD, PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Yasuhito Nannya, MD PhD, Kentaro Ohki, MD PhD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD PhD, Toshihiko Imamura, MD PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Akira Ohara, MD, Masashi Sanada, MD PhD, Mitsuteru Hiwatari, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Junko Takita, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4089.
DOI: https://doi.org/10.1182/blood-2018-99-111092
Published: 2018