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Journal Articles

Plasmin-mediated Cleavage of High Molecular Weight Kininogen Contributes to Acetaminophen-Induced Acute Liver Failure

Michael W. Henderson, Erica M Sparkenbaugh, Shaobin Wang, Anton Ilich, Denis F. Noubouossie, Reiner K. Mailer, Thomas Renné, Matthew J. Flick, James P Luyendyk, Zu-Lin Chen, Sidney Strickland, R. Todd Stravitz, Keith R McCrae, Nigel S Key, Rafal Pawlinski

Blood blood.2020006198.

DOI: https://doi.org/10.1182/blood.2020006198

Published: 2021

Includes: Supplemental data

Journal Articles

First Data from the Phase 3 HOPE-B Gene Therapy Trial: Efficacy and Safety of Etranacogene Dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in Adults with Severe or Moderate-Severe Hemophilia B Treated Irrespective of Pre-Existing Anti-Capsid Neutralizing Antibodies

Steven W. Pipe, MD, Michael Recht, MD PhD, Nigel S. Key, MD, Frank W.G. Leebeek, MD PhD, Giancarlo Castaman, MD, Susan U. Lattimore, R.N., Paul Van Der Valk, Kathelijne Peerlinck, MD PhD, Michiel Coppens, MD, Niamh O'Connell, MD PhD, John Pasi, MB, ChB, PhD FRCP, FRCPath, FRCPCH, Peter Kampmann, MD, Karina Meijer, MD PhD, Annette von Drygalski, MD Pharm D, Guy Young, MD, Cedric Hermans, MDMRCP,PhD, Jan Astermark, MD PhD, Robert Klamroth, MD PhD, Richard S. Lemons, MD, Nathan Visweshwar, MD, Shelley Crary, MD MS, Rashid Kazmi, MBBS, Emily Symington, Miguel A. Escobar, MD, Esteban Gomez, MD, Rebecca Kruse-Jarres, MD, Adam Kotowski, MD, Doris Quon, MD PhD, Michael Wang, MD, Allison P. Wheeler, MD, Eileen K Sawyer, PhD, Stephanie Verweij, BSc, Valerie Colletta, MSc, Naghmana Bajma, MD, Robert Gut, MD PhD, Wolfgang A. Miesbach, MD PhD

Blood (2020) 136 (Supplement_2): LBA-6.

DOI: https://doi.org/10.1182/blood-2020-143560

Published: 2020

Journal Articles

Utility of Inferior Vena Cava Filter in the Management of Venous Thromboembolism Among Patients with Brain Metastases: A Population-Based Study

Vaibhav Kumar, MBBS,MS, Ann M Brunson, MS, Anjlee Mahajan, MD, Nigel S. Key, MD, Ted Wun, MD

Blood (2020) 136 (Supplement 1): 47–48.

DOI: https://doi.org/10.1182/blood-2020-138790

Published: 2020

Journal Articles

Venous Thromboembolism Incidence and Impact on Survival in Patients with Brain Metastases

Vaibhav Kumar, MBBS,MS, Xi Zhou, Benjamin Shiang Wu, MSc,PharmD, Joshua Herb, MD, Tzy-Mey Kuo, Laura Green, Chris D Baggett, PhD, Bradford Jackson, Nigel S. Key, MD, Jennifer L Lund, PhD, Katherine E Reeder-Hayes

Blood (2020) 136 (Supplement 1): 1.

DOI: https://doi.org/10.1182/blood-2020-136117

Published: 2020

Journal Articles

Thrombin-Induced Endothelial Cell Damage Is Mitigated By Human Anti-Thrombin III in a Microfluidic Device

William Wulftange, Erdem Kucukal, PhD, Yuncheng Man, Ran An, PhD, Karamoja Monchamp, Olabimpe Olayiwola, MS, Jane A. Little, MD, Nigel S. Key, MD, Umut A. Gurkan, PhD

Blood (2020) 136 (Supplement 1): 24–25.

DOI: https://doi.org/10.1182/blood-2020-141583

Published: 2020

Journal Articles

Etranacogene Dezaparvovec (AAV5-Padua hFIX variant), an Enhanced Vector for Gene Transfer in Adults with Severe or Moderate-Severe Hemophilia B: Two Year Data from a Phase 2b Trial

Annette von Drygalski, Adam Giermasz, MD PhD, Giancarlo Castaman, MD, Nigel S. Key, MD, Susan U. Lattimore, Frank W.G. Leebeek, MD PhD, Wolfgang A. Miesbach, MD, Michael Recht, MD PhD, Esteban Gomez, MD, Robert Gut, Steven W. Pipe, MD

Blood (2020) 136 (Supplement 1): 13.

DOI: https://doi.org/10.1182/blood-2020-139295

Published: 2020

Journal Articles

Effects of Tranexamic Acid Prophylaxis on Bleeding Outcomes in Hematologic Malignancy: The a-TREAT Trial

Terry B. Gernsheimer, MD, Siobhan P Brown, PhD, Darrell J Triulzi, MD, Nigel S. Key, MD, Nahed El Kassar, MD PhD, Heather Herren, RN, MPH, Susanne May, PhD

Blood (2020) 136 (Supplement 1): 1–2.

DOI: https://doi.org/10.1182/blood-2020-138920

Published: 2020

Journal Articles

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Brief Report

Erica M. Sparkenbaugh, Chunsheng Chen, Tomasz Brzoska, Julia Nguyen, Shaobin Wang, Gregory M. Vercellotti, Nigel S. Key, Prithu Sundd, John D. Belcher, Rafal Pawlinski

Blood (2020) 135 (20): 1783–1787.

DOI: https://doi.org/10.1182/blood.2019003543

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways

Denis F. Noubouossie, Michael W. Henderson, Micah Mooberry, Anton Ilich, Patrick Ellsworth, Mark Piegore, Sarah C. Skinner, Rafal Pawlinski, Ian Welsby, Thomas Renné, Maureane Hoffman, Dougald M. Monroe, Nigel S. Key

Blood (2020) 135 (10): 755–765.

DOI: https://doi.org/10.1182/blood.2019001643

Published: 2020

Includes: Supplemental data

Journal Articles

Enhanced VTE Risk Stratification in Ambulatory Patients with Cancer

Joseph R. Shaw, MD, Ranjeeta Mallick, PhD MSc, BSc, Marc Carrier, MD, Anton Ilich, MD, Nigel S. Key, MBChB, FRCP, Philip S. Wells, MDMSc,FRCP

Blood (2019) 134 (Supplement_1): 634.

DOI: https://doi.org/10.1182/blood-2019-126306

Published: 2019

Journal Articles

One Year Data from a Phase 2b Trial of AMT-061 (AAV5-Padua hFIX variant), an Enhanced Vector for Gene Transfer in Adults with Severe or Moderate-Severe Hemophilia B

Steven Pipe, MD, Adam Giermasz, MD PhD, Giancarlo Castaman, MD, Nigel S. Key, MBChB, FRCP, Susan U Lattimore, Frank Leebeek, MD PhD, Wolfgang Miesbach, MD PhD, Michael Recht, MD PhD, Esteban Gomez, MD, Alison Long, Robert Gut, Annette von Drygalski, MD PharmD

Blood (2019) 134 (Supplement_1): 3348.

DOI: https://doi.org/10.1182/blood-2019-128765

Published: 2019

Journal Articles

All-Cause and Inhibitor-Related Mortality in Non-Severe Hemophilia Α Patients in the United States

Ming Y. Lim, MBBChir,MA, Dunlei Cheng, PhD, Christine L. Kempton, MD MSc, Nigel S. Key, MBChB, FRCP

Blood (2019) 134 (Supplement_1): 902.

DOI: https://doi.org/10.1182/blood-2019-122991

Published: 2019

Journal Articles

High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice

Michael Wayne Henderson, MSc, Erica Sparkenbaugh, PhD BS, Denis Noubouossie, MD PhD, Reiner Mailer, Thomas Renne, MD PhD, Keith R McCrae, MD, Nigel S. Key, MBChB, FRCP, Rafal Pawlinski, PhD

Blood (2019) 134 (Supplement_1): 3621.

DOI: https://doi.org/10.1182/blood-2019-127206

Published: 2019

Journal Articles

Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease

Camille Faes, Anton Ilich, Amandine Sotiaux, Erica M. Sparkenbaugh, Michael W. Henderson, Laura Buczek, Joan D. Beckman, Patrick Ellsworth, Denis F. Noubouossie, Lantarima Bhoopat, Mark Piegore, Céline Renoux, Wolfgang Bergmeier, Yara Park, Kenneth I. Ataga, Brian Cooley, Alisa S. Wolberg, Nigel S. Key, Rafal Pawlinski

Blood (2019) 133 (23): 2529–2541.

DOI: https://doi.org/10.1182/blood.2019000424

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Neutrophils: back in the thrombosis spotlight

Denis F. Noubouossie, Brandi N. Reeves, Brian D. Strahl, Nigel S. Key

Blood (2019) 133 (20): 2186–2197.

DOI: https://doi.org/10.1182/blood-2018-10-862243

Published: 2019

Journal Articles

Recombinant Porcine Factor VIII Use in Bleed Treatment in Non-Severe Hemophilia a Inhibitor Patients: Dosing Strategies and Efficacy

Patrick Ellsworth, MD, Sheh-Li Chen, PharmD, Yasmina L. Abajas, MD, Stephan Moll, MD, Nigel S. Key, MBChB, FRCP, Alice D. Ma, MD

Blood (2018) 132 (Supplement 1): 1202.

DOI: https://doi.org/10.1182/blood-2018-99-119196

Published: 2018

Journal Articles

Association of Sickle Cell Trait with Measures of Cognitive Function and Dementia in African Americans

Chen Nemin, BS, Christina Caruso, MD, Alvaro Alonso, MD PhD, Vimal K. Derebail, MD, Abhijit V Kshirsagar, MD, Richey Sharrett, MD DrPH, Nigel S. Key, MBChB, FRCP, Rebecca Gottesman, MD PhD, Megan Grove, MS, Jan Bressler, PhD, Eric Boerwinkle, PhD, B. Gwen Windham, MD MHS, Thomas H Mosley, Jr., PhD, Hyacinth I Hyacinth, MDPhDMPH

Blood (2018) 132 (Supplement 1): 1099.

DOI: https://doi.org/10.1182/blood-2018-99-109832

Published: 2018

Journal Articles

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

Brandi Reeves, MD, Soo Jin Kim, MS, Jihyun Song, PhD, Radhika Gangaraju, MD, Rafal Pawlinski, PhD, Perumal Thiagarajan, MD, Victor R. Gordeuk, MD, Nigel S. Key, MBChB, FRCP, Josef T. Prchal, MD

Blood (2018) 132 (Supplement 1): 2513.

DOI: https://doi.org/10.1182/blood-2018-99-117812

Published: 2018

Journal Articles

Histones Induce the Release of Extracellular Hemoglobin and Red Blood Cell-Derived Microvesicles with Procoagulant Activity

Denis Noubouossie, MD PhD, Juraj Sokol, MD PhD, Mark Gerard Piegore, BS, Anton Ilich, MD, Michael Wayne Henderson, MSc, Micah Mooberry, MD, Dougald Monroe, PhD, Nigel S. Key, MBChB, FRCP

Blood (2018) 132 (Supplement 1): 2514.

DOI: https://doi.org/10.1182/blood-2018-99-118769

Published: 2018

Journal Articles

Recombinant Porcine FVIII in Acquired Hemophilia: Decreased Product Usage When Used Upfront, Non-Utility of Baseline Porcine Bethesda Titer, and Confirmation of Dosing Algorithm

Patrick Ellsworth, MD, Sheh-Li Chen, PharmD, Nigel S. Key, MBChB, FRCP, Raj S. Kasthuri, MD, Micah J. Mooberry, MD, Alice D. Ma, MD

Blood (2018) 132 (Supplement 1): 2474.

DOI: https://doi.org/10.1182/blood-2018-99-118839

Published: 2018

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NARROW

Plasmin-mediated Cleavage of High Molecular Weight Kininogen Contributes to Acetaminophen-Induced Acute Liver Failure

First Data from the Phase 3 HOPE-B Gene Therapy Trial: Efficacy and Safety of Etranacogene Dezaparvovec (AAV5-Padua hFIX variant; AMT-061) in Adults with Severe or Moderate-Severe Hemophilia B Treated Irrespective of Pre-Existing Anti-Capsid Neutralizing Antibodies

Utility of Inferior Vena Cava Filter in the Management of Venous Thromboembolism Among Patients with Brain Metastases: A Population-Based Study

Venous Thromboembolism Incidence and Impact on Survival in Patients with Brain Metastases

Thrombin-Induced Endothelial Cell Damage Is Mitigated By Human Anti-Thrombin III in a Microfluidic Device

Etranacogene Dezaparvovec (AAV5-Padua hFIX variant), an Enhanced Vector for Gene Transfer in Adults with Severe or Moderate-Severe Hemophilia B: Two Year Data from a Phase 2b Trial

Effects of Tranexamic Acid Prophylaxis on Bleeding Outcomes in Hematologic Malignancy: The a-TREAT Trial

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease

Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways

Enhanced VTE Risk Stratification in Ambulatory Patients with Cancer

One Year Data from a Phase 2b Trial of AMT-061 (AAV5-Padua hFIX variant), an Enhanced Vector for Gene Transfer in Adults with Severe or Moderate-Severe Hemophilia B

All-Cause and Inhibitor-Related Mortality in Non-Severe Hemophilia Α Patients in the United States

High Molecular Weight Kininogen but Not Factor XII Deficiency Attenuates Acetaminophen-Induced Liver Injury in Mice

Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease

Neutrophils: back in the thrombosis spotlight

Recombinant Porcine Factor VIII Use in Bleed Treatment in Non-Severe Hemophilia a Inhibitor Patients: Dosing Strategies and Efficacy

Association of Sickle Cell Trait with Measures of Cognitive Function and Dementia in African Americans

Upregulation of Tissue Factor May Contribute to Thrombosis in Polycythemia Vera and Essential Thrombocythemia

Histones Induce the Release of Extracellular Hemoglobin and Red Blood Cell-Derived Microvesicles with Procoagulant Activity

Recombinant Porcine FVIII in Acquired Hemophilia: Decreased Product Usage When Used Upfront, Non-Utility of Baseline Porcine Bethesda Titer, and Confirmation of Dosing Algorithm

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American Society of Hematology

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American Society of Hematology

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