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Journal Articles

Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia

Lubica Rauova, Khalil Bdeir, Ann H Rux, Manu Thomas Kalathottukaren, Jenna Oberg, Chanel C. La, David Thiam En Lim, Vincent M Hayes, Gavin T. Koma, Amrita Sarkar, Mortimer Poncz, Jayachandran N Kizhakkedathu, Douglas B. Cines

Blood blood.2024025653.

https://doi.org/10.1182/blood.2024025653

Published: 2025

Includes: Supplemental data

Journal Articles

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Amrita Sarkar, Santosh K Yadav, Conroy O Field, Kandace Gollomp, Keith R. McCrae, Thomas L. Ortel, Yves Gruel, Jérôme Rollin, Gowthami M Arepally, Lubica Rauova, Douglas B. Cines, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2611.

https://doi.org/10.1182/blood-2024-200849

Published: 2024

Journal Articles

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Conroy O Field, Amrita Sarkar, Khalil Bdeir, Keith R. McCrae, Thomas L. Ortel, M. Anna Kowalska, Lubica Rauova, Douglas B. Cines, Kandace Gollomp, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 185.

https://doi.org/10.1182/blood-2024-201682

Published: 2024

Journal Articles

Mechanistic Insights and Clinical Implications of the Thrombotic Risks of a Highly Prevalent GRK5 Variant Affecting Platelets

Yanki Yarman, Xuefei Zhao, Hyun Sook Ahn, Hannah Thomson, Meghan Roberts, Deborah L. French, Jeffrey Benovic, Timothy J. Stalker, Mortimer Poncz, Peisong Ma

Blood (2024) 144 (Supplement 1): 424.

https://doi.org/10.1182/blood-2024-205760

Published: 2024

Journal Articles

Platelet Factor 4 (PF4) Binding to Neutrophil Extracellular Traps (NETs) and Von Willebrand Factor (vWF) Improves Bacterial Capture and Killing in an Electrostatic Charge-Dependent Manner

Santosh K Yadav, Abigail E Skidmore, Anh T.P. Ngo, Veronica Bochenek, Manuela Roggiani, Mark Goulian, Mortimer Poncz, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 3986.

https://doi.org/10.1182/blood-2024-206506

Published: 2024

Journal Articles

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Amrita Sarkar, Conroy O Field, Keith R. McCrae, Thomas L. Ortel, Gow Arepally, Roxanne Cofiell, Sung-Kwon Kim, Lubica Rauova, Mortimer Poncz

Blood (2024) 144 (Supplement 1): 2606.

https://doi.org/10.1182/blood-2024-198182

Published: 2024

Journal Articles

Complement Activation As a Biomarker for Platelet Activating Antibodies in Heparin-Induced Thrombocytopenia (HIT)

Sooho S Myoung, Samuel Francis, Jonah Chen, Grace M Lee, Lubica Rauova, Mortimer Poncz, Douglas B. Cines, Maragatha Kuchibhatla, Sanjay Khandelwal, Gow Arepally

Blood (2024) 144 (Supplement 1): 2605.

https://doi.org/10.1182/blood-2024-208062

Published: 2024

Journal Articles

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Anh T.P. Ngo, Veronica Bochenek, Hyunjun Kim, Nate Levine, Samir Maarouf, Jenna Oberg, Manuela Roggiani, Amrita Sarkar, Lubica Rauova, Caroline Diorio, Zachary Martinez, Mark Goulian, Mortimer Poncz, Victor Nizet, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 1231.

https://doi.org/10.1182/blood-2024-211717

Published: 2024

Journal Articles

Why Do Peptidyl Arginine Deiminase (PAD) 4-Deficient Mice Have Improved Survival Following Cecal Ligation and Puncture (CLP) Sepsis? Implications for the Role Neutrophil Extracellular Trap (NETs) in Immune Homeostasis

Veronica Bochenek, Abigail E Skidmore, Anh T.P. Ngo, Samir Maarouf, Weiming Hu, Santosh K Yadav, Ethan Mack, M. Anna Kowalska, Mortimer Poncz, Kandace Gollomp

Blood (2024) 144 (Supplement 1): 2528.

https://doi.org/10.1182/blood-2024-203321

Published: 2024

Journal Articles

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Veronica Bochenek, Nate Levine, Anh T.P. Ngo, Samir Maarouf, Abigail E Skidmore, M. Anna Kowalska, Caroline Diorio, Zachary Martinez, Mortimer Poncz, Kandace Gollomp

Blood (2023) 142 (Supplement 1): 1169.

https://doi.org/10.1182/blood-2023-189931

Published: 2023

Journal Articles

Murine Infusion Studies of Infused Human Megakaryocytes Support a “Catch-and-Release” Model of Thrombopoiesis

Hyunjun Kim, Kiwon Lee, Gavin Merschel, Mortimer Poncz

Blood (2023) 142 (Supplement 1): 2561.

https://doi.org/10.1182/blood-2023-181421

Published: 2023

Journal Articles

RUNX1 Haplodeficiency Reduces Platelet Endocytosis of Albumin and Fibrinogen and Impairs Megakaryocyte Intracellular Trafficking

Fabiola Del Carpio-Cano, Guangfen Mao, Lawrence E. Goldfinger, Jeremy Wurtzel, Liying Guan, Afaque Mohammad Alam, Kiwon Lee, Mortimer Poncz, Angara Koneti Rao

Blood (2023) 142 (Supplement 1): 1218.

https://doi.org/10.1182/blood-2023-186668

Published: 2023

Journal Articles

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Lubica Rauova, Jenna Oberg, Nate Levine, Khalil Bdeir, Douglas B. Cines, Sarah Gilbert, Mortimer Poncz, Gowthami Arepally

Blood (2023) 142 (Supplement 1): 2631.

https://doi.org/10.1182/blood-2023-186729

Published: 2023

Journal Articles

Platelet Factor 4 Enhances Antimicrobial Function of the Endothelium and Improves Outcome in a Murine Model of Sepsis

Anh T.P. Ngo, Nate Levine, Abigail E Skidmore, Amrita Sarkar, Veronica Bochenek, Manuela Roggiani, Mark Goulian, Mortimer Poncz, Kandace Gollomp

Blood (2023) 142 (Supplement 1): 1198.

https://doi.org/10.1182/blood-2023-186989

Published: 2023

Journal Articles

SLFN14 ribosomopathy and platelet dysfunction

Kiwon Lee, Mortimer Poncz

Blood (2023) 141 (18): 2170–2172.

https://doi.org/10.1182/blood.2023019949

Published: 2023

Journal Articles

RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects

Kiwon Lee, Hyun Sook Ahn, Brian Estevez, Mortimer Poncz

Blood (2023) 141 (3): 260–270.

https://doi.org/10.1182/blood.2022017561

Published: 2023

Includes: Supplemental data

Journal Articles

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Anh T.P. Ngo, Amrita Sarkar, Nathan Levine, Veronica Bochenek, Guohua Zhao, Lubica Rauova, M. Anna Kowalska, Kaitlyn Eckart, Nilam S. Mangalmurti, Ann Rux, Douglas B. Cines, Mortimer Poncz, Kandace Gollomp

Blood (2022) 140 (Supplement 1): 5529–5530.

https://doi.org/10.1182/blood-2022-169709

Published: 2022

Journal Articles

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Lubica Rauova, Khalil Bdeir, Zheng Cai, Serge Yarovoi, Gowthami M. Arepally, Sanjay Khandelwal, Mortimer Poncz, Mark Greene, Douglas B. Cines

Blood (2022) 140 (Supplement 1): 2643–2644.

https://doi.org/10.1182/blood-2022-163590

Published: 2022

Journal Articles

Fusion of uPA to Anti-aII b b3 Scfv Facilitates Its Uptake By in Vitro-Generated CD34+ Megakaryocytes (MKs) to Promote Targeted Fibrinolysis

Sergey Zaytsev, Hyunsook Ahn, M. Anna Kowalska, Rodney Camire, Douglas B. Cines, Mortimer Poncz, Victoria Stepanova

Blood (2022) 140 (Supplement 1): 1969–1970.

https://doi.org/10.1182/blood-2022-168072

Published: 2022

Journal Articles

Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs

Kandace Gollomp, Irina Chernysh, Anh T.P. Ngo, Nathan Levine, Sergey Zaytsev, Veronica Bochenek, Lubica Rauova, Nicholas Parenti, Susan R Weiss, John W. Weisel, Douglas B. Cines, Mortimer Poncz

Blood (2022) 140 (Supplement 1): 1405–1406.

https://doi.org/10.1182/blood-2022-170781

Published: 2022

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Destabilization of PF4-antigenic complexes in heparin-induced thrombocytopenia

Anti-Phospholipid Syndrome (APS) Antibody (Ab)-Induced Thrombosis Can be Blocked By Platelet Factor 4 (PF4)-Directed Abs: A Novel Therapeutic Approach for APS?

Antiphospholipid Syndrome (APS) Is a Platelet Factor 4 (PF4)-Centric Immunothrombotic Disorder

Mechanistic Insights and Clinical Implications of the Thrombotic Risks of a Highly Prevalent GRK5 Variant Affecting Platelets

Platelet Factor 4 (PF4) Binding to Neutrophil Extracellular Traps (NETs) and Von Willebrand Factor (vWF) Improves Bacterial Capture and Killing in an Electrostatic Charge-Dependent Manner

The PF4-Centric Immunothrombotic Disorders, HIT, Vitt and APS, Lead to Complement Activation Responsive to Complement-Blocking Therapeutics

Complement Activation As a Biomarker for Platelet Activating Antibodies in Heparin-Induced Thrombocytopenia (HIT)

Platelet Factor 4 Enhances Endothelial Cell Antimicrobial Activity in Vitro and Promotes Bacterial Clearance In Vivo , Improving Sepsis Outcomes

Why Do Peptidyl Arginine Deiminase (PAD) 4-Deficient Mice Have Improved Survival Following Cecal Ligation and Puncture (CLP) Sepsis? Implications for the Role Neutrophil Extracellular Trap (NETs) in Immune Homeostasis

Peptidyl Arginine Deiminase (PAD) 4 Modulates the GI Microbiome and Baseline Inflammation in Mice: Implications for Sepsis

Murine Infusion Studies of Infused Human Megakaryocytes Support a “Catch-and-Release” Model of Thrombopoiesis

RUNX1 Haplodeficiency Reduces Platelet Endocytosis of Albumin and Fibrinogen and Impairs Megakaryocyte Intracellular Trafficking

A Novel Adenovirus (Adv)-Vaccinated Murine Model Simulates the Prothrombotic Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT) Clinical Disorder

Platelet Factor 4 Enhances Antimicrobial Function of the Endothelium and Improves Outcome in a Murine Model of Sepsis

SLFN14 ribosomopathy and platelet dysfunction

RUNX1-deficient human megakaryocytes demonstrate thrombopoietic and platelet half-life and functional defects

Neutrophil Extracellular Traps (NETs) Thrombogenicity and Endothelial Cell Toxicity Are Ameliorated By Platelet Factor 4 (PF4): Implications to the Treatment of Sepsis

Modulation of Ultralarge Immune Complexes in Heparin-Induced Thrombocytopenia

Fusion of uPA to Anti-aII b b3 Scfv Facilitates Its Uptake By in Vitro-Generated CD34+ Megakaryocytes (MKs) to Promote Targeted Fibrinolysis

Aggregation of Enveloped Viruses By Platelet Factor 4 (PF4) and Neutrophil Extracellular Traps (NETs): Implications for the Anti-Viral Properties of NETs

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