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Mark Wunderlich
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Journal Articles

Single-Cell Multi-Omic Analysis of KMT2A -Rearranged Pediatric Acute Leukemia Clonal Evolution

Free
Morgan Drucker, Dalia Dhingra, Mark Wunderlich, John Perentesis, Daniel Starczynowski, Robert L. Bowman, Linde A. Miles
Journal: Blood
Blood (2024) 144 (Supplement 1): 66.
https://doi.org/10.1182/blood-2024-202590
Published: 2024
Journal Articles

Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML

Free
Xueer Wang, Honghai Zhang, Lei Dong, Xiaoxu Zhang, Meilin Xue, Lili Ren, Hongjie Bi, Lucy Y. Ghoda, Mark Wunderlich, James C. Mulloy, Chun-Wei David Chen, Ling Li, Lin Xu, Bin Zhang, Guido Marcucci, Steven T. Rosen, Nora Heisterkamp, Marcin Kortylewski, Jianjun Chen, Rui Su
Journal: Blood
Blood (2024) 144 (Supplement 1): 625.
https://doi.org/10.1182/blood-2024-201916
Published: 2024
Journal Articles

The Mechanism of Therapy Resistance By Lineage Plasticity in AML and How to Overcome It

Free
Sean Walulik, Sarai Dean, Eric J Vick, Xiaoqin Zhu, Mark Wunderlich, Chih-Hsing Chou, Kwangmin Choi, H. Leighton Grimes, Daniel T. Starczynowski, Linde A. Miles, Andrew Volk
Journal: Blood
Blood (2023) 142 (Supplement 1): 1410.
https://doi.org/10.1182/blood-2023-186180
Published: 2023
Journal Articles

Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML

Free
Joshua Bennett, Chiharu Ishikawa, Puneet Agarwal, Jennifer Yeung, Avery Sampson, Emma Uible, Eric Vick, Lyndsey C. Bolanos, Kathleen Hueneman, Mark Wunderlich, Amal Kolt, Kwangmin Choi, Andrew Volk, Kenneth D. Greis, Jan Rosenbaum, Scott B. Hoyt, Craig J. Thomas, Daniel T. Starczynowski
Journal: Blood
Blood (2023) 142 (11): 989–1007.
https://doi.org/10.1182/blood.2022018718
Published: 2023
Includes: Supplemental data
Journal Articles

TRIM13 Is a Novel Cell Cycle Hub Regulated By CHAF1B to Promote Acute Myeloid Leukemogenesis

Free
Sarai Dean, Chiharu Ishikawa, Xiaoqin Zhu, Timothy Nixon, Sean Walulik, Michael Wyder, Jessica Jordan, Mark Wunderlich, Daniel T. Starczynowski, Nathan Salomonis, Ken Greis, Andrew Volk
Journal: Blood
Blood (2022) 140 (Supplement 1): 2978–2979.
https://doi.org/10.1182/blood-2022-169879
Published: 2022
Journal Articles

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Free
Yangchan Li, Xiaolan Deng, Lei Dong, Li Han, Le Xuan Truong Nguyen, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Meilin Xue, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, James C Mulloy, Bin Zhang, David A Horne, Steve T Rosen, Guido Marcucci, Mingjiang Xu, Zejuan Li, Minjie Wei, Rui Su, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 2975–2977.
https://doi.org/10.1182/blood-2022-162619
Published: 2022
Journal Articles

IRAK1 Contributes to IRAK4 Inhibitor Resistance Via Non-Canonical Signaling Mechanisms in MDS/AML

Free
Josh Bennett, Jennifer Yeung, Avery Sampson, Kathleen Hueneman, Mark Wunderlich, Kwangmin Choi, Andrew Volk, Scott B. Hoyt, Craig J. Thomas, Daniel T. Starczynowski
Journal: Blood
Blood (2022) 140 (Supplement 1): 2240–2241.
https://doi.org/10.1182/blood-2022-167526
Published: 2022
Journal Articles

ASXL1 Mutations Are Associated with a Response to the Combination of Alvocidib and 5-Azacytidine in Higher-Risk Myelodysplastic Syndromes

Free
Vladimir Riabov, Qingyu Xu, Nanni Schmitt, Alexander Streuer, Guo Ge, Johann-Christoph Jann, Alina Wein, Eva Altrock, Felicitas Rapp, Verena Nowak, Nadine Weimer, Julia Obländer, Iris Palme, Melda Göl, Mark Wunderlich, Ahmed Jawhar, Ali Darwich, Patrick Wuchter, Christel Weiss, Jason M Foulks, Daniel T. Starczynowski, Feng-Chun Yang, Georgia Metzgeroth, Laurenz Steiner, Wolf-Karsten Hofmann, Daniel Nowak, Mohamad Jawhar
Journal: Blood
Blood (2022) 140 (Supplement 1): 9749–9750.
https://doi.org/10.1182/blood-2022-165298
Published: 2022
Journal Articles

In Vivo Crispr Screening Identifies Novel Vulnerabilities in ETO2/GLIS2- rearranged Leukemia

Free
Mark Wunderlich, Jason Clark, Jing Chen, Lynn Lee
Journal: Blood
Blood (2022) 140 (Supplement 1): 3431–3432.
https://doi.org/10.1182/blood-2022-169837
Published: 2022
Journal Articles

JMJD1C Interacts with the Ncor Corepressor Complex and Is Required for Human MLL-AF9 Leukemogenesis

Free
Olivia Arnold, Luke Christiansen, Jesus Izaguirre-Carbonell, Theresa Bluemn, Mark Wunderlich, Nan Zhu
Journal: Blood
Blood (2022) 140 (Supplement 1): 8700–8701.
https://doi.org/10.1182/blood-2022-166806
Published: 2022
Journal Articles

Epigenetic regulator genes direct lineage switching in  MLL/AF4 leukemia

Free
Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
Journal: Blood
Blood (2022) 140 (17): 1875–1890.
https://doi.org/10.1182/blood.2021015036
Published: 2022
Includes: Supplemental data
Journal Articles

Unleashing Cell-Intrinsic Inflammation As a Strategy to Kill AML Blasts

Free
Jana M Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Maxim Pimkin, Linda Ross, Neekesh V Dharia, Amanda L Robinchaud, Amy Conway, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3305.
https://doi.org/10.1182/blood-2021-151511
Published: 2021
Journal Articles

SLC5A3 Transports Myo-Inositol to Support the Growth of Acute Myeloid Leukemia

Free
Shan Lin, Nastassja K. Scheidegger, Gabriela Alexe, Bo Kyung A. Seong, Neekesh V Dharia, Caroline Wechsler, Guillaume Kugener, Amanda L Robinchaud, Amy Conway, Biniam Adane, Scott Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 3319.
https://doi.org/10.1182/blood-2021-152023
Published: 2021
Journal Articles

An In Vivo CRISPR Screening Platform to Identify New Therapeutic Targets in AML

Free
Shan Lin, Clement Larrue, Nastassja K. Scheidegger, Bo Kyung A. Seong, Neekesh V Dharia, Caroline Wechsler, Guillaume Kugener, Amanda L Robinchaud, Amy Conway, Biniam Adane, Scott Younger, Federica Piccioni, Lynn Lee, Mark Wunderlich, Jerome Tamburini, Kimberly Stegmaier
Journal: Blood
Blood (2021) 138 (Supplement 1): 266.
https://doi.org/10.1182/blood-2021-153039
Published: 2021
Journal Articles

Momelotinib Is a Highly Potent Inhibitor of FLT3-Mutant AML

Free
Mohammad Azhar, Zachary Kincaid, Meenu Kesarwani, Mark Wunderlich, Tahir Latif, Daniel Starczynowski, Mohammad Azam
Journal: Blood
Blood (2021) 138 (Supplement 1): 206.
https://doi.org/10.1182/blood-2021-148822
Published: 2021
Journal Articles

Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo

Free
Yusuke Tarumoto, Shan Lin, Jinhua Wang, Joseph P. Milazzo, Yali Xu, Bin Lu, Zhaolin Yang, Yiliang Wei, Sofya Polyanskaya, Mark Wunderlich, Nathanael S. Gray, Kimberly Stegmaier, Christopher R. Vakoc
Journal: Blood
Blood (2020) 135 (1): 56–70.
https://doi.org/10.1182/blood.2019001576
Published: 2020
Includes: Supplemental data
Journal Articles

Global Gene Expression and Mutation Signatures Are Preserved in PDX Models of Pediatric AML and Aid Discovery of Targeted Therapy for Cases with CBFA2T3/GLIS2 Rearrangement

Free
Mark Wunderlich, MS, Jing Chen, Eric O'Brien, BSc, Nicole Manning, Christina Sexton, Luke Byerly, John P Perentesis, Benjamin Mizukawa, James C Mulloy
Journal: Blood
Blood (2019) 134 (Supplement_1): 3766.
https://doi.org/10.1182/blood-2019-129225
Published: 2019
Journal Articles

The GPR68/BCL2 Axis Remodels Metabolism in AML By Relocating Calcium

Free
Xiaofei He, B.S., Caleb Hawkins, B.S., Lauren Lawley, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, Xiang-ming Zha, PhD, Stephanie Halene, MD, Jing Fang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2661.
https://doi.org/10.1182/blood-2019-125455
Published: 2019
Journal Articles

Overcoming Adaptive Therapy Resistance in AML By Targeting Immune Response Pathways

Free
Katelyn M. Melgar, PhD, LaQuita M Jones, DO, Mackenzie Walker, Lyndsey C Bolanos, BSc, Kathleen Hueneman, Mark Wunderlich, MS, Jiang-Kang Jiang, Kelli Wilson, Xiaohu Zhang, Patrick Sutter, Xin Xu, Kwangmin Choi, PhD, Gregory Tawa, Donald Lorimer, Jan Abendroth, Eric O'Brien, BSc, Scott Hoyt, Ellin Berman, MD, Christopher Famulare, MS, James C Mulloy, Ross L. Levine, MD, Jan S Rosenbaum, John P Perentesis, Craig J Thomas, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3934.
https://doi.org/10.1182/blood-2019-124178
Published: 2019
Journal Articles

Modeling Effective AML Therapies - Comparative Anti-Leukemic Synergy of BCL2 and MCL1 Inhibition Combined and with Chemotherapy

Free
Eric O'Brien, BSc, Brett VanCauwenbergh, BSc, Jackson Alexander, Mitali Basu, MSc, Mark Wunderlich, MS, Mayur Sarangdhar, PhD, Benjamin Mizukawa, John P Perentesis
Journal: Blood
Blood (2019) 134 (Supplement_1): 3370.
https://doi.org/10.1182/blood-2019-131613
Published: 2019