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Marina Y. Konopleva
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Journal Articles

DNTT-mediated DNA Damage Response Drives Inotuzumab Ozogamicin Resistance in B-cell Acute Lymphoblastic Leukemia

Carolin S. Escherich, Takaya Moriyama, Zhenhua Li, YuChih Hsiao, Wenjian Yang, Yizhen Li, Noemi Reyes, Megan Walker, Amit Budhraja, Sheetal Bhatara, Ernesto Diaz-Flores, Wendy Stock, Elisabeth Paietta, Marina Y. Konopleva, Steven M Kornblau, Mark R Litzow, Hiroto Inaba, Ching-Hon Pui, Joseph T. Opferman, Mignon L. Loh, Jiyang Yu, Maureen O'Brien, William E. Evans, Jun J. Yang
Journal: Blood
Blood blood.2024026085.
https://doi.org/10.1182/blood.2024026085
Published: 2024
Includes: Supplemental data
Journal Articles

A STAT3 Degrader Demonstrates Pre-Clinical Efficacy in Venetoclax Resistant Acute Myeloid Leukemia

Samarpana Chakraborty, Claudia Morganti, Joyoti Dey, Hui Zhang, Srinivas Aluri, Nadege Gitego, Kith Pradhan, Bianca Rivera, Yogesh Chutake, Anna Skwarska, Ioannis Mantzaris, Mendel Goldfinger, Eric J Feldman, Gaurav S Choudhary, Stefan Hubner, Yihua Qiu, Brandon D. Brown, Amit Verma, Evripidis Gavathiotis, Marina Y. Konopleva, Steven M. Kornblau, Jared Gollob, Keisuke Ito, Aditi Shastri
Journal: Blood
Blood (2023) 142 (Supplement 1): 2787.
https://doi.org/10.1182/blood-2023-186947
Published: 2023
Journal Articles

Molecular Profiling of Response and Resistance to Venetoclax-Decitabine Therapy in Acute Myeloid Leukemia

Abdullah Khasawneh, Faith Jessica Paran, Rieko Oyama, Abhishek Maiti, Hussein A Abbas, Bofei Wang, Poonam N Desai, Kala Hayes, Joe R Harman, Xiaoping Su, Courtney D. DiNardo, Michael Andreeff, Thomas A Milne, Marina Y. Konopleva, Yoko Tabe
Journal: Blood
Blood (2023) 142 (Supplement 1): 4159.
https://doi.org/10.1182/blood-2023-180463
Published: 2023
Journal Articles

Venetoclax Synergizes with IMGN632, a Novel CD123-Targeting Antibody Conjugated to a DNA Alkylating Payload, By Suppressing DNA Damage Response and Potentiating Apoptosis in Acute Myeloid Leukemia in Vitro Models

Anna Skwarska, Vinitha Mary Kuruvilla, Qi Zhang, Sovira Chaudhry, Naval Daver, Krystal Watkins, Callum Mortimer Sloss, Patrick A. Zweidler-McKay, Deepa Sampath, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4155.
https://doi.org/10.1182/blood-2023-187018
Published: 2023
Journal Articles

Targeting BCL-XL with a Novel VHL-Based BCL-XL Degrader DT-2216 in Pre-Clinical JAK2 -Mutant AML Post-MPN Models

Zhe WANG, Qi Zhang, Anna Skwarska, Cassandra L. Ramage, Guangrong Zheng, Kira Gritsman, Kapil N. Bhalla, Naveen Pemmaraju, Daohong Zhou, Jeffrey W Tyner, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4154.
https://doi.org/10.1182/blood-2023-178813
Published: 2023
Journal Articles

A Study Evaluating Financial Toxicity Amongst Hematologic Malignancy Patients in the Bronx

Lemchukwu Amaeshi, Alex Sisto, Lauren Laufer, Kateryna Fedorov, Rosmi Mathew, David Levitz, Ioannis Mantzaris, Noah Kornblum, Mendel Goldfinger, Alejandro Sica, Dennis L Cooper, Marina Y. Konopleva, Bruce Rapkin, Amit Verma, Aditi Shastri, Nishi Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 7397.
https://doi.org/10.1182/blood-2023-188024
Published: 2023
Journal Articles

Safety and Tolerability of AZD0466 As Monotherapy for Patients with Advanced Hematologic Malignancies. Results from a Phase I/II Trial

Shukaib Arslan, Giovanni Marconi, Giovanni Martinelli, Shaun Fleming, Antonio Curti, Shira N. Dinner, James S Blachly, Matteo Giovanni Della Porta, Ashish Bajel, Tim Sauer, Martina Crysandt, Arnaud Pigneux, Lars Fransecky, Claudia D Baldus, Marina Y. Konopleva, Yotvat Marmor, Shringi Sharma, Nairouz Elgeioushi, Patricia Cheung, Emily Rowe, Ekaterina Jahn, Ting Yu, Jamal Saeh, Raoul Tibes, Fathima Zumla Cader, Nitin Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 5907.
https://doi.org/10.1182/blood-2023-179168
Published: 2023
Journal Articles

Ibrutinib, Fludarabine, Cyclophosphamide and Obinutuzumab (iFCG) for Firstline Treatment of Patients with CLL with Mutated IGHV and without Del(17p)/ TP53 Mutation: Six-Year Follow-up Analyses

Nitin Jain, Philip Thompson, Akhil Jain, Jan A. Burger, Alessandra Ferrajoli, Jayastu Senapati, Koichi Takahashi, Mahesh Swaminathan, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan M. Kadia, Naveen Pemmaraju, Koji Sasaki, Divyam Bansal, Marina Y. Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Wei Wang, Sa A. Wang, Jeffrey L. Jorgensen, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop M. Kantarjian, Susan M. O'Brien, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3267.
https://doi.org/10.1182/blood-2023-188084
Published: 2023
Journal Articles

Venetoclax Combined with “7+3” Induction Chemotherapy Induces High Rates of MRD-Negative Remission in Newly Diagnosed AML Patients Fit for Intensive Chemotherapy Irrespective of Age

Ioannis Mantzaris, Mendel Goldfinger, Nishi Shah, Annemarie Munoz, Aradhika Dhawan, Nicole Chambers, Karen Fehn, Joel Victor, Aditi Shastri, Kira Gritsman, Noah Kornblum, Alejandro Sica, Dennis L Cooper, Amit Verma, Mimi Kim, Ulrich Steidl, Eric J Feldman, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4257.
https://doi.org/10.1182/blood-2023-188176
Published: 2023
Journal Articles

Dual-Targeting CD33/CD123 NANOBODY ® T Cell Engager Targeting Leukemia Blasts and Stem/Progenitor Cells in Relapsed AML

Zhihong Zeng, Annelies Roobrouck, Geert Deschamps, Helene Bonnevaux, Stephane Guerif, Veronique De Brabandere, Amara Céline, Eline Jonckheere, Angela Virone-Oddos, Marielle Chiron, Melissa Dullaers, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 1418.
https://doi.org/10.1182/blood-2023-186012
Published: 2023
Journal Articles

Minimal Residual Disease in Acute Myeloid Leukemia Following Induction Chemotherapy Can be Effectively Eradicated By Targeting Mitochondrial Metabolism

Natalia Baran, Lina Han, Lucille Stuani, Antonio Cavazos, Laurie Cooper, Cassandra L. Ramage, Vinitha MARY Kuruvilla, Qi Zhang, Marie Sabtier, Emeline Boet, Jason P Gay, Ninping Feng, Venkata Lokesh Battula, Emeline Chu-Van, Florence Castelli, Martin Carroll, Sergej Naumovich Konoplev, Beenu Thakral, Naval Daver, Joseph R Marszalek, Yubin Ge, Michael Andreeff, Jean-Emmanuel Sarry, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2952.
https://doi.org/10.1182/blood-2023-186514
Published: 2023
Journal Articles

Comparison of the Prognostic Performance of European Leukemianet 2017 and 2022 Classifications in a Minority-Rich Population of Adult Patients with Acute Myeloid Leukemia

Kateryna Fedorov, Alexander Sisto, Josette Kamel, Mark Forsberg, Kith Pradhan, Nishi Shah, Aditi Shastri, Mendel Goldfinger, Noah Kornblum, Alejandro Sica, Dennis L Cooper, Kira Gritsman, Amit K. Verma, Eric J Feldman, Marina Y. Konopleva, Ioannis Mantzaris
Journal: Blood
Blood (2023) 142 (Supplement 1): 2968.
https://doi.org/10.1182/blood-2023-180856
Published: 2023
Journal Articles

IFNγ Signaling in Acute Myeloid Leukemia Mediates Immunomodulation and Reveals Therapeutic Strategies

Bofei Wang, Patrick K Reville, Fatima Z Jelloul, Poonam N Desai, Pamella Borges, Christopher Ly, Ivo Veletic, Enes Dasdemir, Jared K. Burks, Guilin Tang, Shengnan Guo, Nicole Vaugh, Natalia Baran, Qing Deng, Jairo Matthews, Preethi Gunaratne, Dinler A Antunes, Suhendan Ekmekcioglu, Koji Sasaki, Miriam B. Garcia, Branko Cuglievan, Dapeng Hao, Naval Daver, Michael R. Green, Marina Y. Konopleva, Andy Futreal, Sean M. Post, Hussein A Abbas
Journal: Blood
Blood (2023) 142 (Supplement 1): 2796.
https://doi.org/10.1182/blood-2023-175010
Published: 2023
Journal Articles

Tagraxofusp in Combination with Azacitidine and Venetoclax in Newly Diagnosed CD123+ Acute Myeloid Leukemia, Expansion Cohort of a Phase 1b Multicenter Trial

Andrew A. Lane, Jacqueline S. Garcia, Evangeline G. Raulston, Jada L. Garzon, Ilene Galinsky, Emilie W. Baxter, Rebecca Leonard, Daniel J. DeAngelo, Marlise R. Luskin, Christopher R. Reilly, Maximilian Stahl, Richard M Stone, Rahul Vedula, Martha Wadleigh, Eric S. Winer, Tariq Mughal, Christopher Brooks, Ira V. Gupta, Kristen E. Stevenson, Donna S. Neuberg, Siyang Ren, Marina Y. Konopleva, Anthony Stein, Naveen Pemmaraju
Journal: Blood
Blood (2023) 142 (Supplement 1): 4277.
https://doi.org/10.1182/blood-2023-180010
Published: 2023
Journal Articles

Transportation Cost Is a Significant Barrier to Quality Care for Hematologic Malignancy Patients in a Minority-Rich, Socioeconomically Disadvantaged Population

Lauren Laufer, Lemchukwu Amaeshi, Alex Sisto, Kateryna Fedorov, Rosmi Mathew, David Levitz, Ioannis Mantzaris, Noah Kornblum, Mendel Goldfinger, Alejandro Sica, Dennis L Cooper, Marina Y. Konopleva, Bruce Rapkin, Amit Verma, Aditi Shastri, Nishi Shah
Journal: Blood
Blood (2023) 142 (Supplement 1): 2350.
https://doi.org/10.1182/blood-2023-186867
Published: 2023
Journal Articles

Synergistic Growth Inhibition of NPM1 Mutant AML PDX By Combined Therapy with BCL-2 Inhibitor Venetoclax (ABT-199) and Menin Inhibitor DS-1594b In Vivo

Valerio Ciaurro, Marina Y. Konopleva, Naval Daver, Anna Skwarska, Maria Paola Martelli
Journal: Blood
Blood (2023) 142 (Supplement 1): 4169.
https://doi.org/10.1182/blood-2023-182026
Published: 2023
Journal Articles

Effective and Safe Molecular-Pharmacodynamic Once Weekly Dosing of Decitabine and Venetoclax Is a Highly Effective and Well-Tolerated Induction Therapy for AML: Interim Results of a Phase 2 Trial

Mendel Goldfinger, Abigail Epstein, Ioannis Mantzaris, Aditi Shastri, Kira Gritsman, Noah Kornblum, Alejandro Sica, Nishi Shah, Dennis L Cooper, Swati Goel, David Levitz, Lauren Shapiro, Kith Pradhan, Annemarie Munoz, Monica Comas, Karen Fehn, Aradhika Dhawan, Joel Victor, Yogen Saunthararajah, Amit Verma, Marina Y. Konopleva, Eric J Feldman
Journal: Blood
Blood (2023) 142 (Supplement 1): 4258.
https://doi.org/10.1182/blood-2023-185379
Published: 2023
Journal Articles

Mini-Hyper-CVD Plus Venetoclax for Treatment of Older Adults with Newly Diagnosed Ph-Negative B-ALL or T-ALL

Marlise R. Luskin, Shai Shimony, Julia Keating, Wendy Stock, Hanno Hock, Jacqueline S. Garcia, Maximilian Stahl, Ilene Galinksy, Rebecca Leonard, Howard Weiner, Yael Flamand, Donna S. Neuberg, Richard M Stone, Anthony G. Letai, Eric S. Winer, Marina Y. Konopleva, Nitin Jain, Daniel J. DeAngelo
Journal: Blood
Blood (2023) 142 (Supplement 1): 2875.
https://doi.org/10.1182/blood-2023-174269
Published: 2023
Journal Articles

The Impact of Age and Genomics on Drug Sensitivity in 1,076 Children and Adults with B-Cell Acute Lymphoblastic Leukemia

Satoshi Yoshimura, Zhenhua Li, Yoshihiro Gocho, Wenjian Yang, Kristine R Crews, Shawn H.R. Lee, Kathryn G. Roberts, Charles G. Mullighan, Mary V. Relling, Federico Antillon-Klussmann, Allen Eng Juh Yeoh, Mignon L. Loh, Mark R. Litzow, Sima Jeha, Seth E. Karol, Hiroto Inaba, Ching-Hon Pui, Marina Y. Konopleva, Nitin Jain, Wendy Stock, Elisabeth Paietta, Elias Jabbour, Steven M. Kornblau, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2023) 142 (Supplement 1): 596.
https://doi.org/10.1182/blood-2023-181788
Published: 2023
Journal Articles

Phase II Trial of 10-Day ASTX727 (Decitabine/Cedazuridine) with Venetoclax for Relapsed or Refractory Acute Myeloid Leukemia

Abhishek Maiti, Courtney D. DiNardo, Maro Ohanian, Naval Daver, Gautam Borthakur, Kelly S. Chien, Ghayas C. Issa, Koichi Takahashi, Lucia Masarova, Yesid Alvarado Valero, Elias Jabbour, William G. Wierda, Nicholas J. Short, Melissa MacFarland, Allison Pike, Tapan M. Kadia, Farhad Ravandi, Hagop M. Kantarjian, Guillermo Garcia-Manero, Marina Y. Konopleva
Journal: Blood
Blood (2023) 142 (Supplement 1): 4289.
https://doi.org/10.1182/blood-2023-182901
Published: 2023