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Journal Articles

Evolution of the Genetic and Biological Studies Performed at Diagnosis in Patients with Acute Myeloid Leukemia Included in the Pethema Epidemiological Registry (REALMOL Study)

Jorge Labrador, David Martinez-Cuadron, Blanca Boluda, Josefina Serrano, Cristina Gil, Jose A. Perez-Simon, Teresa Bernal del Castillo, Juan Miguel Bergua Burgués, Joaquín Martínez-López, Carlos Rodriguez, María Belén Vidriales, Raimundo García-Boyero, Jesús Lorenzo Algarra, Marta Polo, Maria Jose Sayas, Mar Tormo, Pilar Herrera, Esperanza Lavilla, Fernando Ramos, Maria Luz Amigo, Susana Vives, Joaquín Sánchez-Garcia, Cristina Bilbao, María Carmen Chillón Santos, Maria Jose Larrayoz, Rosa Ayala, Eva Barragán, Miguel A. Sanz, Pau Montesinos, Juan Manuel Alonso-Dominguez
Journal: Blood
Blood (2022) 140 (Supplement 1): 9100–9102.
DOI: https://doi.org/10.1182/blood-2022-163016
Published: 2022
Journal Articles

Conventional PCR Versus Next Generation Sequencing for Diagnosis of FLT3 , IDH and NPM1 Mutations in Acute Myeloid Leukemia: Interim Analysis of the PCR-LMA Protocol of the Pethema Group

Blanca Boluda, Claudia Sargas, Rosa Ayala, Maria Jose Larrayoz, María Carmen Chillón Santos, Estrella Carrillo-Cruz, Cristina Bilbao, Esther Prados de La Torre, Irene Navarro-Vicente, David Martinez-Cuadron, Rebeca Rodríguez-Veiga, Cristina Gil, Teresa Bernal del Castillo, Juan Miguel Bergua Burgués, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso Dominguez, Raimundo García-Boyero, Maria Luz Amigo, Pilar Herrera, Maria Jose Sayas, Esperanza Lavilla, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, Jose A. Perez-Simon, María Teresa Gómez-Casares, Joaquín Sánchez-Garcia, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3438–3440.
DOI: https://doi.org/10.1182/blood-2022-160136
Published: 2022
Journal Articles

Transcriptional and Genomic Characterization of Measurable Residual Disease (MRD) Cells in Acute Myeloid Leukemia (AML)

Catia Patricia Simoes, Sara Villar, Beñat Ariceta, Juan-José Garcés, Leire Burgos, Diego Alignani, Sarvide Sarai, David Martinez-Cuadron, Juan Miguel Bergua Burgués, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, María Belén Vidriales, María Carmen Chillón Santos, Jorge Labrador, José F. Falantes, Maria Jose Sayas, Rosa Ayala, Joaquín Martínez-López, Ana Alfonso-Pierola, María José Calasanz, Felipe Prosper, Jesús San-Miguel, Miguel A. Sanz, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2022) 140 (Supplement 1): 2270–2272.
DOI: https://doi.org/10.1182/blood-2022-163159
Published: 2022
Journal Articles

Pethema NGS-AML Project. Final Analysis and Clinical Validation of New Genomic Classifications

Claudia Sargas, Rosa Ayala, Maria Jose Larrayoz, Carmen Chillon, Estrella Carrillo, Cristina Bilbao, Esther Prados de La Torre, David Martinez-Cuadron, Rebeca Rodríguez-Veiga, Cristina Gil, Teresa Bernal, Juan Miguel Bergua Burgués, Lorenzo Algarra, Mar Tormo, Pilar Martínez Sánchez, Elena Soria, Josefina Serrano, Juan Manuel Alonso Dominguez, Raimundo García-Boyero, Maria Luz Amigo, Pilar Herrera, María J. Sayas, Esperanza Lavilla, Joaquín Martínez-López, María José Calasanz, Ramón García-Sanz, Jose A. Perez-Simon, María Teresa Gómez-Casares, Joaquín Sánchez-Garcia, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3422–3424.
DOI: https://doi.org/10.1182/blood-2022-166639
Published: 2022
Journal Articles

Supervised Machine Learning Improves Risk Stratification in Newly Diagnosed Myelodysplastic Syndromes: An Analysis of the Spanish Group of Myelodysplastic Syndromes

Adrian Mosquera Orgueira, Manuel Perez Encinas, Nicolas A Diaz Varela, Elvira Mora, Marina Díaz-Beyá, María Julia Montoro, Helena Pomares, Fernando Ramos, Mar Tormo, Andres Jerez, Josep F Nomdedeu, Carlos De Miguel Sanchez, Arenillas Leonor, Paula Cárcel, Maria Teresa Cedena Romero, Blanca Xicoy, Eugenia Rivero, Rafael Andres del Orbe Barreto, Maria Diez-Campelo, Luis E. Benlloch, Davide Crucitti, David Valcárcel
Journal: Blood
Blood (2022) 140 (Supplement 1): 1132–1134.
DOI: https://doi.org/10.1182/blood-2022-159429
Published: 2022
Journal Articles

Prognostic Impact of NPM1 and FLT3 -ITD Mutations in Patients Treated with Non-Intensive Regimens: A Pethema Registry Study

Edwin Uriel Suárez, Juan Manuel Alonso, Blanca Boluda, Esperanza Lavilla, Mar Tormo, Carmen Botella, Susana Vives, Carlos Rodriguez, Josefina Serrano, María José Sayas, Pilar Martínez Sánchez, Fernando Ramos, Teresa Bernal del Castillo, Lorenzo Algarra, Juan Miguel Bergua Burgués, José Pérez-Simón, Pilar Herrera, Manuel Barrios-García, Víctor Noriega-Concepción, Jóse Ángel Raposo-Puglia, Rosa Ayala, Eva Barragán, David Martinez-Cuadron, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 6077–6079.
DOI: https://doi.org/10.1182/blood-2022-167365
Published: 2022
Journal Articles

RAS Mutations in Adult Acute Myeloid Leukemia (AML). Frequency, Mutational Spectrum, and Identification of a Comutation Bias for KRAS K117 ( TET2 / ASXL1 )

Alícia Artigas-Baleri, Helena Castellet, Marta Pratcorona, Lurdes Zamora, Monica Lopez-Guerra, Bárbara Tazón, Susana Vives, Mar Tormo, Montserrat Arnan, Antoni Garcia-Guiñon, Rosa Coll., Antonia Sampol, Joan Bargay, Ferran Vall-Llovera, Olga Salamero, Felix Lopez-Cadenas, Ana Garrido Díaz, Jordi Esteve, Jorge Sierra, Josep F Nomdedeu
Journal: Blood
Blood (2022) 140 (Supplement 1): 11821–11823.
DOI: https://doi.org/10.1182/blood-2022-164718
Published: 2022
Journal Articles

Indolent Acute Myeloid Leukemia with Long Survival in Patients Treated with Best Supportive Care Only: A Pethema Registry Study

Jorge Labrador, Josefina Serrano, Laura Torres, Evelyn Acuña-Cruz, Jose A. Perez-Simon, Maria Lopez-Pavia, Gabriela Rodriguez Macias, Carmen Botella, Carlos Rodriguez, Pilar Martinez Sanchez, Maria Luz Amigo, Maria Victoria Cuevas, Teresa Bernal del Castillo, María Carmen Montes, Celina Benavente, Juan Ignacio Rodriguez-Gutierrez, Mar Tormo, Raimundo García-Boyero, Aurelio Lopez Martínez, Rafael Lluch Garcia, Jesús Lorenzo Algarra, Esperanza Lavilla, David Martinez-Cuadron, Miguel A. Sanz, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 8919–8920.
DOI: https://doi.org/10.1182/blood-2022-162591
Published: 2022
Journal Articles

Genomic Data Improves Prognostic Stratification in Adult T-Cell Acute Lymphoblastic Leukemia Patients Enrolled in Measurable Residual Disease-Oriented Trials

Celia González-Gil, Mireia Morgades, Francisco Fuster-Tormo, Jesus García-Chica, Pau Montesinos, Anna Torrent, Marina Diaz-Beyá, Rosa Coll, Jordi Ribera, Ran Zhao, Maria Lourdes Hermosin, Santiago Mercadal, José González-Campos, M Teresa Artola, Ferran Vall-Llovera, Mar Tormo, Cristina Gil, Pere Barba, Andrés Novo, Teresa Bernal del Castillo, Maria Queipo De Llano, Pilar Martínez, Teresa González, Antonia Cladera, Alfons Serrano, Rosa Fernández-Martín, Maria C. Ardaiz, Maria Jesus Vidal, Ángela Baena, Nuria Lopez-Bigas, Anna Bigas, Jaroslaw P. Maciejewski, Alberto Orfao, Josep-Maria Ribera, Eulàlia Genescà
Journal: Blood
Blood (2021) 138 (Supplement 1): 3486.
DOI: https://doi.org/10.1182/blood-2021-148263
Published: 2021
Journal Articles

Germline and Somatic Variants Co-Ocurrence Profile in Early Onset Adult Myelodysplastic Syndromes without a Preexisting Disorder

Tzu Hua Chen-Liang, Salvador Carrillo-Tornel, Marta Santiago, Bernardo López Andrade, Francisca Maria Hernandez, Paloma García-Martín, Félix López Cadenas, Mar Tormo, María Lourdes Hermosín, Teresa Bernal del Castillo, Esperanza Tuset, Ángeles Medina Perez, Helena Pomares, Teresa Arquero, María Julia Montoro, Blanca Xicoy, Francesc Solé, Guillermo Sanz, David Valcarcel, Maria Diez-Campelo, Andres Jerez
Journal: Blood
Blood (2021) 138 (Supplement 1): 2595.
DOI: https://doi.org/10.1182/blood-2021-152128
Published: 2021
Journal Articles

Clinical and Biological Characterization of Low Risk MDS Patients According to Ring Sideroblasts (RS). Comparison between the 3 Subgroups in WHO2017 Classification. Study from the Spanish MDS Registry

Félix López Cadenas, Teresa Bernal del Castillo, Guillermo Sanz, Montserrat Arnan Sangerman, Fernando Ramos, Carme Pedro, Mar Tormo, Maria T Ardanaz, Ana Vicente, Gema Azaceta Reinares, Carlos Fernández, Asunción Mora Casado, Alba Redondo Guijo, Maria Vahi, Carlos Aguilar, Ángeles Medina Perez, Yapci Ramos de León, Laura Vicente, David Valcárcel, Maria Diez-Campelo
Journal: Blood
Blood (2021) 138 (Supplement 1): 2610.
DOI: https://doi.org/10.1182/blood-2021-152678
Published: 2021
Journal Articles

Treatment Patterns and Overall Survival in Patients with Intermediate-Risk MDS: A Retrospective Analysis in the Spanish MDS Registry

María Diez-Campelo, Luis E. Benlloch, Emma Sasse, David Wormser, Leyla Hernandez Donoso, Silvia Colicino, Teresa Bernal, Antonieta Molero Yordi, Mar Tormo, Montserrat Arnan Sangerman, Guillermo Sanz, Marina Díaz-Beyá, María Teresa Cedena Romero, Andres Jerez, Brayan Merchán, David Valcárcel
Journal: Blood
Blood (2021) 138 (Supplement 1): 2605.
DOI: https://doi.org/10.1182/blood-2021-146019
Published: 2021
Journal Articles

Patterns of Salvage Therapy in Patients with Acute Myeloid Leukemia Treated Upfront with Azacitidine or Decitabine: Results from the Pethema AML Registry

Jorge Labrador, Adolfo de la Fuente, David Martínez-Cuadrón, Rebeca Rodríguez-Veiga, Josefina Serrano, Mar Tormo, Jose Pérez-Simón, Fernando Ramos, Teresa Bernal del Castillo, Maria López-Pavía, Fernanda Trigo, Pilar Martinez Sanchez, Juan Ignacio Rodriguez-Gutierrez, Carlos Rodriguez, Cristina Gil, Daniel Garcia, Susana Vives, Maria Angeles Foncillas, Manuel Perez Encinas, Andrés Novo, Isabel Recio, Gabriela Rodriguez Macias, Juan Miguel Bergua Burgues, Victor Noriega Concepcion, Esperanza Lavilla, Alicia Roldán Pérez, Miguel A. Sanz, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1255.
DOI: https://doi.org/10.1182/blood-2021-150544
Published: 2021
Journal Articles

Long-Term Subgroup Analyses from Azacitidine Vs. Decitabine in Unfit Newly Diagnosed Acute Myeloid Leukemia Patients: Results from the Pethema Registry

Jorge Labrador, Adolfo de la Fuente, David Martínez-Cuadrón, Rebeca Rodríguez-Veiga, Josefina Serrano, Mar Tormo, Jose Pérez-Simón, Fernando Ramos, Teresa Bernal del Castillo, Maria López-Pavía, Fernanda Trigo, Pilar Martinez Sanchez, Juan Ignacio Rodriguez-Gutierrez, Carlos Rodriguez, Cristina Gil, Daniel Garcia, Susana Vives, Maria Angeles Foncillas, Manuel Perez Encinas, Andrés Novo, Isabel Recio, Gabriela Rodriguez Macias, Juan Miguel Bergua Burgues, Victor Noriega Concepcion, Esperanza Lavilla, Alicia Roldán Pérez, Miguel A. Sanz, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1256.
DOI: https://doi.org/10.1182/blood-2021-150649
Published: 2021
Journal Articles

Nationwide Laboratory Network for AML Cross-Validated NGS Studies: Results from a Real-Life Cohort of the Pethema Group

Claudia Sargas, Rosa Ayala, Carmen Chillon, Maria Jose Larrayoz, Estrella Carrillo, Cristina Bilbao, Manuel Yébenes, Marta Llop, Inmaculada Rapado, Ramon Garcia-Sanz, Iria Vazquez, Elena Soria, Santiago Sánchez-Sosa, Kamila Janusz, Carmen Botella, Josefina Serrano, David Martinez-Cuadron, Juan-Miguel Bergua, Maria Luz Amigo, Pilar Martinez Sanchez, Mar Tormo, Teresa Bernal, Pilar Herrera-Puente, Raimundo García-Boyero, Lorenzo Algarra, Maria Jose Sayas, Lisette Costilla-Barriga, Esther Pérez-Santolalla, Inmaculada Marchante, Esperanza Lavilla-Rubira, Víctor Noriega, Juan Manuel Alonso Dominguez, Miguel A. Sanz, Joaquín Sánchez, María Teresa Gómez-Casares, Jose A. Perez-Simon, María José Calasanz, Marcos González, Joaquín Martínez-López, Eva Barragán, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1302.
DOI: https://doi.org/10.1182/blood-2021-152353
Published: 2021
Journal Articles

Venetoclax Therapy in a Heavily Treated Cohort of Patients with Relapsed or Refractory Acute Myeloid Leukemia: Update of the Pethema Registry Experience

Jorge Labrador, Miriam Saiz-Rodríguez, Maria Dunia De Miguel, Almudena De Laiglesia, Carlos Rodriguez, María Belén Vidriales, Manuel Pérez-Encinas, Maria Jose Sanchez, Rebeca Cuello, Alicia Roldán Pérez, Susana Vives, Gonzalo Benzo Callejo, Mercedes Colorado Araujo, María García-Fortes, Maria Jose Sayas, Carmen Olivier, Isabel Recio, Diego Conde, Alvaro Bienert Garcia, Maria Vahi, Carmen Muñoz García, Cristina Seri, Mar Tormo, Ferran Vall-llovera, Maria Angeles Foncillas, David Martínez-Cuadrón, Miguel A. Sanz, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 2325.
DOI: https://doi.org/10.1182/blood-2021-150231
Published: 2021
Journal Articles

Chemotherapy or allogeneic transplantation in high-risk Philadelphia chromosome–negative adult lymphoblastic leukemia

Clinical Trials & Observations
Josep-Maria Ribera, Mireia Morgades, Juana Ciudad, Pau Montesinos, Jordi Esteve, Eulàlia Genescà, Pere Barba, Jordi Ribera, Irene García-Cadenas, María José Moreno, Daniel Martínez-Carballeira, Anna Torrent, Pilar Martínez-Sánchez, Silvia Monsalvo, Cristina Gil, Mar Tormo, María Teresa Artola, Marta Cervera, José González-Campos, Carlos Rodríguez, Arancha Bermúdez, Andrés Novo, Beatriz Soria, Rosa Coll, María-Luz Amigo, Aurelio López-Martínez, Rosa Fernández-Martín, Josefina Serrano, Santiago Mercadal, Antònia Cladera, Alberto Giménez-Conca, María-Jesús Peñarrubia, Eugènia Abella, Ferran Vall-llovera, Jesús-María Hernández-Rivas, Antoni Garcia-Guiñon, Juan-Miguel Bergua, Beatriz de Rueda, María-José Sánchez-Sánchez, Alfons Serrano, María Calbacho, Natalia Alonso, Jose-Ángel Méndez-Sánchez, Raimundo García-Boyero, Matxalen Olivares, Susana Barrena, Lurdes Zamora, Isabel Granada, Ludovic Lhermitte, Evarist Feliu, Alberto Orfao
Journal: Blood
Blood (2021) 137 (14): 1879–1894.
DOI: https://doi.org/10.1182/blood.2020007311
Published: 2021
Includes: Supplemental data
Journal Articles

Outcome of Adults with Relapsed T-Cell Acute Lymphoblastic Leukemia (T-ALL) Included in Minimal Residual Disease (MRD)-Oriented Trials

Josep-Maria Ribera, Eduardo Cerello Chapchap, MD, Mireia Morgades, M.Prob.S, Eulàlia Genescà, PhD, Cristina Gil, Irene García-Cadenas, Pere Barba, MD PhD, José González-Campos, MD, Anna Torrent, Teresa Bernal del Castillo, MD PhD, Maria Paz Queipo De Llano, MD, María-Luz Amigo, MD, Mar Tormo, MD, Rosa Coll, MD, Ferran Vall-Llovera, MD, Jordi Ribera, PhD, Maria Jose Sanchez, MD, Beatriz Soria, MD, Antonia Cladera, María Teresa Artola, MD, Antoni Garcia-Guiñon, MD, Alberto Giménez Conca, MD, Lourdes Amador Barciela, MD, Juana Ciudad, PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
DOI: https://doi.org/10.1182/blood-2020-137383
Published: 2020
Journal Articles

Validation of the European Leukemianet 2017 Prognostic Classification for Patients with De Novo Acute Myeloid Leukemia Treated with a Risk-Adapted Protocol (CETLAM 2012)

Alex Bataller, MD, Ana Garrido, MD, Francesca Guijarro, MD, Marina Diaz-Beyá, MD, Guadalupe Oñate, MD, Montserrat Hoyos, Montserrat Arnan, MD, Mar Tormo, MD, Susana Vives, MD, Maria Paz Queipo De Llano, MD, Olga Salamero, MD, Rosa Coll, MD, David Gallardo, MD, Ferran Vall-Llovera, MD, Lourdes Escoda, MD, Antonia Sampol, MD, Antonio Garcia-Guiñon, MD, Brayan Merchan, MD, Joan Bargay, MD, Monica Lopez-Guerra, PhD, Marta Pratcorona, MD, Lurdes Zamora, PhD, Salut Brunet, MD, Josep F Nomdedeu, MD, Jorge Sierra, MD, Jordi Esteve
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
DOI: https://doi.org/10.1182/blood-2020-140670
Published: 2020
Journal Articles

Azacitidine Vs. Decitabine in Unfit Newly Diagnosed Acute Myeloid Leukemia Patients: Results from the Pethema Registry

Jorge Labrador, David Martínez-Cuadrón, MD, Adolfo de la Fuente, Rebeca Rodríguez-Veiga, MD, Josefina Serrano, MD, Mar Tormo, MD, Jose Antonio Pérez-Simón, MD, Fernando Ramos, Teresa Bernal del Castillo, MD PhD, Maria López-Pavía, Fernanda Trigo, Pilar Martinez Sanchez, Juan Ignacio Rodriguez-Gutierrez, Carlos Rodriguez, Cristina Gil, Daniel Garcia, Susana Vives, MD, Maria Angeles Foncillas, Manuel Perez Encinas, MD, Andrés Novo, MD, Isabel Recio, Gabriela Rodriguez-Macías, MD, Juan Miguel Bergua Burgues, MD, Victor Noriega Concepcion, Esperanza Lavilla, Alicia Roldán Pérez, Miguel A. Sanz, MD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–27.
DOI: https://doi.org/10.1182/blood-2020-141213
Published: 2020