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Journal Articles

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Blood (2022) 139 (19): 2983–2997.

DOI: https://doi.org/10.1182/blood.2021014557

Published: 2022

Includes: Supplemental data

Journal Articles

Low Rates of Venoocclusive Disease and Non-Relapse Mortality in Pediatric Patients Undergoing Allogeneic Hematopoietic Cell Transplantation Following Inotuzumab Ozogamicin Reinduction for Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia

Jonathan D. Paolino, Jiemin Yang, Andrew E. Place, Christine N. Duncan, Steven P. Margossian, Leslie E. Lehmann, John T. Horan, Malika Kapadia, Jennifer S. Whangbo, Francesca Alvarez Calderon, Melissa A. Burns, Leslie S. Kean, Lewis B. Silverman, Donna S. Neuberg, Susanne H.C. Baumeister

Blood (2021) 138 (Supplement 1): 2853.

DOI: https://doi.org/10.1182/blood-2021-152857

Published: 2021

Journal Articles

Peri-Transplant Alemtuzumab Levels Predict Risk of Secondary Graft Failure and Inversely Impact CXCL9 Levels after RIC HCT (A Correlative Biology Study to BMT-CTN 1204 RICHI)

Ashley V Geerlinks, Brooks Scull, Christa Krupski, Ryan Fleischmann, Michael A. Pulsipher, Mary Eapen, Jim A. Connelly, Catherine M. Bollard, Sung-Yun Pai, Christine N. Duncan, Leslie S Kean, K. Scott Baker, Lauri S Burroughs, Jeffrey R. Andolina, Michael B Jordan, Tsz-Kwong Man, Carl E. Allen, Rebecca A. Marsh

Blood (2021) 138 (Supplement 1): 748.

DOI: https://doi.org/10.1182/blood-2021-145629

Published: 2021

Journal Articles

MI-Immune/1801: Lessons from an Ongoing, Multi-Center Trial Involving Biospecimen Collection for Prospective Microbiome and Immune Profiling in Patients Undergoing Reduced Intensity Conditioning Allogeneic HCT

Blood (2021) 138 (Supplement 1): 2955.

DOI: https://doi.org/10.1182/blood-2021-149313

Published: 2021

Journal Articles

Improved Overall Survival of Patients Treated with Abatacept in Combination with a Calcineurin Inhibitor and Methotrexate Following 7/8 HLA-Matched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation: Analysis of the Center for International Blood and Marrow Transplant Research Database

Leslie S Kean, Linda J Burns, Tzuyung Douglas Kou, Roxanne Kapikian, Xiao-Ying Tang, Mei-Jie Zhang, Michael Hemmer, Sean E Connolly, Martin Polinsky, Brian Gavin, Andres Gomez, Marcelo C Pasquini

Blood (2021) 138 (Supplement 1): 3912.

DOI: https://doi.org/10.1182/blood-2021-150742

Published: 2021

Journal Articles

Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Blood (2021) 137 (8): 1090–1103.

DOI: https://doi.org/10.1182/blood.2020005628

Published: 2021

Includes: Supplemental data

Journal Articles

Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates

Blake J. Rust, Leslie S. Kean, Lucrezia Colonna, Katherine E. Brandenstein, Nikhita H. Poole, Willimark Obenza, Mark R. Enstrom, Colby R. Maldini, Gavin I. Ellis, Christine M. Fennessey, Meei-Li Huang, Brandon F. Keele, Keith R. Jerome, James L. Riley, Hans-Peter Kiem, Christopher W. Peterson

Blood (2020) 136 (15): 1722–1734.

DOI: https://doi.org/10.1182/blood.2020006372

Published: 2020

Includes: Supplemental data

Journal Articles

Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis

Leslie S. Kean

Blood (2018) 131 (24): 2630–2639.

DOI: https://doi.org/10.1182/blood-2018-02-785881

Published: 2018

Journal Articles

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Scott N. Furlan, Benjamin Watkins, Victor Tkachev, Sarah Cooley, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, Daniel J. Hunt, John B. Schell, Katie Zeleski, Alison Yu, Cynthia R. Giver, Edmund K. Waller, Jeffrey S. Miller, Bruce R. Blazar, Leslie S. Kean

Blood (2016) 128 (21): 2568–2579.

DOI: https://doi.org/10.1182/blood-2016-07-726547

Published: 2016

Includes: Supplemental data

Journal Articles

CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire

Blood (2015) 125 (25): 3835–3850.

DOI: https://doi.org/10.1182/blood-2015-03-631853

Published: 2015

Includes: Supplemental data

Journal Articles

T-Cell Transcriptome Analysis Reveals the Mechanisms Controlling Synergy Between Costimulation Blockade and mTOR Inhibition during Graft Versus Host Disease Prevention

Scott N. Furlan, MD, Benjamin Watkins, MD, Kelly Hanby, Aneesah P. Garrett, Angela Panoskaltsis-Mortari, PhD, Bruce R. Blazar, MD, Leslie S. Kean

Blood (2014) 124 (21): 3824.

DOI: https://doi.org/10.1182/blood.V124.21.3824.3824

Published: 2014

Journal Articles

Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival

Benjamin Watkins, MD, Aneesah P. Garrett, Jingyang Chen, Scott N. Furlan, MD, Kelly Hamby, Bernard Vanhove, PhD, Leslie S. Kean, MD PhD

Blood (2014) 124 (21): 2425.

DOI: https://doi.org/10.1182/blood.V124.21.2425.2425

Published: 2014

Journal Articles

Defining the Primate T Cell Transcriptome during Graft Versus Host Disease: New Data Implicating the Hedgehog and Aurora Kinase Pathways in Pathogenesis and Prevention

Scott N. Furlan, MD, Benjamin Watkins, MD, Ryan P Flynn, Swetha Ramakrishnan, Karnail Singh, PhD, Cynthia R. Giver, PhD, Kelly Hanby, Linda Stempora, Aneesah P. Garrett, Carly GK Ziegler, Gregory Tharp, Steven Bosinger, Bruce R. Blazar, MD, Edmund K. Waller, MD PhD, Leslie S. Kean, MD PhD

Blood (2014) 124 (21): 2432.

DOI: https://doi.org/10.1182/blood.V124.21.2432.2432

Published: 2014

Journal Articles

CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis

Saravanan Kaliyaperumal, Benjamin Watkins, Prachi Sharma, Scott Furlan, Swetha Ramakrishnan, Cynthia Giver, Anapatricia Garcia, Cynthia Courtney, Heather Knight, Elizabeth Strobert, Eric Elder, Timothy Crenshaw, Bruce R. Blazar, Edmund K. Waller, Susan Westmoreland, Leslie S. Kean

Blood (2014) 123 (12): 1967–1969.

DOI: https://doi.org/10.1182/blood-2014-01-547612

Published: 2014

Journal Articles

Humoral Immunity Induced By Viral Infection Provides a Major Barrier To Hematopoietic Cell Transplantation

Ravi Ruhil, Daniel Huang, Ozlem P Bulut, Stuart J Knechtle, Leslie S. Kean, Neal N Iwakoshi

Blood (2013) 122 (21): 894.

DOI: https://doi.org/10.1182/blood.V122.21.894.894

Published: 2013

Journal Articles

Rapamycin Rescues The Rapid Disappearance and Loss Of Phenotypic Integrity Of Autologous, Ex-Vivo Expanded Rhesus Macaque Natural Regulatory T Cells After Adoptive Transfer

Karnail Singh, Ph.D., Linda Stempora, Allan D Kirk, MD, PhD, Christian P Larsen, MD, DPhil, Bruce R Blazar, MD, Leslie S. Kean

Blood (2013) 122 (21): 895.

DOI: https://doi.org/10.1182/blood.V122.21.895.895

Published: 2013

Journal Articles

Alloimmunization To HLA Class I Antigens But Not H-Y Antigens Is Associated With Transfusion In Children With Sickle Cell Disease

Robert S. Nickel, MD, Jeanne E. Hendrickson, MD, Leslie S. Kean, MD, PhD, Marianne E. McPherson Yee, MD, MSc, Robert A. Bray, PhD, Howard M. Gebel, PhD, David B. Miklos, MD, PhD, John T. Horan, MD, MPH

Blood (2013) 122 (21): 39.

DOI: https://doi.org/10.1182/blood.V122.21.39.39

Published: 2013

Journal Articles

Alterations In Specific Immune Cell Subsets In Children With Sickle Cell Disease

Robert S. Nickel, MD, Jeanne E. Hendrickson, MD, John T. Horan, MD, MPH, Aneesah P. Garrett, Jennifer M. Robertson, PhD, Ifeyinwa Osunkwo, MD, MPH, Leslie S. Kean, MD, PhD

Blood (2013) 122 (21): 2208.

DOI: https://doi.org/10.1182/blood.V122.21.2208.2208

Published: 2013

Journal Articles

Defining the Primate GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus

Natalia Kozyr, Ph.D., Carly GK Ziegler, Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Taylor Deane, Linda Stempora, Bruce R. Blazar, MD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 1888.

DOI: https://doi.org/10.1182/blood.V120.21.1888.1888

Published: 2012

Journal Articles

A First-in-Disease Trial of in Vivo Costimulation Blockade for Acute GvHD Prevention: The Addition of Abatacept to Standard GvHD Prophylaxis Controls Early CD4+ T Cell Proliferation and Is Associated with Low Rates of Severe Acute GvHD

Divya Tiwari, MD, John Horan, Amelia Langston, MD, Muna Qayed, M.D., M.Sc., Jennifer Carr, Heather Renfroe, Couture Cynthia, Hanna J. Khoury, MD, Robertson Jennifer, R. Donald Harvey, PharmD, Aneesh Mehta, Edmund K. Waller, MD, PhD, Leslie S. Kean, MD, PhD

Blood (2012) 120 (21): 741.

DOI: https://doi.org/10.1182/blood.V120.21.741.741

Published: 2012

NARROW

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Low Rates of Venoocclusive Disease and Non-Relapse Mortality in Pediatric Patients Undergoing Allogeneic Hematopoietic Cell Transplantation Following Inotuzumab Ozogamicin Reinduction for Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia

Peri-Transplant Alemtuzumab Levels Predict Risk of Secondary Graft Failure and Inversely Impact CXCL9 Levels after RIC HCT (A Correlative Biology Study to BMT-CTN 1204 RICHI)

MI-Immune/1801: Lessons from an Ongoing, Multi-Center Trial Involving Biospecimen Collection for Prospective Microbiome and Immune Profiling in Patients Undergoing Reduced Intensity Conditioning Allogeneic HCT

Improved Overall Survival of Patients Treated with Abatacept in Combination with a Calcineurin Inhibitor and Methotrexate Following 7/8 HLA-Matched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation: Analysis of the Center for International Blood and Marrow Transplant Research Database

Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates

Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire

T-Cell Transcriptome Analysis Reveals the Mechanisms Controlling Synergy Between Costimulation Blockade and mTOR Inhibition during Graft Versus Host Disease Prevention

Preventing Primate GvHD Using a Novel Antagonistic Anti-CD28 Antibody Plus Rapamycin: Downregulation of CD8 Activation and Preservation of the Naïve Cell Phenotype Predicts GvHD-Free Survival

Defining the Primate T Cell Transcriptome during Graft Versus Host Disease: New Data Implicating the Hedgehog and Aurora Kinase Pathways in Pathogenesis and Prevention

CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis

Humoral Immunity Induced By Viral Infection Provides a Major Barrier To Hematopoietic Cell Transplantation

Rapamycin Rescues The Rapid Disappearance and Loss Of Phenotypic Integrity Of Autologous, Ex-Vivo Expanded Rhesus Macaque Natural Regulatory T Cells After Adoptive Transfer

Alloimmunization To HLA Class I Antigens But Not H-Y Antigens Is Associated With Transfusion In Children With Sickle Cell Disease

Alterations In Specific Immune Cell Subsets In Children With Sickle Cell Disease

Defining the Primate GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus

A First-in-Disease Trial of in Vivo Costimulation Blockade for Acute GvHD Prevention: The Addition of Abatacept to Standard GvHD Prophylaxis Controls Early CD4+ T Cell Proliferation and Is Associated with Low Rates of Severe Acute GvHD

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American Society of Hematology

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American Society of Hematology

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