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Journal Articles

Epigenetic Enzyme Mutations in Myeloid Malignancies Are Selected By Chromatin-Remodeling Requirements That Vary By Lineage- and Maturation-Stage

Sunisa Kongkiatkamon, Xiaorong Gu, Kwok Peng Ng, Simona Pagliuca, Vera Adema, Wencke Walter, Yasunobu Nagata, Cassandra M Kerr, Cassandra M Kerr, Manja Meggendorfer, Hassan Awada, Stephan Hutter, Carmelo Gurnari, Claudia Haferlach, Babal K. Jha, Valeria Visconte, Torsten Haferlach, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah
Journal: Blood
Blood (2021) 138 (Supplement 1): 1148.
https://doi.org/10.1182/blood-2021-153618
Published: 2021
Journal Articles

A First-in-Class Inhibitor of ISWI-Mediated (ATP-Dependent) Transcription Repression Releases Terminal-Differentiation in AML Cells While Sparing Normal Hematopoiesis

Ashwin Kishtagari, MBBS, Kwok Peng Ng, PhD, Charlotte Jarman, Anand D. Tiwari, PhD, James G Phillips, PhD, Caroline Schuerger, Babal K. Jha, Yogenthiran Saunthararajah, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 216.
https://doi.org/10.1182/blood-2018-99-119311
Published: 2018
Journal Articles

Somatic Mutations in Schinzel-Giedion Syndrome Gene SETBP1 Determine Progression in Myeloid Malignancies

Hideki Makishima, MD, PhD, Kenichi Yoshida, MD, Nhu Nguyen, PhD, Masashi Sanada, MD, Yusuke Okuno, MD, PhD, Kwok Peng Ng, PhD, Bartlomiej P Przychodzen, Kristbjorn O Gudmundsson, PhD, Bandana A Vishwakarma, PhD, Andres Jerez, MD, Ines Gomez-Segui, MD, Mariko Takahashi, MD, Yuichi Shiraishi, PhD, Yasunobu Nagata, MD, Kathryn M Guinta, Hiraku Mori, MD, PhD, Mikkael A. Sekeres, MD, MS, Kenichi Chiba, BA, Hideki Muramatsu, MD, PhD, Hirotoshi Sakaguchi, MD, Ronald Paquette, MD, PhD, Michael A McDevitt, MD, PhD, Seiji Kojima, Yogen Saunthararajah, MD, Satoru Miyano, PhD, Lee-Yung Shih, MD, PhD, Yang Du, PhD, Seishi Ogawa, MD, PhD, Jaroslaw P. Maciejewski, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2.
https://doi.org/10.1182/blood.V120.21.2.2
Published: 2012
Journal Articles

STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia

Andres Jerez, Michael J. Clemente, Hideki Makishima, Hanna Koskela, Francis LeBlanc, Kwok Peng Ng, Thomas Olson, Bartlomiej Przychodzen, Manuel Afable, Ines Gomez-Segui, Kathryn Guinta, Lisa Durkin, Eric D. Hsi, Kathy McGraw, Dan Zhang, Marcin W. Wlodarski, Kimmo Porkka, Mikkael A. Sekeres, Alan List, Satu Mustjoki, Thomas P. Loughran, Jaroslaw P. Maciejewski
Journal: Blood
Blood (2012) 120 (15): 3048–3057.
https://doi.org/10.1182/blood-2012-06-435297
Published: 2012
Includes: Supplemental data
Journal Articles

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

Donald Lavelle, Kestis Vaitkus, Yonghua Ling, Maria A. Ruiz, Reda Mahfouz, Kwok Peng Ng, Soledad Negrotto, Nicola Smith, Pramod Terse, Kory J. Engelke, Joseph Covey, Kenneth K. Chan, Joseph DeSimone, Yogen Saunthararajah
Journal: Blood
Blood (2012) 119 (5): 1240–1247.
https://doi.org/10.1182/blood-2011-08-371690
Published: 2012
Includes: Supplemental data
Journal Articles

Consequences of UTX Dysfunction in Myelodysplastic Syndrome

Anna M Jankowska, PhD, Hadrian Szpurka, PhD, Venugopalan Cheriyath, PhD, Kwok Peng Ng, PhD, Zhenbo Hu, MD, Michael A McDevitt, MD, Yogen Saunthararajah, MD, Jaroslaw P. Maciejewski, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2427.
https://doi.org/10.1182/blood.V118.21.2427.2427
Published: 2011
Journal Articles

Runx1 Haploinsufficiency Permits Lineage-Commitment but Impairs Activation of a Key Late Differentiation Gene

Zhenbo Hu, MD, Kwok Peng Ng, PhD, Quteba Ebrahem, MD, Yogen Saunthararajah, MD
Journal: Blood
Blood (2011) 118 (21): 2442.
https://doi.org/10.1182/blood.V118.21.2442.2442
Published: 2011
Journal Articles

Runx1 Regulates Pu.1 Coactivator/Corepressor Exchange

Xiaorong Gu, PhD, Zhenbo Hu, MD, Quteba Ebrahem, MD, Kwok Peng Ng, PhD, Jack S Crabb, MS, John W Crabb, PhD, Yogen Saunthararajah, MD
Journal: Blood
Blood (2011) 118 (21): 2372.
https://doi.org/10.1182/blood.V118.21.2372.2372
Published: 2011
Journal Articles

Effective and Non-Cytotoxic p53 Independent Epigenetic-Differentiation Therapy In Xeno-Transplant Models of Human Acute Myeloid Leukemia

Kwok Peng Ng, PhD, Quteba Ebrahem, MD, Soledad Negrotto, PhD, Reda Mahfouz, MD, Kevin Link, PhD, Zhenbo Hu, MD, Xiaorong Gu, PhD, Anjali Advani, MD, Matt Kalaycio, MD, Mikkael A. Sekeres, MD, MS, Edward A. Copelan, MD, Jaroslaw P Maciejewski, MD, PhD, FACP, James C. Mulloy, PhD, Yogenthiran Saunthararajah, MD
Journal: Blood
Blood (2010) 116 (21): 3309.
https://doi.org/10.1182/blood.V116.21.3309.3309
Published: 2010
Journal Articles

Non-p53 Dependent, Leukemia Initiating-Cell Selective, Therapy.

Kwok Peng Ng, Soledad Negrotto, Zhenbo Hu, Kevin A Link, Santosh L Saraf, MD, Anjali Advani, M.D., Mikkael A. Sekeres, MD, MS, Jaroslaw P. Maciejewski, MD, PhD, James C. Mulloy, PhD, Yogenthiran Saunthararajah, M.D.
Journal: Blood
Blood (2009) 114 (22): 2077.
https://doi.org/10.1182/blood.V114.22.2077.2077
Published: 2009
Journal Articles

Involvement of TET2 in Regulation of Epigenetic Silencing in MDS and Related Myeloid Malignancies.

Hadrian Szpurka, PhD, MSc, Anna M. Jankowska, MSc, Kwok Peng Ng, PhD, Joshua R. Clevenger, Yogen Saunthararajah, MD, Jaroslaw P. Maciejewski, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2908.
https://doi.org/10.1182/blood.V114.22.2908.2908
Published: 2009