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Journal Articles

Ex vivo venetoclax sensitivity predicts clinical response in acute myeloid leukemia in the prospective VenEx trial

Clinical Trials & Observations
Sari Kytölä, Ida Vänttinen, Tanja Ruokoranta, Anu Partanen, Annasofia Holopainen, Joseph Saad, Milla E. L. Kuusisto, Sirpa Koskela, Riikka Räty, Maija Itälä-Remes, Imre Västrik, Minna Suvela, Alun Parsons, Kimmo Porkka, Krister Wennerberg, Caroline A. Heckman, Tero Jalkanen, Teppo Huttunen, Pia Ettala, Johanna Rimpiläinen, Timo Siitonen, Marja Pyörälä, Heikki Kuusanmäki, Mika Kontro
Journal: Blood
Blood (2025) 145 (4): 409–421.
https://doi.org/10.1182/blood.2024024968
Published: 2025
Includes: Supplemental data
Journal Articles

Genomic Subtypes of AML Define Sensitivity to NK Cell Cytotoxicity

Hanna Duàn, Emmi Jokinen, Hanna Lähteenmäki, Jay Klievink, Jonas Bouhlal, Essi Laajala, Jason Theodoropoulos, Heikki Kuusanmäki, Tanja Ruokoranta, Pauliina Rumm, Dean Anthony Lee, Esa Pitkänen, Tomi P Mäkelä, Kimmo Porkka, Oscar E. Brück, Olli Dufva, Satu Mustjoki
Journal: Blood
Blood (2024) 144 (Supplement 1): 329.
https://doi.org/10.1182/blood-2024-199448
Published: 2024
Journal Articles

Enabling Population-Scale Screening of Myeloid Neoplasms Using Blood Cell Count Dynamics

Oona Rinkinen, Laura Toivanen, Kimmo Porkka, Oscar E. Brück
Journal: Blood
Blood (2024) 144 (Supplement 1): 3612.
https://doi.org/10.1182/blood-2024-207261
Published: 2024
Journal Articles

Computational Cytomorphological Analyses Identifies Bone Marrow Erythroblast Proportion As a Biomarker of Treatment-Free Remission in CML

Mikko Purhonen, Mikael Tatun, Kevin Hung, Oda Tafjord, Shady Adnan-Awad, Perttu Koskenvesa, Sanna Siitonen, Kimmo Porkka, Satu Mustjoki, Signe Danielsson, Henrik Hjorth-Hansen, Ulla Olsson-Strömberg, Takashi Kumagai, Shinya Kimura, David M Ross, Oscar E. Brück
Journal: Blood
Blood (2024) 144 (Supplement 1): 1780.
https://doi.org/10.1182/blood-2024-207253
Published: 2024
Journal Articles

Comparison of Anti-PD1, Anti-CTLA4 and Anti-TIM3 in Treatment of AML Patients with Single-Cell Transcriptomics Displays Different Effects on Immune Subtypes

Sofia Forstén, Livius Penter, Oscar E. Brück, Johannes Smolander, Karita Peltonen, Harri Lähdesmäki, Mika Kontro, Kimmo Porkka, Hussein A. Abbas, Catherine J. Wu, Jani Huuhtanen, Satu Mustjoki
Journal: Blood
Blood (2024) 144 (Supplement 1): 1529.
https://doi.org/10.1182/blood-2024-199471
Published: 2024
Journal Articles

Predictors of Response and Rational Combinations for the Novel MCL-1 Inhibitor MIK665 in Acute Myeloid Leukemia

Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh B. Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman
Journal: Blood
Blood (2024) 144 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2024-207199
Published: 2024
Journal Articles

A First in Human Study of VOB560 in Combination with MIK665 in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma, Acute Myeloid Leukemia, or Multiple Myeloma

Harinder Gill, Ine Moors, Kimmo Porkka, Yakir Moshe, Sung Soo Yoon, Naval Daver, Enrique M Ocio, Masafumi Fukaya, Tim Sauer, Maria-Victoria Mateos, Frank Stegelmann, Marta Ubezio, Alessia Campagna, Massimo Magagnoli, Heiko Maacke, Laurent Susini, Kae Ishihara, Ines Cordeiro Filipe, Xiaozhou Zhang, Richard Ducray, Lidiya Bebrevska, Ensar Halilovic, Amy Luyt, Armando Santoro
Journal: Blood
Blood (2024) 144 (Supplement 1): 5997.
https://doi.org/10.1182/blood-2024-199074
Published: 2024
Journal Articles

Deep Learning Models for Predicting Overall Survival of Acute Myeloid Leukemia Using Short-Term Longitudinal Blood Measurements and the Omop Common Data Model

Salma Rachidi, Alexey Ryzhenkov, Valtteri Nieminen, Tomi P Mäkelä, Oscar Brück, Kimmo Porkka, Eric Fey
Journal: Blood
Blood (2024) 144 (Supplement 1): 1476.
https://doi.org/10.1182/blood-2024-209871
Published: 2024
Journal Articles

Integrating Computational Cytomorphological Analysis of Bone Marrow Smears and Clinical Data for Predicting Response to Venetoclax and Hypomethylating Agents in AML

Henri Sundquist, Mikael Tatun, Mikko Purhonen, Laura Toivanen, Johanna Rimpiläinen, Samuli Rounioja, Timo Siitonen, Marja Pyörälä, Pentti Mäntymaa, Sari Kytölä, Kimmo Porkka, Sanna Siitonen, Heikki Kuusanmäki, Mika Kontro, Oscar E. Brück
Journal: Blood
Blood (2024) 144 (Supplement 1): 4320.
https://doi.org/10.1182/blood-2024-206949
Published: 2024
Journal Articles

The Laip-Based-Dfn Approach Is Superior in Terms of Useful MRD Results As Compared to the Laip Approach after Cycle II in Acute Myeloid Leukemia

Lok Lam Ngai, Diana Hanekamp, Angèle Kelder, Willemijn Scholten, Jannemieke Carbaat-Ham, Mona M.H.E Fayed, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Tim R. Mocking, Vincent H.J. Van Der Velden, Jennichjen Slomp, Willemijn Hobo, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Arjan A. van de Loosdrecht, Gert Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 142 (Supplement 1): 1572.
https://doi.org/10.1182/blood-2023-181709
Published: 2023
Journal Articles

Targeting Mitochondrial Apoptotic Priming State to Personalize Therapy for Relapsed Acute Myeloid Leukemia

Elyse Olesinski, Karanpreet Bhatia, Chuqi Wang, Marissa Pioso, Shu Xuan Ng, Xiao Xian Lin, Vedant Sandhu, Binyam Yilma, Stephan Rainer Maximilian Bohl, Jeremy Ryan, Disha Malani, Marlise R. Luskin, Olli Kallioniemi, Kimmo Porkka, Allen Yeoh, Sophia Adamia, Wee Joo Chng, Motomi Osato, David M. Weinstock, Jacqueline S. Garcia, Anthony G. Letai, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 48.
https://doi.org/10.1182/blood-2023-189156
Published: 2023
Journal Articles

Primary Acute Myeloid Leukemia Cells Trigger Distinct Activation Patterns in Expanded NK Cells

Hanna Duàn, Olli Dufva, Emmi Jokinen, Hanna Lähteenmäki, Jay Klievink, Jonas Bouhlal, Jason Theodoropoulos, Heikki Kuusanmäki, Tanja Ruokoranta, Pauliina Rumm, Dean Anthony Lee, Esa Pitkänen, Tomi P Mäkelä, Kimmo Porkka, Oscar Brück, Satu Mustjoki
Journal: Blood
Blood (2023) 142 (Supplement 1): 66.
https://doi.org/10.1182/blood-2023-174037
Published: 2023
Journal Articles

Prognostic Value of Measurable Residual Disease in High-Risk Myelodysplastic Syndromes with Intensive Chemotherapy Treatment: Analysis of HOVON-SAKK Studies

Lok Lam Ngai, Coen R. Veenstra, Patrycja Gradowska, Angèle Kelder, Willemijn Scholten, Alexander N. Snel, Jesse M. Tettero, Costa Bachas, Dimitri Breems, Thomas Fischer, Bjorn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan Maertens, Markus G. Manz, Thomas Pabst, Jakob Passweg, Sr., Kimmo Porkka, Canan Alhan, Theresia M. Westers, Peter J. M. Valk, David C. de Leeuw, Bob Lowenberg, Gert Ossenkoppele, Jacqueline Cloos, Arjan A. van de Loosdrecht
Journal: Blood
Blood (2023) 142 (Supplement 1): 323.
https://doi.org/10.1182/blood-2023-184703
Published: 2023
Journal Articles

Prospective validation of the prognostic relevance of CD34 + CD38 – AML stem cell frequency in the HOVON-SAKK132 trial

Clinical Trials & Observations
Lok Lam Ngai, Diana Hanekamp, Fleur Janssen, Jannemieke Carbaat-Ham, Maaike A. M. A. Hofland, Mona M. H. E Fayed, Angèle Kelder, Laura Oudshoorn-van Marsbergen, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn T. Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Arjan A. van de Loosdrecht, Johan A. Maertens, Markus G. Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Peter J. M. Valk, Patrycja Gradowska, Bob Löwenberg, David C. de Leeuw, Jeroen J. W. M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2023) 141 (21): 2657–2661.
https://doi.org/10.1182/blood.2022019160
Published: 2023
Includes: Supplemental data
Journal Articles

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

Heikki Kuusanmäki, Olli Dufva, Markus Vähä-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan-Awad, Cristina Mancebo-Pérez, Joseph Saad, Juho Miettinen, Komal K. Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Kim Theilgaard-Mönch, Ulla Wartiovaara-Kautto, Mikko Keränen, Kimmo Porkka, Marina Konopleva, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2023) 141 (13): 1610–1625.
https://doi.org/10.1182/blood.2021011094
Published: 2023
Includes: Supplemental data
Journal Articles

Integrated High-Throughput Drug Profiling and CRISPR Screening Identify Novel Pathway Vulnerabilities of Leukemic Stem Cells in Chronic Myeloid Leukemia

Shady Adnan Awad, Olli Dufva, Jay Klievink, Ella Karjalainen, Aleksandr Ianevski, Paavo Pietarinen, Daehong Kim, Swapnil Potdar, Maija Wolf, Kourosh Lotfi, Tero Aittokallio, Krister Wennerberg, Kimmo Porkka, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 799–800.
https://doi.org/10.1182/blood-2022-165247
Published: 2022
Journal Articles

Monosomy 7 and Del(7q) Cause Selective Sensitivity to Inhibitors of Nicotinamide Phosphoribosyltransferase in Acute Myeloid Leukemia

Joseph Saad, Samuli Eldfors, Vilma Ikonen, Bjørn Tore Gjertsen, Mika Kontro, Kimmo Porkka, Caroline A. Heckman
Journal: Blood
Blood (2022) 140 (Supplement 1): 1033–1035.
https://doi.org/10.1182/blood-2022-163242
Published: 2022
Journal Articles

Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML

Ana Rio-Machin, Findlay Bewicke-Copley, Jiexin Zheng, Pedro Casado Izquierdo, Juho J. Miettinen, Naeem Khan, Jonas Demeulemeester, Szilvia Krizsán, Christopher Middleton, Sam Benkwitz-Bedford, Joseph Saad, Amaia Vilas-Zornoza, Teresa Ezponda, William Grey, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Farideh Miraki-Moud, Janet Matthews, Marianne Grantham, Ryan J Colm, Jonathan Bond, Doriana Di Bella, Krister Wennerberg, Alun Parsons, Andy G.X. Zeng, Hannah Armes, Karina Close, Fadimana Kaya, Kevin Rouault-Pierre, John G. Gribben, Felipe Prosper, James Cavenagh, John E. Dick, Sylvie D Freeman, Peter Van Loo, Csaba Bödör, Guy Sauvageau, Kimmo Porkka, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro Cutillas, Jude Fitzgibbon
Journal: Blood
Blood (2022) 140 (Supplement 1): 1030–1032.
https://doi.org/10.1182/blood-2022-159069
Published: 2022
Journal Articles

Erythroid/Megakaryocytic Differentiation Confers BCL-XL Dependency and Venetoclax Resistance in Acute Myeloid Leukemia

Olli Dufva, Heikki Kuusanmäki, Markus Vaha-Koskela, Aino-Maija Leppä, Jani Huuhtanen, Ida Vänttinen, Petra Johanna Nygren, Jay Klievink, Jonas Bouhlal, Petri Pölönen, Qi Zhang, Shady Adnan Awad, Cristina Mancebo, Joseph Saad, Juho J. Miettinen, Komal Kumar Javarappa, Sofia Aakko, Tanja Ruokoranta, Samuli Eldfors, Merja Heinäniemi, Ulla Wartiovaara-Kautto, Marina Konopleva, Mikko A Keränen, Kimmo Porkka, Krister Wennerberg, Mika Kontro, Caroline A. Heckman, Satu Mustjoki
Journal: Blood
Blood (2022) 140 (Supplement 1): 101–103.
https://doi.org/10.1182/blood-2022-158694
Published: 2022
Journal Articles

Prospective Validation of CD34+CD38- Leukemic Stem Cell Frequency in the HOVON-SAKK 132 Trial: Perspectives for Future Improvements

Lok Lam Ngai, Diana Hanekamp, Fleur Janssen, Jannemieke Carbaat-Ham, Maaike A.M. Hofland, Mona M.H.E Fayed, Angèle Kelder, Laura Oudshoorn-van Marsbergen, Willemijn J. Scholten, Alexander N. Snel, Costa Bachas, Jesse M. Tettero, Dimitri A. Breems, Thomas Fischer, Bjørn Tore Gjertsen, Laimonas Griškevičius, Gunnar Juliusson, Johan A. Maertens, Markus G Manz, Thomas Pabst, Jakob R. Passweg, Kimmo Porkka, Patrycja Gradowska, Bob Lowenberg, David C. de Leeuw, Jeroen J.W.M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Journal: Blood
Blood (2022) 140 (Supplement 1): 9125–9127.
https://doi.org/10.1182/blood-2022-157753
Published: 2022