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Journal Articles

Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons ( Papio anubis )

Vinzon Ibanez, Kestis Vaitkus, Robert Molokie, Yogenthiran Saunthararajah, Donald Lavelle

Blood (2023) 142 (Supplement 1): 1109.

https://doi.org/10.1182/blood-2023-189523

Published: 2023

Journal Articles

Prolonged Combinatorial Pharmacological Therapy Targeting the Epigenome Increases Fetal Hemoglobin to Clinically Relevant Levels in Normal, Nonanemic Baboons

Vinzon Ibanez, Kestis Vaitkus, Robert E. Molokie, Jagadeesh Ramasamy, Yogenthiran Saunthararajah, Donald Lavelle

Blood (2022) 140 (Supplement 1): 961–962.

https://doi.org/10.1182/blood-2022-155954

Published: 2022

Journal Articles

Effect of the NAMPT Activator P7C3-A20 on γ-Globin Expression in Baboon CD34+ Erythroid Cell Cultures

Vinzon Ibanez, Kestis Vaitkus, Jagadeesh Ramasamy, Yogenthiran Saunthararajah, Robert E. Molokie, Donald Lavelle

Blood (2021) 138 (Supplement 1): 961.

https://doi.org/10.1182/blood-2021-145126

Published: 2021

Journal Articles

Combinatorial Administration of Pharmacological Inhibitors Targeting DNMT1 and KDM1A Produces Synergistic and Additive Increases in F Retiulocytes and γ-Globin Expression in Normal Baboons

Vinzon Ibanez, B.S., Kestis Vaitkus, Robert E. Molokie, MD, Yogenthiran Saunthararajah, MD, Donald Lavelle, PhD

Blood (2020) 136 (Supplement 1): 5.

https://doi.org/10.1182/blood-2020-136599

Published: 2020

Journal Articles

Effect of Nicotinamide, 1-Methylnicotinamide, and N'-Methylnicotinamide on Erythroid Colony Formation and γ-Globin Expression in Cultured Baboon CD34+ Cells

Donald Lavelle, PhD, Vinzon Ibanez, B.S., Kestis Vaitkus, Yogenthiran Saunthararajah, MD, Robert E. Molokie, MD

Blood (2020) 136 (Supplement 1): 4–5.

https://doi.org/10.1182/blood-2020-133974

Published: 2020

Journal Articles

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Kestis Vaitkus, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Ramasamy Jagadeeswaran, PhD, Yogenthiran Saunthararajah, MD, James Douglas Engel, PhD, Joseph DeSimone, PhD, Angela Rivers, MD, Donald Lavelle, PhD

Blood (2018) 132 (Supplement 1): 1054.

https://doi.org/10.1182/blood-2018-99-113539

Published: 2018

Journal Articles

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Ramasamy Jagadeeswaran, PhD MSc, Vinzon Ibanez, B.S., Maria Armila Ruiz, B.S., Filippo Ciceri, PhD, Fernando Cavalcanti, PhD, Robert E. Molokie, MD, Donald Lavelle, PhD

Blood (2017) 130 (Supplement 1): 356.

https://doi.org/10.1182/blood.V130.Suppl_1.356.356

Published: 2017

Journal Articles

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

Vinzon Ibanez, Kestis Vaitkus, Angela Rivers, Robert Molokie, Shuaiying Cui, James Douglas Engel, Joseph DeSimone, Donald Lavelle

Blood (2017) 129 (2): 260–263.

https://doi.org/10.1182/blood-2016-10-746727

Published: 2017

Journal Articles

Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

Kestis Vaitkus, Vinzon Ibanez, Robert E Molokie, MD, Angela Rivers, MD PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2016) 128 (22): 324.

https://doi.org/10.1182/blood.V128.22.324.324

Published: 2016

Journal Articles

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

Ramasamy Jagadeeswaran, PhD, Yash Agarwal, Vinzon Ibanez, Maria Armila Ruiz, Kestis Vaitkus, Joseph DeSimone, PhD, Donald Lavelle, PhD, Angela Rivers, MD PhD

Blood (2015) 126 (23): 3386.

https://doi.org/10.1182/blood.V126.23.3386.3386

Published: 2015

Journal Articles

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Maria Armila Ruiz, Ramaswamy Jagadeeswaran, PhD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2015) 126 (23): 642.

https://doi.org/10.1182/blood.V126.23.642.642

Published: 2015

Journal Articles

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

Maria Armila Ruiz, B.S., Angela Rivers, MD PhD, Kestis Vaitkus, Vinzon Ibanez, Robert E. Molokie, MD, Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 334.

https://doi.org/10.1182/blood.V124.21.334.334

Published: 2014

Journal Articles

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

Angela Rivers, MD PhD, Kestis Vaitkus, Maria Armila Ruiz, B.S., Vinzon Ibanez, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, PhD

Blood (2014) 124 (21): 336.

https://doi.org/10.1182/blood.V124.21.336.336

Published: 2014

Journal Articles

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Angela Rivers, MD, PhD, Maria Armila Ruiz, BS, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Donald Lavelle, Ph.D.

Blood (2013) 122 (21): 561.

https://doi.org/10.1182/blood.V122.21.561.561

Published: 2013

Journal Articles

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

Maria Armila Ruiz, BS, Angela Rivers, MD, PhD, Kestis Vaitkus, Tatiana Kouznetsova, M.S., Nadim Mahmud, MD, PhD, Joseph DeSimone, PhD, Donald Lavelle, PH.D.

Blood (2013) 122 (21): 438.

https://doi.org/10.1182/blood.V122.21.438.438

Published: 2013

Journal Articles

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Maria Armila Ruiz, B.S., Kestis Vaitkus, Aparna Vasanthakumar, PhD, Angela Rivers, MD, PhD, Tatiana Kouznetsova, M.S., Joseph DeSimone, PhD, Lucy A. Godley, MD, PhD, Donald Lavelle, Ph.D.

Blood (2012) 120 (21): 824.

https://doi.org/10.1182/blood.V120.21.824.824

Published: 2012

Journal Articles

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

Donald Lavelle, Ph.D., Kestis Vaitkus, Maria Armila Ruiz, B.S., Angela Rivers, MD, PhD, James D. Engel, PhD, Joseph DeSimone, PhD

Blood (2012) 120 (21): 249.

https://doi.org/10.1182/blood.V120.21.249.249

Published: 2012

Journal Articles

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

Donald Lavelle, Kestis Vaitkus, Yonghua Ling, Maria A. Ruiz, Reda Mahfouz, Kwok Peng Ng, Soledad Negrotto, Nicola Smith, Pramod Terse, Kory J. Engelke, Joseph Covey, Kenneth K. Chan, Joseph DeSimone, Yogen Saunthararajah

Blood (2012) 119 (5): 1240–1247.

https://doi.org/10.1182/blood-2011-08-371690

Published: 2012

Includes: Supplemental data

Journal Articles

γ-Globin Gene (HBG) Promoter Methylation and Gene Expression Is Affected by the Micro-Environment In Adult but Not Fetal Erythroid Cells

Donald Lavelle, Ph.D., Yogenthiran Saunthararajah, MD, Nadim Mahmud, MBBS, PhD, Vinzon Ibanez, PhD, Maria Armila Ruiz, PhD, Kestis Vaitkus, PhD, Tatiana Kouznetsova, Joseph DeSimone, PhD

Blood (2010) 116 (21): 4271.

https://doi.org/10.1182/blood.V116.21.4271.4271

Published: 2010

Journal Articles

Tetrahydrouridine Co-Administration Improves Oral Bioavailability and Dampens Inter-Individual Variability of Decitabine Pharmacokinetics In Baboons

Donald Lavelle, Ph.D., Kestis Vaitkus, YongHua Ling, Nicola Smith, Kenneth K. Chan, PhD, Joseph DeSimone, PhD, Yogenthiran Saunthararajah, MD

Blood (2010) 116 (21): 2081.

https://doi.org/10.1182/blood.V116.21.2081.2081

Published: 2010

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Effect of the Oral LSD1 Inhibitor Ory-1001 on F-Retics in Baboons ( Papio anubis )

Prolonged Combinatorial Pharmacological Therapy Targeting the Epigenome Increases Fetal Hemoglobin to Clinically Relevant Levels in Normal, Nonanemic Baboons

Effect of the NAMPT Activator P7C3-A20 on γ-Globin Expression in Baboon CD34+ Erythroid Cell Cultures

Combinatorial Administration of Pharmacological Inhibitors Targeting DNMT1 and KDM1A Produces Synergistic and Additive Increases in F Retiulocytes and γ-Globin Expression in Normal Baboons

Effect of Nicotinamide, 1-Methylnicotinamide, and N'-Methylnicotinamide on Erythroid Colony Formation and γ-Globin Expression in Cultured Baboon CD34+ Cells

The LSD1 Inhibitor RN-1 Increases γ-Globin Expression in Baboons By Targeting an Early Event Responsible for γ-Globin Repression

Oral Administration of the LSD1 Inhibitor OG-S1335 Increases Fetal Hemoglobin in Humanized Transgenic Sickle Cell Disease Mice and in Baboons

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

Efficacy and Safety of Long-Term Treatment with the LSD1 Inhibitor RN-1 to Increase HbF in Normal, Non-Anemic Baboons

Investigation of Two Combination HbF Induction Regimens, RN-1 and Hydroxyurea Versus RN-1 and Decitabine, in a Humanized Sickle Cell Mouse Model

The LSD1 Inhibitor RN-1 Recapitulates the Fetal Pattern of Hemoglobin Synthesis in Anemic and Normal, Non-Anemic Baboons

The Tet Dioxygenase Co-Factor Ascorbic Acid Reduces DNA Methylation and Increases Expression of the γ-Globin Gene and Acts in a Combinatorial Manner with HbF-Inducing Drugs Targeting Repressive Epigenetic Modifications

RN-1, a Potent and Selective LSD1 Inhibitor, Induces High Levels of Fetal Hemoglobin (HbF) in Anemic Baboons ( P. anubis )

RN-1, a New and Potent Lsd-1 Inhibitor, Increases γ-Globin Expression In a Humanized Sickle Cell Mouse Model

Elevated Levels Of γ-Globin Gene Promoter 5-Hydroxymethylcytosine are Associated With Increased DNA Hypomethylation and HbF Expression

Dynamic Regulation of 5-Hydroxymethylcytosine At the γ-Globin Promoter During Erythroid Differentiation

Combinatorial Effect of Pharmacological Inhibitors of Lsd-1 and DNMT on γ-Globin Synthesis in Cultured Baboon Bone Marrow Erythroid Progenitors

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

γ-Globin Gene (HBG) Promoter Methylation and Gene Expression Is Affected by the Micro-Environment In Adult but Not Fetal Erythroid Cells

Tetrahydrouridine Co-Administration Improves Oral Bioavailability and Dampens Inter-Individual Variability of Decitabine Pharmacokinetics In Baboons

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