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Journal Articles

Desensitization to Pegaspargase in Children with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Is Safe and Does Not Require Intensive Care - a Single Center Experience

Keith J August, Tristan Flatt, Joy M. Fulbright, Alan S. Gamis, Julia A. Hays, Maxine J Hetherington, Karen Lewing, Amanda August, Erin Guest

Blood (2022) 140 (Supplement 1): 6037–6038.

DOI: https://doi.org/10.1182/blood-2022-167549

Published: 2022

Journal Articles

Correlation of Minimal Residual Disease (MRD) at the End of Induction (EOI) and Event Free Survival (EFS) in T-Cell Lymphoblastic Lymphoma (T-LL), a Report from the Children's Oncology Group (COG) Trial AALL1231

Blood (2022) 140 (Supplement 1): 6387–6389.

DOI: https://doi.org/10.1182/blood-2022-159694

Published: 2022

Journal Articles

Premedication and Therapeutic Drug Monitoring (TDM) for Pegaspargase: A Prospective Multicenter Multi-Ethnic Study of Pediatric and Adolescent Patients

Van T Huynh, Sonia Morales, Anurag K. Agrawal, Christine L. Phillips, Keith J August, Erin Guest, Beth Apsel Winger, Catherine Aftandilian, Janel R. Long-Boyle, Kirsten Kasper, Keri Zabokrtsky, Carol Hwang Lin

Blood (2022) 140 (Supplement 1): 8893–8895.

DOI: https://doi.org/10.1182/blood-2022-159255

Published: 2022

Journal Articles

Intensification of Chemotherapy Using a Modified BFM Backbone for Children, Adolescents and Young Adults with T-Cell Acute Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Identifies Highly Chemorefractory Patients Who Benefit from Allogeneic Hematopoietic Stem Cell Transplantation

Blood (2021) 138 (Supplement 1): 3487.

DOI: https://doi.org/10.1182/blood-2021-151837

Published: 2021

Journal Articles

Cranial Radiation Can be Eliminated in Most Children with T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Bortezomib Potentially Improves Survival in Children with T-Cell Lymphoblastic Lymphoma (T-LL): Results of Children's Oncology Group (COG) Trial AALL1231

Blood (2020) 136 (Supplement 1): 11–12.

DOI: https://doi.org/10.1182/blood-2020-134730

Published: 2020

Journal Articles

Successful Treatment of Refractory Acute Lymphoblastic Leukemia with Tisagenlecleucel in the Setting of Life-Threatening Infection

Keith J August, MDMS, Terrie Flatt, DO,MA, Erin Marie Hall, MD, Doug Myers, MD

Blood (2019) 134 (Supplement_1): 5125.

DOI: https://doi.org/10.1182/blood-2019-130880

Published: 2019

Journal Articles

Cuplike nuclear morphology is highly associated with IKZF1 deletion in pediatric precursor B-cell ALL

Weijie Li, Linda D. Cooley, Keith J. August, Aida I. Richardson, Lei Shao, Atif A. Ahmed, Midhat S. Farooqi, David L. Zwick

Blood (2019) 134 (3): 324–329.

DOI: https://doi.org/10.1182/blood.2019000604

Published: 2019

Journal Articles

CTL019 Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor (CAR) T Cells to Characterize the Impact of Tocilizumab on Expansion and to Identify Correlates of Cytokine Release Syndrome Severity

Andrew M Stein, Stephan A Grupp, MD PhD, John E Levine, MD, Theodore W Laetsch, MD, Michael A Pulsipher, MD, Michael W Boyer, MD, Keith J August, MD MS, Bruce L Levine, PhD, Carl H June, MD, Lori Tomassian, MS, Sweta Shah, PharmD, Mimi Leung, MPH, Pai-Hsi Huang, Sebastien Jolivet, Rakesh Awasthi, PhD, Karen Thudium Mueller, PharmD,MSc, Patricia A Wood, MD PhD, Shannon L Maude, MD PhD

Blood (2017) 130 (Supplement 1): 2561.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2561.2561

Published: 2017

Journal Articles

Bortezomib Combined with Mitoxantrone, Vincristine, Peg-Asparaginase and Dexamethasone for Children with Relapsed Acute Lymphoblastic Leukemia

Keith J August, MD MS, Alan S Gamis, MD MPH, Julia A. Hays, MD, Karen Lewing, MD, Erin Guest, MD

Blood (2017) 130 (Supplement 1): 5039.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.5039.5039

Published: 2017

Journal Articles

Impact of Humoral Immunogenicity (Anti-mCAR19 Antibodies) on CTL019 Cellular Kinetics, Efficacy, and Safety

Karen Thudium Mueller, PharmD,MSc, Edward Waldron, PhD, Denise Sickert, PhD, Stephan A Grupp, MD PhD, Shannon L Maude, MD PhD, John E Levine, MD, Theodore W Laetsch, MD, Michael A Pulsipher, MD, Michael W Boyer, MD, Keith J August, MD MS, Rakesh Awasthi, PhD, Bruce L Levine, PhD, Carl H June, MD, Tetiana Taran, MD, Patricia A Wood, MD PhD, Gary Douglas Myers, MD

Blood (2017) 130 (Supplement 1): 1281.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1281.1281

Published: 2017

Journal Articles

Circulating CD2 Negative T Cells in Pediatric Acute Leukemia

Weijie Li, MD, Lei Shao, MD, Atif Ahmed, MD, Doug Myers, MD, Keith J August, MD MS

Blood (2016) 128 (22): 5151.

DOI: https://doi.org/10.1182/blood.V128.22.5151.5151

Published: 2016

Journal Articles

Efficacy and Safety of CTL019 in the First US Phase II Multicenter Trial in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of an Interim Analysis

Shannon L Maude, MD PhD, Michael A Pulsipher, MD, Michael W Boyer, MD, Stephan A Grupp, MD PhD, Stella M Davies, MBBS, PhD, Christine L Phillips, MD, Michael R Verneris, MD, Keith J August, MD MS, Krysta Schlis, MD, Timothy A Driscoll, MD, Rajen Mody, MD MS, Christian M Capitini, MD, Carl H June, MD, Bruce L Levine, PhD, Patricia A Wood, MD PhD, Lan Yi, PhD, John E Levine, MD MS

Blood (2016) 128 (22): 2801.

DOI: https://doi.org/10.1182/blood.V128.22.2801.2801

Published: 2016

Journal Articles

Effect of Intrathecal Methotrexate on CSF and RBC Folate Levels in Children Receiving Treatment for Acute Lymphoblastic Leukemia

Keith J. August, MD MS, Leon van Haandel, PhD, J. Steven Leeder, PharmD, PhD

Blood (2015) 126 (23): 2486.

DOI: https://doi.org/10.1182/blood.V126.23.2486.2486

Published: 2015

Journal Articles

Relative Oral Bioequivalence of Two 6-Mercaptopurine (6-MP) Liquid Formulations in Children with Acute Lymphoblastic Leukemia (ALL)

Jaszianne A. Tolbert, MD, Keith J. August, MD MS, Susan M Abdel-Rahman, PharmD, Scott J Weir, PharmD, PhD, J Steven Leeder, PharmD, PhD, Kathleen A Neville, MD MS

Blood (2014) 124 (21): 2242.

DOI: https://doi.org/10.1182/blood.V124.21.2242.2242

Published: 2014

Journal Articles

Adolescents and Young Adults (AYA) with Acute Myeloid Leukemia (AML) Have Increased Treatment-Related Mortality with Similar Outcomes -- a Report from the Children's Oncology Group Trials AAML03P1 and AAML0531

Keith J. August, MD MS, Richard Aplenc, MD PhD, Lillian Sung, MD PhD, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, John T. Horan, MD MPH, Todd A. Alonzo, PhD, Robert B. Gerbing, MA, Yi-Cheng Jim Wang, MS, Samir Kahwash, MD, Amy Heerema-McKenney, MD, Soheil Meshinchi, MD PhD, Alan S. Gamis, MD MPH

Blood (2014) 124 (21): 3672.

DOI: https://doi.org/10.1182/blood.V124.21.3672.3672

Published: 2014

Journal Articles

Pneumocystis Jirovecii Pneumonia (PCP) in Children with Cancer: A Retrospective Cohort Analysis from the Pediatric Health Information System (PHIS) Database, 2004-2009

Erin M. Guest, MD, Matt Hall, PhD, Samir S. Shah, MD MSCE, Keith J. August, MD MSc, Joy M. Fulbright, MD, Jennifer L. Goldman, MD, Ram V. Kalpatthi, MD, Mohamed A. Radhi, MD, Alan S. Gamis, MD MPH

Blood (2014) 124 (21): 4836.

DOI: https://doi.org/10.1182/blood.V124.21.4836.4836

Published: 2014

Journal Articles

Chemosensitization and Mobilization Of AML/ALL/MDS With Plerixafor (AMD 3100), a CXCR4 Antagonist: A Phase I Study Of Plerixafor + Cytarabine and Etoposide In Pediatric Patients With Acute Leukemia and MDS

Todd Michael Cooper, Sharyn D. Baker, PharmD, PhD, Jennifer Direnzo, Tanya M. Trippett, Lia Gore, MD, Aru Narendran, MD, PhD, Keith J. August, M.D., M.Sc., Michael J. Absalon, MD, PhD, Jessica Boklan, MD, Jessica Pollard, MD, Daniel Magoon, Edward Allan R. Sison, MD, Patrick Brown, MD

Blood (2013) 122 (21): 2680.

DOI: https://doi.org/10.1182/blood.V122.21.2680.2680

Published: 2013

Journal Articles

A Phase I Study Of AC220 (Quizartinib) In Combination With Cytarabine and Etoposide In Relapsed/Refractory Childhood ALL and AML: A Therapeutic Advances In Childhood Leukemia & Lymphoma (TACL) Study

Todd Michael Cooper, Jemily Malvar, M.S., Jeannette Cassar, Elena Eckroth, CCRC, Richard Sposto, PhD, Paul Gaynon, MD, Steven Dubois, MD, Lia Gore, MD, Margaret E. Macy, M.D., Keith J. August, M.D., M.Sc., Blythe Thomson, MD, Javier Oesterheld, MD, Guy Gammon, MD, Daniel Magoon, Colleen E. Annesley, MD, Patrick Brown, MD

Blood (2013) 122 (21): 624.

DOI: https://doi.org/10.1182/blood.V122.21.624.624

Published: 2013

Journal Articles

A Phase I Study of AC220 in Combination with Cytarabine and Etoposide in Relapsed/Refractory Childhood ALL and AML: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study

Todd Cooper, DO, Richard Sposto, PhD, Jeannette Cassar, Elena Eckroth, CCRC, Jemily Malvar, M.S., Paul Gaynon, MD, Steven Dubois, MD, Bill H Chang, MD, PhD, Lia Gore, MD, Keith J. August, M.D., M.Sc., Blythe Thomson, MD, Guy Gammon, MD, Daniel Magoon, Colleen E. Annesley, MD, Patrick Brown, MD

Blood (2012) 120 (21): 3605.

DOI: https://doi.org/10.1182/blood.V120.21.3605.3605

Published: 2012

Journal Articles

An Unusual Presentation of Congenital Dyserythropoietic Anemia Type II (CDAII) Associated with Severe Anemia in a Patient with a Novel Mutation of the SEC23B Gene

Melanie A Villanueva, DO, Carol J Saunders, Ph.D, David Zwick, MD, Laurie Smith, MD, PhD, Darrell Dinwiddie, PhD, Emily Farrow, PhD, Neil Miller, BA, Stephen Kingsmore, M.B., Ch.B., B.A.O., D.Sc., Keith J. August, M.D., M.Sc.

Blood (2012) 120 (21): 990.

DOI: https://doi.org/10.1182/blood.V120.21.990.990

Published: 2012

NARROW

Desensitization to Pegaspargase in Children with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Is Safe and Does Not Require Intensive Care - a Single Center Experience

Correlation of Minimal Residual Disease (MRD) at the End of Induction (EOI) and Event Free Survival (EFS) in T-Cell Lymphoblastic Lymphoma (T-LL), a Report from the Children's Oncology Group (COG) Trial AALL1231

Premedication and Therapeutic Drug Monitoring (TDM) for Pegaspargase: A Prospective Multicenter Multi-Ethnic Study of Pediatric and Adolescent Patients

Cranial Radiation Can be Eliminated in Most Children with T-Cell Acute Lymphoblastic Leukemia (T-ALL) and Bortezomib Potentially Improves Survival in Children with T-Cell Lymphoblastic Lymphoma (T-LL): Results of Children's Oncology Group (COG) Trial AALL1231

Successful Treatment of Refractory Acute Lymphoblastic Leukemia with Tisagenlecleucel in the Setting of Life-Threatening Infection

Cuplike nuclear morphology is highly associated with IKZF1 deletion in pediatric precursor B-cell ALL

CTL019 Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor (CAR) T Cells to Characterize the Impact of Tocilizumab on Expansion and to Identify Correlates of Cytokine Release Syndrome Severity

Bortezomib Combined with Mitoxantrone, Vincristine, Peg-Asparaginase and Dexamethasone for Children with Relapsed Acute Lymphoblastic Leukemia

Impact of Humoral Immunogenicity (Anti-mCAR19 Antibodies) on CTL019 Cellular Kinetics, Efficacy, and Safety

Circulating CD2 Negative T Cells in Pediatric Acute Leukemia

Efficacy and Safety of CTL019 in the First US Phase II Multicenter Trial in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of an Interim Analysis

Effect of Intrathecal Methotrexate on CSF and RBC Folate Levels in Children Receiving Treatment for Acute Lymphoblastic Leukemia

Relative Oral Bioequivalence of Two 6-Mercaptopurine (6-MP) Liquid Formulations in Children with Acute Lymphoblastic Leukemia (ALL)

Adolescents and Young Adults (AYA) with Acute Myeloid Leukemia (AML) Have Increased Treatment-Related Mortality with Similar Outcomes -- a Report from the Children's Oncology Group Trials AAML03P1 and AAML0531

Pneumocystis Jirovecii Pneumonia (PCP) in Children with Cancer: A Retrospective Cohort Analysis from the Pediatric Health Information System (PHIS) Database, 2004-2009

Chemosensitization and Mobilization Of AML/ALL/MDS With Plerixafor (AMD 3100), a CXCR4 Antagonist: A Phase I Study Of Plerixafor + Cytarabine and Etoposide In Pediatric Patients With Acute Leukemia and MDS

A Phase I Study Of AC220 (Quizartinib) In Combination With Cytarabine and Etoposide In Relapsed/Refractory Childhood ALL and AML: A Therapeutic Advances In Childhood Leukemia & Lymphoma (TACL) Study

A Phase I Study of AC220 in Combination with Cytarabine and Etoposide in Relapsed/Refractory Childhood ALL and AML: A Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study

An Unusual Presentation of Congenital Dyserythropoietic Anemia Type II (CDAII) Associated with Severe Anemia in a Patient with a Novel Mutation of the SEC23B Gene

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