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Kathryn G. Roberts
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Journal Articles

IKZF1 plus Confers a Strong Adverse Prognostic Effect in Total Therapy Studies (XV/XVI)

Ruth Wangondu, Emily Ashcraft, Kathryn G Roberts, Cheng Cheng, Hiroto Inaba, Charles G. Mullighan
Journal: Blood
Blood (2022) 140 (Supplement 1): 118–120.
DOI: https://doi.org/10.1182/blood-2022-158319
Published: 2022
Journal Articles

Pharmacotypes across the Genomic Landscape of Pediatric Acute Lymphoblastic Leukemia and Impact on Treatment Response

Shawn Lee, Wenjian Yang, Yoshihiro Gocho, August John, Lauren Rowland, Brandon Smart, Hannah Williams, Dylan Maxwell, Jeremy Hunt, Wentao Yang, Kristine R. Crews, Kathryn G Roberts, Sima Jeha, Cheng Cheng, Seth E. Karol, Mary V. Relling, Gary Rosner, Hiroto Inaba, Charles G. Mullighan, Ching-Hon Pui, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 1730–1731.
DOI: https://doi.org/10.1182/blood-2022-156699
Published: 2022
Journal Articles

Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia

Shunsuke Kimura, Lindsey Montefiori, Ilaria Iacobucci, Yaqi Zhao, Qingsong Gao, Elisabeth M. Paietta, Claudia Haferlach, A. Douglas Laird, Paul E. Mead, Zhaohui Gu, Wendy Stock, Mark Litzow, Jacob M. Rowe, Selina M. Luger, Stephen P. Hunger, Georgina L. Ryland, Breon Schmidt, Paul G. Ekert, Alicia Oshlack, Sean M. Grimmond, Jacqueline Rehn, James Breen, David Yeung, Deborah L. White, Ibrahim Aldoss, Elias J. Jabbour, Ching-Hon Pui, Manja Meggendorfer, Wencke Walter, Wolfgang Kern, Torsten Haferlach, Samuel Brady, Jinghui Zhang, Kathryn G. Roberts, Piers Blombery, Charles G. Mullighan
Journal: Blood
Blood (2022) 139 (24): 3519–3531.
DOI: https://doi.org/10.1182/blood.2022015444
Published: 2022
Includes: Supplemental data
Journal Articles

CDX2 and IDH1/2: new potential players in ALL

Kathryn G. Roberts
Journal: Blood
Blood (2022) 139 (12): 1778–1779.
DOI: https://doi.org/10.1182/blood.2021014429
Published: 2022
Journal Articles

Degradation of Janus kinases in CRLF2 -rearranged acute lymphoblastic leukemia

Yunchao Chang, Jaeki Min, Jamie A. Jarusiewicz, Marisa Actis, Shanshan Yu-Chen Bradford, Anand Mayasundari, Lei Yang, Divyabharathi Chepyala, Lisa J. Alcock, Kathryn G. Roberts, Stanley Nithianantham, Dylan Maxwell, Lauren Rowland, Randolph Larsen, Aman Seth, Hiroaki Goto, Toshihiko Imamura, Koshi Akahane, Baranda S. Hansen, Shondra M. Pruett-Miller, Elisabeth M. Paietta, Mark R. Litzow, Chunxu Qu, Jun J. Yang, Marcus Fischer, Zoran Rankovic, Charles G. Mullighan
Journal: Blood
Blood (2021) 138 (23): 2313–2326.
DOI: https://doi.org/10.1182/blood.2020006846
Published: 2021
Includes: Supplemental data
Journal Articles

The age of the bone marrow microenvironment influences B-cell acute lymphoblastic leukemia progression via CXCR5-CXCL13

Costanza Zanetti, Rahul Kumar, Joscha Ender, Parimala S. Godavarthy, Mark Hartmann, Joschka Hey, Kersten Breuer, Eva S. Weissenberger, Valentina R. Minciacchi, Christina Karantanou, Zhaohui Gu, Kathryn G. Roberts, Markus Metzler, Wendy Stock, Charles G. Mullighan, Clara D. Bloomfield, Natalie Filmann, Katrin Bankov, Sylvia Hartmann, Robert P. Hasserjian, Antony F. Cousins, Christina Halsey, Christoph Plass, Daniel B. Lipka, Daniela S. Krause
Journal: Blood
Blood (2021) 138 (19): 1870–1884.
DOI: https://doi.org/10.1182/blood.2021011557
Published: 2021
Includes: Multimedia, Supplemental data
Journal Articles

The Impact of Genetic Ancestry on the Biology and Prognosis of Childhood Acute Lymphoblastic Leukemia

Shawn Lee, Federico Antillón, Deqing Pei, Wenjian Yang, Kathryn G Roberts, Zhenhua Li, Meenakshi Devidas, Wentao Yang, Cesar Najera, Hai Peng Lin, Ah Moy Tan, Hany Ariffin, Cheng Cheng, William E. Evans, Stephen P Hunger, Sima Jeha, Charles G. Mullighan, Mignon L. Loh, Allen Eng Juh Yeoh, Ching-Hon Pui, Jun J. Yang
Journal: Blood
Blood (2021) 138 (Supplement 1): 3476.
DOI: https://doi.org/10.1182/blood-2021-145655
Published: 2021
Journal Articles

Comparison of Current and Enhanced Risk Stratification of 21,199 Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia Using Objective Risk Categorization Criteria: A Children's Oncology Group Report

Natalie Delrocco, Mignon L. Loh, Michael Borowitz, Karen R Rabin, Patrick A Zweidler-McKay, Kelly W Maloney, Leonard A. Mattano, Eric C Larsen, Anne L Angiolillo, Reuven J Schore, Michael J. Burke, Wanda L Salzer, Brent L. Wood, Andrew J Carroll, Nyla A. Heerema, Shalini C Reshmi, Julie M Gastier-Foster, Richard C Harvey, I-Ming L Chen, Kathryn G Roberts, Charles G. Mullighan, Cheryl L Willman, Naomi J Winick, William L. Carroll, Stephen P. Hunger, Elizabeth A. Raetz, Meenakshi Devidas, John Kairalla
Journal: Blood
Blood (2021) 138 (Supplement 1): 2382.
DOI: https://doi.org/10.1182/blood-2021-148593
Published: 2021
Journal Articles

Amino Acid Stress Response Genes Promote L-Asparaginase Resistance in Pediatric Acute Lymphoblastic Leukemia

Daniel Ferguson, J. Robert McCorkle, Qian Dong, Erik Bonten, Wenjian Yang, Brennan P. Bergeron, Robert J Autry, Jonathan Diedrich, Yoshihiro Gocho, Richa Bajpai, Kristine R. Crews, Shondra M. Pruett-Miller, Kathryn G Roberts, Wendy Stock, Charles G. Mullighan, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Jun J. Yang, Mary V. Relling, William E. Evans, Daniel Savic
Journal: Blood
Blood (2021) 138 (Supplement 1): 3304.
DOI: https://doi.org/10.1182/blood-2021-152940
Published: 2021
Journal Articles

Molecular classification improves risk assessment in adult BCR-ABL1– negative B-ALL

Elisabeth Paietta, Kathryn G. Roberts, Victoria Wang, Zhaohui Gu, Georgina A. N. Buck, Deqing Pei, Cheng Cheng, Ross L. Levine, Omar Abdel-Wahab, Zhongshan Cheng, Gang Wu, Chunxu Qu, Lei Shi, Stanley Pounds, Cheryl L. Willman, Richard Harvey, Janis Racevskis, Jan Barinka, Yanming Zhang, Gordon W. Dewald, Rhett P. Ketterling, David Alejos, Hillard M. Lazarus, Selina M. Luger, Letizia Foroni, Bela Patel, Adele K. Fielding, Ari Melnick, David I. Marks, Anthony V. Moorman, Peter H. Wiernik, Jacob M. Rowe, Martin S. Tallman, Anthony H. Goldstone, Charles G. Mullighan, Mark R. Litzow
Journal: Blood
Blood (2021) 138 (11): 948–958.
DOI: https://doi.org/10.1182/blood.2020010144
Published: 2021
Includes: Supplemental data
Journal Articles

Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL

Clinical Trials & Observations
Yaqi Zhao, Ibrahim Aldoss, Chunxu Qu, Jeremy Chase Crawford, Zhaohui Gu, Emma K. Allen, Anthony E. Zamora, Thomas B. Alexander, Jeremy Wang, Hiroaki Goto, Toshihiko Imamura, Koshi Akahane, Guido Marcucci, Anthony S. Stein, Ravi Bhatia, Paul G. Thomas, Stephen J. Forman, Charles G. Mullighan, Kathryn G. Roberts
Journal: Blood
Blood (2021) 137 (4): 471–484.
DOI: https://doi.org/10.1182/blood.2020006287
Published: 2021
Includes: Supplemental data
Journal Articles

Venetoclax and Navitoclax in Pediatric Patients with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Jeffrey E. Rubnitz, MD, Thomas B. Alexander, MDMPH, Theodore W. Laetsch, MD, Seong Lin Khaw, MD, Vinod A. Pullarkat, MD, Joseph T. Opferman, PhD, Kathryn G Roberts, PhD, Lindsey Rosenwinkel, Bo Tong, PhD, John C. Pesko, PhD, Mohamed Badawi, Deeksha Vishwamitra, PhD, Su Young Kim, Charles G Mullighan, MBBS, MD, Norman J. Lacayo, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
DOI: https://doi.org/10.1182/blood-2020-134582
Published: 2020
Journal Articles

Enhanced Risk Stratification of 21,178 Children, Adolescents, and Young Adults with Acute Lymphoblastic Leukemia (ALL) Incorporating White Blood Count (WBC), Age, and Minimal Residual Disease (MRD) at Day 8 and 29 As Continuous Variables: A Children's Oncology Group (COG) Report

Mignon L. Loh, MD, Natalie DelRocco, Michael J Borowitz, MD PhD, Karen R Rabin, MDPhD, Patrick A Zweidler-McKay, MDPhD, Kelly W Maloney, MD, Leonard A. Mattano, MD, Eric C Larsen, MD, Anne L Angiolillo, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Brent L Wood, MD PhD, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Richard C Harvey, PhD, I-Ming L Chen, DVM, MS, Cheryl L Willman, MD, Naomi J Winick, MD, William Carroll, MD, Stephen P Hunger, MD, Elizabeth A. Raetz, MD, Meenakshi Devidas, PhD, John Kairalla, Kathryn G Roberts, PhD, Charles G Mullighan, MBBS, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
DOI: https://doi.org/10.1182/blood-2020-139081
Published: 2020
Journal Articles

Outcomes of Patients with Down Syndrome and CRLF2 -Overexpressing Acute Lymphoblastic Leukemia (ALL): A Report from the Children's Oncology Group (COG)

Karen R Rabin, MDPhD, Meenakshi Devidas, PhD, Zhiguo Chen, Yunfeng Dai, PhD, Sarah K Tasian, MD, Johann K Hitzler, MD, Kathryn G Roberts, PhD, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Michael J Borowitz, MD PhD, Brent L Wood, MD PhD, Charles G Mullighan, MBBS, MD, Richard C Harvey, PhD, I-Ming L Chen, Cheryl L Willman, MD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Kelly W Maloney, MD, Eric C Larsen, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Naomi J Winick, MD, William L. Carroll, MD, Elizabeth A. Raetz, MD, Anne Angiolillo, MD, Mignon L. Loh, MD, Stephen P Hunger, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 44–45.
DOI: https://doi.org/10.1182/blood-2020-143165
Published: 2020
Journal Articles

Outcomes of Patients with CRLF2 -Overexpressing Acute Lymphoblastic Leukemia without Down Syndrome: A Report from the Children's Oncology Group

Sarah K Tasian, MD, Yunfeng Dai, PhD, Meenakshi Devidas, PhD, Kathryn G Roberts, PhD, Richard C Harvey, PhD, I-Ming L Chen, DVM, MS, Andrew J Carroll, PhD, Nyla A Heerema, PhD, Shalini C Reshmi, PhD, Julie M Gastier-Foster, PhD, Michael J Borowitz, MD PhD, Brent L Wood, MD PhD, Charles G Mullighan, MBBS, MD, Cheryl L Willman, MD, Kelly W Maloney, MD, Eric C Larsen, MD, Anne L Angiolillo, MD, Reuven J Schore, MD, Michael J Burke, MD, Wanda L Salzer, MD, Naomi J Winick, MD, William L. Carroll, MD, Stephen P Hunger, MD, Elizabeth A. Raetz, MD, Karen R Rabin, MDPhD, Mignon L. Loh, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 45–46.
DOI: https://doi.org/10.1182/blood-2020-134327
Published: 2020
Journal Articles

Inotuzumab Ozogamicin (Ino) May Overcome the Impact of Philadelphia Chromosome (Ph)-like Phenotype in Adult Patients (pts) with Relapsed/Refractory (R/R) Acute Lymphoblastic Leukemia (ALL)

Elias Jabbour, MD, Kathryn G. Roberts, PhD, Koji Sasaki, MD, Yaqi Zhao, MSc, Chunxu Qu, PhD, Zhaohui Gu, PhD, Nitin Jain, MD, Keyur P. Patel, MBBS, PhD, Farhad Ravandi, MD, Nicholas J. Short, MD, Guillermo Garcia-Manero, MD, Rebecca Garris, MSc, Steven Kornblau, Marina Y Konopleva, MD PhD, Charles G. Mullighan, MBBS, MD, Hagop M. Kantarjian, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1641.
DOI: https://doi.org/10.1182/blood-2019-126940
Published: 2019
Journal Articles

The Influence of the Age of the Bone Marrow Microenvironment on Leukaemia Progression

Costanza Zanetti, MSc, Joscha Ender, Mark Hartmann, Joschka Hey, MSc, BSc, Parimala Sonika Godavarthy, MSc, Eva Weissenberger, Rahul Kumar, PhD, Markus Metzler, MD PhD, Zhaohui Gu, PhD, Kathryn G. Roberts, PhD, Natalie Filmann, Clara D. Bloomfield, MD, Wendy Stock, MD, Charles G. Mullighan, MBBS, MD, Daniel B. Lipka, Daniela S. Krause, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2748.
DOI: https://doi.org/10.1182/blood-2019-122797
Published: 2019
Journal Articles

Phase II Study of the Hyper-CVAD Regimen in Combination with Ofatumumab (HCVAD-O) As Frontline Therapy for Adult Patients (pts) with CD20-Positive B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Guillaume Richard-Carpentier, MD, Hagop M. Kantarjian, MD, Marina Y Konopleva, MD PhD, Keyur P. Patel, MBBS, PhD, Kathryn G. Roberts, PhD, Zhaohui Gu, PhD, Farhad Ravandi, MD, Nitin Jain, MD, Nicholas J. Short, MD, Guillermo Garcia-Manero, MD, Heather M Schroeder, Monica Kwari, BSN, Rebecca Garris, MSc, Rita Khouri, Mike Jones, RDC, Christopher Loiselle, BS, Jorge E. Cortes, MD, Koji Sasaki, MD, Ghayas C. Issa, MD, Tapan M. Kadia, MD, Courtney D. DiNardo, MDMSc, Srdan Verstovsek, MD PhD, Naval G. Daver, MD, Charles G. Mullighan, MBBS, MD, Susan M. O'Brien, MD, Elias Jabbour, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2577.
DOI: https://doi.org/10.1182/blood-2019-129884
Published: 2019
Journal Articles

The Genomic Landscape of Childhood Acute Lymphoblastic Leukemia

Kathryn G. Roberts, PhD, Samuel W. Brady, PhD, Zhaohui Gu, PhD, Lei Shi, PhD, Stanley Pounds, PhD, Deqing Pei, MS, Cheng Cheng, PhD, Yunfeng Dai, PhD, Meenakshi Devidas, PhD, Chunxu Qu, PhD, Ashley Hill, BS, Xiaotu Ma, Lei Wei, PhD, Sasi Arunachalam, PhD, Kohei Hagiwara, MD, Yangling Liu, Diane Flasch, Yu Liu, PhD, Matthew Parker, PhD, Xiaolong Chen, PhD, Yongjin Li, PhD, Yiping Fan, PhD, Robert Michael, PhD, Michael Rusch, BS, Mark Wilkinson, Scott Foy, PhD, Dale Hedges, PhD, Scott Newman, PhD, Xin Zhou, PhD, Jian Wang, Shalini C. Reshmi, PhD, Julie M. Gastier-Foster, PhD, Patee Gesuwan, Malcolm A Smith, MD PhD, Daniela S. Gerhard, PhD, Naomi Winick, MD, Andrew J. Carroll, PhD, Nyla A. Heerema, PhD, Richard C. Harvey, PhD, Cheryl L. Willman, MD, Eric Larsen, MD, Elizabeth A. Raetz, MD, Michael J. Borowitz, MD PhD, Brent L Wood, MD PhD, William L. Carroll, MD, Patrick A. Zweidler-McKay, MD PhD, Karen R. Rabin, MD PhD, Leonard A. Mattano, MD, Kelly Maloney, MD, Stuart S. Winter, MD, Michael J. Burke, MD, Wanda L. Salzer, MD, Kimberly P. Dunsmore, Anne Angiolillo, MD, Kristine R Crews, PharmD, James R. Downing, MD, Sima Jeha, MD, William E. Evans, PharmD, Ching-Hon Pui, MD, Jun J. Yang, PhD, Mary V. Relling, PharmD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Jinghui Zhang, PhD, Charles G. Mullighan, MBBS, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 649.
DOI: https://doi.org/10.1182/blood-2019-124881
Published: 2019
Journal Articles

Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics

Brief Report
Maoxiang Qian, Heng Xu, Virginia Perez-Andreu, Kathryn G. Roberts, Hui Zhang, Wenjian Yang, Shouyue Zhang, Xujie Zhao, Colton Smith, Meenakshi Devidas, Julie M. Gastier-Foster, Elizabeth Raetz, Eric Larsen, Esteban G. Burchard, Naomi Winick, W. Paul Bowman, Paul L. Martin, Michael Borowitz, Brent Wood, Federico Antillon-Klussmann, Ching-Hon Pui, Charles G. Mullighan, William E. Evans, Stephen P. Hunger, Mary V. Relling, Mignon L. Loh, Jun J. Yang
Journal: Blood
Blood (2019) 133 (7): 724–729.
DOI: https://doi.org/10.1182/blood-2018-07-862946
Published: 2019
Includes: Supplemental data