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Journal Articles

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Dominic W. Chung, Kimsey Platten, Koya Ozawa, Raymond Adili, Nathalie Pamir, Forrest D Nussdorfer, Alexander E St. John, Minhua Ling, Jennie Le, Jeff Harris, Junmei Chen, Sergio Fazio, Jonathan Lindner, José A. López

Blood (2022) 140 (Supplement 1): 1660–1661.

DOI: https://doi.org/10.1182/blood-2022-170092

Published: 2022

Journal Articles

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Bojing Shao, Christopher Hoover, Huiping Shi, Yuji Kondo, Robert H. Lee, Junmei Chen, Xindi Shan, Jianhua Song, J. Michael McDaniel, Meixiang Zhou, Samuel McGee, Karen Vanhoorelbeke, Wolfgang Bergmeier, José A. López, James N. George, Lijun Xia

Blood (2022) 139 (16): 2523–2533.

DOI: https://doi.org/10.1182/blood.2021012896

Published: 2022

Includes: Supplemental data

Journal Articles

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

Alexander E St. John, MD, Yi Wang, PhD, Junmei Chen, PhD, Warren Osborn, Xu Wang, MD, Esther Lim, BS, Dominic W. Chung, PhD, Susan Stern, MD, Nathan White, MD, Xiaoyun Fu, PhD, Jose A. Lopez, MDBS

Blood (2020) 136 (Supplement 1): 9–10.

DOI: https://doi.org/10.1182/blood-2020-141361

Published: 2020

Journal Articles

Human Platelets Stored at Room Temperature Demonstrate Diminished Resistance to Oxidative Stress Compared to Those Stored at 4°C

Xiaoyun Fu, PhD, Warren Osborn, Yu Shen, Yi Wang, PhD, Jeffrey Miles, Lydia Fang, M.S., Barbara Osborne, RN, Junmei Chen, PhD, José A. López, MDBS, Moritz Stolla, MD

Blood (2020) 136 (Supplement 1): 24.

DOI: https://doi.org/10.1182/blood-2020-143190

Published: 2020

Journal Articles

Targeted Proteomics Reveals That the Dominant Mechanism of Gpibα Loss during Platelet Storage Depends on Temperature of Storage

Moritz Stolla, MD, Yi Wang, PhD, Jeffrey Miles, Barbara Osborne, RN, Yu Shen, Lydia Fang, M.S., Shawn Lawrence Bailey, BS, Warren Osborn, Junmei Chen, PhD, Jose A. Lopez, MDBS, Xiaoyun Fu, PhD

Blood (2020) 136 (Supplement 1): 31–32.

DOI: https://doi.org/10.1182/blood-2020-143077

Published: 2020

Journal Articles

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation

Ian Johnston, Amrita Sarkar, Vincent Hayes, Gavin T. Koma, Gowthami M. Arepally, Junmei Chen, Dominic W. Chung, José A. López, Douglas B. Cines, Lubica Rauova, Mortimer Poncz

Blood (2020) 135 (15): 1270–1280.

DOI: https://doi.org/10.1182/blood.2018881607

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib

Yllka Latifi, Federico Moccetti, Melinda Wu, Aris Xie, William Packwood, Yue Qi, Koya Ozawa, Weihui Shentu, Eran Brown, Toshiaki Shirai, Owen J. McCarty, Zaverio Ruggeri, Javid Moslehi, Junmei Chen, Brian J. Druker, Jose A. López, Jonathan R. Lindner

Blood (2019) 133 (14): 1597–1606.

DOI: https://doi.org/10.1182/blood-2018-10-881557

Published: 2019

Includes: Multimedia, Supplemental data

Journal Articles

Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model

Jessica Morales-Ortíz, Victoria Deal, Fiorella Reyes, Gerónimo Maldonado-Martínez, Nahomy Ledesma, Franklin Staback, Cheyanne Croft, Amanda Pacheco, Humberto Ortiz-Zuazaga, C. Christian Yost, Jesse W. Rowley, Bismark Madera, Alex St. John, Junmei Chen, Jose Lopez, Matthew T. Rondina, Robert Hunter, Angelia Gibson, A. Valance Washington

Blood (2018) 132 (23): 2495–2505.

DOI: https://doi.org/10.1182/blood-2018-03-841593

Published: 2018

Includes: Supplemental data

Journal Articles

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Warren Osborn, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Barbara A Konkle, José A. López, MD

Blood (2018) 132 (Supplement 1): 4911.

DOI: https://doi.org/10.1182/blood-2018-99-117087

Published: 2018

Journal Articles

Inflammation, von Willebrand factor, and ADAMTS13

Junmei Chen, Dominic W. Chung

Blood (2018) 132 (2): 141–147.

DOI: https://doi.org/10.1182/blood-2018-02-769000

Published: 2018

Journal Articles

Thrombosis and Von Willebrand Factor in Chuvash Polycythemia

Victor R. Gordeuk, MD, Dominic W. Chung, PhD, Binal N. Shah, PhD, Junmei Chen, PhD, Adelina Sergueeva, MD, Galina Miasnikova, MD, Josef T. Prchal, MD, José A. López, MD

Blood (2017) 130 (Supplement 1): 2377.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2377.2377

Published: 2017

Journal Articles

Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after CD19 CAR-T Cell Immunotherapy

Cameron J. Turtle, MBBS, PhD, Kevin A. Hay, MD FRCPC, MSc, Laila-Aicha Hanafi, PhD, Juliane Gust, MDPhD, W. Conrad Liles, MDPhD, José A. López, MD, Junmei Chen, PhD, Dominic W. Chung, PhD, Mark M Wurfel, MDPhD, Susanna Harju-Baker, PhD, Hasan Ozpolat, MD, Daniel Li, PhD, David Myerson, MDPhD, Luis F. Gonzalez-Cuyar, MD, Cecilia Yeung, MD, Kathleen R. Fink, MD, Stanley R. Riddell, MD, David G. Maloney, MD PhD

Blood (2017) 130 (Suppl_1): 805.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.805.805

Published: 2017

Journal Articles

Identification of extant vertebrate Myxine glutinosa VWF: evolutionary conservation of primary hemostasis

Marianne A. Grant, David L. Beeler, Katherine C. Spokes, Junmei Chen, Harita Dharaneeswaran, Tracey E. Sciuto, Ann M. Dvorak, Gianluca Interlandi, José A. Lopez, William C. Aird

Blood (2017) 130 (23): 2548–2558.

DOI: https://doi.org/10.1182/blood-2017-02-770792

Published: 2017

Includes: Supplemental data

Journal Articles

Ultra-Low Von Willebrand Factor (VWF) Adsorption Under Shear with a Polymer Coating for Blood-Contacting Devices

Wei Yang, PhD, Junmei Chen, PhD, Jennie Le, BS, José A. López, MD

Blood (2017) 130 (Supplement 1): 1024.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1024.1024

Published: 2017

Journal Articles

Effects of Oral N -Acetylcysteine on Oxidative Stress in Patients with Sickle Cell Disease

Blood (2017) 130 (Supplement 1): 2244.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2244.2244

Published: 2017

Journal Articles

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

Hasan Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Melissa Dominguez, MA, Jennie Le, BS, Minhua Ling, PhD, Sophie Schmitter, BS, Sarah Ruuska, MPH, Dominic W. Chung, PhD, Jose A. Lopez, MD, Barbara Konkle, MD

Blood (2017) 130 (Supplement 1): 2238.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2238.2238

Published: 2017

Journal Articles

Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy

Kevin A. Hay, Laïla-Aïcha Hanafi, Daniel Li, Juliane Gust, W. Conrad Liles, Mark M. Wurfel, José A. López, Junmei Chen, Dominic Chung, Susanna Harju-Baker, Sindhu Cherian, Xueyan Chen, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle

Blood (2017) 130 (21): 2295–2306.

DOI: https://doi.org/10.1182/blood-2017-06-793141

Published: 2017

Includes: Supplemental data

Journal Articles

A Quantitative Assay of In Vivo Cleavage of Von Willebrand Factor By ADAMTS13 Reveals Excessive Cleavage in Type 2B Von Willebrand Disease and Diminished Cleavage in Thrombotic Thrombocytopenic Purpura

Xiaoyun Fu, PhD, Mallory N. Pahl, Yi Wang, PhD, Barbara A. Konkle, MD, Junmei Chen, PhD, Jose A Lopez, MD

Blood (2016) 128 (22): 2532.

DOI: https://doi.org/10.1182/blood.V128.22.2532.2532

Published: 2016

Journal Articles

Pursuing Ultra-Low VWF Adsorption for Blood-Contacting Devices Under Shear

Wei Yang, PhD, Junmei Chen, PhD, Jennie Le, BS, Jose A. Lopez, MD

Blood (2016) 128 (22): 2539.

DOI: https://doi.org/10.1182/blood.V128.22.2539.2539

Published: 2016

Journal Articles

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

Hasan Tahsin Ozpolat, MD, Junmei Chen, PhD, Xiaoyun Fu, PhD, Shelby A Cate, BS, Jennie Le, BS, Minhua Ling, PhD, Colette Norby, MS, Dominic W Chung, PhD, Barbara A. Konkle, MD, Jose A. Lopez, MD

Blood (2016) 128 (22): 1299.

DOI: https://doi.org/10.1182/blood.V128.22.1299.1299

Published: 2016

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NARROW

Elevated Levels of Low Density Lipoprotein (LDL) Trigger VWF Self-Association into Fibers and Bundles and Potentiate Microvascular Thrombosis

Deletion of platelet CLEC-2 decreases GPIbα-mediated integrin αIIbβ3 activation and decreases thrombosis in TTP

Plasma Proteomic Profile Associated with Platelet Dysfunction after Trauma

Human Platelets Stored at Room Temperature Demonstrate Diminished Resistance to Oxidative Stress Compared to Those Stored at 4°C

Targeted Proteomics Reveals That the Dominant Mechanism of Gpibα Loss during Platelet Storage Depends on Temperature of Storage

Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation

Thrombotic microangiopathy as a cause of cardiovascular toxicity from the BCR-ABL1 tyrosine kinase inhibitor ponatinib

Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model

Effect of Intravenous and Oral N-Acetylcysteine Treatment in a Patient with Sickle Cell Disease at Disease Baseline

Inflammation, von Willebrand factor, and ADAMTS13

Thrombosis and Von Willebrand Factor in Chuvash Polycythemia

Endothelial Activation and Blood-Brain Barrier Disruption in Neurotoxicity after CD19 CAR-T Cell Immunotherapy

Identification of extant vertebrate Myxine glutinosa VWF: evolutionary conservation of primary hemostasis

Ultra-Low Von Willebrand Factor (VWF) Adsorption Under Shear with a Polymer Coating for Blood-Contacting Devices

Effects of Oral N -Acetylcysteine on Oxidative Stress in Patients with Sickle Cell Disease

Effects of N-Acetylcysteine Infusion in Patients with Sickle Cell Disease during Vaso-Occlusive Crises

Kinetics and biomarkers of severe cytokine release syndrome after CD19 chimeric antigen receptor–modified T-cell therapy

A Quantitative Assay of In Vivo Cleavage of Von Willebrand Factor By ADAMTS13 Reveals Excessive Cleavage in Type 2B Von Willebrand Disease and Diminished Cleavage in Thrombotic Thrombocytopenic Purpura

Pursuing Ultra-Low VWF Adsorption for Blood-Contacting Devices Under Shear

A Pilot Study of High-Dose N-Acetylcysteine Infusion in Patients with Sickle Cell Disease

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American Society of Hematology

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