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Jonathan D. Licht
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Journal Articles

Gene Editing and Multi-Omics Reveal Novel Metabolic Vulnerabilities in t(4;14)-Associated Multiple Myeloma

Amin Sobh, Charlotte L Kaestner, Alberto Riva, Karthik Vasan, Alisha Patel, Greeshma Surapaneni, Janai Poullard, Elena Encinas, Richard Lynn Bennett, Constantine S. Mitsiades, Lawrence H. Boise, Navdeep S. Chandel, Jonathan D. Licht
Journal: Blood
Blood (2022) 140 (Supplement 1): 5911–5912.
DOI: https://doi.org/10.1182/blood-2022-169256
Published: 2022
Journal Articles

Adenylate Kinase 2 Is a Selective Multiple Myeloma Cell Dependency That Is Preferentially Essential in NSD2-Overexpressing Cells

Amin Sobh, Charlotte L Kaestner, Jianping Li, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht
Journal: Blood
Blood (2021) 138 (Supplement 1): 1586.
DOI: https://doi.org/10.1182/blood-2021-153284
Published: 2021
Journal Articles

Functional Genomic and Immune Response Characterization of PTEN Loss: Therapeutic Implications for Myeloma

Olga Dashevsky, Ricardo De Matos Simoes, Benjamin G Barwick, Sara Gandolfi, Ryosuke Shirasaki, Michal Sheffer, Aedin Culhane, Richard WJ Groen, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 1612.
DOI: https://doi.org/10.1182/blood-2021-153870
Published: 2021
Journal Articles

Dysregulation of Epigenetic Landscape Uncovered the Mechanisms Underlying the Relapse of Pediatric Acute Lymphoblastic Leukemia with NSD2 Mutation

Jianping Li, Priscillia Lhoumaud, Alberto Riva, Crissandra Piper, Daphne Dupere-Richer, Heidi Casellas Roman, Amin Sobh, Charlotte L Kaestner, Alok Swaroop, Marta Kulis, Richard Lynn Bennett, Jane Skok, Jonathan D. Licht
Journal: Blood
Blood (2021) 138 (Supplement 1): 3297.
DOI: https://doi.org/10.1182/blood-2021-149985
Published: 2021
Journal Articles

Functional Oncogenomic and Immune Response Landscape for Genes Recurrently Mutated in Myeloma

Ricardo De Matos Simoes, Benjamin G Barwick, Ryosuke Shirasaki, Olga Dashevsky, Sara Gandolfi, Huihui Tang, Brian Glassner, Richard W.J. Groen, Daniel Auclair, Aedin Culhane, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades
Journal: Blood
Blood (2021) 138 (Supplement 1): 1589.
DOI: https://doi.org/10.1182/blood-2021-154359
Published: 2021
Journal Articles

Functional CRISPR Screening Identifies Ptprg As a Driver of Migration and Adhesion in NSD2-E1099K ALL

Charlotte L Kaestner, Amin Sobh, Jianping Li, Alberto Riva, Richard Lynn Bennett, Jonathan D. Licht
Journal: Blood
Blood (2021) 138 (Supplement 1): 1149.
DOI: https://doi.org/10.1182/blood-2021-154009
Published: 2021
Journal Articles

POU2AF1 As a Master Regulator of Oncogenic Transcription Factor Networks in Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Huihui Tang, PhD, Shizuka Yamano, Benjamin G Barwick, PhD, Sara Gandolfi, MD, Eugen Dhimolea, PhD, Sondra L. Downey-Kopyscinski, PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Michal Sheffer, PhD, Dhvanir Kansara, Megan Bariteau, BSc, Jeffrey Sorrell, BA, Vikas Gupta, MD PhD, Aedin Culhane, PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Larry H. Boise, PhD, Jonathan D. Licht, MD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
DOI: https://doi.org/10.1182/blood-2020-142580
Published: 2020
Journal Articles

Adenylate Kinase 2 Is a Selective Dependency in NSD2-High Multiple Myeloma

Amin Sobh, PhD, Charlotte Kaestner, Jianping Li, MD, Alberto Riva, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 31.
DOI: https://doi.org/10.1182/blood-2020-141266
Published: 2020
Journal Articles

Use of Olfactory Receptor Genes As Controls for Genome-Scale CRISPR Functional Genomic Studies to Define Treatment Resistance Mechanisms

Olga Dashevsky, PhD, Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Sara Gandolfi, MD, Huihui Tang, PhD, Sondra L. Downey-Kopyscinski, PhD, Megan Bariteau, B.Sc., Jeffrey Sorrell, BA, Brian Glassner, PhD, John Doench, PhD, Larry H. Boise, PhD, Jonathan D. Licht, MD, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 36.
DOI: https://doi.org/10.1182/blood-2020-142651
Published: 2020
Journal Articles

KDM6A Controls Genes Modulating Immune Surveillance in Multiple Myeloma

Daphne Dupere-Richer, PhD, Sayantan Maji, PhD, Alberto Riva, PhD, Gabrielle Quickstad, Marta Kulis, Darby Monagle, José I. Martín-Subero, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14.
DOI: https://doi.org/10.1182/blood-2020-141285
Published: 2020
Journal Articles

Interactions with a "Humanized" Mesenchymal Bone Marrow Stromal Niche In Vivo Modify the Patterns of Essential Genes for Myeloma Cells: Therapeutic Implications

Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Ricardo De Matos Simoes, PhD, Olga Dashevsky, Sara Gandolfi, MD, Megan Bariteau, BSc, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Maria Themeli, MD PhD, Jonathan D. Licht, MD, Larry H. Boise, PhD, Richard W.J. Groen, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40.
DOI: https://doi.org/10.1182/blood-2020-143151
Published: 2020
Journal Articles

Functional Genomic Characterization of Endoplasmic Reticulum-Associated Dependencies in Multiple Myeloma - Biologic and Therapeutic Implications

Ryosuke Shirasaki, MD PhD, Ricardo De Matos Simoes, PhD, Shizuka Yamano, Sondra L. Downey-Kopyscinski, PhD, Brian Glassner, PhD, Huihui Tang, PhD, Vikas Gupta, MD PhD, Aviad Tsherniak, PhD, Francisca Vazquez, PhD, Jonathan D. Licht, MD, Larry H. Boise, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
DOI: https://doi.org/10.1182/blood-2020-143117
Published: 2020
Journal Articles

NSD2-E1099K Mutation Leads to Glucocorticoid-Resistant B Cell Lymphocytic Leukemia in Mice

Jianping Li, MD, Crissandra Piper, LATG, Daphne Dupere-Richer, PhD, Heidi Casellas Roman, MS, Alok Swaroop, PhD, Catalina Troche, PhD, Jon Oyer, PhD, Christine Will, MS, Alberto Riva, PhD, Richard Lynn Bennett, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
DOI: https://doi.org/10.1182/blood-2020-141295
Published: 2020
Journal Articles

Oncogenesis by E2A-PBX1 in ALL: RUNX and more

Jonathan D. Licht
Journal: Blood
Blood (2020) 136 (1): 3–4.
DOI: https://doi.org/10.1182/blood.2020005879
Published: 2020
Journal Articles

DNMT3A with Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks

Kartika Venugopal, MS, Daniil E Shabashvili, PhD, Jianping Li, MD, Luisa M Posada, Richard Lynn Bennett, PhD, Yang Feng, MS, Daphne Dupere Richer, PhD, Alberto Riva, PhD, Santhi Pondugula, PhD, Jonathan E. Bird, PhD, Jonathan D. Licht, MD, Olga A Guryanova, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 535.
DOI: https://doi.org/10.1182/blood-2019-128213
Published: 2019
Journal Articles

Systematic Characterization of Genes Representing Preferential Molecular Vulnerabilities for Myeloma Cells Compared to Other Neoplasias - Implications for the Biology and Therapeutic Targeting of Myeloma

Ricardo De Matos Simoes, PhD, Ryosuke Shirasaki, MD PhD, Sondra L. Downey-Kopyscinski, PhD, Geoffrey Matthews, PhD, Hu Yiguo, PhD, Michal Sheffer, PhD, Eugen Dhimolea, PhD, Olga Dashevsky, PhD, Sara Gandolfi, MD, Joshua Dempster, PhD, Robin M. Meyers, PhD, Jordan Bryan, James M. McFarland, Johanna Brueggenthies, Huihui Tang, PhD, Megan Bariteau, BSc, Minasri Borah, Quinlan L Sievers, PhD, Benjamin Ebert, MD, Brian Glassner, PhD, Christopher J. Ott, PhD, Nicholas P Kwiatkowski, PhD, John G Doench, PhD, Daniel Auclair, Joan Levy, PhD, Lawrence H. Boise, PhD, Jonathan J Keats, PhD, Jonathan D. Licht, MD, Richard Groen, Nathanael Gray, Aedin Culhane, PhD, William C. Hahn, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4407.
DOI: https://doi.org/10.1182/blood-2019-130901
Published: 2019
Journal Articles

Identification of Genetic Vulnerabilities and Synthetic-Lethal Targets in NSD2-High Multiple Myeloma

Amin Sobh, PhD, Charlotte Kaestner, Alberto Riva, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3757.
DOI: https://doi.org/10.1182/blood-2019-125951
Published: 2019
Journal Articles

A Gain of Function Mutation in the NSD2 Histone Methyltransferase Drives Glucocorticoid Resistance Via Blocking Receptor Auto-Induction and BIM/Bmf Expression in ALL

Jianping Li, MD, Catalina Troche, PhD, Julia Hlavka Zhang, BS, Jonathan Shrimp, PhD, Jacob S. Roth, PhD, Duohui Jing, PhD, Alok Swaroop, PhD, Marta Kulis, Jon Oyer, PhD, Christine Will, MS, Daphne Dupere-Richer, PhD, Alberto Riva, PhD, Crissandra Pipe, LATG, Amin Sobn, PhD, Sharon Norton, MS, Richard Lynn Bennett, PhD, Min Shen, PhD, Matthew D. Hall, PhD, Richard B. Lock, PhD, Jonathan D. Licht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3758.
DOI: https://doi.org/10.1182/blood-2019-126910
Published: 2019
Journal Articles

Functional Characterization of E3 Ligases and Their Regulators: Therapeutic Implications for Development of New Proteolysis-Targeting Chimeric Degraders of Oncoproteins

Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Ricardo De Matos Simoes, PhD, Geoffrey M Matthews, PhD, Dennis Buckley, Joseline Raja, Quinlan L Sievers, PhD, Olga Dashevsky, PhD, Haley Poarch, Huihui Tang, PhD, Megan Bariteau, BSc, Michal Sheffer, PhD, Sondra L. Downey-Kopyscinski, PhD, Paul Hengeveld, Brian Glassner, PhD, Eugen Dhimolea, PhD, Christopher J. Ott, PhD, Tinghu Zhang, PhD, Nicholas P Kwiatkowski, PhD, Jacob P. Laubach, MD, Robert L. Schlossman, MD, Paul G. Richardson, MD, Aedin Culhane, PhD, Richard W.J. Groen, PhD, Eric Fischer, Benjamin L. Ebert, MD PhD, Francisca Vazquez, PhD, Aviad Tsherniak, PhD, William C. Hahn, MD PhD, Joan Levy, PhD, Daniel Auclair, Jonathan D. Licht, MD, Jonathan J Keats, PhD, Lawrence H. Boise, PhD, James Bradner, MD, Nathanael Gray, Constantine S. Mitsiades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 318.
DOI: https://doi.org/10.1182/blood-2019-130549
Published: 2019
Journal Articles

Epigenetic Regulation and Therapeutic Targeting in Myeloma

Jonathan D. Licht, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): SCI-37.
DOI: https://doi.org/10.1182/blood-2018-99-109522
Published: 2018