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John E. Dick
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Journal Articles

CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells

Christine Surka, Liqing Jin, Nathan Mbong, Chin-Chun Lu, In Sock Jang, Emily Rychak, Derek Mendy, Thomas Clayton, Elizabeth Tindall, Christy Hsu, Celia Fontanillo, Eileen Tran, Adrian Contreras, Stanley W. K. Ng, Mary Matyskiela, Kai Wang, Philip Chamberlain, Brian Cathers, James Carmichael, Joshua Hansen, Jean C. Y. Wang, Mark D. Minden, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, Mark Rolfe, Antonia Lopez-Girona, John E. Dick, Gang Lu
Journal: Blood
Blood (2021) 137 (5): 661–677.
DOI: https://doi.org/10.1182/blood.2020008676
Published: 2021
Includes: Supplemental data
Journal Articles

Opposing Evolutionary Pressures Drive Clonal Evolution and Health Outcomes in the Aging Blood System

Kimberly Skead, Armande Ang Houle, Sagi Abelson, PhD, Marie-Julie Fave, PhD, Boxi Lin, David Soave, PhD, Stephen Wright, PhD, John E. Dick, PhD FRS, Quaid Morris, PhD, Phillip Awadalla, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37.
DOI: https://doi.org/10.1182/blood-2020-142086
Published: 2020
Journal Articles

Nicotinamide Phosphoribosyltransferase Inhibitors Induce Apoptosis of AML Stem Cells through Dysregulation of Lipid Metabolism

Amit Subedi, PhD, Qiang Liu, PhD BSc, David Sharon, PhD, Severine Cathelin, PhD, Gary D Bader, Changjiang Xu, Veronique Voisin, PhD, Angelo D'Alessandro, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Mark D. Minden, Jean C.Y. Wang, MD, Steven M Chan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
DOI: https://doi.org/10.1182/blood-2020-142404
Published: 2020
Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Geethu Emily Thomas, PhDMSc,BSc, Grace Egan, MD, Laura Garcia Prat, PhD BSc, MSc, Botham Aaron, Veronique Voisin, PhD, Elias Orouji, Jordan M Chin, Boaz Nachmias, MDPhD, Kerstin B Kaufmann, PhD, Fieke W Hoff, BSc, Neil Maclean, Rose Hurren, BSc, Xiaoming Wang, Marcela Gronda, MSc, Andrea Arruda, MSc, Mark D. Minden, Gary D Bader, Steven M. Kornblau, MD, John E. Dick, PhD FRS, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
DOI: https://doi.org/10.1182/blood-2020-135858
Published: 2020
Journal Articles

Dichotomous Regulation of Lysosomes By MYC and Tfeb Controls Hematopoietic Stem Cell Fate

Laura Garcia Prat, PhD BSc, MSc, Kerstin B Kaufmann, PhD, Florin Schneiter, Veronique Voisin, PhD, Alex Murison, Michelle Chan-Seng-Yue, Olga I. Gan, PhD, Jessica L. McLeod, Michelle Shoong, Kristele Pan, Kinam Gupta, Shin-Ichiro Takayanagi, PhD, Elvin Wagenblast, PhD, Weijia Wang, Timm Schroeder, PhD, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 34.
DOI: https://doi.org/10.1182/blood-2020-142671
Published: 2020
Journal Articles

Erythropoiesis Failure in Diamond-Blackfan Anemia Starts at the Oligopotent Common Myeloid and Megakaryocyte-Erythroid Progenitor Stage

Richard N Armstrong, PhDBSc, Mariana Benicio, PhD, Houtan Moshiri, PhD, Hongbing Li, PhD, Bozana Zlateska, MD MSc, Olga I. Gan, PhD, Eric R Lechman, PhD, John E. Dick, PhD FRS, Yigal Dror, MD FRCPC
Journal: Blood
Blood (2020) 136 (Supplement 1): 37.
DOI: https://doi.org/10.1182/blood-2020-143103
Published: 2020
Journal Articles

Variation in Stem Cell Driven Hierarchies Underlies Clinical Outcome and Drug Response in AML

Andy G.X. Zeng, BSc, Amanda Mitchell, PhD, Oleksandr Galkin, PhD, Jean C.Y. Wang, MD PhD, James A. Kennedy, MDPhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
DOI: https://doi.org/10.1182/blood-2020-140895
Published: 2020
Journal Articles

Mir-125b Regulates the Self-Renewal of Acute Myeloid Leukemia Stem Cells through PTPN18 and GSK3

Qiang Liu, PhD BSc, Olga I. Gan, PhD, Gabriela Krivdova, BSc, Aaron Trotman-Grant, Stephanie M. Dobson, PhD, Karin G. Hermans, Mark D. Minden, Shai Izraeli, MD, John E. Dick, PhD FRS, Jean C.Y. Wang, MD PhD, Eric R. Lechman,, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16–17.
DOI: https://doi.org/10.1182/blood-2020-141733
Published: 2020
Journal Articles

Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells

Gordon G. L. Wong, BS, Gabriela Krivdova, BSc, Olga I. Gan, PhD, Jessica L. McLeod, John E. Dick, PhD FRS, Eric R. Lechman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32.
DOI: https://doi.org/10.1182/blood-2020-142963
Published: 2020
Journal Articles

Elevated Expression of Mir-130a in t(8,21) AML Reinforces the Aberrant Molecular Program of AML1-ETO

Gabriela Krivdova, BSc, Veronique Voisin, PhD, Sajid Marhon, Schoof E Erwin, Martino Gabra, Jessica L. McLeod, Leonardo Salmena, Mark D. Minden, Eric R. Lechman,, PhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
DOI: https://doi.org/10.1182/blood-2020-142652
Published: 2020
Journal Articles

Divergent Levels of CD112 and INKA1 Define a Subset of Human Hematopoietic Stem Cells That Resists Regenerative Stress to Preserve Stemness

Kerstin B Kaufmann, PhD, Andy G.X. Zeng, BSc, Etienne Coyaud, Laura Garcia Prat, PhD BSc, MSc, Efthymia Papalexi, BA, Estelle MN Laurent, Michelle Chan-Seng-Yue, Olga I. Gan, PhD, Kristele Pan, Jessica L. McLeod, Sasan Zandi, Shin-Ichiro Takayanagi, PhD, Rahul Satija, Brian Raught, Stephanie Zhi-Juan Xie, PhD, John E. Dick, PhD FRS
Journal: Blood
Blood (2020) 136 (Supplement 1): 5.
DOI: https://doi.org/10.1182/blood-2020-137725
Published: 2020
Journal Articles

A Human Model of Down Syndrome Associated Leukemia Reveals Different Cell of Origins for Initiation and Progression

Elvin Wagenblast, PhD, Joana Araújo, MD, Olga I. Gan, PhD, Sarah K Cutting, Alex Murison, Jessica L. McLeod, Gabriela Krivdova, BSc, Maria Azkanaz, Sabrina A Smith, Johann K Hitzler, MD, John E. Dick, PhD FRS, Eric R Lechman, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
DOI: https://doi.org/10.1182/blood-2020-135867
Published: 2020
Journal Articles

Cellular and Molecular Architecture of Hematopoietic Stem Cells and Progenitors in Genetic Models of Bone Marrow Failure

Stephanie C. Heidemann, MD, Brian Bursic, Sasan Zandi, MD PhD, Hongbing Li, PhD, Robert J Klaassen, MD FRCPC, Sharon Abish, MD, Meera Rayar, Vicky R. Breakey, BSc,MDFRCPC, Houtan Moshiri, PhD, Santhosh Dhanraj, PhD, Richard de Borja, PhD, Adam Shlien, PhD, John E. Dick, PhD, Yigal Dror, MDFRCPC, Sagi Abelson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1223.
DOI: https://doi.org/10.1182/blood-2019-130534
Published: 2019
Journal Articles

Understanding Pre-Leukemia in Trisomy 21 Human HSC and Modeling Progression Towards Down Syndrome Associated Leukemia Using CRISPR/Cas9 at Single Cell Resolution

Elvin Wagenblast, PhD, Olga I. Gan, PhD, Maria Azkanaz, Sabrina A. Smith, Joana Araújo, MD, Lorien Shakib, Jessica L. McLeod, Gabriela Krivdova, Johann K. Hitzler, MD, Eric R. Lechman, PhD, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2531.
DOI: https://doi.org/10.1182/blood-2019-129259
Published: 2019
Journal Articles

The Metabolic Enzyme Hexokinase 2 Localizes to the Nucleus in AML and Normal Hematopoietic Stem/Progenitor Cells to Maintain Stemness

Geethu Emily Thomas, PhDMSc,BSc, Grace Egan, MD, Laura Garcia Prat, Boaz Nachmias, MD PhD, Jordan M Chin, Fieke W Hoff, BSc, Kerstin Kaufmann, PhD, Rose Hurren, BSc, Marcela Gronda, MSc, Neil MacLean, Xiaoming Wang, Veronique Voisin, PhD, Aaron Botham, Andrea Arruda, Mark D. Minden, MD PhD, Gary D Bader, Steven M. Kornblau, MD, John E. Dick, PhD, Aaron D Schimmer, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2532.
DOI: https://doi.org/10.1182/blood-2019-123121
Published: 2019
Journal Articles

A Novel Cereblon E3 Ligase Modulator Eradicates Acute Myeloid Leukemia Stem Cells through Degradation of Translation Termination Factor GSPT1

Liqing Jin, MD, Nathan Mbong, Stanley W.K. Ng, PhD, Jean C.Y. Wang, MD, Mark D. Minden, MD PhD, Jinhong Fan, Daniel W. Pierce, Michael Pourdehnad, MD, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3940.
DOI: https://doi.org/10.1182/blood-2019-128450
Published: 2019
Journal Articles

HSCs Fated to Progress to Blast Phase Can be Detected in Myelofibrosis Patients Several Years Prior to Leukemic Transformation

Jenny M. Ho, MD, Jessie J.F. Medeiros, BSc, Michelle Chan-Seng-Yue, Lauren Hummel, BSc, Andrea Arruda, Amanda Mitchell, PhD, Caroline J McNamara, MBBS, James A Kennedy, MD PhD, Anne Tierens, MD PhD, Dawn Maze, MDFRCPC,MSc, Hubert Tsui, MD PhD, Mark D. Minden, MD PhD, Vikas Gupta, MD FRCP, FRCPath, John E. Dick, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1676.
DOI: https://doi.org/10.1182/blood-2019-130923
Published: 2019
Journal Articles

A stemness screen reveals C3orf54/INKA1 as a promoter of human leukemia stem cell latency

Kerstin B. Kaufmann, Laura Garcia-Prat, Qiang Liu, Stanley W. K. Ng, Shin-Ichiro Takayanagi, Amanda Mitchell, Erno Wienholds, Peter van Galen, Christian A. Cumbaa, Mike J. Tsay, Chiara Pastrello, Elvin Wagenblast, Gabriela Krivdova, Mark D. Minden, Eric R. Lechman, Sasan Zandi, Igor Jurisica, Jean C. Y. Wang, Stephanie Z. Xie, John E. Dick
Journal: Blood
Blood (2019) 133 (20): 2198–2211.
DOI: https://doi.org/10.1182/blood-2018-10-881441
Published: 2019
Includes: Supplemental data
Journal Articles

Sphingolipid Perturbation Activates Proteostasis Programs to Govern Human Hematopoietic Stem Cell Self-Renewal

Stephanie Zhi-Juan Xie, PhD, Laura Garcia Prat, Veronique Voisin, PhD, Alex Murison, Olga I. Gan, Robin Ferrari, Naoya Takayama, MD PhD, Kerstin B. Kaufmann, PhD, Ishita Patel, Esther Lee, Gareth Holmes, Tiago Medina, PhD, Aditi Vedi, Chiara Luberto, PhD, Gary D Bader, Elisa Laurenti, PhD, Mathieu Lupien, John E. Dick, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 170.
DOI: https://doi.org/10.1182/blood-2018-170
Published: 2018
Journal Articles

Myelofibrosis Is Initiated and Sustained By Rare Multipotent Stem Cells

Jessie J.F. Medeiros, BSc, Amanda Mitchell, PhD, Aaron Trotman-Grant, Tristan Woo, Jenny M. Ho, MD, Andrea Arruda, Mark D. Minden, MD PhD, John E. Dick, PhD, Vikas Gupta, MD FRCP, FRCPath, Liran I. Shlush, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1790.
DOI: https://doi.org/10.1182/blood-2018-99-119088
Published: 2018