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Journal Articles

Genomic and Transcriptional Profiling Stratifies Vq Myeloma Lines into Two Clusters with Distinct Risk Signatures and Drug Responses

Evan Flietner, Mei Yu, Adhithi Rajagopalan, Yun Zhou, Yubin Feng, Anthony Veltri, Terra Lasho, Zhi Wen, Yuqian Sun, Robert Burns, Mrinal M. Patnaik, Natalie Callander, Fotis Asimakopoulos, Demin Wang, Jing Zhang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9935–9936.
DOI: https://doi.org/10.1182/blood-2022-162827
Published: 2022
Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Hanying Wang, Xin He, Lei Zhang, Haojie Dong, Feiteng Huang, Jie Xian, Min Li, Wei Chen, Xiyuan Lu, Khyatiben V. Pathak, Wenfeng Huang, Zheng Li, Lianjun Zhang, Le Xuan Truong Nguyen, Lu Yang, Lifeng Feng, David J. Gordon, Jing Zhang, Patrick Pirrotte, Chun-Wei Chen, Amandeep Salhotra, Ya-Huei Kuo, David Horne, Guido Marcucci, David B. Sykes, Stefano Tiziani, Hongchuan Jin, Xian Wang, Ling Li
Journal: Blood
Blood (2022) 139 (26): 3752–3770.
DOI: https://doi.org/10.1182/blood.2021015108
Published: 2022
Includes: Supplemental data
Journal Articles

Structural basis of von Willebrand factor multimerization and tubular storage

Jianwei Zeng, Zimei Shu, Qian Liang, Jing Zhang, Wenman Wu, Xuefeng Wang, Aiwu Zhou
Journal: Blood
Blood (2022) 139 (22): 3314–3324.
DOI: https://doi.org/10.1182/blood.2021014729
Published: 2022
Includes: Multimedia, Supplemental data
Journal Articles

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation

Xiaona You, Fabao Liu, Moritz Binder, Alexis Vedder, Terra Lasho, Zhi Wen, Xin Gao, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy Finke, Abhishek Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie Droin, Anthony M. Hunter, Sergey Nikolaev, Maria Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M. Patnaik, Jing Zhang
Journal: Blood
Blood (2022) 139 (7): 1066–1079.
DOI: https://doi.org/10.1182/blood.2021012519
Published: 2022
Includes: Supplemental data
Journal Articles

Clinical Significance of Prolymphocytes in Chinese Patients with Chronic Lymphocytic Leukemia

Lingxiao Xing, Yan Wang, Yi Miao, Huayuan Zhu, Jing Zhang, Li Wang, LEI Fan, Wei Xu, Jianyong Li
Journal: Blood
Blood (2021) 138 (Supplement 1): 4694.
DOI: https://doi.org/10.1182/blood-2021-149099
Published: 2021
Journal Articles

Nras Q61R/+ and Kras −/− cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors

Zhi Wen, Grant Yun, Alexander Hebert, Guangyao Kong, Erik A. Ranheim, Remington Finn, Adhithi Rajagoplan, Shuyi Li, Yun Zhou, Mei Yu, Alisa Damnernsawad, Jeroen P. Roose, Joshua J. Coon, Renren Wen, Demin Wang, Jing Zhang
Journal: Blood
Blood (2021) 137 (23): 3259–3271.
DOI: https://doi.org/10.1182/blood.2020009082
Published: 2021
Includes: Supplemental data
Journal Articles

Expression of Nras Q61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice

Zhi Wen, Adhithi Rajagopalan, Evan D. Flietner, Grant Yun, Marta Chesi, Quinlan Furumo, Robert T. Burns, Athanasios Papadas, Erik A. Ranheim, Adam C. Pagenkopf, Zachary T. Morrow, Remington Finn, Yun Zhou, Shuyi Li, Xiaona You, Jeffrey Jensen, Mei Yu, Alexander Cicala, James Menting, Constantine S. Mitsiades, Natalie S. Callander, P. Leif Bergsagel, Demin Wang, Fotis Asimakopoulos, Jing Zhang
Journal: Blood
Blood (2021) 137 (1): 61–74.
DOI: https://doi.org/10.1182/blood.2020007156
Published: 2021
Includes: Supplemental data
Journal Articles

Developing Novel Targeted Therapies Using the High-Risk Vq Myeloma Model

Evan Flietner, BS, Zhi Wen, PhD, Adhithi Rajagopalan, BS, Joshua Wiesner, BS, Xiaona You, PhD, Yun Zhou, MS, Terra Lasho, PhD, Mrinal M. Patnaik, MDMBBS, Demin Wang, PhD, Robert Burns, MD, Natalie S. Callander, MD, Fotis Asimakopoulos, PhDMBBChir,, Jing Zhang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
DOI: https://doi.org/10.1182/blood-2020-137148
Published: 2020
Journal Articles

Fanconi Anemia Gene Associated Germline Predisposition in Aplastic Anemia and Hematologic Malignancies

Daijing Nie, MD, Fang Wang, MD, Jing Zhang, Xvxin Li, Lili Liu, Wei Zhang, Panxiang Cao, MS, Xue Chen, MD, Yang Zhang, MD, Jiaqi Chen, MD, Xiaosu Zhou, PhD, Qisheng Wu, Hongxing Liu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
DOI: https://doi.org/10.1182/blood-2020-142452
Published: 2020
Journal Articles

Analysis of Risk Factors Related to Relapse and Refractory DLBCL and Study of DLBCL Maintenance Therapy

Jing Zhang, Baoan Chen, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
DOI: https://doi.org/10.1182/blood-2020-135952
Published: 2020
Journal Articles

Increased Adhesiveness of Red Blood Cells from Sickle Cell Trait Carriers after Exposure to Daunirubicin Breast Cancer Chemotherapeutic Agent

Jing Zhang, PhD, Matthew Hadfield, DO, Helen Swede, PhD, Biree Andemariam, MD, George Lykotrafitis, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
DOI: https://doi.org/10.1182/blood-2020-143324
Published: 2020
Journal Articles

YY1 Promotes SCF/c-Kit Signaling and HSC Self-Renewal in Fetal Hematopoiesis

Deependra Kumar Singh, PhD, Zhanping Lu, PhD, Shuai Jia, PhD, Xiaona You, PhD, Jing Zhang, PhD, Xuan Pan, PhD DVM
Journal: Blood
Blood (2020) 136 (Supplement 1): 27.
DOI: https://doi.org/10.1182/blood-2020-137254
Published: 2020
Journal Articles

Repurposing Nelarabine to Induce Differentiation of Acute Myeloid Leukemia

Hanying Wang, Xin He, MD, Feiteng Huang, MS, Haojie Dong, PhD, Wei Chen, PhD, Zheng Li, MS, Jie Sun, PhD, Yinghui Zhu, PhD, Lei Zhang, MD, Yuhui Wu, MD, Lifeng Feng, PhD, Jing Zhang, PhD, Samer Khaled, MD, Guido Marcucci, MD, David Sykes, MD PhD, Hongchuan Jin, MD PhD, Xian Wang, MD PhD, Ling Li, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26.
DOI: https://doi.org/10.1182/blood-2020-139922
Published: 2020
Journal Articles

The Efficacy and Safety of Decitabine in Combination with ATRA, G-CSF and Low Dose Cytarabine(Dlaag Regimen)in Relapsed/Refractory Acute Myeloid Leukemia Not Suitable for Strong Chemotherapy : A Phase 2, Prospective, Single-Arm, Multicenter Study

Li Yang, Ligen Liu, Limin Zhao, Yingting Lu, Jing Zhang, Lihua Sun
Journal: Blood
Blood (2019) 134 (Supplement_1): 5108.
DOI: https://doi.org/10.1182/blood-2019-131671
Published: 2019
Journal Articles

Loss of Asxl1 Cooperates with Oncogenic Nras to Drive CMML Progression

Xiaona You, PhD, Zhi Wen, PhD, Guangyao Kong, Adhithi Rajagopalan, BS, Erik A. Ranheim, MD PhD, Yun Zhou, MS, Mrinal M Patnaik, MDMBBS, Jing Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3790.
DOI: https://doi.org/10.1182/blood-2019-131347
Published: 2019
Journal Articles

The Efficacy and Safety of Cladribine in Combination with Cytarabine ,ATRA, G-CSF and Mitoxantrone(Claag-M Regimen)in Relapsed/Refractory AML : A Phase 1/2, Prospective, Single-Arm, Multicenter Study

Tinghua Zhang, Yinghua Xie, Limin Zhao, Xiyao Han, Yingting Lu, Jing Zhang, Yanhui Xie, Qi Zhu, Lihua Sun, Li Yang, Ligen Liu
Journal: Blood
Blood (2019) 134 (Supplement_1): 3843.
DOI: https://doi.org/10.1182/blood-2019-125739
Published: 2019
Journal Articles

Versican Proteolytic Fragments (Matrikines) Regulate the Intratumoral Dendritic Cell Milieu In Vivo: Implications for in Situ Tumor Vaccination

Athanasios Papadas, MD, Evan Flietner, BS, Zachary Morrow, BS, Joshua Wiesner, Alexander Cicala, Adam Pagenkopf, BS, Chelsea L. Hope, PhD, Adhithi Rajagopalan, BS, Zhi Wen, PhD, Philip Emmerich, Dustin Deming, Shigeki Miyamoto, PhD, Peiman Hematti, MD, Natalie Scott Callander, MD, Alexander Rakhmilevich, Mario Otto, MD PhD, Christian M. Capitini, MD, Jing Zhang, PhD, Fotis Asimakopoulos, PhDMBBChir,
Journal: Blood
Blood (2019) 134 (Supplement_1): 1210.
DOI: https://doi.org/10.1182/blood-2019-131582
Published: 2019
Journal Articles

Traditional Chinese Medicine Is Used to the Maintenance Therapy of Diffuse Large B Cell Lymphoma

Jing Zhang, Bao-An Chen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5316.
DOI: https://doi.org/10.1182/blood-2019-126604
Published: 2019
Journal Articles

Lw-218, a New Flavonoid Compound, Exerts Anti-T-Cell Malignancies Effects Via Autophagy-Mediated Apoptosis

Po Hu, Hui Li, Bao-An Chen, Hua Tang, Zheng Ge, MD PhD, Jing Zhang, Hui Hui, Qing-long Guo
Journal: Blood
Blood (2019) 134 (Supplement_1): 5756.
DOI: https://doi.org/10.1182/blood-2019-122409
Published: 2019
Journal Articles

Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy

The Duy Nguyen, Shabnam Shaid, Olesya Vakhrusheva, Sebastian E. Koschade, Kevin Klann, Marlyn Thölken, Fatima Baker, Jing Zhang, Thomas Oellerich, Duran Sürün, Anja Derlet, Isabella Haberbosch, Stefan Eimer, Heinz D. Osiewacz, Christian Behrends, Christian Münch, Ivan Dikic, Christian H. Brandts
Journal: Blood
Blood (2019) 133 (2): 168–179.
DOI: https://doi.org/10.1182/blood-2018-02-833475
Published: 2019
Includes: Supplemental data