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Jeffrey E. Rubnitz
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Journal Articles

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions

Georgina L. Ryland, Masayuki Umeda, Linda Holmfeldt, Sören Lehmann, Morten Krogh Herlin, Jing Ma, Mahsa Khanlari, Jeffrey E. Rubnitz, Rhonda E. Ries, Hansen J. Kosasih, Paul G. Ekert, Hwee Ngee Goh, Ing S. Tiong, Sean M. Grimmond, Claudia Haferlach, Ryan B. Day, Timothy J. Ley, Soheil Meshinchi, Xiaotu Ma, Piers Blombery, Jeffery M. Klco
Journal: Blood
Blood (2023) 141 (7): 800–805.
DOI: https://doi.org/10.1182/blood.2022017874
Published: 2023
Includes: Supplemental data
Journal Articles

Integrated Gene Expression Analysis Identifies ETS2 Involved in Oncogene Induced Senescence to be Associated with Poor Outcome in Paediatric AML

Phani Krishna Parcha, Xueyuan Cao, Jeffrey E. Rubnitz, Raul C. Ribeiro, Stanley B. Pounds, Jatinder K. Lamba
Journal: Blood
Blood (2022) 140 (Supplement 1): 11781–11782.
DOI: https://doi.org/10.1182/blood-2022-163689
Published: 2022
Journal Articles

Proteomic Analysis Identifies Epigenetic Modifiers and Potential Negative Regulators of Leukemogenesis KMD6A and SETDB1 to be Induced Post In Vivo Decitabine Exposure in Pediatric AML

Jatinder K. Lamba, Xueyuan Cao, Huiyun Wu, Hiroto Inaba, Raul C. Ribeiro, Junmin Peng, Tanja A. Gruber, Jeffrey E. Rubnitz, Stanley B. Pounds
Journal: Blood
Blood (2022) 140 (Supplement 1): 6086–6087.
DOI: https://doi.org/10.1182/blood-2022-166671
Published: 2022
Journal Articles

A Cibersortx Signature Predicts Outcome in Pediatric AML Patients

Francisco Marchi, Fernando Sckaff, Xueyuan Cao, Raul C. Ribeiro, Jeffrey E. Rubnitz, Stanley B. Pounds, Jatinder K. Lamba
Journal: Blood
Blood (2022) 140 (Supplement 1): 3441–3442.
DOI: https://doi.org/10.1182/blood-2022-163366
Published: 2022
Journal Articles

Personalization of Induction Therapy for Pediatric AML to Ara-C+Dauno+ Etoposide (ADE) or Clofarabine+Ara-C According to a Polygenic Ara-C SNP Score- ACS10

Jatinder K. Lamba, Richard J Marrero, Abdelrahman H Elsayed, Xueyuan Cao, Huiyun Wu, Hiroto Inaba, Susana C. Raimondi, Ching-Hon Pui, Raul C. Ribeiro, Jeffrey E. Rubnitz, Stanley B. Pounds
Journal: Blood
Blood (2022) 140 (Supplement 1): 1039–1040.
DOI: https://doi.org/10.1182/blood-2022-159657
Published: 2022
Journal Articles

Genome-Wide CRISPR/Cas9 Screen Identifies AraC-Daunorubicin-Etoposide (ADE) Response Modulators Associated with Clinical Outcomes in Pediatric AML

Nam H.K. Nguyen, Abderrahmane Tagmount, Jeffrey E. Rubnitz, Raul C. Ribeiro, Xueyuan Cao, Stanley B. Pounds, Chris D. Vulpe, Jatinder K. Lamba
Journal: Blood
Blood (2022) 140 (Supplement 1): 5947–5948.
DOI: https://doi.org/10.1182/blood-2022-159322
Published: 2022
Journal Articles

Genome-Wide Association Study Identifies Variants Associated with Clinical Outcomes in Pediatric Patients with Newly Diagnosed Acute Myeloid Leukemia

Richard J Marrero, Xueyuan Cao, Huiyun Wu, Hiroto Inaba, Susana C. Raimondi, Ching-Hon Pui, Raul C. Ribeiro, Jeffrey E. Rubnitz, Stanley B. Pounds, Jatinder K. Lamba
Journal: Blood
Blood (2022) 140 (Supplement 1): 6295–6296.
DOI: https://doi.org/10.1182/blood-2022-159534
Published: 2022
Journal Articles

Safety and Anti-Leukemic Activity of CD123-CAR T Cells in Pediatric Patients with AML: Preliminary Results from a Phase 1 Trial

Swati Naik, Renee M. Madden, Amanda Lipsitt, Timothy Lockey, Jennyfer Bran, Jeffrey E. Rubnitz, Jeffery Klco, Barry Shulkin, Sagar L. Patil, Sarah Schell, Jeoungeun John Park, Janice Riberdy, Na Shang, Jaquelyn T. Zoine, Jennifer Wallace, Elaine Harstead, Catherine Willis, Jean-Yves Metais, Deanna M. Langfitt, Sheng Zhou, Salem M. Akel, Michael M. Meagher, Brandon M. Triplett, Stephen Gottschalk, Mireya Paulina Velasquez
Journal: Blood
Blood (2022) 140 (Supplement 1): 4584–4585.
DOI: https://doi.org/10.1182/blood-2022-170201
Published: 2022
Journal Articles

Integrated Genomic Analysis Identifies UBTF Tandem Duplications As a Subtype-Defining Lesion in Pediatric Acute Myeloid Leukemia

Masayuki Umeda, Jing Ma, Benjamin J. Huang, Kohei Hagiwara, Tamara Westover, Sherif Abdelhamed, Juan Martin Barajas, Melvin Edward Thomas, III, Michael P Walsh, Guangchun Song, Liqing Tian, Yanling Liu, Xiaolong Chen, Pandurang Kolekar, Quang Tran, Scott Foy, Jamie L. Maciaszek, Andrew B Kleist, Amanda R. Leonti, Bensheng Ju, John Easton, Huiyun Wu, Virginia Valentine, Marc Valentine, Yen-Chun Liu, Rhonda E. Ries, Jenny L. Smith, Evan Parganas, Ilaria Iacobucci, Ryan Hiltenbrand, Jonathan Miller, Jason Myers, Evadnie Rampersaud, Delaram Rahbarinia, Michael Rusch, Gang Wu, Hiroto Inaba, Yi-Cheng Wang, Todd A. Alonzo, James R. Downing, Charles G. Mullighan, Stanley B Pounds, M. Madan Babu, Jinghui Zhang, Jeffrey E. Rubnitz, Soheil Meshinchi, Xiaotu Ma, Jeffery M. Klco
Journal: Blood
Blood (2021) 138 (Supplement 2): LBA-4.
DOI: https://doi.org/10.1182/blood-2021-155134
Published: 2021
Journal Articles

Clofarabine-Based Chemotherapy for KMT2A r Infantile Acute Lymphoblastic Leukemia

Tanja Andrea Gruber, Deqing Pei, John Kim Choi, Cheng Cheng, Elaine Coustan-Smith, Dario Campana, Hope Swanson, Jennifer L Pauley, Hiroto Inaba, Monika Metzger, Jeffrey E. Rubnitz, Raul C Ribeiro, Susana C. Raimondi, William E. Evans, Mary V. Relling, Ching-Hon Pui, Sima Jeha
Journal: Blood
Blood (2021) 138 (Supplement 1): 3406.
DOI: https://doi.org/10.1182/blood-2021-148936
Published: 2021
Journal Articles

Impact of SAMHD1 Pharmacogenetics on Clinical Outcome in Pediatric AML

Richard J Marrero, Abdelrahman H Elsayed, Xueyuan Cao, Huiyun Wu, Lei Wang, Raul C Ribeiro, Jeffrey E. Rubnitz, Stanley B Pounds, Jatinder K. Lamba
Journal: Blood
Blood (2021) 138 (Supplement 1): 3429.
DOI: https://doi.org/10.1182/blood-2021-147528
Published: 2021
Journal Articles

Clinical Features and Cytoreduction Therapy in Children with Newly Diagnosed Acute Myeloid Leukemia and Hyperleukocytosis

Georgios E. Christakopoulos, Kendra N Walker, Lei Wang, Clifford Takemoto, Yan Zheng, Ching-Hon Pui, Raul C Ribeiro, Stanley B Pounds, Jeffrey E. Rubnitz, Hiroto Inaba
Journal: Blood
Blood (2021) 138 (Supplement 1): 2295.
DOI: https://doi.org/10.1182/blood-2021-151045
Published: 2021
Journal Articles

Impact of Allogeneic Hematopoietic Stem Cell Transplantation in First Complete Remission and Additional Cytogenetic Aberrations at Diagnosis on Prognosis in 1256 Pediatric Patients with KMT2A-Rearranged Acute Myeloid Leukemia: A Retrospective Study By the I-BFM-SG

Romy E. Van Weelderen, Kim Klein, Christine J. Harrison, Hester A. De Groot-Kruseman, Jonas Abrahamsson, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael Dworzak, Sarah Elitzur, José M. Fernández Navarro, Marta Fiocco, Robert B. Gerbing, Bianca F. Goemans, Erin Guest, Shau-Yin Ha, Henrik Hasle, Kathy Jackson, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Daisuke Tomizawa, Femke Verwer, C. Michel Zwaan, Gertjan J.L. Kaspers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2360.
DOI: https://doi.org/10.1182/blood-2021-148041
Published: 2021
Journal Articles

Liposome-Encapsulated Cytarabine and Daunorubicin (CPX-351) Induces Remission in Newly Diagnosed Pediatric Secondary Myeloid Malignancies

Kenneth J Caldwell, Yixin Hu, Mihaela Onciu, Sara M Federico, Marta Salek, Sara Lewis, Shaohua Lei, Jinghui Zhang, Kim E. Nichols, Clifford M Takemoto, Brandon M Triplett, Jason E Farrar, Jeffrey E. Rubnitz, Raul C Ribeiro, Marcin W. Wlodarski
Journal: Blood
Blood (2021) 138 (Supplement 1): 4415.
DOI: https://doi.org/10.1182/blood-2021-149619
Published: 2021
Journal Articles

How I treat pediatric acute myeloid leukemia

Jeffrey E. Rubnitz, Gertjan J. L. Kaspers
Journal: Blood
Blood (2021) 138 (12): 1009–1018.
DOI: https://doi.org/10.1182/blood.2021011694
Published: 2021
Journal Articles

Clinical Benefit and Tolerability of Crenolanib in Children with Relapsed Acute Myeloid Leukemia Harboring Treatment Resistant FLT3 ITD and Variant FLT3 TKD Mutations Treated on Compassionate Access

Katherine Tarlock, MD, Soheil Meshinchi, MDPhD, Jeffrey E. Rubnitz, MD, Seth E. Karol, MD, Barbara Spitzer, MD, Amit J. Sabnis, MD, Asif Pathan, PhD RPh, Boo Messahel, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
DOI: https://doi.org/10.1182/blood-2020-140399
Published: 2020
Journal Articles

Venetoclax and Navitoclax in Pediatric Patients with Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Jeffrey E. Rubnitz, MD, Thomas B. Alexander, MDMPH, Theodore W. Laetsch, MD, Seong Lin Khaw, MD, Vinod A. Pullarkat, MD, Joseph T. Opferman, PhD, Kathryn G Roberts, PhD, Lindsey Rosenwinkel, Bo Tong, PhD, John C. Pesko, PhD, Mohamed Badawi, Deeksha Vishwamitra, PhD, Su Young Kim, Charles G Mullighan, MBBS, MD, Norman J. Lacayo, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
DOI: https://doi.org/10.1182/blood-2020-134582
Published: 2020
Journal Articles

Outcome of (Novel) Subgroups in 1257 Pediatric Patients with KMT2A-Rearranged Acute Myeloid Leukemia (AML) and the Significance of Minimal Residual Disease (MRD) Status: A Retrospective Study By the I-BFM-SG

Romy E. Van Weelderen, Kim Klein, MD, Bianca F. Goemans, MD PhD, Christian M. Zwaan, MD PhD, Hester A. De Groot-Kruseman, PhD, Jonas Abrahamsson, MD PhD, Nira Arad-Cohen, MD PhD, Emmanuelle Bart-Delabesse, PharmD, PhD, Barbara Buldini, MD PhD, Barbara De Moerloose, MD PhD, Michael Dworzak, MD PhD, Sarah Elitzur, MD, José M. Fernández Navarro, MD, Robert B. Gerbing, MA, Erin Guest, MD, Shau-Yin Ha, MD PhD, Christine J. Harrison, PhD FRCPath, Henrik Hasle, PhD, Kathy Jackson, MD PhD, Charikleia Kelaidi, MD, Hélène Lapillonne, MD PhD, Guy Leverger, MD PhD, Franco Locatelli, MD PhD, Takako Miyamura, MD PhD, Sophia Polychronopoulou, MD PhD, Mareike Rasche, MD, Jeffrey E. Rubnitz, MD, Jan Stary, MD PhD, Daisuke Tomizawa, MD PhD, Femke Verwer, Gertjan J.L. Kaspers, Prof. MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
DOI: https://doi.org/10.1182/blood-2020-136064
Published: 2020
Journal Articles

Proposed Scheme for Dosing Venetoclax in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia: Analysis of Developmental Pharmacokinetics and Exposure-Response Relationships

Mohamed A Badawi, PhD, Sathej Gopalakrishnan, PhD, Benjamin Engelhardt, PhD, Tammy L. Palenski, PhD, Su Young Kim, Seth E. Karol, MD, Jeffrey E. Rubnitz, MD, Rajeev Menon, PhD, Ahmed Hamed Salem, PhD FCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
DOI: https://doi.org/10.1182/blood-2020-139593
Published: 2020
Journal Articles

Risk Score Generated from Ara-C Metabolic Pathway Predicts Leukemic Cell Intracellular Ara-CTP Levels in AML-97 Pediatric Patients

Abdelrahman Elsayed, BSc, MSc, Kristine R Crews, PharmD, Xueyuan Cao, PhD, Jeffrey E Rubnitz, MD PhD, Stanley Pounds, PhD, Jatinder Lamba, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2666.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.2666.2666
Published: 2017