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Journal Articles

Functional Drug Screen Identifies Thiostrepton, NAMPT Inhibitors and Metformin As Potential Candidates to Target the Macrophage Tumor Microenvironment in Acute Myeloid Leukemia

Isabel Weinhaeuser, Diego Pereira-Martins, Jacobien R Hilberink, Emanuele Ammatuna, Gerwin A. Huls, Eduardo M Rego, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 8793–8794.

DOI: https://doi.org/10.1182/blood-2022-165115

Published: 2022

Journal Articles

M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment

Isabel Weinhaeuser, Diego Pereira-Martins, Luciana Yamamoto de Almeida, Jacobien R Hilberink, Douglas RA Silveira, Lynn Quek, César Alexander Ortiz, Antonio R. Lucena-Araujo, Nienke Visser, Emanuele Ammatuna, Gerwin A. Huls, Eduardo M Rego, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 1259–1260.

DOI: https://doi.org/10.1182/blood-2022-165130

Published: 2022

Journal Articles

Full Spectrum 40-Parameter Single-Tube Flow Cytometry Analysis for Longitudinal Immunophenotyping and Tracing of Clonal Heterogeneity in AML

Nisha K. Van Der Meer, Duy le Minh, Diego Pereira-Martins, Dimitrios Kleftogiannis, Albertus T.J. Wierenga, Kees Meijer, Andre B. Mulder, Gerwin A. Huls, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 9140–9141.

DOI: https://doi.org/10.1182/blood-2022-165438

Published: 2022

Journal Articles

Functional and Molecular Characterisation of Prospectively Isolated Subclones in Individual AML Patients Reveals Distinct Gene Regulatory Networks Linked to Targetable Metabolic Vulnerabilities

Shanna M Hogeling, Roos Houtsma, Nisha K Van Der Meer, Salam A. Assi, Paulynn Chin, Alan Cunningham, Peter Keane, Dominique Sternadt Alexandre Ramos, Lieve Oudejans, Gerwin A. Huls, Constance Bonifer, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 5844–5845.

DOI: https://doi.org/10.1182/blood-2022-159999

Published: 2022

Journal Articles

Impaired Metabolic Plasticity Under Stress Constitutes a Therapeutic Vulnerability in IDH1/2 -Mutant Acute Myeloid Leukemia

Dominique Sternadt, Diego Pereira-Martins, Douglas RA Silveira, Prodromos Chatzikyriakou, Maria del Pilar Casares Alaez, Isabel Weinhaeuser, Shanna M Hogeling, Emanuele Ammatuna, Gerwin A. Huls, Lynn Quek, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 8813–8814.

DOI: https://doi.org/10.1182/blood-2022-163282

Published: 2022

Journal Articles

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Keli Lima, Diego A Pereira-Martins, Lívia Bassani Lins de Miranda, Juan L Coelho-Silva, Giovana da Silva Leandro, Isabel Weinhäuser, Rita de Cassia Cavaglieri, Wellington F Silva, Aline Medeiros Leal, Ana Paula Alencar de Lima Lange, Elvira Deolinda Rodrigues Pereira Velloso, Emmanuel Griessinger, Jacobien R Hilberink, Gerwin A. Huls, Jan Jacob Schuringa, João Agostinho Machado-Neto, Eduardo M Rego

Blood (2022) 140 (Supplement 1): 5965–5966.

DOI: https://doi.org/10.1182/blood-2022-165172

Published: 2022

Journal Articles

Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia

Blood (2022) 140 (Supplement 1): 5928–5929.

DOI: https://doi.org/10.1182/blood-2022-168921

Published: 2022

Journal Articles

High MN1 Expression Is Associated with an Lspc-Enriched Phenotype and Glycolysis Representing a New Vulnerability in Acute Myeloid Leukemia

Diego Pereira-Martins, Noortje van Dijk, Isabel Weinhaeuser, Douglas RA Silveira, Juan Coelho Da Silva, Thiago M Bianco, César Alexander Ortiz, Fabiola Traina, Lorena L Figueiredo-Pontes, Emanuele Ammatuna, Lynn Quek, Gerwin A. Huls, Antonio R. Lucena-Araujo, Eduardo M Rego, Jan Jacob Schuringa

Blood (2022) 140 (Supplement 1): 6265–6266.

DOI: https://doi.org/10.1182/blood-2022-165151

Published: 2022

Journal Articles

Dietary methionine starvation impairs acute myeloid leukemia progression

Blood (2022) 140 (19): 2037–2052.

DOI: https://doi.org/10.1182/blood.2022017575

Published: 2022

Includes: Supplemental data

Journal Articles

Clinical Significance of Mitochondrial DNA Content in Acute Promyelocytic Leukemia

Antonio R. Lucena-Araujo, Diego A Pereira-Martins, Juan L Coelho-Silva, Isabel Weinhäuser, Pedro Luis Franca-Neto, Douglas RA Silveira, Marinus M Lima, Jan Jacob Schuringa, Luisa C Koury, Raul Antônio Morais Melo, Rosane Bittencourt, Katia B Pagnano, Elenaide C. Nunes, Evandro Maranhão Fagundes, Fabio R. Kerbauy, Lorena Figueredo-Pontes, Eduardo M Rego

Blood (2021) 138 (Supplement 1): 3474.

DOI: https://doi.org/10.1182/blood-2021-151265

Published: 2021

Journal Articles

Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia In Vivo

Isabel Weinhäuser, Diego A Pereira-Martins, Jacobien R Hilberink, Luciana Yamamoto Almeida, Douglas RA Silveira, Lynn Quek, Shanna M Hogeling, Jose Mauricio Mota, Emanuele Ammatuna, Antonio R. Lucena-Araujo, Gerwin A. Huls, Jan Jacob Schuringa, Eduardo M Rego

Blood (2021) 138 (Supplement 1): 3472.

DOI: https://doi.org/10.1182/blood-2021-150699

Published: 2021

Journal Articles

RUNX1 Mutations Lead to a Myeloid Differentiation Block in Association with Enhanced Proliferation By Altering the RUNX1 Transcriptional Program

Mylène Gerritsen, MSc, Esther Tijchon, PhD, Guoqiang Yi, PhD, Jorren Kuster, BSc, Jan Jacob Schuringa, PhD, Joost H.A. Martens, Edo Vellenga, MD

Blood (2017) 130 (Supplement 1): 1229.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1229.1229

Published: 2017

Journal Articles

Putative Autophagy Protein VMP1 Amplifies Protective Autophagy Under Stress Conditions in AML Cells

Hendrik Folkerts, MSc, Albertus T.J. Wierenga, PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD

Blood (2017) 130 (Supplement 1): 3918.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3918.3918

Published: 2017

Journal Articles

Smart niche usage: release its fat and burn it!

Jan Jacob Schuringa

Blood (2017) 129 (10): 1239–1240.

DOI: https://doi.org/10.1182/blood-2017-01-761551

Published: 2017

Journal Articles

Establishing human leukemia xenograft mouse models by implanting human bone marrow–like scaffold-based niches

Antonella Antonelli, Willy A. Noort, Jenny Jaques, Bauke de Boer, Regina de Jong-Korlaar, Annet Z. Brouwers-Vos, Linda Lubbers-Aalders, Jeroen F. van Velzen, Andries C. Bloem, Huipin Yuan, Joost D. de Bruijn, Gert J. Ossenkoppele, Anton C. M. Martens, Edo Vellenga, Richard W. J. Groen, Jan Jacob Schuringa

Blood (2016) 128 (25): 2949–2959.

DOI: https://doi.org/10.1182/blood-2016-05-719021

Published: 2016

Includes: Supplemental data

Journal Articles

RUNX1 Mutations Cause a Myeloid Differentiation Block Leading to the Formation of a Long Term Expanding CD34 + /CD33 + /CD45RA + /CD123 + Cell Population

Myléne Gerritsen, MSc, Esther Tijchon, PhD, Amit Mandoli, PhD, Joost H.A. Martens, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2016) 128 (22): 1979.

DOI: https://doi.org/10.1182/blood.V128.22.1979.1979

Published: 2016

Journal Articles

Blocking the Autophagy Pathway As Potential Target for the Treatment of Wild Type P53 AMLs

Hendrik Folkerts, MSc, Susan Hilgendorf, MSc, Albertus T. Wierenga, PhD, Paul J. Coffer, PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2016) 128 (22): 770.

DOI: https://doi.org/10.1182/blood.V128.22.770.770

Published: 2016

Journal Articles

Following Autologous Stem Cell Transplantation (1 Yr) Mesenchymal Stem Cells Are Functionally Impaired with Reduced Hematopoietic Support

Catharina Hazenberg, MD, Fiona A.J. van den Heuvel, Edo Vellenga, MD PhD, Annet Z. Brouwers-Vos, Gerbrig Berger, BSc, Jan Jacob Schuringa, PhD

Blood (2016) 128 (22): 3888.

DOI: https://doi.org/10.1182/blood.V128.22.3888.3888

Published: 2016

Journal Articles

Targeting Autophagy As a Potential Therapeutic Strategy for the Treatment of AML

Hendrik Folkerts, MSc, Bart-Jan A.T.J. Wierenga, PhD, Paul J. Coffer, PhD, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2015) 126 (23): 3831.

DOI: https://doi.org/10.1182/blood.V126.23.3831.3831

Published: 2015

Journal Articles

Loss of ASXL1 Triggers an Apoptotic Response in Human Hematopoietic Stem and Progenitor Cells

Susan Hilgendorf, MSc, Hendrik Folkerts, MSc, Jan Jacob Schuringa, PhD, Edo Vellenga, MD PhD

Blood (2015) 126 (23): 4107.

DOI: https://doi.org/10.1182/blood.V126.23.4107.4107

Published: 2015

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NARROW

Functional Drug Screen Identifies Thiostrepton, NAMPT Inhibitors and Metformin As Potential Candidates to Target the Macrophage Tumor Microenvironment in Acute Myeloid Leukemia

M2 Macrophages Drive Resistance to Phagocytosis and Improve Mitochondrial Metabolism in Acute Myeloid Leukemia Facilitating Leukemic Transformation and In Vivo Engraftment

Full Spectrum 40-Parameter Single-Tube Flow Cytometry Analysis for Longitudinal Immunophenotyping and Tracing of Clonal Heterogeneity in AML

Functional and Molecular Characterisation of Prospectively Isolated Subclones in Individual AML Patients Reveals Distinct Gene Regulatory Networks Linked to Targetable Metabolic Vulnerabilities

Impaired Metabolic Plasticity Under Stress Constitutes a Therapeutic Vulnerability in IDH1/2 -Mutant Acute Myeloid Leukemia

Targeting PIP4K2 Lipid Kinases through Thz-P1-2 Reveals Vulnerabilities Related to Mitochondrial Homeostasis and Autophagy in Acute Leukemia

Pharmacological Characterization of JNJ-75276617, a Menin-KMT2A Inhibitor, As Targeted Treatment for KMT2A-Altered and NPM1-Mutant Acute Leukemia

High MN1 Expression Is Associated with an Lspc-Enriched Phenotype and Glycolysis Representing a New Vulnerability in Acute Myeloid Leukemia

Dietary methionine starvation impairs acute myeloid leukemia progression

Clinical Significance of Mitochondrial DNA Content in Acute Promyelocytic Leukemia

Tumor Associated Macrophages Promoted Fatal Patient Derived Acute Promyelocytic Leukemia In Vivo

RUNX1 Mutations Lead to a Myeloid Differentiation Block in Association with Enhanced Proliferation By Altering the RUNX1 Transcriptional Program

Putative Autophagy Protein VMP1 Amplifies Protective Autophagy Under Stress Conditions in AML Cells

Smart niche usage: release its fat and burn it!

Establishing human leukemia xenograft mouse models by implanting human bone marrow–like scaffold-based niches

RUNX1 Mutations Cause a Myeloid Differentiation Block Leading to the Formation of a Long Term Expanding CD34 + /CD33 + /CD45RA + /CD123 + Cell Population

Blocking the Autophagy Pathway As Potential Target for the Treatment of Wild Type P53 AMLs

Following Autologous Stem Cell Transplantation (1 Yr) Mesenchymal Stem Cells Are Functionally Impaired with Reduced Hematopoietic Support

Targeting Autophagy As a Potential Therapeutic Strategy for the Treatment of AML

Loss of ASXL1 Triggers an Apoptotic Response in Human Hematopoietic Stem and Progenitor Cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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