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Jan A. Burger
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Journal Articles

T-bet suppresses proliferation of malignant B cells in chronic lymphocytic leukemia

Philipp M. Roessner, Isabelle Seufert, Vicente Chapaprieta, Ruparoshni Jayabalan, Hannah Briesch, Ramon Massoni-Badosa, Pavle Boskovic, Julian Benckendorff, Tobias Roider, Lavinia Arseni, Mariana Coelho, Supriya Chakraborty, Alicia M. Vaca, Mariela Sivina, Markus Muckenhuber, Sonia Rodriguez-Rodriguez, Alice Bonato, Sophie A. Herbst, Marc Zapatka, Clare Sun, Helene Kretzmer, Thomas Naake, Peter-Martin Bruch, Felix Czernilofsky, Elisa ten Hacken, Martin Schneider, Dominic Helm, Deyan Y. Yosifov, Joseph Kauer, Alexey V. Danilov, Moritz Bewarder, Kristina Heyne, Christof Schneider, Stephan Stilgenbauer, Adrian Wiestner, Jan-Philipp Mallm, Jan A. Burger, Dimitar G. Efremov, Peter Lichter, Sascha Dietrich, José I. Martin-Subero, Karsten Rippe, Martina Seiffert
Journal: Blood
Blood (2024) 144 (5): 510–524.
https://doi.org/10.1182/blood.2023021990
Published: 2024
Includes: Supplemental data
Journal Articles

A First-in-Human Phase 1 Study of ABBV-525, a Small-Molecule MALT1 Inhibitor, in Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Andrew L. Sochacki, Jan A. Burger, Carrianne Ludwig, Wissam Assaily, Wijith Munasinghe, William Pappano, Edward Greenberg, Christine Will, Meghan C. Thompson
Journal: Blood
Blood (2023) 142 (Supplement 1): 3101.
https://doi.org/10.1182/blood-2023-181671
Published: 2023
Journal Articles

Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): 5-Year Follow-up Data

Nitin Jain, Michael J. Keating, Philip A. Thompson, Alessandra Ferrajoli, Jayastu Senapati, Jan A. Burger, Gautam Borthakur, Mahesh Swaminathan, Koichi Takahashi, Zeev Estrov, Marina Y. Konopleva, Koji Sasaki, Tapan M. Kadia, Naveen Pemmaraju, Naval Daver, Elias Jabbour, Courtney D. DiNardo, Yesid Alvarado Valero, Musa Yilmaz, Prithviraj Bose, Maro Ohanian, Rashmi Kanagal-Shamanna, Keyur Patel, Jeffrey L. Jorgensen, Sa A. Wang, Sameh Nassar, Naveen Garg, Hyunsoo Hwang, Xuemei Wang, Nichole Cruz, Ana Ayala, William Plunkett, Hagop M. Kantarjian, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 4635.
https://doi.org/10.1182/blood-2023-189711
Published: 2023
Journal Articles

Azacitidine Plus Venetoclax Maintenance in Acute Myeloid Leukemia Produces Sustained Remissions with Low Toxicity: Results of a Phase 2 Study

Alexandre Bazinet, Hagop M. Kantarjian, Gautam Borthakur, Musa Yilmaz, Prithviraj Bose, Elias Jabbour, Yesid Alvarado Valero, Kelly S. Chien, Naveen Pemmaraju, Koichi Takahashi, Nicholas J. Short, Naval Daver, Ghayas C. Issa, Nitin Jain, Danielle E. Hammond, Debra Bull-Linderman, Courtney D. DiNardo, Jan A. Burger, Alessandra Ferrajoli, Guillermo Montalban-Bravo, Koji Sasaki, Guillermo Garcia-Manero, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2023) 142 (Supplement 1): 2884.
https://doi.org/10.1182/blood-2023-172882
Published: 2023
Journal Articles

Nelarabine (NEL), Pegylated Asparginase (PEG) and Venetoclax (VEN) Incorporated to HCVAD Chemotherapy in the Frontline Treatment of Adult Patients with T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma (T-ALL/T-LBL)

Jayastu Senapati, Hagop M. Kantarjian, Elias Jabbour, Rodrick Babakhanlou, Tapan M. Kadia, Gautam Borthakur, Marina Y. Konopleva, William G. Wierda, Jan A. Burger, Ghayas C. Issa, Abhishek Maiti, Hayley S. Balkin, Mary Kelly, Rebecca Garris, Alessandra Ferrajoli, Guillermo Garcia-Manero, Yesid Alvarado Valero, Partow Kebriaei, Nicholas J. Short, Nitin Jain, Farhad Ravandi
Journal: Blood
Blood (2023) 142 (Supplement 1): 963.
https://doi.org/10.1182/blood-2023-179562
Published: 2023
Journal Articles

NK Cell Dysfunction in CLL Is Mediated through SHP-1 Signaling and Is Associated with Poor Prognosis

Hila Shaim, Hind Rafei, Mecit Kaplan, Rafet Basar, May Daher, MD, Mayra Shanley, Pinaki Banerjee, Bijender Kumar, Ana K. Nunez Cortes, Sanjida Islam, Xin Ru Jiang, Lucila Nassif Kerbauy, Paul Lin, Elif Gokdemir, Nadima Uprety, Sunil Acharya, Mayela Carolina Mendt, Luciana Melo Garcia, Alexander Biederstädt, Bin Liu, Enli Liu, Sonny Ang, Jan A. Burger, William G. Wierda, Alessandra Ferrajoli, Elizabeth J. Shpall, Katayoun Rezvani
Journal: Blood
Blood (2023) 142 (Supplement 1): 1895.
https://doi.org/10.1182/blood-2023-189671
Published: 2023
Journal Articles

CLL Cell-Derived Exosomes Impair Immune Function and Normal Hematopoiesis in CLL

Ivo Veletic, David M. Harris, Uri Rozovski, Ping Li, Zhiming Liu, Taghi Manshouri, Maria Teresa S. Bertilaccio, George A. Calin, Rares-Constantin Drula, Koichi Takahashi, Ken Furudate, Muharrem Muftuoglu, Anwar Hossain, Alessandra Ferrajoli, Jan A. Burger, Nitin Jain, William G. Wierda, Srdan Verstovsek, Michael J. Keating, Zeev Estrov
Journal: Blood
Blood (2023) 142 (Supplement 1): 3264.
https://doi.org/10.1182/blood-2023-190712
Published: 2023
Journal Articles

Ibrutinib, Fludarabine, Cyclophosphamide and Obinutuzumab (iFCG) for Firstline Treatment of Patients with CLL with Mutated IGHV and without Del(17p)/ TP53 Mutation: Six-Year Follow-up Analyses

Nitin Jain, Philip Thompson, Akhil Jain, Jan A. Burger, Alessandra Ferrajoli, Jayastu Senapati, Koichi Takahashi, Mahesh Swaminathan, Zeev Estrov, Gautam Borthakur, Prithviraj Bose, Tapan M. Kadia, Naveen Pemmaraju, Koji Sasaki, Divyam Bansal, Marina Y. Konopleva, Elias Jabbour, Naveen Garg, Xuemei Wang, Rashmi Kanagal-Shamanna, Keyur P. Patel, Wei Wang, Sa A. Wang, Jeffrey L. Jorgensen, Wanda Lopez, Ana Ayala, William Plunkett, Varsha Gandhi, Hagop M. Kantarjian, Susan M. O'Brien, Michael J. Keating, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 3267.
https://doi.org/10.1182/blood-2023-188084
Published: 2023
Journal Articles

Tailor: Interventional Study Evaluating Physician's Choice of Ibrutinib Monotherapy or Ibrutinib-Venetoclax Combination Using Dose Modifications and Alternate Dosing Approaches in Patients with Untreated Chronic Lymphocytic Leukemia

Jeff P. Sharman, Jan A. Burger, Jacqueline Barrientos, Philip Kuruvilla, Sima Patel, Gabriel Krigsfeld, Sowmya Srikanthan, Bothayna Messahel, Wasiulla Khan, Emma Smith, Paolo Ghia
Journal: Blood
Blood (2023) 142 (Supplement 1): 6564.
https://doi.org/10.1182/blood-2023-174751
Published: 2023
Journal Articles

Time-Limited Therapy with Zanubrutinib Plus Rituximab in Treatment-Naïve Chronic Lymphocytic Leukemia: Early Results of an Ongoing Phase 2 Trial

Jan A. Burger, Ekaterina Kim, Mariela Sivina, Thomas Mathew, Danielle E. Hammond, Fadi G. Haddad, Alessandra Ferrajoli, William G. Wierda
Journal: Blood
Blood (2023) 142 (Supplement 1): 6524.
https://doi.org/10.1182/blood-2023-178774
Published: 2023
Journal Articles

Changes in the T Helper Cell Compartment during Treatment with the BTK Inhibitor Acalabrutinib

Alicia Vaca, Mariela Sivina, Ekaterina Kim, Alessandra Ferrajoli, William G. Wierda, Jan A. Burger
Journal: Blood
Blood (2022) 140 (Supplement 1): 9855–9856.
https://doi.org/10.1182/blood-2022-159743
Published: 2022
Journal Articles

Combined Ibrutinib and Venetoclax for First-Line Treatment of Patients with Chronic Lymphocytic Leukemia (CLL): 4-Year Follow-up Data

Nitin Jain, Michael J. Keating, Philip A. Thompson, Alessandra Ferrajoli, Jayastu Senapati, Jan A. Burger, Gautam Borthakur, Koichi Takahashi, Zeev E. Estrov, Marina Konopleva, Koji Sasaki, Tapan M. Kadia, Naveen Pemmaraju, Naval Daver, Elias Jabbour, Courtney D. DiNardo, Yesid Alvarado, Musa Yilmaz, Prithviraj Bose, Maro Ohanian, Rashmi Kanagal-Shamanna, Keyur Patel, Jeffrey L. Jorgensen, Sa A Wang, Sameh Nassar, Naveen Garg, Hyunsoo Hwang, Xuemei Wang, Nichole Cruz, Ana Ayala, William Plunkett, Hagop Kantarjian, Varsha Gandhi, William G. Wierda
Journal: Blood
Blood (2022) 140 (Supplement 1): 234–237.
https://doi.org/10.1182/blood-2022-170850
Published: 2022
Journal Articles

Long-Term Follow-up of Low-Dose Dasatinib (50mg Daily) As Frontline Therapy in Newly Diagnosed Chronic Myeloid Leukemia

Georgina Gener-Ricos, Fadi Haddad, Koji Sasaki, Ghayas C. Issa, Jeffrey Skinner, Koichi Takahashi, Lucia Masarova, Jan A. Burger, Gautam Borthakur, Prithviraj Bose, Guillermo Garcia-Manero, Elias Jabbour, Hagop Kantarjian
Journal: Blood
Blood (2022) 140 (Supplement 1): 1493–1494.
https://doi.org/10.1182/blood-2022-167764
Published: 2022
Journal Articles

Early Treatment with Ofatumumab in Patients with High-Risk CLL

Sai Prasad Desikan, Michael J. Keating, Alessandra Ferrajoli, Nitin Jain, Maro Ohanian, Naveen Pemmaraju, Courtney D. DiNardo, Marina Konopleva, Tapan M. Kadia, Susan O'Brien, Zeev E. Estrov, Deborah A Thomas, Jan A. Burger, Philip A. Thompson, William G. Wierda
Journal: Blood
Blood (2022) 140 (Supplement 1): 9876–9878.
https://doi.org/10.1182/blood-2022-167284
Published: 2022
Journal Articles

Initiating First-Line (1L) Ibrutinib (Ibr) in Patients (pts) with Chronic Lymphocytic Leukemia (CLL) Improves Overall Survival (OS) Outcomes to Rates Approximating an Age-Matched Population of ≥65 Years

Paolo Ghia, Carolyn Owen, Jacqueline C. Barrientos, Paul M. Barr, Anthony R. Mato, Chunxue Shi, Anita Szoke, Chris Abbazio, Gabriel S. Krigsfeld, Jan A. Burger
Journal: Blood
Blood (2022) 140 (Supplement 1): 4159–4161.
https://doi.org/10.1182/blood-2022-163257
Published: 2022
Journal Articles

High Cell Death Rates at Start of Ibrutinib Therapy Predict for Deeper Remissions in Patients with Chronic Lymphocytic Leukemia (CLL)

Ekaterina Kim, Mariela Sivina, Alicia Vaca, Alessandra Ferrajoli, Nitin Jain, Philip A. Thompson, William G. Wierda, Dominik Wodarz, Nicholas Chiorazzi, Jan A. Burger
Journal: Blood
Blood (2022) 140 (Supplement 1): 4140–4141.
https://doi.org/10.1182/blood-2022-160238
Published: 2022
Journal Articles

Updated Results from a Phase I/II Study of the Triplet Combination of Azacitidine, Venetoclax and Gilteritinib for Patients with FLT3 -Mutated Acute Myeloid Leukemia

Nicholas Short, Courtney D. DiNardo, Naval Daver, Walid Macaron, Musa Yilmaz, Gautam Borthakur, Guillermo Montalban-Bravo, Guillermo Garcia-Manero, Ghayas C. Issa, Koji Sasaki, Philip A. Thompson, Jan A. Burger, Abhishek Maiti, Yesid Alvarado, Monica Kwari, Ricardo Delumpa, Jennifer Thankachan, Ejiroghene Mayor, Christopher Loiselle, Anna Milton, Glenda Banks, Tapan M. Kadia, Marina Konopleva, Hagop Kantarjian, Farhad Ravandi
Journal: Blood
Blood (2022) 140 (Supplement 1): 2007–2009.
https://doi.org/10.1182/blood-2022-157210
Published: 2022
Journal Articles

A Phase II Study of Azacitidine Plus Venetoclax As Maintenance Therapy in Acute Myeloid Leukemia: Durable Responses with Longer Term Follow-up

Alexandre Bazinet, Hagop Kantarjian, Gautam Borthakur, Musa Yilmaz, Prithviraj Bose, Elias Jabbour, Yesid Alvarado, Kelly S. Chien, Naveen Pemmaraju, Koichi Takahashi, Nicholas Short, Naval Daver, Ghayas C. Issa, Nitin Jain, Debra Bull Linderman, Courtney D. DiNardo, Jan A. Burger, Alessandra Ferrajoli, Guillermo Montalban-Bravo, Guillermo Garcia-Manero, Koji Sasaki, Farhad Ravandi, Tapan M. Kadia
Journal: Blood
Blood (2022) 140 (Supplement 1): 9005–9007.
https://doi.org/10.1182/blood-2022-162918
Published: 2022
Journal Articles

A Phase II Study of Inotuzumab Ozogamicin for the Treatment of Measurable Residual Disease-Positive B-Cell Acute Lymphoblastic Leukemia

Jayastu Senapati, Nicholas Short, Yesid Alvarado, Jan A. Burger, Nitin Jain, Marina Konopleva, Farhad Ravandi, Courtney D. DiNardo, Lucia Masarova, Koji Sasaki, Philip A. Thompson, Alessandra Ferrajoli, Jovitta Jacob, Ejiroghene Mayor, Anna Milton, Christopher Loiselle, Rebecca Garris, Hagop Kantarjian, Elias Jabbour
Journal: Blood
Blood (2022) 140 (Supplement 1): 3253–3255.
https://doi.org/10.1182/blood-2022-170667
Published: 2022
Journal Articles

A Phase II Study of Mini-Hyper-CVD Plus Inotuzumab Ozogamicin, with or without Blinatumomab, in Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative B-Cell Acute Lymphoblastic Leukemia: Updated Results and Predictors for Outcomes

Patrice Nasnas, Elias Jabbour, Nicholas Short, Farhad Ravandi, Xuelin Huang, Nitin Jain, Tapan M. Kadia, Yesid Alvarado, Jan A. Burger, Naval Daver, Gautam Borthakur, Courtney D. DiNardo, Marina Konopleva, Guillermo Garcia-Manero, William G. Wierda, Jovitta Jacob, Wuliamatu Deen, Monica Kwari, Christopher Loiselle, Edith Roy, Anna Milton, Juan Rivera, Rebecca Garris, Hagop Kantarjian
Journal: Blood
Blood (2022) 140 (Supplement 1): 11679–11682.
https://doi.org/10.1182/blood-2022-168052
Published: 2022