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Journal Articles

Targeting cell-surface VISTA expression on allospecific naïve T cells promotes tolerance

Blood (2025) 145 (15): 1687–1700.

https://doi.org/10.1182/blood.2024025884

Published: 2025

Includes: Supplemental data

Journal Articles

Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD

Michael C. Zaiken, Sujeong Jin, Cameron McDonald-Hyman, Christina Hartigan, Peter Sage, Keli L. Hippen, Brent H Koehn, Angela Panoskaltsis-Mortari, Megan J Riddle, Cindy Eide, Jakub Tolar, Geoffrey R Hill, Leo Luznik, Corey S. Cutler, Jerome Ritz, Leslie S Kean, Ageliki Tsagaratou, Anjana Rao, Bruce R Blazar

Blood blood.2024025036.

https://doi.org/10.1182/blood.2024025036

Published: 2025

Includes: Supplemental data

Journal Articles

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Blood (2024) 143 (21): 2201–2216.

https://doi.org/10.1182/blood.2023023549

Published: 2024

Includes: Supplemental data

Journal Articles

Long-Term Outcomes after Unrelated Marrow Transplantation for Aplastic Anemia with Optimized Cyclophosphamide Dose (BMT CTN 0301)

Mary Eapen, Joseph Antin, Jakub Tolar, Sally Arai, Mitchell Horwitz, Jainqun Kou, Eric Leifere, John M. McCarty, Ryotaro Nakamura, Michael A. Pulsipher, Mary M. Horowitz, H Joachim Deeg

Blood (2023) 142 (Supplement 1): 235.

https://doi.org/10.1182/blood-2023-178093

Published: 2023

Journal Articles

Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo

Blood (2023) 141 (11): 1337–1352.

https://doi.org/10.1182/blood.2022018440

Published: 2023

Includes: Supplemental data

Journal Articles

Radiation Sparing Reduced Intensity Conditioning for Allogeneic Cell Transplantation in Patients with Dyskeratosis Congenita Comparable to Standard of Care: A Phase III Single Institution Trial

Marketa Dimitrov, Svatava Merkle, Gregory M. Vercellotti, Shernan G Holtan, Jakub Tolar, Christen L. Ebens

Blood (2022) 140 (Supplement 1): 7611–7612.

https://doi.org/10.1182/blood-2022-165290

Published: 2022

Journal Articles

Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients

Jing Du, Ryan Flynn, Katelyn Paz, Hong-Gang Ren, Yuko Ogata, Qing Zhang, Philip R. Gafken, Barry E. Storer, Nathan H. Roy, Janis K. Burkhardt, Wendy Mathews, Jakub Tolar, Stephanie J. Lee, Bruce R. Blazar, Sophie Paczesny

Blood (2018) 131 (15): 1743–1754.

https://doi.org/10.1182/blood-2017-08-800623

Published: 2018

Includes: Supplemental data

Journal Articles

FANCN Hypomorphic Mutation Retains BRCA1 Binding Domain

Elizabeth Thompson, MS, Jakub Tolar, MD PhD, Eric A. Hendrickson, PhD

Blood (2016) 128 (22): 2676.

https://doi.org/10.1182/blood.V128.22.2676.2676

Published: 2016

Journal Articles

CD16-IL15-CD33 Trispecific Killer Engager (TriKE) Overcomes Cancer-Induced Immune Suppression and Induces Natural Killer Cell-Mediated Control of MDS and AML Via Enhanced Killing Kinetics

Martin Felices, PhD, Dhifaf Sarhan, PhD, Ludwig Brandt, Karolin Guldevall, Ron McElmurry, Alexander Lenvik, Sami Chu, Jakub Tolar, MD PhD, Elizabeth Taras, Stephen R Spellman, MS, Erica D. Warlick, MD, Michael R. Verneris, MD, Sarah Cooley, MD, Daniel Weisdorf, MD, Bruce R. Blazar, MD, Bjorn Onfelt, PhD, Dan Vallera, PhD, Jeffrey S. Miller, MD

Blood (2016) 128 (22): 4291.

https://doi.org/10.1182/blood.V128.22.4291.4291

Published: 2016

Journal Articles

Continuous IL-15 Signaling Leads to Functional Exhaustion of Human Natural Killer Cells through Metabolic Changes That Alters Their In Vivo Anti-Tumor Activity

Martin Felices, PhD, Alexander Lenvik, Sami Chu, Ron McElmurry, Sarah Cooley, MD, Jakub Tolar, MD PhD, Bruce R. Blazar, MD, Jeffrey S. Miller, MD

Blood (2016) 128 (22): 551.

https://doi.org/10.1182/blood.V128.22.551.551

Published: 2016

Journal Articles

Trispecific Killer Engagers (TriKEs) that contain IL-15 to make NK cells antigen specific and to sustain their persistence and expansion

Jeffrey S. Miller, MD, Martin Felice, Ron McElmurry, Valerie McCullar, Xianzheng Zhou, Jakub Tolar, MD PhD, Joerg Uwe Schmohl, Angela Panoskaltsis-Mortari, PhD, Bin Zhang, Elizabeth Taras, Michael R. Verneris, MD, Sarah Cooley, MD, Daniel J. Weisdorf, MD, Bruce R. Blazar, MD, Dan Vallera, PhD

Blood (2015) 126 (23): 232.

https://doi.org/10.1182/blood.V126.23.232.232

Published: 2015

Journal Articles

Mucocutaneous Engraftment and Type VII Collagen (C7) Replacement after Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Recessive Dystrophic Epidermolysis Bullosa (RDEB)

Jakub Tolar, MD, PhD, John A McGrath, MD, Mark J. Osborn, PhD, Douglas R Keene, BS, Kristen Hook, MD, Maria Hordinsky, MD, David Woodley, MD, Mei Chen, PhD, Alain Hovnanian, MD PhD, Katsuto Tamai, MD PhD, Bruce R. Blazar, MD, John E Wagner, MD

Blood (2015) 126 (23): 402.

https://doi.org/10.1182/blood.V126.23.402.402

Published: 2015

Journal Articles

Megatal, Crispr/Cas9, and Talen T-Cell Receptor Gene Editing

Mark J. Osborn, PhD, Beau R Webber, PhD, Friederike Knipping, Cara-lin Lonetree, Anthony DeFeo, Amber McElroy, Colby Starker, PhD, Richard Gabriel, Sarah Merkel, Keli L. Hippen, PhD, Daniel Voytas, PhD, Christof von Kalle, MD, Manfred Schmidt, PhD, Jeffrey S. Miller, MD, Jordan Jarjour, PhD, Alexander Astrakhan, PhD, Andrew M Scharenberg, MD, Jakub Tolar, MD, PhD, Bruce R. Blazar, MD

Blood (2015) 126 (23): 2045.

https://doi.org/10.1182/blood.V126.23.2045.2045

Published: 2015

Journal Articles

Outcomes after Donor Lymphocyte Infusion for Insufficient Donor Chimerism Following Hematopoietic Cell Transplantation for Non-Malignant Disorders

Carter Biewen, BA, Angela R Smith, MD MS, Jakub Tolar, MD, PhD, Weston P Miller, IV, MD

Blood (2015) 126 (23): 1969.

https://doi.org/10.1182/blood.V126.23.1969.1969

Published: 2015

Journal Articles

GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Brent H. Koehn, Petya Apostolova, Jessica M. Haverkamp, Jeffrey S. Miller, Valarie McCullar, Jakub Tolar, David H. Munn, William J. Murphy, Willie June Brickey, Jonathan S. Serody, Dmitry I. Gabrilovich, Vincenzo Bronte, Peter J. Murray, Jenny P.-Y. Ting, Robert Zeiser, Bruce R. Blazar

Blood (2015) 126 (13): 1621–1628.

https://doi.org/10.1182/blood-2015-03-634691

Published: 2015

Includes: Supplemental data

Journal Articles

Sickle cell and silent spleen

Jakub Tolar

Blood (2015) 125 (17): 2589–2590.

https://doi.org/10.1182/blood-2015-03-633933

Published: 2015

Journal Articles

Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation: an international multicenter study

Blood (2015) 125 (13): 2164–2172.

https://doi.org/10.1182/blood-2014-11-608075

Published: 2015

Includes: Supplemental data

Journal Articles

Optimized Cyclophosphamide (CY) Dosing in Combination with Fludarabine, TBI and ATG As Conditioning for Unrelated Donor Bone Marrow Transplantation (BMT) in Severe Aplastic Anemia (SAA): A Phase I/II Study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN)

Paolo Anderlini, MD, Juan Wu, MS, H. Joachim Deeg, MD, Iris Gersten, MS, Marian Ewell, ScD, Jakub Tolar, MD PhD, Joseph H. Antin, MD, Sally Arai, MD, Mitchell E. Horwitz, MD, John M. McCarty, MD, Ryotaro Nakamura, MD, Michael A. Pulsipher, MD, Roberta H. Adams, MD, Eric Leifer, PhD, Shelly L Carter, ScD, Nancy L DiFronzo, PhD, Mary M. Horowitz, MD MS, Dennis L. Confer, MD, Mary Eapen, MBBS, MS

Blood (2014) 124 (21): 541.

https://doi.org/10.1182/blood.V124.21.541.541

Published: 2014

Journal Articles

Mitochondrial Haplotype As an Independent Predictor of Outcomes Following Allogeneic Hematopoietic Cell Transplantation (HCT)

Julie A. Ross, PhD, Jakub Tolar, MD PhD, Logan G. Spector, PhD, Todd E. Defor, MS, Troy C. Lund, MDPhD, Daniel J. Weisdorf, MD, Anthony J. Hooten, B.S., Bharat Thyagarajan, MD PhD, Erica Langer, BS, Michelle K. Gleason, PhD, John E Wagner, MD, Kimberly Robien, PhD RD, Michael R. Verneris, MD

Blood (2014) 124 (21): 683.

https://doi.org/10.1182/blood.V124.21.683.683

Published: 2014

Journal Articles

DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo

Beau R. Webber, Michelina Iacovino, Si Ho Choi, Jakub Tolar, Michael Kyba, Bruce R. Blazar

Blood (2013) 122 (17): 2978–2986.

https://doi.org/10.1182/blood-2013-03-489369

Published: 2013

Includes: Supplemental data

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Targeting cell-surface VISTA expression on allospecific naïve T cells promotes tolerance

Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD

Alloengraftment without significant toxicity or GVHD in CD45 antibody-drug conjugate–conditioned Fanconi anemia mice

Long-Term Outcomes after Unrelated Marrow Transplantation for Aplastic Anemia with Optimized Cyclophosphamide Dose (BMT CTN 0301)

Prevention of acute GVHD using an orthogonal IL-2/IL-2Rβ system to selectively expand regulatory T cells in vivo

Radiation Sparing Reduced Intensity Conditioning for Allogeneic Cell Transplantation in Patients with Dyskeratosis Congenita Comparable to Standard of Care: A Phase III Single Institution Trial

Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients

FANCN Hypomorphic Mutation Retains BRCA1 Binding Domain

CD16-IL15-CD33 Trispecific Killer Engager (TriKE) Overcomes Cancer-Induced Immune Suppression and Induces Natural Killer Cell-Mediated Control of MDS and AML Via Enhanced Killing Kinetics

Continuous IL-15 Signaling Leads to Functional Exhaustion of Human Natural Killer Cells through Metabolic Changes That Alters Their In Vivo Anti-Tumor Activity

Trispecific Killer Engagers (TriKEs) that contain IL-15 to make NK cells antigen specific and to sustain their persistence and expansion

Mucocutaneous Engraftment and Type VII Collagen (C7) Replacement after Allogeneic Hematopoietic Cell Transplantation (HCT) in Patients with Recessive Dystrophic Epidermolysis Bullosa (RDEB)

Megatal, Crispr/Cas9, and Talen T-Cell Receptor Gene Editing

Outcomes after Donor Lymphocyte Infusion for Insufficient Donor Chimerism Following Hematopoietic Cell Transplantation for Non-Malignant Disorders

GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Sickle cell and silent spleen

Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation: an international multicenter study

Optimized Cyclophosphamide (CY) Dosing in Combination with Fludarabine, TBI and ATG As Conditioning for Unrelated Donor Bone Marrow Transplantation (BMT) in Severe Aplastic Anemia (SAA): A Phase I/II Study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN)

Mitochondrial Haplotype As an Independent Predictor of Outcomes Following Allogeneic Hematopoietic Cell Transplantation (HCT)

DNA methylation of Runx1 regulatory regions correlates with transition from primitive to definitive hematopoietic potential in vitro and in vivo

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