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Jakub Svoboda
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Journal Articles

CD5-Deleted Chimeric Antigen Receptor Cells (Senza5™ CART5) to Enhance Immunotherapy Against T-Cell Non-Hodgkin Lymphoma: A First-in-Human Phase I Clinical Trial

Stefan K. Barta, Marco Ruella, Stephen J. Schuster, Jakub Svoboda, Jordan Carter, Elise A. Chong, Daniel J. Landsburg, Sunita D. Nasta, Colin Thomas, Ruchi P. Patel, Guido Ghilardi, Patrizia Porazzi, Steven Yang, Dean Qian, Raymone Pajarillo, Yunlin Zhang, Aditya Nimmagadda, Trang Vu, Lavanya Peddada, Adam E. Snook, Nicholas A. Siciliano, Rosemary Mazanet
Journal: Blood
Blood (2024) 144 (Supplement 1): 7221.
https://doi.org/10.1182/blood-2024-201063
Published: 2024
Journal Articles

PRIMAVERA: A Modular Phase I/II Study to Evaluate the Safety, Tolerability, and Efficacy of AZD3470, a Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, in Participants with Relapsed/Refractory Hematologic Malignancies

Tae Min Kim, Katharine L. Lewis, Juan Pablo Alderuccio, Hun Ju Lee, Enrico Derenzini, Pier Luigi Zinzani, Marco Ladetto, Elizabeth H. Phillips, Hervé Ghesquieres, François Lemonnier, Franck Morschhauser, Ana Sureda Balari, Antonia Rodriguez Izquierdo, Peter Borchmann, Matthew Weinstock, Jakub Svoboda, Emma Dean, Jelena Urosevic, Stefanie Meyer, Robert Chen, Richard Olsson, Kaitlyn Beyfuss, Graham P. Collins
Journal: Blood
Blood (2024) 144 (Supplement 1): 1674.2.
https://doi.org/10.1182/blood-2024-203060
Published: 2024
Journal Articles

Efficacy and Safety of Anti-CD19 and Anti-BCMA Chimeric Antigen Receptor (CAR) T-Cell Therapies in Patients with Autoimmune Disease and Lymphoma or Myeloma

Luca Paruzzo, Riemke Bouvier, Guido Ghilardi, Eugenio Fardella, Bria Fulmer, Ivan J Cohen, Elise A. Chong, Jakub Svoboda, Sunita D. Nasta, Daniel J. Landsburg, Vrutti Patel, Li Ziyu, Raymone Pajarillo, Adam Waxman, Adam D. Cohen, Dan T. Vogl, Stefan K. Barta, Patrizia Porazzi, Joseph A. Fraietta, Vijay Bhoj, Alfred L. Garfall, Edward A. Stadtmauer, Stephen J. Schuster, Jordan S. Carter, Sokratis A. Apostolidis, Sandra Susanibar-Adaniya, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 7243.
https://doi.org/10.1182/blood-2024-206608
Published: 2024
Journal Articles

Pembrolizumab and Involved Site Radiation Therapy Alone As an Alternative to Transplant in Patients with Localized Failure Following Chemotherapy for Hodgkin Lymphoma: A Prospective Multicenter Phase II Study

Alexandra Dreyfuss, Nivetha Ganesan, Alvaro J Alencar, Alexander P. Boardman, Philip Caron, Tiffany Chang, Theresa Davey, Kevin A. David, Ahmet Dogan, Zachary D. Epstein-Peterson, Lorenzo Falchi, Beatrice Fregonese, Paola Ghione, Paul A. Hamlin, Steven Horwitz, Brandon S. Imber, Andrew M. Intlekofer, Derek Isrow, Erel Joffe, William T. Johnson, Anita Kumar, Michael Lariviere, Jennifer Kimberly Lue, Efrat Luttwak, Michael McNicholas, Zachary Moore, Brittney Munayirji, Ariela Noy, Colette Owens, Maria Lia Palomba, Jaldhi Patel, John P Plastaras, Alayna M. Santarosa, Heiko Schoder, Gunjan L. Shah, Raphael E. Steiner, Robert Stuver, Jakub Svoboda, Pallawi Torka, Santosha A. Vardhana, Andrew D. Zelenetz, Gilles Salles, Joachim Yahalom, Craig H. Moskowitz, Alison Moskowitz
Journal: Blood
Blood (2024) 144 (Supplement 1): 4434.
https://doi.org/10.1182/blood-2024-210689
Published: 2024
Journal Articles

Pembrolizumab Gemcitabine Vinorelbine and Liposomal Doxorubicin (P-GVD) for Classical Hodgkin Lymphoma (CHL) in the Real-World Setting

Grace T. Baek, Gaurav Varma, Samuel Yamshon, Herman van Besien, Nancy L. Bartlett, Marcus P. Watkins, Harsh R. Shah, Kelsey Baron, Reid W. Merryman, Ayo S Falade, Jakub Svoboda, Sara Prischak, Christopher R D'Angelo, Joe D. Lukowski, Ranjana H. Advani, Austin H. Yeung, Maya C. Rosenberg, Jenna M. Voutsinas, Mengyang Di, Ryan C Lynch, Christina Poh, Vikram Raghunathan, Mazyar Shadman, Stephen D. Smith, Brian G. Till, Chaitra S. Ujjani, Catherine S. Diefenbach, Ajay K. Gopal
Journal: Blood
Blood (2024) 144 (Supplement 1): 4431.
https://doi.org/10.1182/blood-2024-200719
Published: 2024
Journal Articles

PET-Directed Therapy with ABVD Vs. Bv+AVD Followed By Nivolumab in Patients with Early Stage Hodgkin Lymphoma: A Propensity Score Matched Analysis of CALGB50604 and ACCRULY1601

Steven I. Park, Stephen M. Ansell, Danielle Boselli, Sharmila Giri, Jakub Svoboda, Stephen D Smith, Tatyana Feldman, L. Elizabeth Budde, Andrew J Ness, Philip Bierman, Hun Ju Lee
Journal: Blood
Blood (2024) 144 (Supplement 1): 458.
https://doi.org/10.1182/blood-2024-202207
Published: 2024
Journal Articles

Impact of Broad-Spectrum Antibiotic Exposure on CAR-T Therapy Outcomes in B-Cell Lymphoma: A Multicenter International Study

Roni Shouval, Teng Fei, Giulia Gabrielli, Natalie Grier Smith, Guido Ghilardi, John Slingerland, Jonathan U. Peled, Ying Taur, Sunita D. Nasta, Alejandro Luna, Magdalena Corona, Kai Rejeski, Sophia Stock, Ronit Marcus, Noa Golan Accav, Ofrat Beyar-Katz, Hazim Khatib, Sandeep S. Raj, Alexander P. Boardman, Parastoo B Dahi, Richard J. Lin, Michael Scordo, Lorenzo Falchi, Jakub Svoboda, Elise A. Chong, Stefan K. Barta, Daniel J. Landsburg, Avichai Shimoni, Arnon Nagler, Gunjan L. Shah, Maria Lia Palomba, Gilles Salles, Jae H. Park, Stephen J. Schuster, Tsila Zuckerman, Marion Subklewe, Abraham Avigdor, Miguel Angel Perales, Marcel R.M. van den Brink, Marco Ruella
Journal: Blood
Blood (2024) 144 (Supplement 1): 1746.
https://doi.org/10.1182/blood-2024-203871
Published: 2024
Journal Articles

Title: Development of a Pathologic Prognostic Index (PPI) for Newly Diagnosed Large B Cell Lymphoma Patients Treated with R-CHOP

Vincent Ni, Sunita D. Nasta, Stefan K. Barta, Stephen J. Schuster, Elise A. Chong, Jakub Svoboda, Jennifer JD Morrissette, Ashley Barlev, Adam Bagg, Salvatore F. Priore, Daniel J. Landsburg
Journal: Blood
Blood (2024) 144 (Supplement 1): 3083.
https://doi.org/10.1182/blood-2024-203448
Published: 2024
Journal Articles

Concomitant Use of Antibiotics During Immune Checkpoint Inhibitor (CPI)-Based Salvage Therapy Does Not Impact Post-ASCT Outcomes in Patients with Relapsed/Refractory Hodgkin Lymphoma (RRHL)

Gaurav Varma, Maya C. Rosenberg, Erica C. Agbadiba, Austin H. Yeung, Ayo S. Falade, Marcus P. Watkins, Grace T. Baek, Herman van Besien, Kelsey Baron, Meghana K. Subramanian, Sara Prischak, Joe D. Lukowski, Christopher D'Angelo, Jakub Svoboda, Joanna M. Rhodes, Harsh R. Shah, Samuel Yamshon, Ajay K. Gopal, Nancy L. Bartlett, Reid W. Merryman, Ranjana H. Advani, Sairah Ahmed, Catherine S. Diefenbach
Journal: Blood
Blood (2024) 144 (Supplement 1): 4425.
https://doi.org/10.1182/blood-2024-197923
Published: 2024
Journal Articles

Curing CLL: Long-Term Outcomes of Chronic Lymphocytic Leukemia Patients with at Least One Year of Response to CART-19 Therapy

Benjamin F. Frost, Noelle Frey, Elizabeth O. Hexner, Stephen J. Schuster, Sunita D. Nasta, Alison W Loren, Jakub Svoboda, Daniel J. Landsburg, Bruce Levine, Joseph A. Fraietta, J. Joseph Melenhorst, Elizabeth Veloso, Wei-Ting Hwang, Carl H. June, David L. Porter, Saar Gill
Journal: Blood
Blood (2024) 144 (Supplement 1): 588.
https://doi.org/10.1182/blood-2024-204197
Published: 2024
Journal Articles

Real-World Outcomes of Early Relapsed/Refractory Large B Cell Lymphoma Patients Treated with 2 nd Line CAR T Therapy

Michael Schneider, Elise A. Chong, Stefan K. Barta, Sunita D. Nasta, Jakub Svoboda, Jordan Carter, Michael Roderick Cook, Nasheed Hossain, Stephen J. Schuster, Heather Difilippo, John P Plastaras, Michael Lariviere, Marco Ruella, David L. Porter, Noelle Frey, Daniel J. Landsburg
Journal: Blood
Blood (2024) 144 (Supplement 1): 5123.
https://doi.org/10.1182/blood-2024-202736
Published: 2024
Journal Articles

Outcomes in Primary CNS Lymphoma: A Single Institution Experience from the Abramson Cancer Center at the University of Pennsylvania

Nikita Dave, Veronica Carvajal, Jordan Carter, Donald Edward Tsai, Stephen J. Schuster, James Gerson, Stefan K. Barta, Jakub Svoboda, Elise A. Chong, Daniel J. Landsburg, Sunita D. Nasta
Journal: Blood
Blood (2024) 144 (Supplement 1): 1699.
https://doi.org/10.1182/blood-2024-207781
Published: 2024
Journal Articles

Comparison of CRS- and Icans-Related Outcomes for Large B Cell Lymphoma Patients Treated with Commercial Axicabtagene Ciloleucel with or without Prophylactic Dexamethasone

Alison Carulli, Hayden Elliott, Brendan Mangan, James Whittenburg, Elise A. Chong, Sunita D. Nasta, Jakub Svoboda, Stefan K. Barta, David L. Porter, Jordan S. Carter, Michael Roderick Cook, Nasheed Hossain, Saar Gill, Alfred L. Garfall, Christopher Catania, Colleen R. Kucharczuk, Stephen J. Schuster, Noelle Frey, Daniel J. Landsburg
Journal: Blood
Blood (2024) 144 (Supplement 1): 2275.
https://doi.org/10.1182/blood-2024-203726
Published: 2024
Journal Articles

Clinical Activity of Tisagenlecleucel in Large B Cell Lymphomas According to the 5 th Edition of the Who Classification

Guido Ghilardi, Emeline R. Chong, Luca Paruzzo, Giulia Gabrielli, Sunita D. Nasta, Vrutti Patel, Eugenio Fardella, Daniel J. Landsburg, Jordan Carter, Colin Thomas, Stefan K. Barta, Elise A. Chong, Jakub Svoboda, Marco Ruella, Stephen J. Schuster
Journal: Blood
Blood (2024) 144 (Supplement 1): 1750.
https://doi.org/10.1182/blood-2024-206027
Published: 2024
Journal Articles

Safety of CAR-T Cell Therapy in Asymptomatic Patients with Positive Respiratory Viral Testing Prior to CAR-T Infusions

Reid M. Muenzen, Emeline R. Chong, Dylan Therwhanger, Daniel J. Landsburg, Sunita D. Nasta, Jakub Svoboda, Stefan K. Barta, Mitchell E. Hughes, Elizabeth Weber, Marco Ruella, Noelle V. Frey, David L. Porter, Stephen J. Schuster, Elise A. Chong
Journal: Blood
Blood (2023) 142 (Supplement 1): 2341.
https://doi.org/10.1182/blood-2023-190434
Published: 2023
Journal Articles

Evaluation of a Prognostic 23-Gene Expression Panel in a Set of 390 Multiethnic Hodgkin Lymphoma Patients

Anthony Colombo, Jia Yin Wan, Aixiang Jiang, Jose Aparicio, Esther Lam, Tomohiro Aoki, Joo Y Song, Sheeja Pullarkat, Chun Chao, Juan Manuel Mejia-Arangure, Brenda Hernandez, Pamela B. Allen, Christopher R. Flowers, Sophia S. Wang, Juanita Evans, Owen Chan, Jakub Svoboda, Anja Mottok, Leon Bernal-Mizrachi, Megan Lim, David W. Scott, Imran Siddiqi, David Conti, Christian Steidl, Wendy Cozen
Journal: Blood
Blood (2023) 142 (Supplement 1): 4379.
https://doi.org/10.1182/blood-2023-182906
Published: 2023
Journal Articles

Allogeneic Stem Cell Transplant and CD30 Directed CART Cell Therapies Are Associated with Improved Survival in Classical Hodgkin Lymphoma Refractory or Intolerant to Brentuximab Vedotin and Anti-PD-1 Therapy: Real World Analysis from 14 U.S. Academic Centers

Timothy Voorhees, Natalie S. Grover, Eric McLaughlin, Jorge A Florindez, Tamara K. Moyo, Heather Reves, Nuttavut Sumransub, Saarang Deshpande, Ashley Rose, Cassandra Duarte, Muhammad Salman Faisal, Showkat Hamid, Suki Subbiah, Sabarish R. Ayyappan, Lauren Kelly Shea, Matthew J Cortese, Krish Patel, Ajay Major, Hayder Saeed, Jakub Svoboda, Sanjal H. Desai, Praveen Ramakrishnan Geethakumari, Pallawi Torka, Narendranath Epperla
Journal: Blood
Blood (2023) 142 (Supplement 1): 900.
https://doi.org/10.1182/blood-2023-182385
Published: 2023
Journal Articles

TP53 Mutations Detected By Clinical Laboratory Mutation Analysis Predict for Inferior Clinical Outcomes in Patients with Newly-Diagnosed Aggressive B Cell Lymphomas, Including Those with High-Risk Features

Daniel J. Landsburg, Jennifer JD Morrissette, Sunita D. Nasta, Stefan K. Barta, Stephen J Schuster, Jakub Svoboda, Elise A. Chong, Adam Bagg
Journal: Blood
Blood (2023) 142 (Supplement 1): 1739.
https://doi.org/10.1182/blood-2023-186343
Published: 2023
Journal Articles

Treatment Patterns and Outcomes for Patients with Classic Hodgkin Lymphoma (cHL) and Cardiomyopathy with Low Ejection Fraction (EF): Real-World Evidence (RWE) from 16 US Academic Centers

Kaitlin Annunzio, Eric McLaughlin, Timothy Voorhees, Lauren Kelly Shea, Nuttavut Sumransub, Ashley Rose, Adam J Olszewski, Neil Bailey, Krish Patel, Tamara K. Moyo, Farrukh T. Awan, Gulrayz Ahmed, Natalie S. Grover, Adam Adika, Erica L Andres, Muhammad Salman Faisal, Beth Christian, Jacob Anna, Steven M. Bair, Nicholas Kendsersky, Colin Thomas, Pallawi Torka, Jakub Svoboda, Jordan S Carter, Mehdi Hamadani, Hayder Saeed, Sanjal H. Desai, Andrew M Evens, Narendranath Epperla
Journal: Blood
Blood (2023) 142 (Supplement 1): 382.
https://doi.org/10.1182/blood-2023-182389
Published: 2023
Journal Articles

Impact of Psychological Distress on Immune Phenotype in CLL/SLL Patients Managed By Active Observation

Carolyn Y. Fang, Jakub Svoboda, Adam D. Cohen, Henry C. Fung, Richard I. Fisher, Elizabeth Handorf, Hatcher Ballard, Stefan K. Barta, Daniel J. Landsburg, Dwivedy S. Nasta, Stephen J Schuster, Rashmi Khanal, Alexander W. MacFarlane, Kerry S. Campbell
Journal: Blood
Blood (2023) 142 (Supplement 1): 6526.
https://doi.org/10.1182/blood-2023-189330
Published: 2023