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Journal Articles

BCL6-Mediated Escape from Negative Selection Enables RAS-Driven B-Cell Transformation

Lai N. Chan, Christian Hurtz, Mark E. Robinson, Etienne Leveille, Huimin Geng, Rebecca Caeser, Liang Xu, Kohei Kume, Gang Xiao, Markus Müschen
Journal: Blood
Blood (2022) 140 (Supplement 1): 9177–9178.
DOI: https://doi.org/10.1182/blood-2022-169946
Published: 2022
Journal Articles

A Phosphatase Membrane-Shuttle Enables Feedback Control of B-Cell Signaling

Jaewoong Lee, Kohei Kume, Mark E. Robinson, Ruifeng Sun, Ning Ma, Zhengshan Chen, Gang Xiao, Kadriye Nehir Cosgun, Lai N. Chan, Etienne Leveille, Lars Klemm, Vivasvan Vykunta, Brian Shy, Huimin Geng, Selina M. Luger, Mark R. Litzow, Alexander Marson, Elisabeth Paietta, Nagarajan Vaidehi, Eric Meffre, Markus Müschen
Journal: Blood
Blood (2022) 140 (Supplement 1): 1698–1699.
DOI: https://doi.org/10.1182/blood-2022-170324
Published: 2022
Journal Articles

Next-Generation Sequencing of Newly-Diagnosed Primary CNS Lymphoma Reveals Alterations in BTG1, ETV6, and 6p Are Associated with Chemoresistance and Inferior Progression-Free Survival

Shirley S. Mo, Huimin Geng, Miguel Cerejo, Kwun Wah Wen, David A. Solomon, James L. Rubenstein
Journal: Blood
Blood (2022) 140 (Supplement 1): 3516–3517.
DOI: https://doi.org/10.1182/blood-2022-170569
Published: 2022
Journal Articles

Structural Elements of the BCR Determine Permissiveness to Oncogenic RAS-Driven B-Cell Transformation

Lai N. Chan, Mark E. Robinson, Kadriye Nehir Cosgun, Xiaohui Yu, Etienne Leveille, Huimin Geng, Markus Müschen
Journal: Blood
Blood (2022) 140 (Supplement 1): 8758–8759.
DOI: https://doi.org/10.1182/blood-2022-170079
Published: 2022
Journal Articles

Identification of BCL6 As Synthetic Lethality in RAS-Driven B-Cell Transformation

Lai N. Chan, Christian Hurtz, Etienne Leveille, Kohei Kume, Mark E. Robinson, Huimin Geng, Kadriye Nehir Cosgun, Markus Müschen
Journal: Blood
Blood (2021) 138 (Supplement 1): 792.
DOI: https://doi.org/10.1182/blood-2021-148653
Published: 2021
Journal Articles

Structural Basis of Feedback Control of Oncogenic Signaling in B-Lymphoid Malignancies

Jaewoong Lee, Mark E. Robinson, Ning Ma, Kohei Kume, Dewan Artadji, Teresa Sadras, Kadriye Nehir Cosgun, Huimin Geng, Elisabeth M. Paietta, Maike Buchner, Nagarajan Vaidehi, David M. Weinstock, Markus Müschen
Journal: Blood
Blood (2021) 138 (Supplement 1): 355.
DOI: https://doi.org/10.1182/blood-2021-149189
Published: 2021
Journal Articles

BTG1 Mutation Promotes Aggressive Lymphoma Development By Lowering the Threshold to MYC Activation and Generating "Super-Competitor" B Cells

Coraline Mlynarczyk, Matthew Teater, Juhee Pae, Theinmozhi Arulraj, Christopher R Chin, Ling Wang, Jonatan Ersching, Ekaterina Kots, Amy Chadburn, Ersilia Barin, Hui Xian Poh, Hannah M Isles, Chen Zhengming, Hao Shen, Arnab Bandyopadhyay, Kenneth B Hoehn, Diu T.T. Nguyen, Ashley S Doane, Huimin Geng, Muhammad H Rehman, Jonah Melnick, Wyatt Morgan, Olivier Elemento, Michael G Kharas, David W. Scott, Samie R Jaffrey, Michael Meyer-Hermann, George Khelashvili, Gabriel Victora, Ari Melnick
Journal: Blood
Blood (2021) 138 (Supplement 1): 359.
DOI: https://doi.org/10.1182/blood-2021-149921
Published: 2021
Journal Articles

Leveraging Pathway-Interference to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Lai N. Chan, Mark A. Murakami, Christian Hurtz, Kohei Kume, Jaewoong Lee, Kadriye Nehir Cosgun, Huimin Geng, Shai Izraeli, David M. Weinstock, Markus Müschen
Journal: Blood
Blood (2021) 138 (Supplement 1): 616.
DOI: https://doi.org/10.1182/blood-2021-149773
Published: 2021
Journal Articles

Functional Multi-Omics Reveals Genetic and Pharmacologic Regulation of Surface CD38 in Multiple Myeloma

Priya Choudhry, Olivia Gugliemini, Huimin Geng, Vishesh Sarin, Letitia Sarah, Yu-Hsiu T. Lin, Neha Paranjape, Poornima Ramkumar, Makeba Marcoulis, Donghui Wang, Paul Phojanakong, Veronica Steri, Byron Hann, Martin Kampmann, Arun P Wiita
Journal: Blood
Blood (2021) 138 (Supplement 1): 2648.
DOI: https://doi.org/10.1182/blood-2021-147007
Published: 2021
Journal Articles

Regulation of CNS Lymphoma Progression By the Myeloid Microenvironment

Hua-Xin Gao, Eleanor Fraser, Mario Merlini, Huimin Geng, Lingjing Chen, Ming Lu, Yasmin Moshfegh, Joseph Cleveland, Jae Ryu, Jigyasa Sharma, David A. Solomon, Katerina Akassoglou, Clifford Lowell, James L. Rubenstein
Journal: Blood
Blood (2021) 138 (Supplement 1): 448.
DOI: https://doi.org/10.1182/blood-2021-153839
Published: 2021
Journal Articles

Survival and Patient-Reported Outcomes of Older Adults with Primary Central Nervous System Lymphoma on Low-Dose Lenalidomide

Mazie Tsang, MD, Joseph Cleveland, MD, Miguel Carlos Cerejo, DO, Huimin Geng, PhD, James L. Rubenstein, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
DOI: https://doi.org/10.1182/blood-2020-143070
Published: 2020
Journal Articles

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia

Eun Ji Gang, Hye Na Kim, Yao-Te Hsieh, Yongsheng Ruan, Heather A. Ogana, Solomon Lee, Jennifer Pham, Huimin Geng, Eugene Park, Lars Klemm, Cheryl L. Willman, William L. Carroll, Steven D. Mittelman, Etan Orgel, Matthew J. Oberley, Chintan Parekh, Hisham Abdel-Azim, Deepa Bhojwani, Alan S. Wayne, Adèle De Arcangelis, Elisabeth Georges-Labouesse, Elizabeth Wayner, Halvard Bonig, Aspram Minasyan, Johanna ten Hoeve, Thomas G. Graeber, Markus Müschen, Nora Heisterkamp, Yong-Mi Kim
Journal: Blood
Blood (2020) 136 (2): 210–223.
DOI: https://doi.org/10.1182/blood.2019001417
Published: 2020
Includes: Supplemental data
Journal Articles

E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia

Wen-Chieh Pi, Jun Wang, Miho Shimada, Jia-Wei Lin, Huimin Geng, Yu-Ling Lee, Rui Lu, Dongxu Li, Gang Greg Wang, Robert G. Roeder, Wei-Yi Chen
Journal: Blood
Blood (2020) 136 (1): 11–23.
DOI: https://doi.org/10.1182/blood.2019003312
Published: 2020
Includes: Supplemental data
Journal Articles

Potential Genetic and Immunologic Mechanisms of Therapeutic Resistance and Disease Progression in CNS Lymphoma Elucidated Via Whole Brain Autopsy Studies

David A. Solomon, MD, PhD, Huimin Geng, PhD, Raymond A. Sobel, MD, Lakshmi Subbaraj, B.S., Mazie Tsang, MD, James L. Rubenstein, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1494.
DOI: https://doi.org/10.1182/blood-2019-131302
Published: 2019
Journal Articles

Paraoxonase 2 Enables Initiation of B-ALL By Subverting Metabolic Gatekeeper Functions

Lili Pan, MD, Chao Hong, PhD, Gang Xiao, PhD, Huimin Geng, PhD, Shaoyuan Wang, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 746.
DOI: https://doi.org/10.1182/blood-2019-125171
Published: 2019
Journal Articles

Lgr5 Functions As a Critical Negative Regulator of Wnt/β-Catenin Signaling and Is Essential for B-Lymphopoiesis and Malignant B-Cell Transformation

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Jaewoong Lee, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Lu Yang, PhD, Huimin Geng, PhD, John Chan, MD, Joo Y. Song, MD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 748.
DOI: https://doi.org/10.1182/blood-2019-127263
Published: 2019
Journal Articles

Rationale for Targeting BCL6 in MLL-Rearranged B-ALL

Lai N Chan, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Erica Ballabio, Gang Xiao, PhD, Gauri Deb, MS, PhD, Haytham Khoury, MD PhD, Scott A. Armstrong, MD PhD, Patricia Ernst, PhD, Ari Melnick, MD, Tom Arthur Milne, PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1239.
DOI: https://doi.org/10.1182/blood-2019-131565
Published: 2019
Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Jaewoong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MD PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Liting Chen, PhD, Lai N Chan, PhD, Lars Klemm, MS, Chun-Wei David Chen, PhD, Ning Ma, PhD, Wing C. Chan, MD, Stephen J Forman, MD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina M. Luger, MD FRCPC, Mark Litzow, MD, Michael T McManus, PhD, Nagarajan Vaidehi, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, David M. Weinstock, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 393.
DOI: https://doi.org/10.1182/blood-2019-131270
Published: 2019
Journal Articles

Targeting Unique Synthetic Lethal Interactions between PI3K and MYC in B-ALL

Gang Xiao, PhD, Kohei Kume, PhD, Huimin Geng, PhD, Than Than Han, MS, Lars Klemm, MS, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3785.
DOI: https://doi.org/10.1182/blood-2019-128719
Published: 2019
Journal Articles

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Jaewoong Lee, PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Huimin Geng, PhD, Ning Ma, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Matthew Nix, PhD, Zhengshan Chen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD, Vishal Khairnar, PhD, Arun P. Wiita, MD PhD, Andrei Thomas-Tikhonenko, PhD, Michael Farzan, MD PhD, Michael S. Diamond, PhD, Jae U Jung, PhD, Nagarajan Vaidehi, PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2782.
DOI: https://doi.org/10.1182/blood-2019-127615
Published: 2019