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Journal Articles

Poor Prognostic Combination of Additional Chromosomal Abnormalities in Ph + ALL : JALSG Ph+ALL TKI- SCT Study

Satoshi Nishiwaki, Isamu Sugiura, Shin Fujisawa, Yoshihiro Hatta, Noriko Doki, Shingo Kurahashi, Yasunori Ueda, Nobuaki Dobashi, Tomoya Maeda, Yasuhiro Taniguchi, Masatsugu Tanaka, Shinichi Kako, Tatsuo Ichinohe, Takahiro Fukuda, Yoshiko Atsuta, Shigeki Ohtake, Yuichi Ishikawa, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki
Journal: Blood
Blood (2022) 140 (Supplement 1): 6030–6032.
DOI: https://doi.org/10.1182/blood-2022-165864
Published: 2022
Journal Articles

Risk Stratified Therapy with Nelarabine and Intensified Administration of L-Asparaginase for Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia in Adolescents and Young Adults (JPLSG T-11/JALSG T-ALL-211-U): An Intergroup Phase 2 Study

Yoshihiro Hatta, Atsushi Sato, Akiko Kada, Akiko Moriya Saito, Fumihiko Hayakawa, Arata Watanabe, Tatsuhiro Sakamoto, Katsuhiro Miura, Yoshifumi Shimizu, Junya Kanda, Yasushi Onishi, Noboru Asada, Yasuhiro Okamoto, Chihaya Imai, Koichi Oshima, Katsuyoshi Koh, Atsushi Manabe, Keizo Horibe, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki
Journal: Blood
Blood (2022) 140 (Supplement 1): 124–126.
DOI: https://doi.org/10.1182/blood-2022-156613
Published: 2022
Journal Articles

iPSC-Derived HLA-A2 CAR Tregs Showed Suppression of GvHD in a Xenograft Model

Hisashi Yano, Takayuki Sato, Tokuyuki Shinohara, Keiko Koga, Shoichi Iriguchi, Atsushi Matsuda, Yasuyuki Miyake, Yoshiaki Kassai, Hitoshi Kiyoi, Shin Kaneko
Journal: Blood
Blood (2022) 140 (Supplement 1): 2365–2366.
DOI: https://doi.org/10.1182/blood-2022-156904
Published: 2022
Journal Articles

Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations

Clinical Trials & Observations
Takahiko Yasuda, Masashi Sanada, Masahito Kawazu, Shinya Kojima, Shinobu Tsuzuki, Hiroo Ueno, Eisuke Iwamoto, Yuka Iijima-Yamashita, Tomomi Yamada, Takashi Kanamori, Rieko Nishimura, Yachiyo Kuwatsuka, Satoru Takada, Masatsugu Tanaka, Shuichi Ota, Nobuaki Dobashi, Etsuko Yamazaki, Asao Hirose, Tohru Murayama, Masahiko Sumi, Shinya Sato, Naoyuki Tange, Yukinori Nakamura, Yuna Katsuoka, Emiko Sakaida, Toyotaka Kawamata, Hiroatsu Iida, Yuichi Shiraishi, Yasuhito Nannya, Seishi Ogawa, Masafumi Taniwaki, Norio Asou, Yoshihiro Hatta, Hitoshi Kiyoi, Itaru Matsumura, Keizo Horibe, Hiroyuki Mano, Tomoki Naoe, Yasushi Miyazaki, Fumihiko Hayakawa
Journal: Blood
Blood (2022) 139 (12): 1850–1862.
DOI: https://doi.org/10.1182/blood.2021011921
Published: 2022
Includes: Supplemental data
Journal Articles

Nilotinib and Dasatinib Evoked Distinct Immune Effects during Tfr Phase of Each Discontinuation Trial

Yuki Fujioka, Naoto Takahashi, Shigeki Ohtake, Yoshiko Atsuta, Yosuke Minami, Noriyoshi Iriyama, Hitoshi Kiyoi, Yasushi Miyazaki, Itaru Matsumura
Journal: Blood
Blood (2021) 138 (Supplement 1): 3580.
DOI: https://doi.org/10.1182/blood-2021-147312
Published: 2021
Journal Articles

Outcomes of Transplant-Eligible Patients with Myelodysplastic Syndrome-Refractory Anemia with Excess Blasts Registered in a Prospective Observational Study: The JALSG-CS11-MDS-SCT

Noriharu Nakagawa, Ken Ishiyama, Kensuke Usuki, Satoru Takada, Tatsuki Tomikawa, Hiroshi Handa, Yuna Katsuoka, Daiki Hirano, Nobuo Sezaki, Masahiko Sumi, Shin Fujisawa, Yasuhiro Taniguchi, Takuro Yoshimura, Eiichi Ohtsuka, Ken Takase, Youko Suehiro, Shuichi Ota, Tomohiro Kajiguchi, Tomoya Maeda, Masahide Yamamoto, Shigeki Ohtake, Akira Katsumi, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki
Journal: Blood
Blood (2021) 138 (Supplement 1): 2925.
DOI: https://doi.org/10.1182/blood-2021-147587
Published: 2021
Journal Articles

Impact of Nelarabine, Intensive L-Asparaginase, and Protracted Intrathecal Therapy on Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia: Results from the Japanese Pediatric Leukemia/Lymphoma Study Group and the Japan Adult Leukemia Study Group

Atsushi Sato, Yoshihiro Hatta, Chihaya Imai, Koichi Oshima, Yasuhiro Okamoto, Takao Deguchi, Yoshiko Hashii, Takashi Fukushima, Toshinori Hori, Nobutaka Kiyokawa, Motohiro Kato, Shoji Saito, Kenichi Anami, Tatsuhiro Sakamoto, Akiko Kada, Akiko M Saito, Atsushi Manabe, Hitoshi Kiyoi, Itaru Matsumura, Keizo Horibe, Katsuyoshi Koh, Yasushi Miyazaki, Arata Watanabe
Journal: Blood
Blood (2021) 138 (Supplement 1): 3393.
DOI: https://doi.org/10.1182/blood-2021-149110
Published: 2021
Journal Articles

Frequent genetic alterations in immune checkpoint–related genes in intravascular large B-cell lymphoma

Kazuyuki Shimada, Kenichi Yoshida, Yasuhiro Suzuki, Chisako Iriyama, Yoshikage Inoue, Masashi Sanada, Keisuke Kataoka, Masaaki Yuge, Yusuke Takagi, Shigeru Kusumoto, Yasufumi Masaki, Takahiko Ito, Yuichiro Inagaki, Akinao Okamoto, Yachiyo Kuwatsuka, Masahiro Nakatochi, Satoko Shimada, Hiroaki Miyoshi, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Yusuke Shiozawa, Yasuhito Nannya, Asako Okabe, Kei Kohno, Yoshiko Atsuta, Koichi Ohshima, Shigeo Nakamura, Seishi Ogawa, Akihiro Tomita, Hitoshi Kiyoi
Journal: Blood
Blood (2021) 137 (11): 1491–1502.
DOI: https://doi.org/10.1182/blood.2020007245
Published: 2021
Includes: Supplemental data
Journal Articles

Nilotinib Vs. Dasatinib in Achieving MR 4.5 for Newly Diagnosed Chronic Myeloid Leukemia: Results of the Prospective Randomized Phase 3 Study, JALSG CML212

Itaru Matsumura, MDPhD, Shigeki Ohtake, MD PhD, Yoshiko Atsuta, MD PhD, Mio Kurata, Yosuke Minami, MDPhD, Naoto Takahashi, MD PhD, Chiaki Nakaseko, MDPhD, Noriyoshi Iriyama, MD PhD, Katsumichi Fujimaki, MD, Kazuhiko Kakihana, MD PhD, Yoji Ogasawara, Takaaki ONO, MD PhD, Masaya Okada, MD, Tetsuzo Tauchi, MD PhD, Toshihiro Miyamoto, MD PhD, Kazunori Ohnishi, MD, Emiko Sakaida, MDPhD, Shin Fujisawa, MD, Yukio Kobayashi, MDDSc, Norio Asou, MDPhD, Hitoshi Kiyoi, MD PhD, Yasushi Miyazaki, MD PhD, Tomoki Naoe, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
DOI: https://doi.org/10.1182/blood-2020-134168
Published: 2020
Journal Articles

Staurosporine Induces Caspase-Dependent Proteolysis of MEF2D-Fusion Protein and Cell Death Selective to MEF2D-Fusion-Positive ALL Cells

Naoyuki Tange, MD, Fumihiko Hayakawa, MD, PhD, Takahiko Yasuda, MD, PhD, Hideyuki Yamamoto, MD, Daiki Hirano, MD, PhD, Shinobu Tsuzuki, MD,PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1349.
DOI: https://doi.org/10.1182/blood-2019-123602
Published: 2019
Journal Articles

Prospective Evaluation of Allogeneic HSCT at the First Remission for Younger Adults with FLT3 -ITD Positive Acute Myeloid Leukemia: The JALSG AML209-FLT3-SCT Study

Naomi Kawashima, MD PhD, Yuichi Ishikawa, MD PhD, Yoshiko Atsuta, MD PhD, Masashi Sawa, MD PhD, Yukiyasu Ozawa, MD PhD, Masaki Hayashi, MD, Akio Kohno, MD PhD, Akihiro Tomita, MD PhD, Tomoya Maeda, MD PhD, Emiko Sakaida, MD PhD, Kensuke Usuki, MD PhD, Maki Hagihara, MD PhD, Heiwa Kanamori, MD PhD, Hiroshi Matsuoka, MD PhD, Miki Kobayashi, MD PhD, Norio Asou, MD PhD, Shigeki Ohtake, MD PhD, Itaru Matsumura, MD PhD, Yasushi Miyazaki, MD PhD, Tomoki Naoe, MD PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1328.
DOI: https://doi.org/10.1182/blood-2019-124394
Published: 2019
Journal Articles

Phase I Study of Cord Blood Transplantation with Intra-Bone Marrow Injection of Mesenchymal Stem Cells

Tatsunori Goto, MD, Makoto Murata, MD PhD, Tetsuya Nishida, MD PhD, Seitaro Terakura, MD PhD, Sonoko Kamoshita, MD, Yuichi Ishikawa, MD PhD, Yoko Ushijima, MD PhD, Yoshiya Adachi, MD PhD, Katsuyoshi Kato, PhD, Akihiro Hirakawa, PhD, Satoshi Nishiwaki, MD PhD, Nobuhiro Nishio, MD PhD, Yoshiyuki Takahashi, MD PhD, Yoshihisa Kodera, MD, Tadashi Matsushita, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2004.
DOI: https://doi.org/10.1182/blood-2019-122101
Published: 2019
Journal Articles

Prospective Comparison of Azacitidine Treatment between 7-Days and 5-Days Schedules for Patients with Higher-Risk Myelodysplastic Syndromes; Results of Japan Adult Leukemia Study Group MDS212 Trial

Toru Kiguchi, MD PhD, Shinya Sato, MD, Kensuke Usuki, MD PhD, Ken Ishiyama, Yoshikazu Ito, MD PhD, Takahiro Suzuki, MD PhD, Jun Taguchi, MD PhD, Shigeru Chiba, MD PhD, Nobuaki Dobashi, MD, Akihiro Tomita, MD PhD, Hironori Harada, MD PhD, Hiroshi Handa, MD PhD, Shigeo Horiike, MD PhD, Tomoya Maeda, MD PhD, Mitsuhiro Matsuda, MD PhD, Motoshi Ichikawa, MD, Tomoko Hata, MD, PhD, Sumihisa Honda, Satoshi Iyama, MD PhD, Hitoshi Suzushima, MD PhD, Yukiyoshi Moriuchi, MD, Toshiro Kurokawa, MD PhD, Takahiro Yamauchi, MD PhD, Hitoshi Kiyoi, MD PhD, Tomoki Naoe, MD PhD, Yasushi Miyazaki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 845.
DOI: https://doi.org/10.1182/blood-2019-122802
Published: 2019
Journal Articles

The Optimal Treatment Strategy for Adult Patients with Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in First Complete Remission in the Era of High-Intensity Chemotherapy

Shinichi Kako, MD, Fumihiko Hayakawa, MD, PhD, Kiyotoshi Imai, Junji Tanaka, MD PhD, Shuichi Mizuta, Satoshi Nishiwaki, MD PhD, Heiwa Kanamori, MD PhD, Noriko Doki, MD PhD, Naoyuki Uchida, MD PhD, Kazuhiro Ikegame, MD PhD, Takahiro Fukuda, Tatsuo Ichinohe, Shuichi Ota, Yoshinori Tanaka, MD, Tohru Murayama, MD PhD, Shingo Kurahashi, MD PhD, Toru Sakura, Noriko Usui, MD PhD, Shigeki Ohtake, MD PhD, Hitoshi Kiyoi, MD PhD, Itaru Matsumura, MD PhD, Yasushi Miyazaki, MD PhD, Yoshiko Atsuta, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4589.
DOI: https://doi.org/10.1182/blood-2019-126012
Published: 2019
Journal Articles

Efficacy and Safety of Blinatumomab in Asian Adults with Relapsed/Refractory B-Precursor ALL

Yukio Kobayashi, Iekuni Oh, MD PhD, Toshihiro Miyamoto, MD PhD, Won-Sik Lee, Hiroatsu Iida, MD PhD, Hironobu Minami, MD PhD, Yoshinobu Maeda, MD PhD, Jun Ho Jang, Sung-Soo Yoon, MD PhD, Su-Peng Yeh, MD, Qui Tran, Joan Morris, Janet L. Franklin, Ka-Wing Chong, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5069.
DOI: https://doi.org/10.1182/blood-2019-124582
Published: 2019
Journal Articles

FF-10101 Retains Potent Inhibitory Activities Against Resistant Mutations to FLT3 Inhibitors, Newly Identified in Random Mutagenesis Screens

Yuichi Ishikawa, MD PhD, Koichi Saito, PhD, Naomi Kawashima, MD PhD, Michie Morimoto, Hidetoshi Murao, PhD, Daisuke Terada, Takeshi Yamaura, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2672.
DOI: https://doi.org/10.1182/blood-2019-124632
Published: 2019
Journal Articles

Guided Polarization of iPSC-Derived CD4SP Helper T Cells By CRISPR/Cas9-Based Genome-Editing

Hisashi Yano, MD, Tokuyuki Shinohara, PhD, Keiko Koga, PhD, Shoichi Iriguchi, PhD, Yasuyuki Miyake, Xuewei Song, Megumi Tada, Yoshiaki Kassai, PhD, Hitoshi Kiyoi, MD PhD, Shin Kaneko, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1937.
DOI: https://doi.org/10.1182/blood-2019-122193
Published: 2019
Journal Articles

Discovery of a Novel Dihydroorotate Dehydrogenase Inhibitor That Induces Differentiation and Overcomes Ara-C Resistance of Acute Myeloid Leukemia Cells

Satoshi Kitazawa, PhD, Yukiko Ishii, PhD, Keiko Makita-Suzuki, Koichi Saito, PhD, Kensuke Takayanagi, Hiromi Sugihara, Shun Matsuda, PhD, Takayuki Yamakawa, PhD, Yasuhiro Tsutsui, Tadashi Tanaka, Tomohisa Hatta, PhD, Tohru Natsume, PhD, Toru Kondo, PhD, Yuichi Ishikawa, MD PhD, Shinji Hagiwara, PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2663.
DOI: https://doi.org/10.1182/blood-2019-121869
Published: 2019
Journal Articles

Development of Predictive Biomarker and Optimal Treatment Strategy with FLT3 Inhibitors in Acute Myeloid Leukemia

Jeong Hui Kim, Yasuhiko Harada, MD PhD, Yuichi Ishikawa, MD PhD, Naomi Kawashima, MD PhD, Marie Nakashima, MD, Yoko Ushijima, MD PhD, Takahiro Nishiyama, MD PhD, Tatsunori Goto, MD PhD, Nobuaki Fukushima, MD PhD, Rika Kihara, MD PhD, Tomohiro Kajiguchi, MD PhD, Koichi Watamoto, MD PhD, Akio Kohno, MD PhD, Kunio Kitamura, MD PhD, Yukiyasu Ozawa, MD PhD, Hitoshi Kiyoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1418.
DOI: https://doi.org/10.1182/blood-2019-127610
Published: 2019
Journal Articles

Favorable Outcomes of Newly Diagnosed Intravascular Large B-Cell Lymphoma Patients Treated with R-CHOP Combined with High-Dose Methotrexate Plus Intrathecal Chemotherapy: Results from a Multicenter Phase 2 Trial (PRIMEUR-IVL)

Kazuyuki Shimada, MD, Motoko Yamaguchi, MD PhD, Yoshiko Atsuta, MD PhD, Kosei Matsue, MD PhD, Keijiro Sato, MD, Shigeru Kusumoto, MD PhD, Hirokazu Nagai, MD PhD, Jun Takizawa, MD PhD, Noriko Fukuhara, MD PhD, Koji Nagafuji, MD PhD, Kana Miyazaki, MD PhD, Eiichi Ohtsuka, MD, Masataka Okamoto, MD PhD, Yasumasa Sugita, MD PhD, Toshiki Uchida, MD PhD, Satoshi Kayukawa, MD, Atsushi Wake, MD PhD, Daisuke Ennishi, MD PhD, Yukio Kondo, MD, Tohru Izumi, MD, Yoshihiro Kin, MD, Kunihiro Tsukasaki, MD PhD, Daigo Hashimoto, Masaaki Yuge, MD PhD, Atsumi Yanagisawa, Yachiyo Kuwatsuka, MD PhD, Satoko Shimada, MD, Yasufumi Masaki, MD PhD, Nozomi Niitsu, MD PhD, Hitoshi Kiyoi, MD PhD, Ritsuro Suzuki, MD PhD, Takashi Tokunaga, MD PhD, Shigeo Nakamura, MD, Tomohiro Kinoshita, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 350.
DOI: https://doi.org/10.1182/blood-2019-126798
Published: 2019