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Journal Articles

Single-Cell RNA-Seq Analysis of CD138-Depleted Bone Marrow Samples Reveals Genetic Alterations and Disease Progression Correlate with Tumor and Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Lijun Yao, Tianjiao Wang, Sato Kazuhiro, Reyka G Jayasinghe, William Pilcher, Edgar Gonzalez-Kozlova, Yered Pita-Juarez, Taxiarchis Kourelis, Deon Doxie, Beena E Thomas, Brian Lee, Swati S Bhasin, Bhaskar Upadhyaya, Mark A Fiala, Julie Fortier, Travis Dawson, John Leech, Shaji Kumar, Hearn Jay Cho, Seunghee Kim-Schulze, Bee Raj, Stephen T. Oh, John F. DiPersio, Ravi Vij, Adeeb H Rahman, Ioannis Vlachos, Shaadi Mehr, Mark Hamilton, Daniel Auclair, Surendra Dasari, David Avigan, Madhav V Dhodapkar, Sacha Gnjatic, Manoj Bhasin, Li Ding
Journal: Blood
Blood (2021) 138 (Supplement 1): 2691.
DOI: https://doi.org/10.1182/blood-2021-154081
Published: 2021
Journal Articles

Clinical Outcomes and Treatment Strategies for Relapsed/Refractory Myeloma Patients after Relapse on BCMA-Targeted CAR T

Oliver Van Oekelen, Tarek H. Mouhieddine, Darren Pan, Megan Metzger, Sarita Agte, Adolfo Aleman, David T. Melnekoff, Guido Lancman, Alessandro Lagana, Shambavi Richard, Larysa Sanchez, Joshua Richter, Hearn Jay Cho, Ajai Chari, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2021) 138 (Supplement 1): 2704.
DOI: https://doi.org/10.1182/blood-2021-152243
Published: 2021
Journal Articles

Interim Analysis of Mmrf Curecloud Research Initiative Identifies High Prevalence and Patterns of Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations in a Real World Myeloma Cohort

Reyka G Jayasinghe, Annette S. Kim, Teni Dowdell, Carrie Cibulskis, Jennifer Yesil, Debanjana Chatterjee, Michele Likens, Shaadi Mehr, Cartik Saravanamuthu, Jean-Baptiste Alberge, Emily Lapinskas, Steven E Labkoff, Keith L Ligon, Hearn Jay Cho, Irene M. Ghobrial, Daniel Auclair
Journal: Blood
Blood (2021) 138 (Supplement 1): 2197.
DOI: https://doi.org/10.1182/blood-2021-148782
Published: 2021
Journal Articles

Normalization of the Immune Microenvironment during Lenalidomide Maintenance Is Associated with Sustained MRD Negativity in Patients with Multiple Myeloma

David G. Coffey, Francesco Maura, Edgar Gonzalez-Kozlova, Javier Diaz-Mejia3, Ping Luo, Yong Zhang, Yuexin Xu, Edus H. Warren, Eric L Smith, Hearn Jay Cho, Alexander Lesokhin, Benjamin Diamond, Dickran Kazandjian, Trevor J. Pugh, Damian J. Green, Sacha Gnjatic, Ola Landgren
Journal: Blood
Blood (2021) 138 (Supplement 1): 329.
DOI: https://doi.org/10.1182/blood-2021-154506
Published: 2021
Journal Articles

Transcriptomic Correlates of Response to Selinexor in Multiple Myeloma Reveal a Predictive Signature

Paula Restrepo, Sherry Bhalla, Adolfo Aleman, Violetta Leshchenko, Sarita Agte, Yogita Ghodke-Puranik, Joy Jiang, Mark M. Stevens, Deepu Madduri, Joshua Richter, Shambavi Richard, Ajai Chari, Hearn Jay Cho, Sundar Jagannath, Christopher J Walker, Yosef Landesman, Alessandro Lagana, Samir Parekh
Journal: Blood
Blood (2021) 138 (Supplement 1): 457.
DOI: https://doi.org/10.1182/blood-2021-150522
Published: 2021
Journal Articles

Pathogenic Germline Variants in Multiple Myeloma

Santiago Thibaud, Aaron Etra, Ryan Subaran, Zachry Soens, Scott Newman, Rong Chen, Ajai Chari, Hearn Jay Cho, Sundar Jagannath, Deepu Madduri, David T. Melnekoff, Shambavi Richard, Joshua Richter, Larysa Sanchez, Kuan-lin Huang, Alessandro Lagana, Samir Parekh, Kenan Onel
Journal: Blood
Blood (2021) 138 (Supplement 1): 399.
DOI: https://doi.org/10.1182/blood-2021-151495
Published: 2021
Journal Articles

Characterization of T-Cell Exhaustion in Rapid Progressing Multiple Myeloma Using Cross Center Scrna-Seq Study

William Pilcher, Beena E Thomas, Swati S Bhasin, Reyka G Jayasinghe, Adeeb H Rahman, Seunghee Kim-Schulze, Edgar Gonzalez-Kozlova, Taxiarchis Kourelis, Madhav V Dhodapkar, Ravi Vij, Shaji Kumar, Shaadi Mehr, Mark Hamilton, Hearn Jay Cho, Daniel Auclair, David Avigan, Sacha Gnjatic, Li Ding, Manoj Bhasin
Journal: Blood
Blood (2021) 138 (Supplement 1): 401.
DOI: https://doi.org/10.1182/blood-2021-153863
Published: 2021
Journal Articles

Characterization and Management of Oral and Dermatological Toxicities in Patients Receiving the CD3 X GPRC5D Bispecific Antibody Talquetamab (JNJ-64407564) for the Treatment of Relapsed and/or Refractory Multiple Myeloma

Stefania Stefania Mancia, Annamaria Farrell, Karen Louw, Erika Florendo, Elizabeth Aronson, Kiah Purcell, Donna D Catamero, Juliet Escalon, Joanne Thomas, Annel Aponte, Angela Lamb, Diana Kirke, Aimee Lucas, Sundar Jagannath, Hearn Jay Cho, Samir Parekh, Joshua Richter, Larysa Sanchez, Ajai Chari
Journal: Blood
Blood (2021) 138 (Supplement 1): 1658.
DOI: https://doi.org/10.1182/blood-2021-153817
Published: 2021
Journal Articles

Clinical Outcomes of Relapsed/Refractory Multiple Myeloma Patients Following Treatment with Bispecific Antibodies (BiAbs)

Tarek H. Mouhieddine, Oliver Van Oekelen, Darren Pan, Sarita Agte, Adolfo Aleman, David T. Melnekoff, Guido Lancman, Santiago Thibaud, Larysa Sanchez, Shambavi Richard, Joshua Richter, Hearn Jay Cho, Ajai Chari, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2021) 138 (Supplement 1): 821.
DOI: https://doi.org/10.1182/blood-2021-151585
Published: 2021
Journal Articles

Characterization of Plasma and Immune Cells Molecular Landscape That Play a Role in Rapid Progression of Multiple Myeloma Using Cross Center Scrna-Seq Study

Manoj Bhasin, PhD, Beena E Thomas, Reyka G Jayasinghe, PhD, Nicolas Fernandez, PhD, Swati S Bhasin, PhD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Ravi Vij, Shaji K. Kumar, MD, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, Li Ding, PhD, David E. Avigan, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–8.
DOI: https://doi.org/10.1182/blood-2020-143350
Published: 2020
Journal Articles

A Next Generation Liquid Biopsy Approach for Multiple Myeloma

Daniel Auclair, Mark Bustoros, MD, Carrie Cibulskis, BSc, Teni Dowdell, BSc, Svetlana Gavrilov, MD PhD, Cody J Boehner, BS, Jennifer Yesil, MSc, Steven E. Labkoff, MD, Shaadi Mehr, PhD, Romanos Sklavenitis-Pistofidis, MD, Salomon Manier, MD PhD, Elizabeth D. Lightbody, PhD, Annette S. Kim, MDPhD, Justin Rhoades, Keith L Ligon, MD PhD, Niall Lennon, PhD, Viktor Adalsteinsson, PhD, Jane Wilkinson, PhD, Hearn Jay Cho, MD PhD, Irene M. Ghobrial, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33.
DOI: https://doi.org/10.1182/blood-2020-136865
Published: 2020
Journal Articles

Integrated Cytof, Scrna-Seq and Cite-Seq Analysis of Bone Marrow Immune Microenvironment in the Mmrf Commpass Study

Lijun Yao, MS, Reyka G Jayasinghe, PhD, Beena E Thomas, Swati S Bhasin, PhD, Nicolas Fernandez, PhD, Taxiarchis Kourelis, MD, Deon Doxie, David E. Avigan, MD, Madhav V. Dhodapkar, MD, Shaji K. Kumar, MD, Ravi Vij, MBBS, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, PhD, Manoj Bhasin, PhD, Li Ding, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
DOI: https://doi.org/10.1182/blood-2020-142534
Published: 2020
Journal Articles

Effect of Intravenous Immunoglobulin on Infections in Multiple Myeloma (MM) Patients Receiving Daratumumab

Guido Lancman, MD, Dahniel Sastow, BA, Minira Aslanova, MD, Erin Moshier, MS, Hearn Jay Cho, MD PhD, Sundar Jagannath, MD, Deepu Madduri, MD, Samir Parekh, MD, Shambavi Richard, MD, Joshua Richter, MD, Larysa Sanchez, MD, Ajai Chari, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 6–7.
DOI: https://doi.org/10.1182/blood-2020-140056
Published: 2020
Journal Articles

Phase 2 Trial of Pomalidomide, Ixazomib and Dexamethasone in Patients with Multiple Myeloma with Extramedullary Disease or Plasma Cell Leukemia

Francis K. Buadi, MB, CHB, Martha Q. Lacy, MD, Gabriela Perez, MS, Liang Phuong-Dung, Ankit Kansagra, MD, Thomas E. Witzig, MD, Dania Kaehlyn Helgeson, Karen Woolley, Daniel Auclair, Hearn Jay Cho, MD PhD, Shaji K. Kumar, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
DOI: https://doi.org/10.1182/blood-2020-142641
Published: 2020
Journal Articles

Identification and Validation of CD138- Multiple Myeloma Immune and Tumor Subpopulations Using Cross Center Scrna-Seq Data

Reyka G Jayasinghe, PhD, Lijun Yao, MS, Beena Thomas, Swati S Bhasin, PhD, Nicolas Fernandez, PhD, David E. Avigan, MD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Ravi Vij, MD MBA, Shaadi Mehr, PhD, Mark Hamilton, PhD, Hearn Jay Cho, MD PhD, Daniel Auclair, Sacha Gnjatic, Li Ding, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 15.
DOI: https://doi.org/10.1182/blood-2020-143256
Published: 2020
Journal Articles

Open Label, Multicenter, Dose-Escalation/ Expansion Phase Ib Study to Evaluate Safety and Activity of BET Inhibitor RO6870810 (RO), Given As Monotherapy to Patients (pts) with Advanced Multiple Myeloma

Karthik Ramasamy, Ajay Nooka, MDMPH, Hang Quach, MDFRACP,FRCPA,MBBS, Myo Htut, MD, Rakesh Popat, Michaela Liedtke, MD, Sascha A Tuchman, MD, Jacob P. Laubach, MD, Cristina Gasparetto, MD, Asher A. Chanan-Khan, MD, Mark Hertzberg, MBBS PhDFRACP FRCPA, Mark Demario, MD MPH, Eveline Nueesch, PhD, Evelyne Chesne, PhD, Izolda Franjkovic, PhD, Katharina Lechner, Martin Kornacker, MD, Hearn Jay Cho, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–14.
DOI: https://doi.org/10.1182/blood-2020-136392
Published: 2020
Journal Articles

28-Day Metronomic Therapy for Relapsed Refractory Multiple Myeloma

Tarek H Mouhieddine, MD, Julia Hieulle, Erin Moshier, MS, Josh R. Richter, MD, Hearn Jay Cho, MD PhD, Samir Parekh, MD, Ajai Chari, MD, Bart Barlogie, MD PhD, Sundar Jagannath, MD, Deepu Madduri, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13.
DOI: https://doi.org/10.1182/blood-2020-142210
Published: 2020
Journal Articles

Architecture of Sample Preparation and Data Governance of Immuno-Genomic Data Collected from Bone Marrow and Peripheral Blood Samples Obtained from Multiple Myeloma Patients

Shaadi Mehr, PhD, Daniel Auclair, Mark Hamilton, PhD, Leon Rozenblit, Hearn Jay Cho, MD PhD, Lijun Yao, MS, Reyka G Jayasinghe, PhD, Manoj Bhasin, PhD, Steven E. Labkoff, MD, Taxiarchis Kourelis, MD, Madhav V. Dhodapkar, MD, Deon Doxie, Sacha Gnjatic, Cassandra Dewitt, Sergey Miron
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
DOI: https://doi.org/10.1182/blood-2020-142882
Published: 2020
Journal Articles

Dynamics of Activated CD8+ T-cells and Decreased Osteoclasts in the Tumor Microenvironment are Associated with Clinical Efficacy of Anti-PD-L1 and Anti-CD38 Combination Treatment in Relapsed or Refractory Multiple Myeloma

Aparna Raval, PhD, Hearn Jay Cho, MD PhD, Cherie Green, BS, Elisabeth Wassner Fritsch, PharmD, Connie Ma, MS, Naomi Chang, MSc, Mark Yan, PhD, Mark Kockx, MD PhD, Shine Shen, MS, Ling-Yuh Huw, PhD, Emily Balestiere, BA, Marina Lipkind, BS, Huang Huang, MSc, Michelle Byrtek, PhD, Dawn Colburn, PharmD, BCOP, Sandy W. Wong, Jeffrey M. Venstrom, MD PhD, Joanne I Adamkewicz, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1907.
DOI: https://doi.org/10.1182/blood-2019-123652
Published: 2019
Journal Articles

Outcomes in Multiple Myeloma Patients Progressing on Lenalidomide Maintenance

Larysa Sanchez, MD, Erin Moshier, MS, Alexander Coltoff, MD, Ali Mustafa, MD, Darren Pan, MD BS, Hearn Jay Cho, MD PhD, Sundar Jagannath, MD, Deepu Madduri, MD, Samir Parekh, MD, Shambavi Richard, MD, Joshua Richter, MD, Ajai Chari, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1779.
DOI: https://doi.org/10.1182/blood-2019-128441
Published: 2019