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Journal Articles

Heterogeneous Genetic Alterations and Novel Pathogenic Pathways in Relapsed DLBCL Revealed By Whole Exome Sequencing

Jiao Ma, PhD, Kui Nie, PhD, Giorgio Inghirami, MD, Kenneth Eng, B.S., Olivier Elemento, PhD, Rex Au-Yeung, Yajie Shen, BSA, Gopesh Srivastava, Jerald Gong, MD, Mina L Xu, MD, Leonard H.C. Tan, Wayne Tam, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2770.
https://doi.org/10.1182/blood-2019-125448
Published: 2019
Journal Articles

Integrative Analysis of 1001 Diffuse Large B Cell Lymphoma Identifies Novel Oncogenic Roles for Rhoa

Jenny Zhang, BSc, Anupama Reddy, PhD, Nicholas Davis, BSc, Andrea Moffitt, PhD, Cassandra Love, Alexander Waldrop, PhD, Sirpa Leppa, MD, Annika Pasanen, MD, Leo Meriranta, MS, Marja-Liisa Karjalainen-Lindsberg, Peter H. Norgaard, MDPhD, Mette Ø Pedersen, MD, Anne Ortved Gang, Estrid Hogdall, PhD, Tayla Heavican, Waseem Lone, PhD, Javeed Iqbal, MSc, PhD, Guojie Li, PhD, So Young Kim, PhD, Jane Healy, MD PhD, Kristy L. Richards, MD PhD, Yuri Fedoriw, MD, Leon Bernal-Mizrachi, MD, Jean L. Koff, MD, Ashley D. Staton, MD, Christopher Flowers, MD, Ora Paltiel-Clarfield, Neta Goldschmidt, MD, Maria Calaminici, MD PhD, Andrew James Clear, BSc, John G. Gribben, MDDSc FMedSci, Evelyn Nguyen, Magdalena Czader, MD PhD, Sarah L. Ondrejka, MD, Angela Collie, MD PhD, Eric D. Hsi, MD, Eric Tse, MBBS, PhD FRCP, FRCPath, Rex Au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, William Choi, MBBS,MRCP, Andrew M Evens, DO,MSc, Monika Pilichowska, MD PhD, Manju Sengar, MD DM, Nishitha Reddy, MD MSCI, MBBS, Shaoying Li, MD, Amy Chadburn, MD, Leo I. Gordon, MD, Elaine S. Jaffe, MD, Rachel Rempel, Tiffany Tzeng, Tushar Dave, Lanie Happ, Deepthi Rajagopalan, Jyotishka Datta, David Dunson, Sandeep Dave, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 37.
https://doi.org/10.1182/blood.V130.Suppl_1.37.37
Published: 2017
Journal Articles

Integrative Genetic and Clinical Analysis through Whole Exome Sequencing in 1001 Diffuse Large B Cell Lymphoma (DLBCL) Patients Reveals Novel Disease Drivers and Risk Groups

Jenny Zhang, Anupama Reddy, Cassandra Love, Andrea B. Moffitt, Deepthi Rajagopalan, Sirpa Leppä, Annika Pasanen, MD PhD, Leo Meriranta, MS, Marja-Liisa Karjalainen-Lindsberg, Peter H Norgaard, MD PhD, Mette Pederson, Anne Ortved Gang, Estrid Hogdall, Kristy L. Richards, PhD MD, Yuri D. Fedoriw, MD, Leon Bernal-Mizrachi, MD, Jean L. Koff, MD, Ashley D. Staton, MD, Christopher Flowers, MDMS, Ora Paltiel-Clarfield, Neta Goldschmidt, MD, Maria Calaminici, Andrew James Clear, John Gribben, Evelyn Nguyen, Magdalena Czader, MD PhD, Sarah Lynn Ondrejka, DO, Angela Collie, MD PhD, Eric D Hsi, MD, Rex au-Yeung, Kwong Yok-Lam, Wai Lap Choi, MD, Gopesh Srivastava, Andrew M Evens, DO, MSc, FACP, Monika Pilichowska, MD PhD, Manju Sengar, Nishitha Reddy, MD MSCI, MBBS, Shaoying Li, MD, Elaine S. Jaffe, MD, Tiffany Tzeng, Jyotishka Datta, David Dunson, Sandeep Dave, MD
Journal: Blood
Blood (2016) 128 (22): 1087.
https://doi.org/10.1182/blood.V128.22.1087.1087
Published: 2016
Journal Articles

Whole Exome Sequencing of Type 1 and Type 2 Enteropathy-Associated T Cell Lymphoma Reveals Genetic Basis of Eatl Oncogenesis

Sarah Lynn Ondrejka, DO, Andrea B. Moffitt, Eric Tse, MBBS, PhD, Eric D. Hsi, MD, John R. Goodlad, MD, Rex au-Yeung, Yok-Lam Kwong, Gopesh Srivastava, Randy D. Gascoyne, Deepthi Rajagopalan, Cassandra Love, Sandeep Dave, MD
Journal: Blood
Blood (2015) 126 (23): 575.
https://doi.org/10.1182/blood.V126.23.575.575
Published: 2015
Journal Articles

Receptor-type tyrosine-protein phosphatase κ directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma

Yun-Wen Chen, Tianhuan Guo, Lijun Shen, Kai-Yau Wong, Qian Tao, William W. L. Choi, Rex K. H. Au-Yeung, Yuen-Piu Chan, Michelle L. Y. Wong, Johnny C. O. Tang, Wei-Ping Liu, Gan-Di Li, Norio Shimizu, Florence Loong, Eric Tse, Yok-Lam Kwong, Gopesh Srivastava
Journal: Blood
Blood (2015) 125 (10): 1589–1600.
https://doi.org/10.1182/blood-2014-07-588970
Published: 2015
Includes: Supplemental data
Journal Articles

Strand-Specific Total RNA Sequencing Establishes the Complete Transcriptome and Alternative Splicing Repertoire in Diffuse Large B Cell Lymphoma

Adrienne Greenough, PhD, Andrea Moffitt, Dereje Jima, Jane Healy, MD PhD, Amee Patel, Kristy L. Richards, MDPhD, Yuri D. Fedoriw, MD, Cherie Dunphy, William W. L. Choi, MD PhD, Gopesh Srivastava, PhD, Magdalena Czader, MD PhD, Karen P. Mann, MD PhD, Christopher R. Flowers, MD, Leon Bernal-Mizrachi, MD, Kikkeri Naresh, Amy Chadburn, MD, Leo I. Gordon, MD, Andrew M. Evens, DO, MSc, Javed Gill, MD, Angela M. B. Collie, MD PhD, Eric D. Hsi, MD, Cassandra L Love, MS, Sandeep S. Dave, MD
Journal: Blood
Blood (2014) 124 (21): 864.
https://doi.org/10.1182/blood.V124.21.864.864
Published: 2014
Journal Articles

Whole Genome and Exome Sequencing Defines The Genetic Landscape Of Hepatosplenic T-Cell Lymphoma

Paula Scotland, PhD, Philippe Gaulard, MD, Cassandra L Love, MS, Virginie Fataccioli, PhD, Marion Travert, Laurence De Leval, Dennis D. Weisenburger, MD, Magdalena Czader, MD, PhD, Mayur Parihar, Reena Nair, MD, Manju Sengar, MD, DM, Anne W Beaven, MD, Jennifer H. Crow, MD, Rodney R. Miles, MD, PhD, Leo I. Gordon, MD, Amy Chadburn, M.D., Andrew M Evens, DO, MSc, Javed Gill, MD, Yuri D. Fedoriw, MD, Kristy L. Richards, MD PhD, Gopesh Srivastava, Ph.D, William W. L. Choi, MD, PhD, Christopher R. Flowers, MD, MS, Leon Bernal-Mizrachi, M.D., Karen P. Mann, MD, PhD, Kikkeri Naresh, Eric D. Hsi, MD, Pedro Horna, MD, Jianguo Tao, MD, PhD, Zhen Sun, MS, Kevin Long, Jenny Zhang, Sandeep Dave, MD
Journal: Blood
Blood (2013) 122 (21): 842.
https://doi.org/10.1182/blood.V122.21.842.842
Published: 2013
Journal Articles

ID3 Is a Novel Tumor Suppressor Gene in Burkitt Lymphom

Cassandra L Love, Dereje Jima, MS, Zhen Sun, Rodney R. Miles, MD, PhD, Cherie H. Dunphy, MD, William W. L. Choi, MD, Wing Y Au, Gopesh Srivastava, Ph.D, Patricia Lugar, David A. Rizzieri, MD, Anand S. Lagoo, MD, PhD, Leon Bernal-Mizrachi, M.D., Karen P. Mann, MD, PhD, Christopher R. Flowers, MD, Kikkeri Naresh, Andrew M. Evens, DO, MSc, Amy Chadburn, MD, Leo I. Gordon, MD, Magdalena Czader, MD, PhD, Javed Gill, MD, Eric D. Hsi, MD, Jenny Zhang, Vladimir Grubor, PhD, Shawn Levy, Anjishnu Bunerjee, David Dunson, Guojie Li, Andrea Moffitt, Adrienne Greenough, Matthew S. McKinney, MD, Sandeep S. Dave, MD, MS
Journal: Blood
Blood (2012) 120 (21): 898.
https://doi.org/10.1182/blood.V120.21.898.898
Published: 2012
Journal Articles

Whole Genome and Exome Sequencing Reveals the Genetic Landscape of Burkitt Lymphoma

Cassandra L Love, Dereje Jima, MS, Jenny Zhang, Vladimir Grubor, PhD, Rodney R. Miles, MD, PhD, Cherie H. Dunphy, MD, Kristy L. Richards, PhD, MD, William W. L. Choi, MD, Wing Y Au, Gopesh Srivastava, Ph.D, Amy Chadburn, MD, Leo I. Gordon, MD, FACP, Andrew M. Evens, DO, MSc, Eric D. Hsi, MD, Magdalena Czader, MD, PhD, David A. Rizzieri, MD, Anand S. Lagoo, MD, PhD, Leon Bernal-Mizrachi, MD, Karen P. Mann, MD, PhD, Susan Sunay, Christopher R Flowers, MD, Kikkeri Naresh, Michael A. Thompson, MD, PhD, Javed Gill, MD, Sandeep S. Dave, MD
Journal: Blood
Blood (2011) 118 (21): 433.
https://doi.org/10.1182/blood.V118.21.433.433
Published: 2011
Journal Articles

Epigenetic Silencing of the Receptor Tyrosine Phosphatase, PTPRK , Located At the Frequently Deleted 6q22.33-q23.2 Region, Leads to Tumor Growth Via the Constitutive Activation of STAT3 in Nasal-Type NK/T-Cell Lymphoma

Yun-Wen Chen, Tianhuan Guo, Lijun Shen, Kai-Yau Wong, Wing-Yan Au, MD, Qian Tao, Lok-Yi Wong, Cheuk-On Tang, Wai Lap Choi, Wei-Ping Liu, Gan-Di Li, Norio Shimizu, Junjiro Tsuchiyama, Florence Loong, Raymond Liang, MD, FRCP, Yok Lam Kwong, MD, Gopesh Srivastava, Ph.D
Journal: Blood
Blood (2011) 118 (21): 1378.
https://doi.org/10.1182/blood.V118.21.1378.1378
Published: 2011
Journal Articles

Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs

e-blood
Dereje D. Jima, Jenny Zhang, Cassandra Jacobs, Kristy L. Richards, Cherie H. Dunphy, William W. L. Choi, Wing Yan Au, Gopesh Srivastava, Magdalena B. Czader, David A. Rizzieri, Anand S. Lagoo, Patricia L. Lugar, Karen P. Mann, Christopher R. Flowers, Leon Bernal-Mizrachi, Kikkeri N. Naresh, Andrew M. Evens, Leo I. Gordon, Micah Luftig, Daphne R. Friedman, J. Brice Weinberg, Michael A. Thompson, Javed I. Gill, Qingquan Liu, Tam How, Vladimir Grubor, Yuan Gao, Amee Patel, Han Wu, Jun Zhu, Gerard C. Blobe, Peter E. Lipsky, Amy Chadburn, Sandeep S. Dave, for the Hematologic Malignancies Research Consortium (HMRC)
Journal: Blood
Blood (2010) 116 (23): e118–e127.
https://doi.org/10.1182/blood-2010-05-285403
Published: 2010
Includes: Supplemental data
Journal Articles

Alternative Splicing Is a Major Mechanism of Gene Regulation In Diffuse Large B Cell Lymphoma

Cassandra L Jacobs, MS, Amee Patel, Dereje Jima, MS, Qingquan Liu, PhD, Adrienne Greenough, Jenny Zhang, Cherie Dunphy, MD, Kristy Richards, PhD, MD, Wai Choi, MBBS, MRCP, Gopesh Srivastava, Wing Y Au, Andrew M Evens, DO, MSc, Leo I Gordon, MD, FACP, Magdalena Czader, David A. Rizzieri, MD, Anand S. Lagoo, MD, PhD, Karen P. Mann, MD, PhD, Christopher R Flowers, MD, MS, Leon Bernal-Mizrachi, MD, Kikkeri Naresh, Micah Luftig, PhD, Amy Chadburn, MD, Eric Hsi, MD, Michael A. Thompson, MD, PhD, Javed Gill, MD, Sandeep Dave, MD
Journal: Blood
Blood (2010) 116 (21): 803.
https://doi.org/10.1182/blood.V116.21.803.803
Published: 2010
Journal Articles

CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation

Brief Report
Xiao-Tong Hu, Yun-Wen Chen, Anthony C. T. Liang, Wing-Yan Au, Kai-Yau Wong, Thomas S. K. Wan, Michelle L. Y. Wong, Lijun Shen, Ka-Kui Chan, Tianhuan Guo, Kent-Man Chu, Qian Tao, Chor-Sang Chim, Florence Loong, William W. L. Choi, Liwei Lu, Chi-Chiu So, Li Chong Chan, Yok-Lam Kwong, Raymond H. S. Liang, Gopesh Srivastava
Journal: Blood
Blood (2010) 115 (12): 2458–2461.
https://doi.org/10.1182/blood-2009-09-238782
Published: 2010
Includes: Supplemental data
Journal Articles

A Comprehensive Identification of the Microrna Transcriptome and Its Application in B Cell Malignancies.

Cassandra L. Jacobs, MS, Dereje D Jima, MS, Jenny Zhang, Cherie Dunphy, Kristy L. Richards, PhD, MD, William W.L. Choi, MD, Gopesh Srivastava, Andrew M Evens, MSc, DO, Leo I. Gordon, MD, Magdalena Czader, MD, PhD, David A Rizzieri, Anand S. Lagoo, MD, PhD, Karen P. Mann, MD, PhD, Christopher R. Flowers, MD, Kikkeri Naresh, Micah Luftig, Daphne R Friedman, MD, J. Brice Weinberg, MD, Michael A. Thompson, MD, PhD, Javed Gill, MD, Brad S Kahl, Amy Chadburn, MD, Sandeep Dave, MD
Journal: Blood
Blood (2009) 114 (22): 2403.
https://doi.org/10.1182/blood.V114.22.2403.2403
Published: 2009
Journal Articles

NK-Cell Lymphoma Shares Strikingly Similar Molecular Features with a Distinct Set of γδ T-Cell Lymphoma and Identification of Aurora Kinase A Inhibitor as a Novel Therapeutic Agent.

Javeed Iqbal, Ph.D., Dennis D. Weisenburger, MD, Aparajita Chowdhury, Ph.D, Gopesh Srivastava, Ph.D, Timothy C. Greiner, MS, MD, Karen E Deffenbacher, Ph.D., Can Kucuk, Julie M. Vose, MD, Wing Au, MD, Shigeo Nakamura, MD, PhD, Masao Seto, MD, PhD, Jan Delabie, MD, Francoise Berger, MD, Florence Loong, MD, Young-Hyeh Ko, MD, Ivy Sng, MD, Xin Liu, MD, PhD, Thomas P. Loughran, Jr., MD, Ming Tsai, PhD, James O. Armitage, MD, Wing C. Chan
Journal: Blood
Blood (2009) 114 (22): 313.
https://doi.org/10.1182/blood.V114.22.313.313
Published: 2009
Journal Articles

MicroRNAs Distinguish Burkitt Lymphoma from the Molecular Subsets of Diffuse Large B Cell Lymphoma.

Cassandra L. Jacobs, Anand S. Lagoo, Raj C Dash, Adekunle Raji, Andrew M Evens, Jane N. Winter, Leo I. Gordon, Brad S Kahl, Magdalena Czader, Gopesh Srivastava, Karen P. Mann, Javed Gill, David Rizzieri, Sandeep Dave
Journal: Blood
Blood (2008) 112 (11): 3353.
https://doi.org/10.1182/blood.V112.11.3353.3353
Published: 2008
Journal Articles

Genomic Analyses Reveal Global Functional Alterations That Promote Tumor Growth and Novel Tumor Suppressor Genes in Natural Killer-Cell Malignancies

Can Kucuk, Javeed Iqbal, Ronald J. deLeeuw, Gopesh Srivastava, Wayne Tam, David Klinkebiel, Judith K. Christman, Lijun Shen, Karen Dybkaer, Wing Yan Au, Wan L. Lam, Wing C. Chan
Journal: Blood
Blood (2008) 112 (11): 3792.
https://doi.org/10.1182/blood.V112.11.3792.3792
Published: 2008
Journal Articles

WNT5A is epigenetically silenced in hematologic malignancies and inhibits leukemia cell growth as a tumor suppressor

Jianming Ying, Hongyu Li, Yun-Wen Chen, Gopesh Srivastava, Zifen Gao, Qian Tao
Journal: Blood
Blood (2007) 110 (12): 4130–4131.
https://doi.org/10.1182/blood-2007-06-094870
Published: 2007
Journal Articles

Proteasome inhibitor bortezomib-induced apoptosis in natural killer (NK)–cell leukemia and lymphoma: an in vitro and in vivo preclinical evaluation

Lijun Shen, Wing-Yan Au, Tianhuan Guo, Kai-Yau Wong, Michelle L. Wong, Junjiro Tsuchiyama, Po-Wing Yuen, Yok-Lam Kwong, Raymond H. Liang, Gopesh Srivastava
Journal: Blood
Blood (2007) 110 (1): 469–470.
https://doi.org/10.1182/blood-2007-02-072900
Published: 2007
Journal Articles

Analysis of Gene Expression Patterns and Gene Copy Number Changes in Human NK Cell Malignancies.

Javeed Iqbal, PhD, Huimin Geng, M.Sc, Ronald J. DeLeeuw, M.Sc, Kavita Patel, M.D, Wan L. Lam, Ph.D, Karen Dybkaer, Ph.D, Norio Shimizu, M.D, Gopesh Srivastava, Ph.D, Wing-Chung Chan, M.D
Journal: Blood
Blood (2006) 108 (11): 2228.
https://doi.org/10.1182/blood.V108.11.2228.2228
Published: 2006