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Geoffrey R. Hill
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Journal Articles

A novel RIPK1 inhibitor attenuates GVHD

Geoffrey R. Hill, Motoko Koyama
Journal: Blood
Blood (2023) 141 (9): 969–970.
DOI: https://doi.org/10.1182/blood.2022019019
Published: 2023
Journal Articles

Lithium attenuates graft-versus-host disease via effects on the intestinal stem cell niche

Motoko Koyama, Luke Samson, Kathleen S. Ensbey, Shuichiro Takahashi, Andrew D. Clouston, Paul J. Martin, Geoffrey R. Hill
Journal: Blood
Blood (2023) 141 (3): 315–319.
DOI: https://doi.org/10.1182/blood.2022015808
Published: 2023
Includes: Supplemental data
Journal Articles

Regulatory T Cell Depletion during Stem Cell Mobilization Enhances Anti-Myeloma Immunity after Experimental Autologous Stem Cell Transplantation

Shuichiro Takahashi, Simone A Minnie, Samuel RW Legg, Christine R Schmidt, Kathleen S Ensbey, Damian J. Green, Geoffrey R Hill
Journal: Blood
Blood (2022) 140 (Supplement 1): 2086–2087.
DOI: https://doi.org/10.1182/blood-2022-168117
Published: 2022
Journal Articles

Pilot Trial of IFN-γ and Donor Lymphocyte Infusion to Treat Relapsed AML and MDS after Allogeneic Hematopoietic Stem Cell Transplantation

Sawa Ito, Elizabeth F Krakow, Kedwin Ventura, Amy Rodger, Emily Geramita, Erika Moore, Geoffrey R Hill, Warren D Shlomchik
Journal: Blood
Blood (2022) 140 (Supplement 1): 7678–7679.
DOI: https://doi.org/10.1182/blood-2022-157054
Published: 2022
Journal Articles

Lithium Attenuates Graft-Versus-Host Disease Via Effects on the Intestinal Stem Cell Niche

Motoko Koyama, Luke Samson, Kathleen S Ensbey, Andrew D Clouston, Paul J Martin, Geoffrey R Hill
Journal: Blood
Blood (2022) 140 (Supplement 1): 7328–7329.
DOI: https://doi.org/10.1182/blood-2022-162592
Published: 2022
Journal Articles

Activation of the zinc-sensing receptor GPR39 promotes T-cell reconstitution after hematopoietic cell transplant in mice

Lorenzo Iovino, Kirsten Cooper, Paul deRoos, Sinéad Kinsella, Cindy Evandy, Tamas Ugrai, Francesco Mazziotta, Kathleen S. Ensbey, David Granadier, Kayla Hopwo, Colton Smith, Alex Gagnon, Sara Galimberti, Mario Petrini, Geoffrey R. Hill, Jarrod A. Dudakov
Journal: Blood
Blood (2022) 139 (25): 3655–3666.
DOI: https://doi.org/10.1182/blood.2021013950
Published: 2022
Includes: Supplemental data
Journal Articles

BET-bromodomain and EZH2 inhibitor–treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes

Michael C. Zaiken, Ryan Flynn, Katelyn G. Paz, Stephanie Y. Rhee, Sujeong Jin, Fathima A. Mohamed, Asim Saha, Govindarajan Thangavelu, Paul M. C. Park, Matthew L. Hemming, Peter T. Sage, Arlene H. Sharpe, Michel DuPage, Jeffrey A. Bluestone, Angela Panoskaltsis-Mortari, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, Leo Luznik, Ivan Maillard, Geoffrey R. Hill, Kelli P. A. MacDonald, David H. Munn, Jonathan S. Serody, William J. Murphy, Leslie S. Kean, Yi Zhang, James E. Bradner, Jun Qi, Bruce R. Blazar
Journal: Blood
Blood (2022) 139 (19): 2983–2997.
DOI: https://doi.org/10.1182/blood.2021014557
Published: 2022
Includes: Supplemental data
Journal Articles

Immune control of cytomegalovirus reactivation in stem cell transplantation

Mariapia A. Degli-Esposti, Geoffrey R. Hill
Journal: Blood
Blood (2022) 139 (9): 1277–1288.
DOI: https://doi.org/10.1182/blood.2020010028
Published: 2022
Journal Articles

CMV exposure drives long-term CD57 + CD4 memory T-cell inflation following allogeneic stem cell transplant

Albert C. Yeh, Antiopi Varelias, Anupama Reddy, Sierra M. Barone, Stuart D. Olver, Kate Chilson, Lynn E. Onstad, Kathleen S. Ensbey, Andrea S Henden, Luke Samson, Carla A Jaeger, Timothy Bi, Kimberly B. Dahlman, Tae Kon Kim, Ping Zhang, Mariapia A. Degli-Esposti, Evan W. Newell, Madan H. Jagasia, Jonathan M. Irish, Stephanie J. Lee, Geoffrey R. Hill
Journal: Blood
Blood (2021) 138 (26): 2874–2885.
DOI: https://doi.org/10.1182/blood.2020009492
Published: 2021
Includes: Supplemental data
Journal Articles

The Combination of Anti-Tigit and Lenalidomide Promotes Synergistic Myeloma-Specific Immunity after ASCT

Simone A Minnie, Nicole S Nemychenkov, Kathleen S Ensbey, Christine R Schmidt, Gregory Driessens, Gabriela Campoy, Shuichiro Takahashi, Leona A. Holmberg, Geoffrey R Hill
Journal: Blood
Blood (2021) 138 (Supplement 1): 328.
DOI: https://doi.org/10.1182/blood-2021-154087
Published: 2021
Journal Articles

The IL-2/IL-15 Mimetic NL-201 Prevents Myeloma Relapse after ASCT By Expanding Highly Cytolytic T Cells in the Bone Marrow That Are Resistant to Exhaustion

Simone A Minnie, Nicole S Nemychenkov, Shuichiro Takahashi, Christine R Schmidt, Samuel RW Legg, Kathleen S Ensbey, Geoffrey R Hill
Journal: Blood
Blood (2021) 138 (Supplement 1): 1609.
DOI: https://doi.org/10.1182/blood-2021-153095
Published: 2021
Journal Articles

TIG-007: Study of EOS884448/GSK4428859A Alone, and in Combination with Iberdomide with or without Dexamethasone, in Participants with Relapsed or Refractory Multiple Myeloma

Philippe Moreau, Leona Holmberg, Nathalie Meuleman, Philippa Graham, Olivier De Henau, Gregory Driessens, Yvonne McGrath, Joanne Lager, Geoffrey R Hill
Journal: Blood
Blood (2021) 138 (Supplement 1): 2745.
DOI: https://doi.org/10.1182/blood-2021-152395
Published: 2021
Journal Articles

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Andrea S. Henden, Motoko Koyama, Renee J. Robb, Adriana Forero, Rachel D. Kuns, Karshing Chang, Kathleen S. Ensbey, Antiopi Varelias, Stephen H. Kazakoff, Nicole Waddell, Andrew D. Clouston, Rabina Giri, Jakob Begun, Bruce R. Blazar, Mariapia A. Degli-Esposti, Sergei V. Kotenko, Steven W. Lane, Kate L. Bowerman, Ram Savan, Philip Hugenholtz, Kate H. Gartlan, Geoffrey R. Hill
Journal: Blood
Blood (2021) 138 (8): 722–737.
DOI: https://doi.org/10.1182/blood.2020006375
Published: 2021
Includes: Supplemental data
Journal Articles

A phase 3 double-blind study of the addition of tocilizumab vs placebo to cyclosporin/methotrexate GVHD prophylaxis

Clinical Trials & Observations
Glen A. Kennedy, Siok-Keen Tey, Luke Buizen, Antiopi Varelias, Kate H. Gartlan, Cameron Curley, Stuart D. Olver, Karshing Chang, Jason P. Butler, Ashish Misra, Elango Subramoniapillai, A. James Morton, Simon Durrant, Andrea S. Henden, John Moore, David Ritchie, David Gottlieb, Julian Cooney, Sanjoy K. Paul, Geoffrey R. Hill
Journal: Blood
Blood (2021) 137 (14): 1970–1979.
DOI: https://doi.org/10.1182/blood.2020009050
Published: 2021
Includes: Supplemental data
Journal Articles

Repurposing a novel anti-cancer RXR agonist to attenuate murine acute GVHD and maintain graft-versus-leukemia responses

Govindarajan Thangavelu, Chao Wang, Michael Loschi, Asim Saha, Mark J. Osborn, Scott N. Furlan, Kazutoshi Aoyama, Cameron McDonald-Hyman, Ethan G. Aguilar, Amanda S. Janesick, Roshantha A. Chandraratna, Yosef Refaeli, Angela Panoskaltsis-Mortari, Kelli P. MacDonald, Geoffrey R. Hill, Robert Zeiser, Ivan Maillard, Jonathan S. Serody, William J. Murphy, David H. Munn, Bruce Blumberg, Chrysothemis Brown, Vijay Kuchroo, Leslie S. Kean, Keli L. Hippen, Randolph J. Noelle, Bruce R. Blazar
Journal: Blood
Blood (2021) 137 (8): 1090–1103.
DOI: https://doi.org/10.1182/blood.2020005628
Published: 2021
Includes: Supplemental data
Journal Articles

Cytokines and costimulation in acute graft-versus-host disease

Geoffrey R. Hill, Motoko Koyama
Journal: Blood
Blood (2020) 136 (4): 418–428.
DOI: https://doi.org/10.1182/blood.2019000952
Published: 2020
Journal Articles

Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease

Govindarajan Thangavelu, Jing Du, Katelyn G. Paz, Michael Loschi, Michael C. Zaiken, Ryan Flynn, Patricia A. Taylor, Andrew Kemal Kirchmeier, Angela Panoskaltsis-Mortari, Leo Luznik, Kelli P. MacDonald, Geoffrey R. Hill, Ivan Maillard, David H. Munn, Jonathan S. Serody, William J. Murphy, David Miklos, Corey S. Cutler, John Koreth, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, Carol Dahlberg, Andrew T. Miller, Bruce R. Blazar
Journal: Blood
Blood (2020) 135 (1): 28–40.
DOI: https://doi.org/10.1182/blood.2019000032
Published: 2020
Includes: Supplemental data
Journal Articles

The primacy of gastrointestinal tract antigen-presenting cells in lethal graft-versus-host disease

Motoko Koyama, Geoffrey R. Hill
Journal: Blood
Blood (2019) 134 (24): 2139–2148.
DOI: https://doi.org/10.1182/blood.2019000823
Published: 2019
Includes: Supplemental data
Journal Articles

IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling

Andrew N. Wilkinson, Karshing Chang, Rachel D. Kuns, Andrea S. Henden, Simone A. Minnie, Kathleen S. Ensbey, Andrew D. Clouston, Ping Zhang, Motoko Koyama, Juan Hidalgo, Stefan Rose-John, Antiopi Varelias, Slavica Vuckovic, Kate H. Gartlan, Geoffrey R. Hill
Journal: Blood
Blood (2019) 134 (23): 2092–2106.
DOI: https://doi.org/10.1182/blood.2019000396
Published: 2019
Includes: Supplemental data
Journal Articles

Peri-Transplant Steroids Enhance GVL and Attenuate GVHD By Redistributing Alloreactive Donor T Cells from the Gut into the Bone Marrow

Takayuki Inouye, MD PhD, Motoko Koyama, MD PhD, Ensbey Kathleen, Nicholas Greene, Luke Samson, Hiroyasu Ogawa, MD PhD, Geoffrey R. Hill, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3210.
DOI: https://doi.org/10.1182/blood-2019-129341
Published: 2019