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Journal Articles

Loss of Cpt1a Results in Elevated Mitochondrial Reactive Oxygen Species from Glucose-Fueled Mitochondrial Oxidative Phosphorylation and Defective Hematopoietic Stem Cells

Jue Li, Michihiro Hashimoto, Mingzhe Pan, Hui Zeng, Paul R. Andreassen, Gang Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4035.
https://doi.org/10.1182/blood-2024-206240
Published: 2024
Journal Articles

Pharmacological Evaluation of a First-in-Class Hemoglobin Elevating Agent (HbEA) AND017 in Townes SCD Mouse Model

Gang Huang, Jie Bai, Mingzhe Pan, Dong Liu, Min Xiong, Shaojiang Deng
Journal: Blood
Blood (2024) 144 (Supplement 1): 2488.
https://doi.org/10.1182/blood-2024-208058
Published: 2024
Journal Articles

Luspatercept Promotes Heme Biosynthesis and Erythroblast Island Formation in a Novel Low-Risk MDS Mouse Model

Maiko Sezaki, Asumi Yokota, Xuan Zhang, Mingzhe Pan, Zhihong Wang, Michihiro Hashimoto, Zohra Nooruddin, Eric M. Pietras, Nathan Salomonis, H. Leighton Grimes, Gang Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 877.
https://doi.org/10.1182/blood-2024-203695
Published: 2024
Journal Articles

CD38 Overexpressed Monocytes Play a Critical Role in the Fibrogenesis in Myeloproliferative Neoplasms and Can be Used As a Therapeutic Target to Ameliorate Fibrosis

Yiru Yan, Jinqin Liu, Lin Yang, Gang Huang, Xiaofan Zhu, Raajit Rampal, Zhijian Xiao, Bing Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 874.
https://doi.org/10.1182/blood-2024-202529
Published: 2024
Journal Articles

Pharmacological Evaluation of a First-in-Class Hemoglobin Elevating Agent (HbEA) AND017 in a Mouse MDS Model of an Inducible Mutant c-Myc Knock-in

Gang Huang, Jie Bai, Mingzhe Pan, Dong Liu, Min Xiong, Shaojiang Deng
Journal: Blood
Blood (2024) 144 (Supplement 1): 4140.
https://doi.org/10.1182/blood-2024-207858
Published: 2024
Journal Articles

Chromatin Modifier Hmga1 Maintains Hematopoietic Stem Cell Integrity in Stress Conditions

Jie Bai, Supannika Sorin, Arusyak Ivanyan, Mihoko Iimori, Ai Hamashima, Gang Huang, Kimi Araki, Goro Sashida
Journal: Blood
Blood (2024) 144 (Supplement 1): 26.
https://doi.org/10.1182/blood-2024-212002
Published: 2024
Journal Articles

Aberrant Splicing in CHEK1 Is a Driver of Megakaryocytic Dysplasia in U2AF1 S34F Mutant Myelodysplastic Syndromes

Wenjun Zhang, Jinqin Liu, Gang Huang, Zhijian Xiao, Bing Li
Journal: Blood
Blood (2024) 144 (Supplement 1): 3193.
https://doi.org/10.1182/blood-2024-200825
Published: 2024
Journal Articles

Conserved and Unique Regulatory Mechanisms of RUNX1 in Hematopoietic Stem/Progenitor Cell Subpopulations in Both Normal Hematopoiesis and FPD/AML Development

Chen Wang, Yi Zheng, Cuiqing Fan, Zhaowei Tu, Xiongwei Cai, Jianqiang Wu, Gang Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1314.
https://doi.org/10.1182/blood-2023-190129
Published: 2023
Journal Articles

CPT1a Controls the Function of Long-Term Hematopoietic Stem Cells By Regulating the Balance between Fatty Acid Oxidation and Oxphos in Mitochondria

Michihiro Hashimoto, Jue Li, Paul R. Andreassen, Gang Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4089.
https://doi.org/10.1182/blood-2023-187411
Published: 2023
Journal Articles

U2AF1 S34F Mutation Promote Megakaryopoiesis and Fibrogenesis in MDS

Wenjun Zhang, Jinqin Liu, Lin Yang, Yiru Yan, Tiejun Qin, Zefeng Xu, Gang Huang, Bing Li, Zhijian Xiao
Journal: Blood
Blood (2023) 142 (Supplement 1): 5685.
https://doi.org/10.1182/blood-2023-185678
Published: 2023
Journal Articles

Downregulation of Mitochondrial Complex II (MC II) in Myelodysplastic Syndromes

Maiko Sezaki, Michihiro Hashimoto, Asumi Yokota, Nathan Salomonis, H. Leighton Grimes, Gang Huang
Journal: Blood
Blood (2023) 142 (Supplement 1): 4583.
https://doi.org/10.1182/blood-2023-186829
Published: 2023
Journal Articles

Food for thought (and CML survival)

Maiko Sezaki, Gang Huang
Journal: Blood
Blood (2023) 142 (6): 502–504.
https://doi.org/10.1182/blood.2023021051
Published: 2023
Journal Articles

The Transcriptional Factor ONECUT3 Is a Driver and Therapeutic Target for Complex Karyotype MDS

Yingwan Luo, Xiaomin Feng, Wei Lang, Chen Mei, Rongzhen Xu, Gang Huang, Hongyan Tong
Journal: Blood
Blood (2022) 140 (Supplement 1): 4018–4019.
https://doi.org/10.1182/blood-2022-166618
Published: 2022
Journal Articles

Mutational Landscape, Clonal Evolution and Prognostic Effect of Non-Driver Mutations during Disease Progression of Primary Myelofibrosis

Xin Yan, Zefeng Xu, Shiqiang Qu, Tiejun Qin, Gang Huang, Zhijian Xiao, Bing Li
Journal: Blood
Blood (2022) 140 (Supplement 1): 3965–3967.
https://doi.org/10.1182/blood-2022-165185
Published: 2022
Journal Articles

Ixazomib Based Maintenance Therapy for the Patients with Newly Diagnosed Multiple Myeloma in Real-World Practice

Liye Zhong, Yongqiang Wei, Baohong Ping, Xin Li, Hongling Peng, Yongqain Li, Yuyang Tian, Zelin Liu, Jun Luo, Yongzhong Su, Haifei Chen, Yanjuan He, Hongliang Li, Congming Wu, Zhiqiang Sun, Keqian Shi, Xiaoliang Li, Qing Zhang, Guoyu Hu, Gang Huang, Zhenqian Huang, Weida Wang, Zhongjun Xia
Journal: Blood
Blood (2021) 138 (Supplement 1): 2718.
https://doi.org/10.1182/blood-2021-149058
Published: 2021
Journal Articles

Clonal Architecture Analysis of TET2 Identified Distinct Origins in Myelodysplastic Syndromes

Zhongxun Shi, MD, Bing Li, MD, Tiejun Qin, MD, Zefeng Xu, MD, Lijuan Pan, MD, Shiqiang Qu, MD, Gang Huang, PhD, Zhijian Xiao, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18.
https://doi.org/10.1182/blood-2020-139329
Published: 2020
Journal Articles

RUNX1 Mutation Leads to Megakaryocyte-Primed Hematopoietic Stem Cell Expansion and Familial Platelet Disorder

Chen Wang, MD, Weinan Wang, BS, Lei Huang, PhD, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-140769
Published: 2020
Journal Articles

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Bing Li, MD, Jinqin Liu, Tiejun Qin, Zefeng Xu, MD, Gang Huang, PhD, Zhijian Xiao, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2979.
https://doi.org/10.1182/blood-2019-126346
Published: 2019
Journal Articles

Cell-Intrinsic Inflammation Drives Progression from Myelodysplastic Syndromes to Leukemia

Laura Barreyro, PhD, Avery Sampson, BSc, Kathleen Hueneman, Kwangmin Choi, PhD, Susanne Christie, BSc, Dehua Wang, MD, Gang Huang, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2983.
https://doi.org/10.1182/blood-2019-127307
Published: 2019
Journal Articles

Myelodysplastic Syndromes-Associated Gene Mutations Lead to Pseudohypoxia Condition and Epigenome Hyper-Methylation in Mouse Genetic Models

Asumi Yokota, PhD, Lulu Zhang, PhD, Jianhua Feng, Xiaomin Feng, MD PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1696.
https://doi.org/10.1182/blood-2019-126799
Published: 2019