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First in Human Study of Anti-Viral Veto Cells Enabling Successful Engraftment without Severe Gvhd in Non-Myeloablative T Cell Depleted Haploidentical Hematopoietic Stem Cell Transplantation (HSCT)
Richard E Champlin, Esther Bachar Lustig, Qaiser Bashir, Betul Oran, Steven M. Kornblau, Chitra Hosing, Amin M Alousi, Uday R Popat, Jessica M McCarty, Peter F Thall, Bouthaina S. Dabaja, Wei-Hsin Liu, Giang Dang, Karla Castro, Alejandro Ramirez, Michael Spiotto, Susan Wu, Penny Fang, Indreshpal Kaur, Katy Rezvani, Elizabeth J Shpall, Yair Reisner
Blood (2022) 140 (Supplement 1): 2120–2122.
Proof of Concept for Repair of Sickle Cell Disease By Non-Myeloablative MHC Disparate T Cell Depleted HSCT Combined with Donor-Derived Veto Cells
Aloukick Kumar Singh, PhD, Elias Schetzen, PhD, Esther BACHAR Lustig, PhD, Wei-Hsin Liu, M.Sc, Raj Kumar Yadav, PhD, Sandeep Kumar Yadav, PhD, Kathryn McGinnis, M.Sc, Yair Reisner, PhD
Blood (2019) 134 (Supplement_1): 1919.
Blood (2019) 134 (Supplement_1): 3212.
High Levels of Hematopoietic Progenitors in the Fetal Lung Enable Induction of Immune Tolerance and Co-Transplantation of Epithelial Progenitors for Repair of Lung Injury Across MHC Barriers
Carmit Hillel Karniel, MSc, Chava Rosen, MD PhD, Esther Bachar Lustig, PhD, Elias Shezen, PhD, Yair Reisner, PhD
Blood (2016) 128 (22): 1477.
Next Generation Veto Cells for Non-Myeloablative Haploidentical HSCT: Combining Anti-Viral and Graft Facilitating Activity
Esther Bachar Lustig, PhD, Noga Or Geva, PhD, Assaf Lask, PhD, Rotem Gidron, MD, Sivan Kagan, PhD, Aloukick Kumar Sinqh, PhD, Yair Reisner, PhD
Blood (2016) 128 (22): 3345.
Chimerism Induction Without GVHD Following Low Intensity Conditioning In MHC Disparate Recipients: Combining The Benefit Of Cyclophosphamide Post Transplant With The Tolerogenicity Of Megadose T Cell Depleted HSCT
Blood (2013) 122 (21): 3238.
Murine anti–third-party central-memory CD8 + T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells
Eran Ophir, Noga Or-Geva, Irina Gurevich, Orna Tal, Yaki Eidelstein, Elias Shezen, Raanan Margalit, Assaf Lask, Guy Shakhar, David Hagin, Esther Bachar-Lustig, Shlomit Reich-Zeliger, Andreas Beilhack, Robert Negrin, Yair Reisner
Blood (2013) 121 (7): 1220–1228.
Includes: Multimedia, Supplemental data
Deletion of cognate CD8 T cells by immature dendritic cells: a novel role for perforin, granzyme A, TREM-1, and TLR7
Lior Zangi, Yael Zlotnikov Klionsky, Liran Yarimi, Esther Bachar-Lustig, Yaki Eidelstein, Elias Shezen, David Hagin, Yumi Ito, Toshiyuki Takai, Shlomit Reich-Zeliger, Assaf Lask, Oren Milstein, Steffen Jung, Vera Shinder, Yair Reisner
Blood (2012) 120 (8): 1647–1657.
Includes: Supplemental data
Towards Clinically Feasible Co-Stimulatory Blockade for Tolerance Induction: Transient Treatment with CTLA4-Ig, Anti-CD48 and FTY720 Enables Durable Engraftment of T Cell Depleted BM Allografts Following Non-Myeloablative Conditioning.
Esther Bachar-Lustig, PhD, Dalit Tchorsh-Yutsis, PhD, Eran Ophir, MSc, Yael Zlotnikov Klionsky, MSc, Noga Or-Geva, BSc, Yair Reisner, PhD
Blood (2010) 116 (21): 3726.
Induction of tolerance to bone marrow allografts by donor-derived host nonreactive ex vivo–induced central memory CD8 T cells
Blood (2010) 115 (10): 2095–2104.
Includes: Supplemental data
Tolerance Induction by Immature Dendritic Cells Is Mediated by Distinct MHC Dependent and Independent Mechanisms: A Novel Role for Perforin, Granzyme A and Toll Like Receptor 7.
Lior Zangi, Yaki Edelshtein, Yael Klionsky, Esther Bachar-Lustig, Elias Shezen, Shlomit Reich-Zeliger, PhD, Assaf Lask, Oren Milstein, Vera Shinder, Yair Reisner
Blood (2009) 114 (22): 65.
Ex-Vivo Acquisition of Central Memory Phenotype Is Critical for Tolerance Induction by Donor Anti-3 rd party CD8 T Cells in Allogeneic Bone Marrow Transplantation.
Blood (2008) 112 (11): 2323.
Overcoming Rejection of Bone Marrow Allografts by Treg Cells in a Stringent Mouse Model for T Cell Mediated Rejection: Tolerance Induction by Third Party “Off-the-Shelf” Cells.
Blood (2005) 106 (11): 576.
Immune regulatory activity of CD34 + progenitor cells: evidence for a deletion-based mechanism mediated by TNF-α
Hilit Gur, Rita Krauthgamer, Esther Bachar-Lustig, Helena Katchman, Rinat Arbel-Goren, Alain Berrebi, Tirza Klein, Arnon Nagler, Antonio Tabilio, Massimo F. Martelli, Yair Reisner
Blood (2005) 105 (6): 2585–2593.
Effective Deletion of Anti-Donor Host Memory Effector Cells by Anti-3rd Party Veto CTLs: Implications to Tolerance Induction in Presensitized Bone Marrow Recipients.
Blood (2004) 104 (11): 44.
Anti–third-party veto CTLs overcome rejection of hematopoietic allografts: synergism with rapamycin and BM cell dose
Blood (2003) 102 (6): 1943–1950.
Induction of Donor-Type Chimerism and Transplantation Tolerance Across Major Histocompatibility Barriers in Sublethally Irradiated Mice by Sca-1 + Lin − Bone Marrow Progenitor Cells: Synergism With Non-Alloreactive (Host × Donor)F 1 T Cells
Blood (1999) 94 (9): 3212–3221.