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Eduard J. van Beers
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Journal Articles

Mitapivat Improves Iron Overload in Patients with Pyruvate Kinase Deficiency

Eduard J. van Beers, Hanny Al-Samkari, Rachael F. Grace, Wilma Barcellini, Andreas Glenthøj, Melissa Dibacco, Penelope A. Kosinski, Emily Xu, Vanessa Beynon, Parija Patel, John B. Porter, Kevin H.M. Kuo
Journal: Blood
Blood (2022) 140 (Supplement 1): 2460–2462.
DOI: https://doi.org/10.1182/blood-2022-169098
Published: 2022
Journal Articles

Movement Behavior in Adults with Sickle Cell Disease Compared to Healthy Adults: Preliminary Results

Aaron Heeren, Charlotte F.J. Van Tuijn, Myrthe J. van Dijk, Eduard J. van Beers, Bart J. Biemond, Erfan Nur, Merel Timmer
Journal: Blood
Blood (2022) 140 (Supplement 1): 2558–2559.
DOI: https://doi.org/10.1182/blood-2022-163254
Published: 2022
Journal Articles

Mitapivat Improves Markers of Hemolysis and Erythropoiesis in Patients with Pyruvate Kinase Deficiency Irrespective of Hemoglobin Response

Hanny Al-Samkari, Rachael F. Grace, Eduard J. van Beers, Feng Tai, Jaime Morales-Arias, Vanessa Beynon, Andreas Glenthøj
Journal: Blood
Blood (2022) 140 (Supplement 1): 8159–8160.
DOI: https://doi.org/10.1182/blood-2022-167147
Published: 2022
Journal Articles

An Endogenous Metabolic Modulator Composition Improves Hydration Status and Decreases Adhesion Properties of Red Blood Cells from Patients with Sickle Cell Disease

Myrthe J. van Dijk, Marissa J.M. Traets, Brigitte A. van Oirschot, Jonathan R.A. de Wilde, Jennifer Bos, Wouter W. van Solinge, Margaret J. Koziel, Revati Wani, Eduard J. van Beers, Richard van Wijk, Minke A.E. Rab
Journal: Blood
Blood (2022) 140 (Supplement 1): 8235–8237.
DOI: https://doi.org/10.1182/blood-2022-166177
Published: 2022
Journal Articles

Age of Onset of Complications in Patients with Pyruvate Kinase Deficiency: Analysis from the Peak Registry

Andreas Glenthøj, Rachael F. Grace, Eduard J. van Beers, Joan-Lluis Vives Corrons, Bert Glader, Kevin H.M. Kuo, Carl Lander, Dagmar Pospíšilová, Hitoshi Kanno, Jean Williams, Yan Yan, Bryan McGee, Paola Bianchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 5323–5325.
DOI: https://doi.org/10.1182/blood-2022-156205
Published: 2022
Journal Articles

Comorbidities and Complications in Pediatric Patients with Pyruvate Kinase Deficiency Enrolled in the Peak Registry

Rachael F. Grace, Andreas Glenthøj, Carl Lander, Eduard J. van Beers, Hitoshi Kanno, Joan-Lluis Vives Corrons, Paola Bianchi, Dagmar Pospíšilová, Jean Williams, Yan Yan, Bryan McGee, Bert Glader
Journal: Blood
Blood (2022) 140 (Supplement 1): 5316–5318.
DOI: https://doi.org/10.1182/blood-2022-168799
Published: 2022
Journal Articles

Long-Term Hemoglobin Response and Reduction in Transfusion Burden Are Maintained in Patients with Pyruvate Kinase Deficiency Treated with Mitapivat

Rachael F. Grace, Andreas Glenthøj, Wilma Barcellini, Madeleine Verhovsek, Jennifer A. Rothman, Marta Morado, D. Mark Layton, Oliver Andres, Frédéric Galactéros, Eduard J. van Beers, Koichi Onodera, Vip Viprakasit, Satheesh Chonat, Malia P. Judge, Penelope A. Kosinski, Peter Hawkins, Sarah Gheuens, Emily Xu, Bryan McGee, Vanessa Beynon, Hanny Al-Samkari
Journal: Blood
Blood (2022) 140 (Supplement 1): 5313–5315.
DOI: https://doi.org/10.1182/blood-2022-169125
Published: 2022
Journal Articles

Untargeted Metabolomics on Dried Blood Spots of Patients with Sickle Cell Disease Treated with the Pyruvate Kinase Activator Mitapivat

Myrthe J. van Dijk, Sigrid van der Veen, Minke A.E. Rab, Brigitte A. van Oirschot, Jennifer Bos, Cleo Derichs, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Judith J.M. Jans, Richard van Wijk, Eduard J. van Beers
Journal: Blood
Blood (2022) 140 (Supplement 1): 21–23.
DOI: https://doi.org/10.1182/blood-2022-155997
Published: 2022
Journal Articles

Long-Term Improvements in Patient-Reported Outcomes in Patients with Pyruvate Kinase Deficiency Treated with Mitapivat

Kevin H.M. Kuo, Rachael F. Grace, Eduard J. van Beers, Wilma Barcellini, Andreas Glenthøj, Susanne Holzhauer, Parija Patel, Vanessa Beynon, Junlong Li, Erin Zagadailov, Hanny Al-Samkari
Journal: Blood
Blood (2022) 140 (Supplement 1): 1223–1225.
DOI: https://doi.org/10.1182/blood-2022-168954
Published: 2022
Journal Articles

The Launch of Two Sub-Studies of the Peak Registry, a Global, Longitudinal Study of Pyruvate Kinase Deficiency

Carl Lander, Rachael F. Grace, Eduard J. van Beers, Joan-Lluis Vives Corrons, Bert Glader, Kevin H.M. Kuo, Andreas Glenthøj, Dagmar Pospíšilová, D. Mark Layton, Audra Boscoe, Stephanie Smith, Bryan McGee, Paola Bianchi
Journal: Blood
Blood (2022) 140 (Supplement 1): 11041–11042.
DOI: https://doi.org/10.1182/blood-2022-163079
Published: 2022
Journal Articles

Ferritin Levels Do Not Reflect the Severity of Iron Overload in Diamond Blackfan Anemia

Jonathan de Wilde, Birgit van Dooijeweert, Elise Huisman, Frans Smiers, Eduard J. Van Beers, Wouter Van Solinge, Edward E.S. Nieuwenhuis, Richard van Wijk, Marije Bartels
Journal: Blood
Blood (2021) 138 (Supplement 1): 3078.
DOI: https://doi.org/10.1182/blood-2021-152730
Published: 2021
Journal Articles

A Phase 2/3, Randomized, Double-Blind, Placebo-Controlled Study of Mitapivat in Patients with Sickle Cell Disease

Joanna Howard, Kevin H.M. Kuo, Abdulafeez Oluyadi, Hui Shao, Susan Morris, Ahmar U Zaidi, Eduard J. Van Beers, Swee Lay Thien
Journal: Blood
Blood (2021) 138 (Supplement 1): 3109.
DOI: https://doi.org/10.1182/blood-2021-148370
Published: 2021
Journal Articles

Characterizing Iron Overload By Age in Patients Diagnosed with Pyruvate Kinase Deficiency - a Descriptive Analysis from the Peak Registry

Paola Bianchi, Rachael F. Grace, Joan-Lluis Vives Corrons, Bert Glader, Andreas Glenthøj, Hitoshi Kanno, Kevin H.M. Kuo, Carl Lander, D. Mark Layton, Dagmar Pospíŝilová, Vip Viprakasit, Jean Williams, Yan Yan, Bryan McGee, Eduard J. Van Beers
Journal: Blood
Blood (2021) 138 (Supplement 1): 3074.
DOI: https://doi.org/10.1182/blood-2021-147294
Published: 2021
Journal Articles

Durability of Hemoglobin Response and Reduction in Transfusion Burden Is Maintained over Time in Patients with Pyruvate Kinase Deficiency Treated with Mitapivat in a Long-Term Extension Study

Rachael F. Grace, Andreas Glenthoej, Wilma Barcellini, Madeleine Verhovsek, Jennifer A. Rothman, Marta Morado, D. Mark Layton, Oliver Andres, Frédéric Galactéros, Eduard J. Van Beers, Koichi Onodera, Vip Viprakasit, Satheesh Chonat, John B. Porter, Malia P. Judge, Penelope A. Kosinski, Peter Hawkins, Sarah Gheuens, Emily Xu, Bryan McGee, Vanessa Beynon, Hanny Al-Samkari
Journal: Blood
Blood (2021) 138 (Supplement 1): 848.
DOI: https://doi.org/10.1182/blood-2021-147711
Published: 2021
Journal Articles

Safety and Efficacy of Mitapivat (AG-348), an Oral Activator of Pyruvate Kinase R, in Subjects with Sickle Cell Disease: A Phase 2, Open-Label Study (ESTIMATE)

Myrthe J. van Dijk, Minke A.E. Rab, Anita W. Rijneveld, Erfan Nur, Marije Bartels, Judith J.M. Jans, Wouter W. van Solinge, Roger E.G. Schutgens, Richard van Wijk, Eduard J. Van Beers
Journal: Blood
Blood (2021) 138 (Supplement 1): 2047.
DOI: https://doi.org/10.1182/blood-2021-150234
Published: 2021
Journal Articles

Bone Mineral Density Remains Stable in Pyruvate Kinase Deficiency Patients Receiving Long-Term Treatment with Mitapivat

Hanny Al-Samkari, Rachael F. Grace, Andreas Glenthoej, Oliver Andres, Wilma Barcellini, Frédéric Galactéros, Kevin H.M. Kuo, D. Mark Layton, Marta Morado, Vip Viprakasit, Yan Dong, Feng Tai, Liz Grekas, Karishma Khoja, Sarah Gheuens, Bryan McGee, John B. Porter, Eduard J. Van Beers
Journal: Blood
Blood (2021) 138 (Supplement 1): 924.
DOI: https://doi.org/10.1182/blood-2021-147156
Published: 2021
Journal Articles

Identification of Biomarkers That Are Associated with Clinical Complications of Hemoglobin SC Disease and Sickle Cell Anemia

Minke A.E. Rab, Celeste K. Kanne, Mitchel C. Berrevoets, Jennifer Bos, Brigitte A. van Oirschot, Erik Teske, Roger E.G. Schutgens, Gerard Pasterkamp, Richard van Wijk, Eduard J. Van Beers, Vivien A. Sheehan
Journal: Blood
Blood (2021) 138 (Supplement 1): 962.
DOI: https://doi.org/10.1182/blood-2021-145376
Published: 2021
Journal Articles

Pharmacodynamic Effects of AG-946, a Highly Potent Next-Generation Activator of Pyruvate Kinase, in Ex Vivo Treatment of Red Blood Cells from Sickle Cell Disease Patients

Minke A.E. Rab, Myrthe J. Van Dijk, Jennifer Bos, Brigitte A. van Oirschot, Johan Gerrits, Penelope A. Kosinski, Charles Kung, Judith J.M. Jans, Eduard J. Van Beers, Lenny Dang, Richard van Wijk
Journal: Blood
Blood (2021) 138 (Supplement 1): 2029.
DOI: https://doi.org/10.1182/blood-2021-145374
Published: 2021
Journal Articles

Mitapivat Improves Ineffective Erythropoiesis and Reduces Iron Overload in Patients with Pyruvate Kinase Deficiency

Eduard J. Van Beers, Hanny Al-Samkari, Rachael F. Grace, Wilma Barcellini, Andreas Glenthoej, Malia P. Judge, Penelope A. Kosinski, Emily Xu, Vanessa Beynon, Bryan McGee, John B. Porter, Kevin H.M. Kuo
Journal: Blood
Blood (2021) 138 (Supplement 1): 2005.
DOI: https://doi.org/10.1182/blood-2021-147317
Published: 2021
Journal Articles

Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Minke A. E. Rab, Jennifer Bos, Brigitte A. van Oirschot, Stephanie van Straaten, Penelope A. Kosinski, Victor Chubukov, Hyeryun Kim, Heidi Mangus, Roger E. G. Schutgens, Gerard Pasterkamp, Lenny Dang, Charles Kung, Eduard J. van Beers, Richard van Wijk
Journal: Blood
Blood (2021) 137 (21): 2997–3001.
DOI: https://doi.org/10.1182/blood.2020008635
Published: 2021
Includes: Supplemental data