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Edmund K Waller
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Journal Articles

Donor Plasmacytoid Dendritic Cells Limit Graft-versus-Host Disease Through Vasoactive Intestinal Polypeptide Expression

Jingru Zhu, Yitong Wang, Jing-Xia Li, Pankoj Kumar Das, Hanwen Zhang, Tenzin Passang, Jian-Ming Li, Tamas Nagy, Khanjan Gandhi, Sruthi Ravindranathan, Cynthia R. Giver, Mojibade Hassan, Yiwen Li, Alina Ulezko Antonova, Shuhua Wang, John D. Roback, Edmund K. Waller
Journal: Blood
Blood blood.2021012561.
DOI: https://doi.org/10.1182/blood.2021012561
Published: 2022
Includes: Supplemental data
Journal Articles

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen, Alexandra Waller, Aditi Sharma, Claudia L. Edgar, Vikas A. Gupta, Shanmuganathan Chandrakasan, Jaquelyn T. Zoine, Andrew Fedanov, Sunil S. Raikar, Jean L. Koff, Christopher R. Flowers, Silvia Coma, Jonathan A. Pachter, Sruthi Ravindranathan, H. Trent Spencer, Mala Shanmugam, Edmund K. Waller
Journal: Blood
Blood (2022) 139 (4): 523–537.
DOI: https://doi.org/10.1182/blood.2021011597
Published: 2022
Includes: Supplemental data
Journal Articles

T-follicular helper cell expansion and chronic T-cell activation are characteristic immune anomalies in Evans syndrome

Deepak Kumar, Chengyu Prince, Carolyn M. Bennett, Michael Briones, Laura Lucas, Athena Russell, Kiran Patel, Satheesh Chonat, Sara Graciaa, Holly Edington, Michael H. White, Lisa Kobrynski, Manar Abdalgani, Suhag Parikh, Sharat Chandra, Jack Bleesing, Rebecca Marsh, Sunita Park, Edmund K. Waller, Sampath Prahalad, Shanmuganathan Chandrakasan
Journal: Blood
Blood (2022) 139 (3): 369–383.
DOI: https://doi.org/10.1182/blood.2021012924
Published: 2022
Includes: Supplemental data
Journal Articles

Impact of Autologous Hematopoietic Cell Transplant (HCT) Followed By Dendritic Cell/Myeloma Fusion Vaccine with Lenalidomide Maintenance in Increasing Multiple Myeloma (MM) Immunity (BMT CTN 1401)

David J. Chung, Nina Shah, Dina Stroopinsky, Juan WU, Lina Bisharat, Natalie S. Callander, Brent R. Logan, Kenneth C. Anderson, Thinle Chodon, Meera Mohan, Steven Devine, Yvonne A. Efebera, Nancy Geller, Peiman Hematti, Leona A. Holmberg, Alan Howard, Bryon Johnson, Hillard M Lazarus, Ehsan Malek, Philip L. McCarthy, David H. McKenna, Adam M. Mendizabal, Nikhil C. Munshi, Lynn O'Donnell, Aaron P. Rapoport, Ajay K. Nooka, Jane Reese, Robert J. Soiffer, Lynne Uhl, Giulia Cheloni, Dimitra Karagkouni, Ioannis Vlachos, James W. Young, Jacalyn Rosenblatt, Edmund K. Waller, Marcelo C Pasquini, David Avigan
Journal: Blood
Blood (2021) 138 (Supplement 1): 899.
DOI: https://doi.org/10.1182/blood-2021-149659
Published: 2021
Journal Articles

PI3K δ /γ Inhibition Enhances the Expansion and Anti-Tumor Cytotoxicity of CART Cells for CLL Patients

Shuhua Wang, Christopher R. Funk, Sruthi Ravindranathan, Kevin Chen, Edmund K. Waller
Journal: Blood
Blood (2021) 138 (Supplement 1): 4795.
DOI: https://doi.org/10.1182/blood-2021-152163
Published: 2021
Journal Articles

Orca-T Results in High Gvhd-Free and Relapse-Free Survival Following Myeloablative Conditioning for Hematological Malignancies: Results of a Single Center Phase 2 and a Multicenter Phase 1b Study

Rasmus T. Hoeg, Anna Moroz, Arpita Gandhi, Lori Muffly, Parveen Shiraz, Caspian Oliai, Rohtesh S. Mehta, Samer A. Srour, Joseph P. McGuirk, Edmund K. Waller, Sally Arai, Laura J. Johnston, Robert Lowsky, Andrew R. Rezvani, Wen-Kai Weng, David B. Miklos, Matthew J. Frank, John Tamaresis, Ying Lu, Vaibhav Agrawal, Nathaniel B Fernhoff, Gerhard Bauer, Amy Putnam, J Scott McClellan, Bronwen E. Shaw, Mehrdad Abedi, Robert S. Negrin, Everett H Meyer
Journal: Blood
Blood (2021) 138 (Supplement 1): 98.
DOI: https://doi.org/10.1182/blood-2021-154191
Published: 2021
Journal Articles

Inhibition of Vasoactive Intestinal Peptide Signaling with More Potent Inhibitors Augments T-Cell Activation and Prolongs Survival in Leukemic Mice

Tenzin Passang Fnu, Jianming Li, Sruthi Ravindranathan, Edmund K. Waller
Journal: Blood
Blood (2021) 138 (Supplement 1): 1868.
DOI: https://doi.org/10.1182/blood-2021-151879
Published: 2021
Journal Articles

Duvelisib Promotes Mitochondrial Fusion and Epigenetic Reprogramming to Drive Therapeutic T Cell Persistence and Function

Kevin Z. Chen, Christopher R. Funk, Shuhua Wang, Aditi Sharma, Edmund K. Waller, Mala Shanmugam
Journal: Blood
Blood (2021) 138 (Supplement 1): 1714.
DOI: https://doi.org/10.1182/blood-2021-153446
Published: 2021
Journal Articles

Donor Plasmacytoid Dendritic Cells Regulate GvHD in a VIP Dependent Manner in Allogeneic BMT Recipients

Jingru Zhu, Pankoj Kumar Das, Yitong Wang, Jingxia Li, Tamas Nagy, Khajan Ghandhi, Sruthi Ravindranathan, Cynthia R. Giver, Jian-Ming Li, Yiwen Li, Alina Ulezko Antonova, John D Roback, Shuhua Wang, Edmund K. Waller
Journal: Blood
Blood (2021) 138 (Supplement 1): 1687.
DOI: https://doi.org/10.1182/blood-2021-152945
Published: 2021
Journal Articles

HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis

Mahasweta Gooptu, Rizwan Romee, Andrew St. Martin, Mukta Arora, Monzr Al Malki, Joseph H. Antin, Christopher N. Bredeson, Claudio G. Brunstein, Saurabh Chhabra, Ephraim J. Fuchs, Nilanjan Ghosh, Michael R. Grunwald, Christopher G. Kanakry, Natasha Kekre, Jospeh P. McGuirk, Ian K. McNiece, Rohtesh S. Mehta, Marco Mielcarek, Fillipo Milano, Dipenkumar Modi, Ran Reshef, Scott R. Solomon, Mark A. Schroeder, Edmund K. Waller, Yoshiro Inamoto, Robert J. Soiffer, Mary Eapen
Journal: Blood
Blood (2021) 138 (3): 273–282.
DOI: https://doi.org/10.1182/blood.2021011281
Published: 2021
Journal Articles

Evaluating Outcomes for Autologous Hematopoietic Cell Transplantation for Diffuse Large B-Cell Lymphoma in the CAR-T Era

Pranav R Santapuram, Manali Rupji, MS, Michael Graiser, PhD, Edmund K. Waller, PhDMD, Kristie A. Blum, MD, Pamela B. Allen, MD MSc, Jean L. Koff, MD, Leonard Heffner, MD, Mary Jo Lechowicz, MD, Sagar Lonial, MD FACP, Jonathan L. Kaufman, MD, Craig C Hofmeister, MDMPH, Madhav V. Dhodapkar, MD, Ajay Nooka, MDMPH, William Blum, MD, Rebecca B. Klisovic, MD, Nisha Joseph, MD, Vikas A. Gupta, MD PhD, Amelia Langston, MD, Jonathon B. Cohen, MDMS
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–21.
DOI: https://doi.org/10.1182/blood-2020-142110
Published: 2020
Journal Articles

Ixazomib with or without Rituximab Following Immunochemotherapy and Autologous Stem Cell Transplant in Mantle Cell Lymphoma

Jason T. Romancik, MD, Pamela B. Allen, MD MSc, Edmund K. Waller, PhDMD, Zhengjia Chen, PhD, Kelly Valla, PharmD, Kaylan Dixon, BS, David J. Reagan, Amanda B. Colbert, Cecilia Rosand, PA-C, Alexandra Palmer, NP-C, Christopher Flowers, MDMS, Jonathon B. Cohen, MDMS
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
DOI: https://doi.org/10.1182/blood-2020-141030
Published: 2020
Journal Articles

Comparison of Outcomes after Haploidentical Relative and HLA Matched Unrelated Donor Transplantation with Post-Transplant Cyclophosphamide Containing Gvhd Prophylaxis Regimens

Mahasweta Gooptu, MD, Andrew St. Martin, MS, Rizwan Romee, MD, Mukta Arora, MD, Monzr M. Al Malki, MD, Joseph H. Antin, MD, Christopher Bredeson, MDFRCPC,MSc, Claudio G. Brunstein, MD PhD, Saurabh Chhabra, MD, Ephraim J. Fuchs, MD MBA, Nilanjan Ghosh, MD PhD, Michael R. Grunwald, MD, Yoshihiro Inamoto, MD, Christopher G. Kanakry, MD, Natasha Kekre, MD MPH, FRCPC, Joseph P. McGuirk, DO, Ian K. McNiece, PhD, Rohtesh S. Mehta, MDMPH,MS, Marco Last Mielcarek, MD, Filipo Milano, MD PhD, Dipenkumar Modi, MD, Ran Reshef, MD, Mark A. Schroeder, MD, Robert J. Soiffer, MD, Scott R. Solomon, MD, Edmund K. Waller, PhDMD, Mary Eapen, MBBS, MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
DOI: https://doi.org/10.1182/blood-2020-137221
Published: 2020
Journal Articles

A new role for an old cytokine: GM-CSF amplifies GVHD

Edmund K. Waller
Journal: Blood
Blood (2020) 135 (8): 520–521.
DOI: https://doi.org/10.1182/blood.2019004681
Published: 2020
Journal Articles

Pentotstatin/TBI Conditioning Is Well-Tolerated and Permits Engraftment of a Second Allogeneic Stem Cell Transplant Following Primary or Secondary Rejection of an Allogeneic Hematopoietic Stem Graft

Ani Gvajaia, MD, Amelia Langston, MD, Natia Esiashvil, MD, Michael Graiser, PhD, Kelly Valla, PharmD, Edmund K. Waller, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5657.
DOI: https://doi.org/10.1182/blood-2019-122467
Published: 2019
Journal Articles

Transplanted Vasoactive Intestinal Peptide-Secreting Donor Plasmacytoid Dendritic Cells Migrate to Lymphoid Organs and GvHD Target Organs

Jingru Zhu, Yitong Wang, MD, Jingxia Li, MD, Yiwen Li, Alina Ulezko Antonova, Cynthia R. Giver, PhD, Jianming Li, PhD, Shuhua Wang, MD, Edmund K. Waller, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1918.
DOI: https://doi.org/10.1182/blood-2019-129628
Published: 2019
Journal Articles

Impact of Tisagenlecleucel Chimeric Antigen Receptor (CAR)-T Cell Therapy Product Attributes on Clinical Outcomes in Adults with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL)

Veronika Bachanova, MD PhD, Constantine S. Tam, MBBS, MD, Peter Borchmann, MD, Ulrich Jaeger, MD, Joseph P. McGuirk, DO, Harald Holte, MD PhD, Edmund K. Waller, PhDMD, Samantha Jaglowski, MDMPH, Michael R. Bishop, MD, Charalambos Andreadis, MD MSCE, Stephen Ronan Foley, MD FRCPC, Jason R. Westin, MD, Isabelle Fleury, MD, P Joy Ho, MBBS(Syd) DPhil(Oxon) FRACP FRCPA FFSc(RCPA), Stephan Mielke, MD, Takanori Teshima, MD, Gilles Salles, MD PhD, Stephen J Schuster, MD, Richard T. Maziarz, MD, Koen Van Besien, MD PhD, Koji Izutsu, MD PhD, Marie Jose Kersten, MD PhD, John M. Magenau, MD, Nina D. Wagner-Johnston, MD, Koji Kato, MD PhD, Paolo Corradini, Jufen Chu, PhD, Irina Gershgorin, PhD, Therese Choquette, PhD, Lida Bubuteishvili Pacaud, MD, Margit Jeschke, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 242.
DOI: https://doi.org/10.1182/blood-2019-128302
Published: 2019
Journal Articles

Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizumab, in Subjects with Newly Diagnosed Acute Graft Versus Host Disease

John Koreth, MBBS, DPhil, Saurabh Chhabra, MD, Joseph Pidala, MD, Thomas C. Shea, MD, Madan Jagasia, MBBS, MS, MMHC, Edmund K. Waller, PhDMD, Ryotaro Nakamura, MD, Marco Mielcarek, MD, George L. Chen, MD, Gabrielle Meyers, MD, Daanish Hoda, MD, Betty K. Hamilton, MD, Cherie Tracy Ng, PhD MPH, Mark Sonnemann, Susan Light, MD, Nuwan Nanayakkara, PhD, David Essayan, MD, Joel Rothman, BS, Stephen Connelly, PhD MBA, Krishna Polu, MD, Leslie Kean, MD PhD, Jerome Ritz, MD, Robert J. Soiffer, MD, Corey Cutler, MD MPH, FRCPC
Journal: Blood
Blood (2019) 134 (Supplement_1): 4516.
DOI: https://doi.org/10.1182/blood-2019-127325
Published: 2019
Journal Articles

Correlative Analyses of Patient and Clinical Characteristics Associated with Efficacy in Tisagenlecleucel-Treated Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients in the Juliet Trial

Jason R. Westin, MD, Constantine S. Tam, MBBS, MD, Peter Borchmann, MD, Ulrich Jaeger, MD, Joseph P. McGuirk, DO, Harald Holte, MD PhD, Edmund K. Waller, PhDMD, Samantha Jaglowski, MDMPH, Michael R. Bishop, MD, Charalambos Andreadis, MD MSCE, Stephen Ronan Foley, MD FRCPC, Isabelle Fleury, MD, P Joy Ho, MBBS(Syd) DPhil(Oxon) FRACP FRCPA FFSc(RCPA), Stephan Mielke, MD, Takanori Teshima, MD, Stephen J Schuster, MD, Veronika Bachanova, MD PhD, Richard T. Maziarz, MD, Koen Van Besien, MD PhD, Koji Izutsu, MD PhD, Marie Jose Kersten, MD PhD, John M. Magenau, MD, Nina D. Wagner-Johnston, MD, Koji Kato, MD PhD, Paolo Corradini, Xia Han, MS, Ranjan Tiwari, MSc, Sergei Agoulnik, PhD, Lamis K. Eldjerou, MD, Lida Bubuteishvili Pacaud, MD, Gilles A. Salles, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4103.
DOI: https://doi.org/10.1182/blood-2019-129107
Published: 2019
Journal Articles

Portia: A Phase 1b Study Evaluating Safety and Efficacy of Tisagenlecleucel and Pembrolizumab in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Ulrich Jaeger, MD, Nina Worel, MD, Joseph P. McGuirk, DO, Peter A. Riedell, MD, Isabelle Fleury, MD, Peter Borchmann, MD, Jufen Chu, PhD, Ahmed M Abdelhady, PhD, Alessandra Forcina, MD, Lida Bubuteishvili Pacaud, MD, Edmund K. Waller, PhDMD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5325.
DOI: https://doi.org/10.1182/blood-2019-129120
Published: 2019