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Dimitar G Efremov
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Journal Articles

Chronic Lymphocytic Leukemia Cells with Mutated Nfkbie Are Positively Selected By Microenvironmental Signals and Display Reduced Sensitivity to Ibrutinib Treatment

Alice Bonato, Riccardo Bomben, Supriya Chakraborty, Giulia Felician, Claudio Martines, Antonella Zucchetto, Annalisa Chiarenza, Giovanni Del Poeta, Roberto Marasca, Agostino Tafuri, Luca Laurenti, Aleksandar J. Dimovski, Valter Gattei, Dimitar G Efremov
Journal: Blood
Blood (2021) 138 (Supplement 1): 248.
DOI: https://doi.org/10.1182/blood-2021-149442
Published: 2021
Journal Articles

Prevalence of Allelic Variants and Clonality of IGHV1-69 Expressing B-Cells in Patients with Different Severity of COVID 19 Disease

Irina Panovska-Stavridis, Nevenka Ridova, Simona Stojanovska, Milena Stevanovic, Tatjana Stojanoska, Ilir Demiri, Nadica Matevska-Geshkovska, Marija Vujovic, Hristina Markoska, Venko Filipce, Aleksandar J. Dimovski, Dimitar G Efremov
Journal: Blood
Blood (2021) 138 (Supplement 1): 994.
DOI: https://doi.org/10.1182/blood-2021-153487
Published: 2021
Journal Articles

B-cell receptor signaling and genetic lesions in TP53 and CDKN2A/CDKN2B cooperate in Richter transformation

Supriya Chakraborty, Claudio Martines, Fabiola Porro, Ilaria Fortunati, Alice Bonato, Marija Dimishkovska, Silvano Piazza, Brijesh S. Yadav, Idanna Innocenti, Rosa Fazio, Tiziana Vaisitti, Silvia Deaglio, Alberto Zamò, Aleksandar J. Dimovski, Luca Laurenti, Dimitar G. Efremov
Journal: Blood
Blood (2021) 138 (12): 1053–1066.
DOI: https://doi.org/10.1182/blood.2020008276
Published: 2021
Includes: Supplemental data
Journal Articles

Combined Genetic Lesions in TP53 and CDKN2A/CDKN2B Drive B Cell Receptor-Dependent/Costimulatory Signal-Independent Proliferation in Richter Syndrome

Supriya Chakraborty, PhD, Claudio Martines, MS, Fabiola Porro, MS, Ilaria Fortunati, BS, Alice Bonato, BA, Marija Dimishkovska, PhD, Brijesh Yadav, PhD, Idanna Innocenti, MDPhD, Rosa Fazio, BA, Tizianna Vaisitti, PhD, Silvia Deaglio, MD, Alberto Zamò, MD PhD, Aleksandar Dimovski, MD PhD, Luca Laurenti, MD, Dimitar G Efremov, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
DOI: https://doi.org/10.1182/blood-2020-136668
Published: 2020
Journal Articles

A CRISPR/Cas9-Generated Murine Model Reveals Cooperation between BCR Signaling and CDKN2A/2B and TP53 Disruption in Richter Syndrome

Supriya Chakraborty, PhD, Ilaria Fortunati, BS, Claudio Martines, MS, Brijesh Yadav, PhD, Marija Dimishkovska, PhD, Idanna Innocenti, MD PhD, Rosa Fazio, BS, Giovanni D'Arena, MD, Aleksandar Dimovski, MD PhD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4278.
DOI: https://doi.org/10.1182/blood-2019-128425
Published: 2019
Journal Articles

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Stefania Gobessi, PhD, Luca Laurenti, MD, Fabiola Porro, MS, Claudio Martines, MS, Rosa Fazio, BS, Elena Xerxa, PhD, Idanna Innocenti, MD PhD, Antonella Zucchetto, Shih-Shih Chen, PhD, Xiao-Jie Yan, MD PhD, Nicholas Chiorazzi, MD, Valter Gattei, MD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4409.
DOI: https://doi.org/10.1182/blood-2018-99-118562
Published: 2018
Journal Articles

Targeting the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Novel Therapeutic Opportunities

Andrea Papait, PhD, Tiziana Vaisitti, PhD, Sara Serra, PhD, Valentina Audrito, PhD, Francesco Tito, Giulia Guerra, Dimitar G Efremov, MDPhD, Silvia Deaglio, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 240.
DOI: https://doi.org/10.1182/blood-2018-99-118057
Published: 2018
Journal Articles

SHP1 Deficiency Is Responsible for the Constitutive Activation of the BCR Pathway in GCB DLBCL

Binu K Sasi, PhD, Sven Turkalj, BS, Hilal Kalkan, BS, Fabiola Porro, MS, Engin Bojnik, PhD, Beata Pyrzynska, PhD, Abdessamad Zerrouqi, PhD, Malgorzata Bobrowicz, PhD, Magdalena Winiarska, PhD, Valdemar Priebe, MS, Francesco Bertoni, MD, Larry Mansouri, PhD, Richard Rosenquist, MD PhD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2860.
DOI: https://doi.org/10.1182/blood-2018-99-118120
Published: 2018
Journal Articles

Hyper-Activation of the Adenosinergic Axis in the Eμ-TCL1 Chronic Lymphocytic Leukemia Mouse Model Offers Therapeutic Opportunities

Tiziana Vaisitti, PhD, Sara Serra, PhD, Cinzia Bologna, PhD, Nicoletta Vitale, PhD, Stefania Gobessi, PhD BS, Dimitar G Efremov, MD PhD, Silvia Deaglio, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1721.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1721.1721
Published: 2017
Journal Articles

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

Malgorzata Bobrowicz, Michal Dwojak, Beata Pyrzynska, Joanna Stachura, Angelika Muchowicz, Elise Berthel, Nicole Dalla-Venezia, Mieszko Kozikowski, Marta Siernicka, Nina Miazek, Piotr Zapala, Antoni Domagala, Kamil Bojarczuk, Agata Malenda, Joanna Barankiewicz, Agnieszka Graczyk-Jarzynka, Agnieszka Zagozdzon, Magdalena Gabrysiak, Jean-Jacques Diaz, Marta Karp, Ewa Lech-Maranda, Malgorzata Firczuk, Krzysztof Giannopoulos, Dimitar G. Efremov, Luca Laurenti, Dunja Baatout, Lukas Frenzel, Agata Malinowska, Mikolaj Slabicki, Thorsten Zenz, Abdessamad Zerrouqi, Jakub Golab, Magdalena Winiarska
Journal: Blood
Blood (2017) 130 (14): 1628–1638.
DOI: https://doi.org/10.1182/blood-2016-08-736066
Published: 2017
Includes: Supplemental data
Journal Articles

The Bcl-2 BH4 Antagonist Bda-366 Induces Apoptosis in CLL and DLBCL Cells through a Bcl-2 Independent Mechanism

Binu K Sasi, PhD, Tamara Vervloessem, PhD, Stefania Gobessi, PhD, Idanna Innocenti, MD, Luca Laurenti, Geert Bultynck, PhD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2014.
DOI: https://doi.org/10.1182/blood.V128.22.2014.2014
Published: 2016
Journal Articles

FcμR Triggering Activates BCR Signaling Pathways and Increases Survival of CLL Cells

Stefania Gobessi, PhD, Binu K Sasi, PhD, Gabriele Pozzato, MD, Idanna Innocenti, MD, Luca Laurenti, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2015.
DOI: https://doi.org/10.1182/blood.V128.22.2015.2015
Published: 2016
Journal Articles

Chlorambucil PLUS Rituximab As FRONT-LINE Therapy for Elderly and/or Unfit CLL Patients. LONG-TERM Follow-up and Correlation with Biologic-Based Risk Stratification

Luca Laurenti, Idanna Innocenti, MD, Francesco Autore, MD, Raffaella Pasquale, Barbara Vannata, MD, Stefania Ciolli, Francesca Romana Mauro, MD PhD, Donato Mannina, MD, Giovanni Del Poeta, MD, Giovanni D'Arena, MD, Massimo Massaia, MD, Marta Coscia, MD PhD, Stefano Molica, MD, Gabriele Pozzato, MD, Dimitar G Efremov, MD PhD, Roberto Marasca, MD, Piero Galieni, Antonio Cuneo, MD, Sonia Orlando, Alfonso Piciocchi, BS, Riccardo Boncompagni, Donatella Iolanda Vincelli, MD, Anna Marina Liberati, MD, Filomena Russo, Robin Foa
Journal: Blood
Blood (2016) 128 (22): 3240.
DOI: https://doi.org/10.1182/blood.V128.22.3240.3240
Published: 2016
Journal Articles

IL-4 regulates B-cell receptor signaling in CLL

Dimitar G. Efremov
Journal: Blood
Blood (2016) 128 (4): 468–469.
DOI: https://doi.org/10.1182/blood-2016-06-719872
Published: 2016
Journal Articles

BCR signaling inhibitors differ in their ability to overcome Mcl-1–mediated resistance of CLL B cells to ABT-199

Kamil Bojarczuk, Binu K. Sasi, Stefania Gobessi, Idanna Innocenti, Gabriele Pozzato, Luca Laurenti, Dimitar G. Efremov
Journal: Blood
Blood (2016) 127 (25): 3192–3201.
DOI: https://doi.org/10.1182/blood-2015-10-675009
Published: 2016
Includes: Supplemental data
Journal Articles

FOXO discriminates tonic from chronic in DLBCL

Dimitar G. Efremov
Journal: Blood
Blood (2016) 127 (6): 669–670.
DOI: https://doi.org/10.1182/blood-2015-12-683441
Published: 2016
Journal Articles

Inhibition of SYK More Effectively Overcomes MCL-1 Mediated ABT-199 Resistance of BCR-Stimulated CLL Cells Than Inhibition of BTK or PI3Kdelta

Kamil Bojarczuk, PhD, Binu K Sasi, PhD, Stefania Gobessi, PhD, Idanna Innocenti, MD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2015) 126 (23): 489.
DOI: https://doi.org/10.1182/blood.V126.23.489.489
Published: 2015
Journal Articles

Serum IgM Activates BCR Signaling Pathways and Increases Survival of Chronic Lymphocytic Leukemia B Cells

Stefania Gobessi, PhD, Binu K Sasi, PhD, Luca Laurenti, MD, Dimitar G Efremov, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4131.
DOI: https://doi.org/10.1182/blood.V126.23.4131.4131
Published: 2015
Journal Articles

Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL

Stefano Iacovelli, Eva Hug, Sara Bennardo, Marcus Duehren-von Minden, Stefania Gobessi, Andrea Rinaldi, Mirza Suljagic, Daniel Bilbao, Giulia Bolasco, Julia Eckl-Dorna, Verena Niederberger, Francesco Autore, Simona Sica, Luca Laurenti, Hongsheng Wang, Richard J. Cornall, Stephen H. Clarke, Carlo M. Croce, Francesco Bertoni, Hassan Jumaa, Dimitar G. Efremov
Journal: Blood
Blood (2015) 125 (10): 1578–1588.
DOI: https://doi.org/10.1182/blood-2014-07-587790
Published: 2015
Includes: Supplemental data
Journal Articles

Bruton’s tyrosine kinase (BTK) function is important to the development and expansion of chronic lymphocytic leukemia (CLL)

Jennifer A. Woyach, Engin Bojnik, Amy S. Ruppert, Matthew R. Stefanovski, Virginia M. Goettl, Kelly A. Smucker, Lisa L. Smith, Jason A. Dubovsky, William H. Towns, Jessica MacMurray, Bonnie K. Harrington, Melanie E. Davis, Stefania Gobessi, Luca Laurenti, Betty Y. Chang, Joseph J. Buggy, Dimitar G. Efremov, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2014) 123 (8): 1207–1213.
DOI: https://doi.org/10.1182/blood-2013-07-515361
Published: 2014
Includes: Supplemental data