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David O'Connor
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Journal Articles

Anti-CCR9 Chimeric Antigen Receptor T cells for T Cell Acute Lymphoblastic Leukemia

Paul Michael Maciocia, Patrycja A Wawrzyniecka, Nicola C Maciocia, Amy Burley, Thaneswari Karpanasamy, Sam Devereaux, Malika Hoekx, David O'Connor, Theresa Elizabeth Leon, Tanya Rapoz-D'Silva, Rachael Pocock, Sunniyat Rahman, Giuseppe Gritti, Diana C Yánez, Susan Ross, Tessa Crompton, Owen Williams, Lydia Sarah Hui Lee, Martin Pule, Marc R. Mansour
Journal: Blood
Blood blood.2021013648.
DOI: https://doi.org/10.1182/blood.2021013648
Published: 2022
Includes: Supplemental data
Journal Articles

Anti-CCR9 CAR-T Cells for T Acute Lymphoblastic Leukemia

Paul M Maciocia, Patrycja Wawrzyniecka, Nicola C Maciocia, Amy Burley, David O'Connor, Theresa E. Leon, Tanya Rapoz-D'Silva, Thaneswari Karpanasamy, Martin Pule, Marc R. Mansour
Journal: Blood
Blood (2021) 138 (Supplement 1): 903.
DOI: https://doi.org/10.1182/blood-2021-146565
Published: 2021
Journal Articles

Blinatumomab for infant acute lymphoblastic leukemia

Clinical Trials & Observations
Katherine Clesham, Vasudha Rao, Jack Bartram, Philip Ancliff, Sara Ghorashian, David O’Connor, Vesna Pavasovic, Anupama Rao, Sujith Samarasinghe, Michelle Cummins, Andrea Malone, Katharine Patrick, Denise Bonney, Beki James, Brenda Gibson, Ajay Vora
Journal: Blood
Blood (2020) 135 (17): 1501–1504.
DOI: https://doi.org/10.1182/blood.2019004008
Published: 2020
Journal Articles

A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia

Clinical Trials & Observations
Amir Enshaei, David O’Connor, Jack Bartram, Jeremy Hancock, Christine J. Harrison, Rachael Hough, Sujith Samarasinghe, Monique L. den Boer, Judith M. Boer, Hester A. de Groot-Kruseman, Hanne V. Marquart, Ulrika Noren-Nystrom, Kjeld Schmiegelow, Claire Schwab, Martin A. Horstmann, Gabriele Escherich, Mats Heyman, Rob Pieters, Ajay Vora, John Moppett, Anthony V. Moorman
Journal: Blood
Blood (2020) 135 (17): 1438–1446.
DOI: https://doi.org/10.1182/blood.2019003191
Published: 2020
Includes: Supplemental data
Journal Articles

How I treat newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma in children

Clinical Trials & Observations
David T. Teachey, David O’Connor
Journal: Blood
Blood (2020) 135 (3): 159–166.
DOI: https://doi.org/10.1182/blood.2019001557
Published: 2020
Journal Articles

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

Sorcha Isabella O'Byrne, BSc, Natalina Elliott, PhD, Gemma Buck, BSc, Siobhan Rice, David O'Connor, Jana Oswald, Hannah Fuchs, Ella-Mae Labbett, Nicholas James Fordham, MBBS, BSc, Anindita Roy, MD PhD, Irene Roberts
Journal: Blood
Blood (2019) 134 (Supplement_1): 1206.
DOI: https://doi.org/10.1182/blood-2019-130180
Published: 2019
Journal Articles

Excellent Response to Blinatumomab in Children and Young Adults with Refractory B Lineage Acute Lymphoblastic Leukaemia for Persistent MRD or after Debulking Chemotherapy for Higher Disease Burden

Vasudha Rao, MD, Katherine Clesham, Jack Luke Bartram, MD, Phil Ancliff, Sara Ghorashian, FRCPath, PhD, David O'Connor, Vesna Pavasovic, Anupama Rao, MD, Sujith Samarasinghe, Carole Cairns, David Marks, David Taussig, PhD MRCP, FRCPath, Ajay Vora, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5201.
DOI: https://doi.org/10.1182/blood-2018-99-117051
Published: 2018
Journal Articles

Refining genetic stratification in T-ALL

Clinical Trials & Observations
David O’Connor
Journal: Blood
Blood (2018) 131 (3): 271–272.
DOI: https://doi.org/10.1182/blood-2017-10-812933
Published: 2018
Journal Articles

The Incidence of Invasive Fungal Infections in Children, Adolescents and Young Adults with Acute Lymphoblastic Leukaemia/Lymphoma Treated with the UKALL2011 Protocol: a Multicentre Retrospective Study

Maeve A O'Reilly, MB, Dinisha Govender, Ajay Vora, MD, Sujith Samarasinghe, Asim Khwaja, Victoria Grandage, Anupama Rao, Phil Ancliff, Danny Cheng, Ben Carpenter, Stephen Daw, David O'Connor, Rachael Hough, MD BMBS, FRCP, FRCPath
Journal: Blood
Blood (2017) 130 (Supplement 1): 102.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.102.102
Published: 2017
Journal Articles

Integrating Genetic Risk Factors with Age, Presenting White Cell Count and MRD Response As Continuous Variables to Predict Relapse in Paediatric Acute Lymphoblastic Leukemia (ALL)

Anthony V. Moorman, PhD, Amir Enshaei, PhD, David O'Connor, MD PhD, Jack Bartram, MD, Jeremy Hancock, PhD, Christine Harrison, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD
Journal: Blood
Blood (2016) 128 (22): 603.
DOI: https://doi.org/10.1182/blood.V128.22.603.603
Published: 2016
Journal Articles

Integration of Minimal Residual Disease with Other Patient Risk Factors Identifies a Population with Very Poor Overall Survival in Pediatric ALL: Results from the UKALL 2003 Trial

David O'Connor, MD PhD, Jack Bartram, MD, Amir Enshaei, PhD, Anthony V Moorman, PhD, Christine Harrison, PhDFRCPath FMedSci, Rachel Wade, MSc, Rachel Clack, MSc, Jeremy Hancock, PhD, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1412.
DOI: https://doi.org/10.1182/blood.V126.23.1412.1412
Published: 2015
Journal Articles

Long Term Overall Survival of Greater Than 98% in Childhood ALL Patients with Good Risk Features and Low Risk MRD:Â Results from a Large Multi-Center Randomized Controlled Trial, UKALL 2003

Jack Bartram, MD, David O'Connor, MD PhD, Amir Enshaei, PhD, Anthony V Moorman, PhD, Christine Harrison, PhDFRCPath FMedSci, Rachel Wade, MSc, Rachel Clack, MSc, Jeremy Hancock, PhD, Sujith Samarasinghe, MD PhD, John Moppett, MD PhD, Ajay J. Vora, Nicholas Goulden, MD PhD
Journal: Blood
Blood (2015) 126 (23): 806.
DOI: https://doi.org/10.1182/blood.V126.23.806.806
Published: 2015
Journal Articles

Trisomy 21-Associated Abnormalities in IGF Signalling and the Fetal Microenvironment Both Contribute to Disruption of Fetal Hematopoiesis in Down Syndrome

David O'Connor, Binbin Liu, Gillian Cowan, Anindita Roy, MDPhD, Katerina Goudevenou, Neha Bhatnagar, MBChB MRCPCH FRCPath, Oliver Tunstall, Josu de la Fuente, PhD FRCP, MRCPCH, FRCPath, Anastasios Karadimitris, Irene Roberts, MDFRCP FRCPCH FRCPath
Journal: Blood
Blood (2014) 124 (21): 1885.
DOI: https://doi.org/10.1182/blood.V124.21.1885.1885
Published: 2014
Journal Articles

Developmental Stage Specific B-Progenitor Expansion in Normal Fetal Bone Marrow Is Absent in Down Syndrome: Implications for Infant ALL

Anindita Roy, MDPhD, Georg Bohn, Katerina Goudevenou, Gillian Cowan, Neha Bhatnagar, David O'Connor, Oliver Tunstall, Jerry Chan, Phillip Bennett, Sailesh Kumar, Deena Iskander, Sarah Inglott, Binbin Liu, Philip Ancliff, Anastasios Karadimitris, Irene Roberts, MDFRCP FRCPCH FRCPath
Journal: Blood
Blood (2014) 124 (21): 4331.
DOI: https://doi.org/10.1182/blood.V124.21.4331.4331
Published: 2014
Journal Articles

Infection-related mortality in children with acute lymphoblastic leukemia: an analysis of infectious deaths on UKALL2003

Clinical Trials & Observations
David O’Connor, Jessica Bate, Rachel Wade, Rachel Clack, Sunita Dhir, Rachael Hough, Ajay Vora, Nick Goulden, Sujith Samarasinghe
Journal: Blood
Blood (2014) 124 (7): 1056–1061.
DOI: https://doi.org/10.1182/blood-2014-03-560847
Published: 2014
Includes: Supplemental data
Journal Articles

Transcriptional and epigenetic basis for restoration of G6PD enzymatic activity in human G6PD-deficient cells

Kalliopi Makarona, Valentina S. Caputo, Joana R. Costa, Binbin Liu, David O’Connor, Deena Iskander, David Roper, Lynn Robertson, Neha Bhatnagar, Evangelos Terpos, Elisabeth Georgiou, Maria Papaioannou, D. Mark Layton, Lucio Luzzatto, Irene Roberts, Anastasios Karadimitris
Journal: Blood
Blood (2014) 124 (1): 134–141.
DOI: https://doi.org/10.1182/blood-2014-02-553792
Published: 2014
Includes: Supplemental data
Journal Articles

Gene-Selective Histone Hyperacetylation and Enhanced Sp1 Occupancy Underpin Transcriptional Modulation of Genes of the Glycolytic-Pentose Phosphate Pathway in Response to Histone Deacetylase Inhibitors - Therapeutic Implications

Kalliopi Makarona, Valentina Caputo, David Roper, Joana Costa, Gillian Cowan, Aristeidis Chaidos, David O'Connor, Elisabeth Georgiou, Maria Papaioannou, Mark Layton, Irene Roberts, Anastasios Karadimitris
Journal: Blood
Blood (2012) 120 (21): 977.
DOI: https://doi.org/10.1182/blood.V120.21.977.977
Published: 2012
Journal Articles

Analysis of Early Disease Response in Childhood ALL: Can Peripheral Blood Replace Bone Marrow Analysis?.

David O'Connor, MD, Jennifer Jesson, Melanie Bahey, Lisa Eyre, Sarah Lawson, MD
Journal: Blood
Blood (2012) 120 (21): 2523.
DOI: https://doi.org/10.1182/blood.V120.21.2523.2523
Published: 2012