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Journal Articles

Smoothened signaling in the mouse osteoblastoid lineage is required for efficient B lymphopoiesis

Wenyan Lu, Dominic Dordai, David Huso, Stephen Desiderio

Blood (2018) 131 (3): 323–327.

https://doi.org/10.1182/blood-2017-06-793539

Published: 2018

Includes: Supplemental data

Journal Articles

High Mobility Group A1 Chromatin Remodeling Protein Regulates Self-Renewal, Niche Formation, and Regenerative Function in Adult Stem Cells through Wnt/β-Catenin Signaling

Linda Resar, MD, Lingling Xian, MD PhD, Tait Huso, Amy Belton, PhDBSc, Leslie Cope, PhDBSc, David Huso, DVM, PhD

Blood (2016) 128 (22): 2647.

https://doi.org/10.1182/blood.V128.22.2647.2647

Published: 2016

Journal Articles

ATM and 53BP1 Function in Nonoverlapping Pathways to Suppress T Lineage Lymphomagenesis.

Ivana Rybanska, PhD, Jeremy Chou, BS, Mansi Prakash, PhD, David Huso, D.V.M., Ph.D., Sonia Franco, MD, PhD

Blood (2012) 120 (21): 2374.

https://doi.org/10.1182/blood.V120.21.2374.2374

Published: 2012

Journal Articles

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model

Sarah Greenblatt, Li Li, Christopher Slape, Bao Nguyen, Rachel Novak, Amy Duffield, David Huso, Stephen Desiderio, Michael J. Borowitz, Peter Aplan, Donald Small

Blood (2012) 119 (12): 2883–2894.

https://doi.org/10.1182/blood-2011-10-382283

Published: 2012

Includes: Supplemental data

Journal Articles

Generation of a FLT3 Kinase Domain Point Mutation (D835Y equivalent) Knock-in Mouse Confers Less Aggressive Disease Compared with FLT3 Internal Tandem Duplication (ITD) Mice

Emily Bailey, DVM, Li Li, PhD, David Huso, D.V.M., Ph.D., Hayley S Wall, Donald Small, MD, PhD

Blood (2011) 118 (21): 924.

https://doi.org/10.1182/blood.V118.21.924.924

Published: 2011

Journal Articles

Knock-in of a FLT3 Internal Tandem Duplication Mutation Cooperates with a NUP98-HOXD13 Fusion to Generate Acute Myeloid Leukemia

Sarah M Greenblatt, Li Li, PhD, Christopher Slape, PhD, Rachel L Novak, PhD, Amy S. Duffield, MD, PhD, Bao Nguyen, M.S., David Huso, D.V.M., Ph.D., Michael J. Borowitz, MD, PhD, Peter Aplan, MD, Donald Small, MD, PhD

Blood (2011) 118 (21): 865.

https://doi.org/10.1182/blood.V118.21.865.865

Published: 2011

Journal Articles

HMGA1 Drives Inflammatory Pathways, Cell Cycle Progression, and Embryonic Stem Cell Genes During Leukemic Transformation

Andrew Schuldenfrei, Amy Belton, Ph.D., Jeanne Kowalski, PhD, C. Conover Talbot, Jr., B.S., Francescopaolo Di Cello, Weijie Poh, Hua-Ling Tsai, MS, Sandeep N Shah, Tait Huso, David Huso, D.V.M., Ph.D., Linda Resar, MD

Blood (2011) 118 (21): 1371.

https://doi.org/10.1182/blood.V118.21.1371.1371

Published: 2011

Journal Articles

Loss of the Wild-Type Allele Contributes to Myeloid Expansion and Disease Aggressiveness in FLT3/ITD Knock-in Mice

Li Li, PhD, Emily Bailey, DVM, Sarah M Greenblatt, David Huso, D.V.M., Ph.D., Donald Small, MD, PhD

Blood (2011) 118 (21): 866.

https://doi.org/10.1182/blood.V118.21.866.866

Published: 2011

Journal Articles

FLT3-ITD Knock-in Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to a Myeloproliferative Neoplasm

S. Haihua Chu, Diane Heiser, Li Li, PhD, Ian M Kaplan, PhD, David Huso, D.V.M., Ph.D., Curt I. Civin, MD, Donald Small, MD, PhD

Blood (2011) 118 (21): 46.

https://doi.org/10.1182/blood.V118.21.46.46

Published: 2011

Journal Articles

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice

Li Li, Emily Bailey, Sarah Greenblatt, David Huso, Donald Small

Blood (2011) 118 (18): 4935–4945.

https://doi.org/10.1182/blood-2011-01-328096

Published: 2011

Journal Articles

Cytoplasmic Nucleophosmin (NPMc+) Mutations and FMS-Like Tyrosine Kinase 3 (Flt3) Internal Tandem Duplication (ITD) Mutations Cooperate to Cause Leukemia In a Mouse Model

Rachel E. Rau, MD, Daniel Magoon, Emily McIntyre, Li Li, PhD, Sarah Greenblatt, David Huso, DVM, PhD, Pier Paolo Pandolfi, MD, PhD, Donald Small, MD, PhD, Patrick Brown, MD

Blood (2010) 116 (21): 145.

https://doi.org/10.1182/blood.V116.21.145.145

Published: 2010

Journal Articles

Retroviral Insertional Mutagenesis Reveals Genes That Cooperate with FLT3-ITD in Leukemogenesis.

Kathleen E Greenberg, BS, Li Li, MD, PhD, David Huso, Linda Wolff, PhD, Donald Small, MD, PhD

Blood (2009) 114 (22): 1960.

https://doi.org/10.1182/blood.V114.22.1960.1960

Published: 2009

Journal Articles

Inactivation of the INK4A/ARF ( CDKN2 ) locus Cooperates with HMGA1 in T-Cell Leukemogenesis.

Linda Resar, MD, Francescopaolo Di Cello, Ph.D., Surajit Dhara, Ph.D., Jeanne Kowalski, Ph.D., Ossama Elbahlouh, M.D., Joelle Hillion, Ph.D., Stuart Winter, MD, Richard S. Larson, MD, PhD, David Huso, D.V.M., Ph.D.

Blood (2009) 114 (22): 3969.

https://doi.org/10.1182/blood.V114.22.3969.3969

Published: 2009

Journal Articles

Knock-in of a FLT3 Internal Tandem Duplication Mutation Cooperates with a NUP98-HOXD13 Fusion to Generate Acute Leukemia in a Mouse Model.

Sarah M Greenblatt, BS, Biology, Li Li, MD, PhD, Christopher Slape, PhD, David Huso, Peter D. Aplan, MD, Donald Small, MD, PhD

Blood (2009) 114 (22): 2961.

https://doi.org/10.1182/blood.V114.22.2961.2961

Published: 2009

Journal Articles

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model

Li Li, Obdulio Piloto, Ho Bao Nguyen, Kathleen Greenberg, Kogo Takamiya, Frederick Racke, David Huso, Donald Small

Blood (2008) 111 (7): 3849–3858.

https://doi.org/10.1182/blood-2007-08-109942

Published: 2008

Journal Articles

Knock-In of an Internal Tandem Duplication Mutation into Murine FLT3 Confers Myeloproliferative Disease in a Mouse Model.

Li Li, Obdulio Piloto, Ho Bao Nguyen, Kathleen Greenberg, Frederick Racke, David Huso, Donald Small

Blood (2006) 108 (11): 386.

https://doi.org/10.1182/blood.V108.11.386.386

Published: 2006

Journal Articles

FLT3 Immunotherapy Can Eliminate Engraftment of ALL Cells in NOD/SCID Mice.

Obdulio Piloto, BS, Bao Nguyen, MS, Patrick Brown, MD, Kyu-Tae Kim, PhD, David Huso, PhD, Yiwen Li, PhD, Larry Witte, PhD, Daniel J. Hicklin, PhD, Donald Small, MD/PhD

Blood (2005) 106 (11): 869.

https://doi.org/10.1182/blood.V106.11.869.869

Published: 2005

Journal Articles

EB10, an Anti-FLT3 Monoclonal Antibody, Prolongs Survival and Reduces NOD/SCID Engraftment of AML Cell Lines and Primary Blasts.

Obdulio Piloto, B.S., Mark Levis, M.D./Ph.D., Li Li, Ph.D., Bao Nguyen, M.S., Kyu-Tae Kim, Ph.D., David Huso, Ph.D., Yiwen Li, Ph.D., Hongli Li, Ph.D., Mei-Nai Wang, Ph.D., Larry Witte, Ph.D., Daniel J. Hicklin, Ph.D., Donald Small, M.D./Ph.D.

Blood (2004) 104 (11): 2534.

https://doi.org/10.1182/blood.V104.11.2534.2534

Published: 2004

Journal Articles

EB10, an Anti-FLT3 Monoclonal Antibody, Selectively Targets ALL Cell Lines and Primary ALL Blasts without Interfering with Normal Hematopoiesis.

Obdulio Piloto, B.S., Patrick Brown, M.D., Li Li, Ph.D., Bao Nguyen, M.S., Kyu-Tae Kim, Ph.D., David Huso, Ph.D., Yiwen Li, Ph.D., Hongli Li, Ph.D., Mei-Nai Wang, Ph.D., Larry Witte, Ph.D., Daniel J. Hicklin, Ph.D., Donald Small, M.D./Ph.D.

Blood (2004) 104 (11): 2744.

https://doi.org/10.1182/blood.V104.11.2744.2744

Published: 2004

NARROW

Smoothened signaling in the mouse osteoblastoid lineage is required for efficient B lymphopoiesis

High Mobility Group A1 Chromatin Remodeling Protein Regulates Self-Renewal, Niche Formation, and Regenerative Function in Adult Stem Cells through Wnt/β-Catenin Signaling

ATM and 53BP1 Function in Nonoverlapping Pathways to Suppress T Lineage Lymphomagenesis.

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model

Generation of a FLT3 Kinase Domain Point Mutation (D835Y equivalent) Knock-in Mouse Confers Less Aggressive Disease Compared with FLT3 Internal Tandem Duplication (ITD) Mice

Knock-in of a FLT3 Internal Tandem Duplication Mutation Cooperates with a NUP98-HOXD13 Fusion to Generate Acute Myeloid Leukemia

HMGA1 Drives Inflammatory Pathways, Cell Cycle Progression, and Embryonic Stem Cell Genes During Leukemic Transformation

Loss of the Wild-Type Allele Contributes to Myeloid Expansion and Disease Aggressiveness in FLT3/ITD Knock-in Mice

FLT3-ITD Knock-in Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to a Myeloproliferative Neoplasm

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice

Cytoplasmic Nucleophosmin (NPMc+) Mutations and FMS-Like Tyrosine Kinase 3 (Flt3) Internal Tandem Duplication (ITD) Mutations Cooperate to Cause Leukemia In a Mouse Model

Retroviral Insertional Mutagenesis Reveals Genes That Cooperate with FLT3-ITD in Leukemogenesis.

Inactivation of the INK4A/ARF ( CDKN2 ) locus Cooperates with HMGA1 in T-Cell Leukemogenesis.

Knock-in of a FLT3 Internal Tandem Duplication Mutation Cooperates with a NUP98-HOXD13 Fusion to Generate Acute Leukemia in a Mouse Model.

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model

Knock-In of an Internal Tandem Duplication Mutation into Murine FLT3 Confers Myeloproliferative Disease in a Mouse Model.

FLT3 Immunotherapy Can Eliminate Engraftment of ALL Cells in NOD/SCID Mice.

EB10, an Anti-FLT3 Monoclonal Antibody, Prolongs Survival and Reduces NOD/SCID Engraftment of AML Cell Lines and Primary Blasts.

EB10, an Anti-FLT3 Monoclonal Antibody, Selectively Targets ALL Cell Lines and Primary ALL Blasts without Interfering with Normal Hematopoiesis.

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ASH Publications

American Society of Hematology

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ASH Publications

American Society of Hematology

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