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Journal Articles

AML Stem Cell Clearance By Inhibiting Selenoprotein Biosynthesis That Causes Cgas-Sting Activation and Ferroptosis

Lingli He, Ting Zhao, Wei Zhong Leong, Azeem Sharda, Christina Mayerhofer, Shenglin Mei, Gracia M. Bonilla, Juan Bautista Menendez-Gonzalez, Karin Gustafsson, Tsuyoshi Fukushima, Trine A. Kristiansen, Ji-Won Lee, Yanxin Xu, Bogdan Budnik, Ruslan Sadreyev, Zhixun Dou, David B. Sykes, David Scadden

Blood (2024) 144 (Supplement 1): 1354.

https://doi.org/10.1182/blood-2024-211314

Published: 2024

Journal Articles

The TEMPI Syndrome: A Monoclonal Gammopathy of Clinical Significance Driving Erythropoietin Production

David B. Sykes, Mohammad Artin Houshmand, Tysheena P. Charles, Jens Wrammert, Wilfried A Schroyens

Blood (2024) 144 (Supplement 1): 3293.

https://doi.org/10.1182/blood-2024-194342

Published: 2024

Journal Articles

CDK9 Inhibition Sensitizes TP53 Mutated AML to Standard Chemotherapy

Elizabeth C. Trull, David B. Sykes, Philip C. Amrein

Blood (2024) 144 (Supplement 1): 5800.

https://doi.org/10.1182/blood-2024-200762

Published: 2024

Journal Articles

Characterizing Thrombotic Risk in TEMPI Syndrome: A Retrospective Case Series

Graham Blake Parker, Justin Cheng, Louis Terriou, Johanna Strobl, Ayesha Iftikhar, Davide Nappi, Meng Pan, Pierre-Yves Sansen, Elisa Diral, Elena Maria Elli, Wilfried A Schroyens, David B. Sykes, Casey L. O'Connell, Caitlin M O'Neill

Blood (2024) 144 (Supplement 1): 5551.

https://doi.org/10.1182/blood-2024-199861

Published: 2024

Journal Articles

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors

Catherine Rhee, Elizabeth W. Scadden, Lai Ping Wong, Giulia Schiroli, Michael C. Mazzola, Phillip L. Chea, Hiroki Kato, Friedrich F. Hoyer, Meeta Mistry, Bum-Kyu Lee, Jonghwan Kim, Matthias Nahrendorf, Michael K. Mansour, David B. Sykes, Ruslan I. Sadreyev, David T. Scadden

Blood (2023) 142 (7): 658–674.

https://doi.org/10.1182/blood.2023020257

Published: 2023

Includes: Supplemental data

Journal Articles

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Blood (2022) 139 (26): 3752–3770.

https://doi.org/10.1182/blood.2021015108

Published: 2022

Includes: Supplemental data

Journal Articles

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

Blood (2020) 136 (11): 1303–1316.

https://doi.org/10.1182/blood.2019001808

Published: 2020

Includes: Supplemental data

Journal Articles

The TEMPI syndrome

David B. Sykes, Casey O’Connell, Wilfried Schroyens

Blood (2020) 135 (15): 1199–1203.

https://doi.org/10.1182/blood.2019004216

Published: 2020

Includes: Supplemental data

Journal Articles

Functionally Distinct Subsets of Monocytes in Mouse and Human Blood

Catherine S Rhee, PhD, Elizabeth W Scadden, Chea L Phillip, Bum-Kyu Lee, PhD, Meeta Mistry, Friedrich F Hoyer, MD, Hiroki Kato, MD PhD, Giovanna Mantica, Jonghwan Kim, PhD, Matthias Nahrendorf, PhD, Michael K Mansour, MD PhD, David B Sykes, MD PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 438.

https://doi.org/10.1182/blood-2019-124054

Published: 2019

Journal Articles

What Links Neutropenia to Immature Cardiolipin in Patients with Barth Syndrome (tafazzin-deficiency)?

Jihee Sohn, PhD, Thomas Brouse, Najihah Aziz, David B Sykes, MD PhD

Blood (2019) 134 (Supplement_1): 3579.

https://doi.org/10.1182/blood-2019-123680

Published: 2019

Journal Articles

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

Youmna Kfoury, PhD, Fei Ji, Michael Mazzola, BS, David B Sykes, MD PhD, Anselmo Anthony, Yasutoshi Akiyama, Allison Scherer, PhD, Francois Mercier, MD FRCPC, Nicolas Severe, PhD, Borja Saez, Jefferson Seidl, BA, Ani Papazian, BS, Thomas Brouse, Michael K Mansour, MD PhD, Pavel Ivanov, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2019) 134 (Supplement_1): 1207.

https://doi.org/10.1182/blood-2019-124794

Published: 2019

Journal Articles

Loss of FLT3 Sensitizes Myeloid Cells to Differentiation Via DHODH Inhibition

Amy N Sexauer, MD PhD, Brian Do, David B Sykes, MD PhD

Blood (2019) 134 (Supplement_1): 2712.

https://doi.org/10.1182/blood-2019-128910

Published: 2019

Journal Articles

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Peggy P. Hsu, MD PhD, Youmna Kfoury, PhD, Najihah Aziz, Jenna Elkhoury, Brittany Hallgren, David T. Scadden, MD, Matthew Vander Heiden, MD PhD, David B Sykes, MD PhD

Blood (2018) 132 (Supplement 1): 2716.

https://doi.org/10.1182/blood-2018-99-113387

Published: 2018

Journal Articles

Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Youmna Kfoury, PhD, Esha Jain, Jason R Myers, MS, Fei Ji, David B Sykes, MD PhD, Francois Mercier, MD FRCPC, Ani Papazian, BS, Cam Le, Mark A Randolph, M.A.Sc., David P. Steensma, MD, Omar I Abdel-Wahab, MD, Laura M. Calvi, MD, Ruslan I Sadreyev, PhD, Michael W. Becker, MD, David T. Scadden, MD

Blood (2018) 132 (Supplement 1): 938.

https://doi.org/10.1182/blood-2018-99-115242

Published: 2018

Journal Articles

Osteoblastic Cell-Derived Extracellular Vesicles Transfer Small RNAs That Alter the Physiology of Hematopoietic Cells In Vivo

Youmna Kfoury, PhD, Anthony Anselmo, PhD, Jefferson Seidl, BA, Ani Papazian, BS, Francois Mercier, MD FRCPC, David B Sykes, MD PhD, Nicolas Severe, PhD, Borja Saez, PhD, Ruslan I Sadreyev, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 93.

https://doi.org/10.1182/blood.V130.Suppl_1.93.93

Published: 2017

Journal Articles

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Francois Mercier, MD, Jiantao Shi, PhD, David B Sykes, MD PhD, Elizabeth Miller, Toshihiko Oki, MD PhD, Cheuk-Him Man, PhD, Xiao-Jing Yan, MD PhD, Youmna Kfoury, PhD, Dongjun Lee, PhD, John G Doench, PhD, Franziska Michor, PhD, David T. Scadden, MD

Blood (2017) 130 (Supplement 1): 2493.

https://doi.org/10.1182/blood.V130.Suppl_1.2493.2493

Published: 2017

Journal Articles

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

David B. Sykes, MD PhD, Youmna Sami Kfoury, PhD, Francois Mercier, MD, Mathias Wawer, PhD, Amir Schajnovitz, PhD, Hanna Meyer, PhD, Kerry A Pierce, PhD, Detlef Stoeckigt, PhD, Clary B Clish, PhD, Paul A Clemons, PhD, Andreas Janzer, PhD, David T. Scadden, MD

Blood (2016) 128 (22): 1656.

https://doi.org/10.1182/blood.V128.22.1656.1656

Published: 2016

Journal Articles

Neutrophils Derived from Ezh2 -/- Progenitor Cells Demonstrate Aberrant Erythroid Lineage Gene Expression

Albert Perez-Ladaga, PhD, Huafeng Xie, PhD, Stuart H. Orkin, MD, David B. Sykes, MD PhD, Benjamin L. Ebert, MD PhD, Rafael Bejar, MDPhD

Blood (2015) 126 (23): 4112.

https://doi.org/10.1182/blood.V126.23.4112.4112

Published: 2015

Journal Articles

Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation

Rahul Palchaudhuri, PhD, Borja Saez, PhD, Jonathan Hoggatt, PhD, Amir Schajnovitz, David B. Sykes, MD PhD, Michael K Mansour, MD PhD, David T. Scadden, MD

Blood (2015) 126 (23): 32.

https://doi.org/10.1182/blood.V126.23.32.32

Published: 2015

Journal Articles

Differentiation Induction In Acute Myeloid Leukemia Using Site-Specific DNA-Targeting

Rahul Palchaudhuri, PhD, Kwan-Keat Ang, Borja Saez, PhD, David B. Sykes, MD, PhD, Gregory L. Verdine, PhD, David T. Scadden, MD

Blood (2013) 122 (21): 3940.

https://doi.org/10.1182/blood.V122.21.3940.3940

Published: 2013

NARROW

AML Stem Cell Clearance By Inhibiting Selenoprotein Biosynthesis That Causes Cgas-Sting Activation and Ferroptosis

The TEMPI Syndrome: A Monoclonal Gammopathy of Clinical Significance Driving Erythropoietin Production

CDK9 Inhibition Sensitizes TP53 Mutated AML to Standard Chemotherapy

Characterizing Thrombotic Risk in TEMPI Syndrome: A Retrospective Case Series

Limited plasticity of monocyte fate and function associated with epigenetic scripting at the level of progenitors

Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

The TEMPI syndrome

Functionally Distinct Subsets of Monocytes in Mouse and Human Blood

What Links Neutropenia to Immature Cardiolipin in Patients with Barth Syndrome (tafazzin-deficiency)?

Niche Transfer of Small Non-Coding RNAs Regulates Hematopoietic Response to Stress

Loss of FLT3 Sensitizes Myeloid Cells to Differentiation Via DHODH Inhibition

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells

Osteoblastic Cell-Derived Extracellular Vesicles Transfer Small RNAs That Alter the Physiology of Hematopoietic Cells In Vivo

A Genome-Wide, In Vivo, Dropout CRISPR Screen in Acute Myeloid Leukemia Identifies an Essential Role for Beta-Galactosylation in Leukemic Cell Homing

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Neutrophils Derived from Ezh2 -/- Progenitor Cells Demonstrate Aberrant Erythroid Lineage Gene Expression

Immunotoxin Enables Non-Genotoxic Conditioning for Hematopoietic Stem Cell Transplantation

Differentiation Induction In Acute Myeloid Leukemia Using Site-Specific DNA-Targeting

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American Society of Hematology

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ASH Publications

American Society of Hematology

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