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David B. Miklos
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Journal Articles

Outcomes of patients with large B-cell lymphoma progressing after axicabtagene ciloleucel therapy

Clinical Trials & Observations
Jay Y. Spiegel, Saurabh Dahiya, Michael D. Jain, John Tamaresis, Loretta J. Nastoupil, Miriam T. Jacobs, Armin Ghobadi, Yi Lin, Matthew Lunning, Lazaros Lekakis, Patrick Reagan, Olalekan Oluwole, Joseph McGuirk, Abhinav Deol, Andre Goy, Khoan Vu, Charalambos Andreadis, Javier Munoz, N. Nora Bennani, Julie M. Vose, Kathleen A. Dorritie, Sattva S. Neelapu, Frederick L. Locke, Aaron P. Rapoport, Brian T. Hill, David B. Miklos
Journal: Blood
Blood (2021) 137 (13): 1832–1835.
DOI: https://doi.org/10.1182/blood.2020006245
Published: 2021
Includes: Supplemental data
Journal Articles

CD22-Directed CAR T-Cell Therapy Induces Complete Remissions in CD19-Directed CAR-Refractory Large B-Cell Lymphoma

Clinical Trials & Observations
John H Baird, Matthew Joshua Frank, Juliana Craig, Shabnum Patel, Jay Y Spiegel, Bita Sahaf, Jean S Oak, Sheren Younes, Michael Ozawa, Eric Yang, Yasodha Natkunam, John S Tamaresis, Zachary Ehlinger, Warren D Reynolds, Sally Arai, Laura Johnston, Robert Lowsky, Everett Meyer, Robert S. Negrin, Andrew R. Rezvani, Parveen Shiraz, Surbhi Sidana, Wen-Kai Weng, Kara L. Davis, Sneha Ramakrishna, Liora Schultz, Chelsea D. Mullins, Allison P Jacob, Ilan R Kirsch, Steven A Feldman, Crystal L Mackall, David B Miklos, Lori Muffly
Journal: Blood
Blood blood.2020009432.
DOI: https://doi.org/10.1182/blood.2020009432
Published: 2020
Includes: Supplemental data
Journal Articles

CD22-Directed CAR T-Cell Therapy Mediates Durable Complete Responses in Adults with Relapsed or Refractory Large B-Cell Lymphoma after Failure of CD19-Directed CAR T-Cell Therapy and High Response Rates in Adults with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia

John H. Baird, MD, Matthew J. Frank, MD PhD, Juliana Craig, BA, Shabnum Patel, PhD, Jay Y. Spiegel, MDFRCPC, Bita Sahaf, PhD, Sheren F. Younes, MD PhD, Jean S. Oak, MD PhD, Yasodha Natkunam, MD PhD, Zachary Ehlinger, MS, Warren D. Reynolds, BS, Sally Arai, MD MS, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Parveen Shiraz, MD, Surbhi Sidana, MD, Wen-Kai Weng, MD PhD, Liora M. Schultz, MD, Sneha Ramakrishna, MD, Kara L Davis, DO, Steven A. Feldman, PhD, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Lori S. Muffly, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
DOI: https://doi.org/10.1182/blood-2020-139087
Published: 2020
Journal Articles

Orca-T, a Precision Treg-Engineered Donor Product, Prevents Acute Gvhd with Less Immunosuppression in an Early Multicenter Experience with Myeloablative HLA-Matched Transplants

Everett H Meyer, MD PhD, Rasmus Hoeg, MD, Anna Moroz, MD PhD, Bryan Xei, BS, Hsin-Hsu Wu, MD, Rahul Pawar, Kartoosh Heydari, MD, David B. Miklos, MD PhD, Parveen Shiraz, MD, Lori S. Muffly, MD MS, Sally Arai, MD MS, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Andrew R. Rezvani, MD, Judith A Shizuru, MD PhD, Wen-Kai Weng, MD PhD, Nathaniel Fernhoff, PhD, Gerhard Bauer, Arpita Gandhi, MD MS, Amy Putnam, J. Scott Scott McClellan, MDPhD, Bronwen E. Shaw, PhD MRCP, FRCPath, Joseph P. McGuirk, DO, Mehrdad Abedi, MD, Robert S. Negrin, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 47–48.
DOI: https://doi.org/10.1182/blood-2020-142974
Published: 2020
Journal Articles

Outcomes of Patients (Pts) in ZUMA-9, a Multicenter, Open-Label Study of Axicabtagene Ciloleucel (Axi-Cel) in Relapsed/Refractory Large B Cell Lymphoma (R/R LBCL) for Expanded Access and Commercial Out-of-Specification (OOS) Product

Caron A. Jacobson, MD, Frederick L. Locke, MD, David B. Miklos, MD PhD, Julie M. Vose, MD MBA, Yi Lin, MD PhD, Lihua E Budde, MD PhD, David G. Maloney, MD PhD, Samantha Jaglowski, MD MPH, Peter A. Riedell, MD, Lazaros J. Lekakis, MD, Miguel-Angel Perales, MD, Jenny J. Kim, MD MS, Jun Kawashima, MD, Yin Yang, MS, John M. Rossi, MS, Lovely Goyal, PhD, Sattva S. Neelapu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
DOI: https://doi.org/10.1182/blood-2020-136136
Published: 2020
Journal Articles

Bleeding and Thrombosis Are Associated with Endothelial Dysfunction in CAR-T Cell Therapy and Are Increased in Patients Experiencing Neurologic Toxicity

Andrew Johnsrud, MD, Juliana Craig, BA, John H. Baird, MD, Jay Y. Spiegel, MDFRCPC, Lori S. Muffly, MD MS, James Zehnder, MD, Robert S. Negrin, MD, Laura J. Johnston, MD, Sally Arai, MD MS, Judith A Shizuru, MD PhD, Robert Lowsky, MD FRCP, Everett H Meyer, MD PhD, Wen-Kai Weng, MD PhD, Parveen Shiraz, MD, Andrew R. Rezvani, MD, Theresa Latchford, RN, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Matthew J. Frank, MD PhD, Surbhi Sidana, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
DOI: https://doi.org/10.1182/blood-2020-142218
Published: 2020
Journal Articles

Profiling T-Cell Receptor Diversity and Dynamics during Lymphoma Immunotherapy Using Cell-Free DNA (cfDNA)

Navika D Shukla, Alexander F. M. Craig, MPhil, Brian Sworder, MD PhD, David M. Kurtz, MDPhD, Charles Macaulay, MSc, BA, Andrea Garofalo, BS, BA, Matthew J. Frank, MD PhD, Stefan Alig, MD, George Duran, BA, Youn H. Kim, MD, James Zehnder, MD, Crystal L. Mackall, MD, David B. Miklos, MD PhD, Maximilian Diehn, MD PhD, Michael S. Khodadoust, MD PhD, Ash A. Alizadeh, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 49–50.
DOI: https://doi.org/10.1182/blood-2020-141655
Published: 2020
Journal Articles

Survival Following Post-HCT Relapse in Adult Acute Lymphoblastic Leukemia Has Improved in the Era of Novel Immunotherapies: A Single Institution Analysis

Juliana Craig, BA, Maria Iglesias, BS, Kristen Cunanan, PhD, Sally Arai, MD MS, Matthew J. Frank, MD PhD, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Everett H Meyer, MD PhD, David B. Miklos, MD PhD, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Judith A Shizuru, MD PhD, Surbhi Sidana, MD, W-K Weng, MD PhD, Parveen Shiraz, MD, Lori S. Muffly, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 48–49.
DOI: https://doi.org/10.1182/blood-2020-141489
Published: 2020
Journal Articles

CD58 Aberrations Limit Durable Responses to CD19 CAR in Large B Cell Lymphoma Patients Treated with Axicabtagene Ciloleucel but Can be Overcome through Novel CAR Engineering

Robbie G. Majzner, MD, Matthew J. Frank, MD PhD, Christopher Mount, MD PhD, Aidan Tousley, David M. Kurtz, MDPhD, Brian Sworder, MD PhD, Katherine A Murphy, Antigoni Manousopoulou, Kennedy Kohler, Maria Caterina Rotiroti, PhD, Jay Y. Spiegel, MDFRCPC, Yasodha Natkunam, MD PhD, Sheren F. Younes, MD PhD, Elena Sotillo, PhD, Vandon Duong, Charles Macaulay, MSc, BA, Zinaida Good, PhD, Peng Xu, MD, Louai Labanieh, Leo D Wang, MD PhD, Ash A. Alizadeh, MD PhD, Michelle Monje, MD PhD, David B. Miklos, MD PhD, Crystal L. Mackall, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 53–54.
DOI: https://doi.org/10.1182/blood-2020-139605
Published: 2020
Journal Articles

Outcomes after Autologous Stem Cell Transplant in Patients with Relapsed Multiple Myeloma

Christopher Lemieux, MD, Juliana Craig, BA, David Iberri, MD, Sally Arai, MD MS, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Lori S. Muffly, MD MS, Parveen Shiraz, MD, Michaela Liedtke, MD, Andrew R. Rezvani, MD, Matthew J. Frank, MD PhD, Wen-Kai Weng, MD PhD, Everett H Meyer, MD PhD, Judith A Shizuru, MD PhD, Robert S. Negrin, MD, David B. Miklos, MD PhD, Surbhi Sidana, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
DOI: https://doi.org/10.1182/blood-2020-137091
Published: 2020
Journal Articles

Monitoring Measurable Residual Disease Using Peripheral Blood in Acute Lymphoblastic Leukemia: Results of a Prospective, Observational Study

Lori S. Muffly, MD MS, Vandana Sundaram, MPH, Connie Chen, Ilana Yurkiewicz, MD BS, Eric Kuo, Sarah Burnash, Jay Y. Spiegel, MDFRCPC, Kelly Chyan, Sally Arai, MD MS, Matthew J. Frank, MD PhD, Laura J. Johnston, MD, Robert Lowsky, MD FRCP, Everett H Meyer, MD PhD, Robert S. Negrin, MD, Andrew R. Rezvani, MD, Surbhi Sidana, MD, Parveen Shiraz, MD, Judith A Shizuru, MD PhD, Wen-Kai Weng, MD PhD, Michaela Liedtke, MD, Hyma T. Vempaty, MD, David B. Miklos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
DOI: https://doi.org/10.1182/blood-2020-138988
Published: 2020
Journal Articles

Long-Term Survival and Gradual Recovery of B Cells in Patients with Refractory Large B Cell Lymphoma Treated with Axicabtagene Ciloleucel (Axi-Cel)

Caron Jacobson, MD MMSc, Frederick L. Locke, MD, Armin Ghobadi, MD, David B. Miklos, MD PhD, Lazaros J. Lekakis, MD, Olalekan O. Oluwole, MBBS, MPH, Yi Lin, MD PhD, Ira Braunschweig, MD, Brian T. Hill, MD, John M. Timmerman, MD, Abhinav Deol, MD, Patrick M. Reagan, MD, Patrick J. Stiff, MD, Ian W. Flinn, MD PhD, Umar Farooq, MD, Andre H. Goy, MD, Peter A. McSweeney, MD, Javier Munoz, MD, Tanya Siddiqi, MD, John M. Rossi, MS, Adrian Bot, MD PhD, Lianqing Zheng, PhD, Remus Vezan, MD PhD, Zahid Bashir, MBBS, Jenny J. Kim, MD MS, Rong Chu, PhD, Sattva S. Neelapu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–42.
DOI: https://doi.org/10.1182/blood-2020-134362
Published: 2020
Journal Articles

One-Year Follow-up of ZUMA-2, the Multicenter, Registrational Study of KTE-X19 in Patients with Relapsed/Refractory Mantle Cell Lymphoma

Michael Wang, MD, Javier Munoz, MD, Andre H. Goy, MD, Frederick L. Locke, MD, Caron A. Jacobson, MD, Brian T. Hill, MD, John M. Timmerman, MD, Houston Holmes, Samantha Jaglowski, MD MPH, Ian W. Flinn, MD PhD, Peter A. McSweeney, MD, David B. Miklos, MD PhD, John M. Pagel, MD PhD, Marie José Kersten, MD PhD, Noel Milpied, Henry C.H. Fung, MD, Max S. Topp, MD, Roch Houot, MD PhD, Amer Beitinjaneh, MD MPH, MSc, Weimin Peng, PhD, Lianqing Zheng, PhD, John M. Rossi, MS, Swaminathan Murugappan, MD PhD, Ioana Kloos, MD, Patrick M. Reagan, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 20–22.
DOI: https://doi.org/10.1182/blood-2020-136382
Published: 2020
Journal Articles

Outcomes after Second Allogeneic Transplantation and Donor Lymphocyte Infusion for Relapse after a First Allogeneic Transplant

Christopher Lemieux, MD, Lori S. Muffly, MD MS, Sally Arai, MD MS, Andrew R. Rezvani, MD, Surbhi Sidana, MD, Laura J. Johnston, MD, Wen-Kai Weng, MD PhD, Parveen Shiraz, MD, Matthew J. Frank, MD PhD, Everett H Meyer, MD PhD, Judith A Shizuru, MD PhD, David B. Miklos, MD PhD, Robert S. Negrin, MD, Robert Lowsky, MD FRCP
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
DOI: https://doi.org/10.1182/blood-2020-134250
Published: 2020
Journal Articles

Long-Term Outcomes of Patients with Peripheral T-Cell Lymphoma after Autologous Hematopoietic Cell Transplantation

Olivier Veilleux, MD, Francisco Socola, MD, Sally Arai, MD MS, Robert Lowsky, MD FRCP, Judith A Shizuru, MD PhD, Parveen Shiraz, MD, Lori S. Muffly, MD MS, Laura J. Johnston, MD, Matthew J. Frank, MD PhD, Surbhi Sidana, MD, Everett H Meyer, MD PhD, Andrew R. Rezvani, MD, David B. Miklos, MD PhD, Robert S. Negrin, MD, Wen-Kai Weng, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
DOI: https://doi.org/10.1182/blood-2020-136493
Published: 2020
Journal Articles

Molecular Imaging of Chimeric Antigen Receptor T Cells By ICOS-Immunopet

Federico Simonetta, MD PhD, Israt S. Alam, PhD, Juliane K. Lohmeyer, MD, Bita Sahaf, PhD, Zinaida Good, PhD, Weiyu Chen, PhD, Zunyu Xiao, MD PhD, Toshihito Hirai, MD PhD, Lukas Scheller, MD, Pujan Engels, M.Sc., Ophir Vermesh, MD PhD, Elise Robinson, Tom Haywood, PhD, Ataya Sathirachindra, Jeanette Baker, Meena B. Malipatlolla, Liora M. Schultz, MD, Jay Y. Spiegel, MDFRCPC, Jason T. Lee, PhD, David B. Miklos, MD PhD, Crystal L. Mackall, MD, Sanjiv S. Gambhir, MD PhD, Robert S. Negrin, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
DOI: https://doi.org/10.1182/blood-2020-136331
Published: 2020
Journal Articles

Outcomes of older patients in ZUMA-1, a pivotal study of axicabtagene ciloleucel in refractory large B-cell lymphoma

Clinical Trials & Observations
Sattva S. Neelapu, Caron A. Jacobson, Olalekan O. Oluwole, Javier Munoz, Abhinav Deol, David B. Miklos, Nancy L. Bartlett, Ira Braunschweig, Yizhou Jiang, Jenny J. Kim, Lianqing Zheng, John M. Rossi, Frederick L. Locke
Journal: Blood
Blood (2020) 135 (23): 2106–2109.
DOI: https://doi.org/10.1182/blood.2019004162
Published: 2020
Includes: Supplemental data
Journal Articles

A Comparison of Two-Year Outcomes in ZUMA-1 (Axicabtagene Ciloleucel) and SCHOLAR-1 in Patients with Refractory Large B Cell Lymphoma

Sattva S Neelapu, MD, Frederick L. Locke, MD, Nancy L Bartlett, MD, Lazaros J Lekakis, MD, Patrick M Reagan, MD, David B. Miklos, MD PhD, Caron A. Jacobson, MD MMSc, Ira Braunschweig, MD, Olalekan O. Oluwole, MBBS, MPH, Tanya Siddiqi, MD, Yi Lin, MD PhD, Michael Crump, MD, John Kuruvilla, MD, Eric Van Den Neste, MD, Umar Farooq, MD, Lynn Navale, MS, Venita DePuy, PhD, Jenny J. Kim, MD MS, Christian Gisselbrecht, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4095.
DOI: https://doi.org/10.1182/blood-2019-125792
Published: 2019
Journal Articles

ZUMA-11: A Phase 1/2 Multicenter Study of Axicabtagene Ciloleucel (Axi-Cel) + Utomilumab Patients with Refractory Large B Cell Lymphoma

Ran Reshef, MDMSc, David B. Miklos, MD PhD, John M. Timmerman, MD, Caron A. Jacobson, MD MMSc, Nabila N. Bennani, MD, John M. Rossi, MS, Marika Sherman, MS, Lianqing Zheng, PhD, Jennifer Sun, MS, Gabrielle Palluconi, BS, Jenny J. Kim, MD MS, Michael D. Jain, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4084.
DOI: https://doi.org/10.1182/blood-2019-123772
Published: 2019
Journal Articles

Ibrutinib for Chronic Pulmonary Graft-Versus-Host-Disease after Progression on Prior Therapy

Surbhi Singhal, MD, Theresa Brondstetter, RN, David B. Miklos, MD PhD, Debra Kate Tierney, RN, PhD, Joe Hsu, MD, Laveena Chhatwani, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4532.
DOI: https://doi.org/10.1182/blood-2019-129171
Published: 2019