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Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL
Sean D. Reiff, Elizabeth M. Muhowski, Daphne Guinn, Amy Lehman, Catherine A. Fabian, Carolyn Cheney, Rose Mantel, Lisa Smith, Amy J. Johnson, Wendy B. Young, Adam R. Johnson, Lichuan Liu, John C. Byrd, Jennifer A. Woyach
Blood (2018) 132 (10): 1039–1049.
the Development and Expansion of Resistant Subclones Precedes Relapse during Ibrutinib Therapy in Patients with CLL
Jennifer A. Woyach, MD, Daphne Guinn, PhD, Amy S. Ruppert, MAS, James S. Blachly, MD, Arletta Lozanski, MS, Nyla A. Heerema, PhD, Weiqiang Zhao, MD PhD, Joshua Coleman, MD, Daniel Jones, Lynne V. Abruzzo, MD PhD, Amber Gordon, MLS, Rose Mantel, Lisa L. Smith, MS, Samantha McWhorter, Melanie Davis, PhD, Tzyy-Jye Doong, PhD, Fan Ny, CNP, Margaret S. Lucas, PA-C, Weihong Chase, CNP, Jeffrey Jones, MD MPH, Joseph M. Flynn, DO, MPH, Kami J. Maddocks, MD, Samantha Jaglowski, MD MPH, Leslie A. Andritsos, MD, Farrukh T. Awan, Kristie Blum, MD, Michael R. Grever, MD, Gerard Lozanski, MD, John C. Byrd, MD, Amy J. Johnson, PhD
Blood (2016) 128 (22): 55.
Exploring the Functional Relevance of BTK Beyond Chronic Lymphocytic Leukemia (CLL) Cells: BTK Expression in Non-Malignant Immune Cells of the Microenvironment Mediates CLL Development and Progression In Vivo
Fabienne McClanahan, MD PhD, Sean D. Reiff, Daphne Guinn, PhD, Minh Tran, Larry Beaver, Samantha McWorther, Rose Mantel, Lisa L. Smith, MS, Amy J. Johnson, PhD, John C. Byrd, MD, Jennifer A. Woyach, MD
Blood (2016) 128 (22): 352.
Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia
Zachary A. Hing, Rose Mantel, Kyle A. Beckwith, Daphne Guinn, Erich Williams, Lisa L. Smith, Katie Williams, Amy J. Johnson, Amy M. Lehman, John C. Byrd, Jennifer A. Woyach, Rosa Lapalombella
Blood (2015) 125 (20): 3128–3132.
Includes: Supplemental data
Pharmacologic Inhibition with Duvelisib (IPI-145) and Genetic Inhibition of PI3K p110δ Antagonizes Intrinsic and Extrinsic Survival Signals in Chronic Lymphocytic Leukemia (CLL)
Shuai Dong, MS, Daphne Guinn, Jason A Dubovsky, PhD, Yiming Zhong, PhD, Amy Lehman, Jeff Kutok, MD, PhD, Jennifer A. Woyach, MD, John C. Byrd, MD, Amy J. Johnson, PhD
Blood (2014) 124 (21): 3324.
Mir-155 Expression Is Associated with Chemoimmunotherapy Outcome and Is Modulated By Bruton’s Tyrosine Kinase Inhibition with Ibrutinib
Daphne Guinn, Amy S. Ruppert, MAS, Kami J. Maddocks, MD, Samantha Jaglowski, MD MPH, Amber L. Gordon, Thomas S. Lin, MD PhD, Richard A. Larson, Guido Marcucci, MD, Erin K Hertlein, PhD, Jennifer A. Woyach, MD, Amy J. Johnson, PhD, John C. Byrd, MD
Blood (2014) 124 (21): 3297.
Shuai Dong, Daphne Guinn, Jason A. Dubovsky, Yiming Zhong, Amy Lehman, Jeffery Kutok, Jennifer A. Woyach, John C. Byrd, Amy J. Johnson
Blood (2014) 124 (24): 3583–3586.
Includes: Supplemental data