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Daphne Guinn
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Journal Articles

Noncovalent inhibition of C481S Bruton tyrosine kinase by GDC-0853: a new treatment strategy for ibrutinib-resistant CLL

Sean D. Reiff, Elizabeth M. Muhowski, Daphne Guinn, Amy Lehman, Catherine A. Fabian, Carolyn Cheney, Rose Mantel, Lisa Smith, Amy J. Johnson, Wendy B. Young, Adam R. Johnson, Lichuan Liu, John C. Byrd, Jennifer A. Woyach
Journal: Blood
Blood (2018) 132 (10): 1039–1049.
DOI: https://doi.org/10.1182/blood-2017-10-809020
Published: 2018
Journal Articles

the Development and Expansion of Resistant Subclones Precedes Relapse during Ibrutinib Therapy in Patients with CLL

Jennifer A. Woyach, MD, Daphne Guinn, PhD, Amy S. Ruppert, MAS, James S. Blachly, MD, Arletta Lozanski, MS, Nyla A. Heerema, PhD, Weiqiang Zhao, MD PhD, Joshua Coleman, MD, Daniel Jones, Lynne V. Abruzzo, MD PhD, Amber Gordon, MLS, Rose Mantel, Lisa L. Smith, MS, Samantha McWhorter, Melanie Davis, PhD, Tzyy-Jye Doong, PhD, Fan Ny, CNP, Margaret S. Lucas, PA-C, Weihong Chase, CNP, Jeffrey Jones, MD MPH, Joseph M. Flynn, DO, MPH, Kami J. Maddocks, MD, Samantha Jaglowski, MD MPH, Leslie A. Andritsos, MD, Farrukh T. Awan, Kristie Blum, MD, Michael R. Grever, MD, Gerard Lozanski, MD, John C. Byrd, MD, Amy J. Johnson, PhD
Journal: Blood
Blood (2016) 128 (22): 55.
DOI: https://doi.org/10.1182/blood.V128.22.55.55
Published: 2016
Journal Articles

Exploring the Functional Relevance of BTK Beyond Chronic Lymphocytic Leukemia (CLL) Cells: BTK Expression in Non-Malignant Immune Cells of the Microenvironment Mediates CLL Development and Progression In Vivo

Fabienne McClanahan, MD PhD, Sean D. Reiff, Daphne Guinn, PhD, Minh Tran, Larry Beaver, Samantha McWorther, Rose Mantel, Lisa L. Smith, MS, Amy J. Johnson, PhD, John C. Byrd, MD, Jennifer A. Woyach, MD
Journal: Blood
Blood (2016) 128 (22): 352.
DOI: https://doi.org/10.1182/blood.V128.22.352.352
Published: 2016
Journal Articles

Selinexor is effective in acquired resistance to ibrutinib and synergizes with ibrutinib in chronic lymphocytic leukemia

Brief Report
Zachary A. Hing, Rose Mantel, Kyle A. Beckwith, Daphne Guinn, Erich Williams, Lisa L. Smith, Katie Williams, Amy J. Johnson, Amy M. Lehman, John C. Byrd, Jennifer A. Woyach, Rosa Lapalombella
Journal: Blood
Blood (2015) 125 (20): 3128–3132.
DOI: https://doi.org/10.1182/blood-2015-01-621391
Published: 2015
Includes: Supplemental data
Journal Articles

Pharmacologic Inhibition with Duvelisib (IPI-145) and Genetic Inhibition of PI3K p110δ Antagonizes Intrinsic and Extrinsic Survival Signals in Chronic Lymphocytic Leukemia (CLL)

Shuai Dong, MS, Daphne Guinn, Jason A Dubovsky, PhD, Yiming Zhong, PhD, Amy Lehman, Jeff Kutok, MD, PhD, Jennifer A. Woyach, MD, John C. Byrd, MD, Amy J. Johnson, PhD
Journal: Blood
Blood (2014) 124 (21): 3324.
DOI: https://doi.org/10.1182/blood.V124.21.3324.3324
Published: 2014
Journal Articles

Mir-155 Expression Is Associated with Chemoimmunotherapy Outcome and Is Modulated By Bruton’s Tyrosine Kinase Inhibition with Ibrutinib

Daphne Guinn, Amy S. Ruppert, MAS, Kami J. Maddocks, MD, Samantha Jaglowski, MD MPH, Amber L. Gordon, Thomas S. Lin, MD PhD, Richard A. Larson, Guido Marcucci, MD, Erin K Hertlein, PhD, Jennifer A. Woyach, MD, Amy J. Johnson, PhD, John C. Byrd, MD
Journal: Blood
Blood (2014) 124 (21): 3297.
DOI: https://doi.org/10.1182/blood.V124.21.3297.3297
Published: 2014
Journal Articles

IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells

Brief Report
Shuai Dong, Daphne Guinn, Jason A. Dubovsky, Yiming Zhong, Amy Lehman, Jeffery Kutok, Jennifer A. Woyach, John C. Byrd, Amy J. Johnson
Journal: Blood
Blood (2014) 124 (24): 3583–3586.
DOI: https://doi.org/10.1182/blood-2014-07-587279
Published: 2014
Includes: Supplemental data