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Journal Articles

Genome-Wide CRISPR Screening Identifies MAPK and Mtorc Pathways As Regulators of Sorafenib Resistance in Acute Myeloid Leukemia

Alisa Damnernsawad, PhD, Tamilla Nechiporuk, PhD, Daniel Bottomly, MS, Stephen E Kurtz, PhD, Christopher A. Eide, Shannon K. McWeeney, PhD, Jeffrey W. Tyner
Blood (2019) 134 (Supplement_1): 2557.
DOI: https://doi.org/10.1182/blood-2019-128877
Published: 2019
Journal Articles

Framework to Identify and Prioritize Candidate Inherited Myeloid Malignancy Germline Variants Leveraging the BEAT AML Cohort

Daniel Bottomly, Nicola Long, Fei Yang, MD, Tiffany Lee, MD, Uma Borate, MD, Beth Wilmot, PhD, Adam S DuVall, MD, Andrea Monteblanco, BS, Karina Thiel-Klare, Gabby Dewson, BA, Richard D. Press, MD PhD, Cristina E. Tognon, Brian J. Druker, Jeffrey W. Tyner, Shannon K. McWeeney, PhD, Anupriya Agarwal, PhD
Blood (2019) 134 (Supplement_1): 1407.
DOI: https://doi.org/10.1182/blood-2019-132224
Published: 2019
Journal Articles

Genome-Wide CRISPR Screening in Acute Myeloid Leukemia Cells Identifies Genes in the PI3K/AKT/mTOR and MEK/ERK Pathways That Define Sensitivity to Trametinib

Tamilla Nechiporuk, PhD, Alisa Damnernsawad, PhD, Daniel Bottomly, MS, Quinlan Morrow, BS, Suyoun Choi, Sofia Beer, Stephen E Kurtz, PhD, Shannon K. McWeeney, PhD, Jeffrey W. Tyner
Blood (2019) 134 (Supplement_1): 1395.
DOI: https://doi.org/10.1182/blood-2019-129117
Published: 2019
Journal Articles

Genomic landscape of neutrophilic leukemias of ambiguous diagnosis

Haijiao Zhang, Beth Wilmot, Daniel Bottomly, Kim-Hien T. Dao, Emily Stevens, Christopher A. Eide, Vishesh Khanna, Angela Rofelty, Samantha Savage, Anna Reister Schultz, Nicola Long, Libbey White, Amy Carlos, Rachel Henson, Chenwei Lin, Robert Searles, Robert H. Collins, Daniel J. DeAngelo, Michael W. Deininger, Tamara Dunn, Than Hein, Marlise R. Luskin, Bruno C. Medeiros, Stephen T. Oh, Daniel A. Pollyea, David P. Steensma, Richard M. Stone, Brian J. Druker, Shannon K. McWeeney, Julia E. Maxson, Jason R. Gotlib, Jeffrey W. Tyner
Blood (2019) 134 (11): 867–879.
DOI: https://doi.org/10.1182/blood.2019000611
Published: 2019
Journal Articles

Biomarkers Predicting Venetoclax Sensitivity and Strategies for Venetoclax Combination Treatment

Haijiao Zhang, Beth Wilmot, PhD, Daniel Bottomly, Stephen E Kurtz, PhD, Christopher A. Eide, Alisa Damnernsawad, Kyle Romine, Shyam Patel, Brian J. Druker, MD, Schannon K Mcweeney, Ravi Majeti, MD PhD, Jeffrey W. Tyner, PhD
Blood (2018) 132 (Supplement 1): 175.
DOI: https://doi.org/10.1182/blood-2018-175
Published: 2018
Journal Articles

Differential Ex Vivo Sensitivity Patterns to Small-Molecule Inhibitors and Combination Therapies Among Acute Myeloid Leukemia Patients Harboring Both FLT3 and NPM1 Mutations

Christopher A. Eide, Stephen E Kurtz, PhD, Andy Kaempf, Andrew Park, Angela Rofelty, Beth Wilmot, PhD, Daniel Bottomly, Shannon K. McWeeney, PhD, Cristina E. Tognon, PhD, Motomi Mori, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD
Blood (2017) 130 (Supplement 1): 1422.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1422.1422
Published: 2017
Journal Articles

Therapeutically Targetable Activating c-ABL1 Mutations in Philadelphia Chromosome-Negative Leukemias

Samantha L Savage, Julia E. Maxson, PhD, Christopher A. Eide, Chelsea Jenkins, B.S., Melissa L Abel, Anna M. Reister Schultz, Daniel Bottomly, Beth Wilmot, PhD, Shannon Mcweeney, PhD, Cristina E. Tognon, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD
Blood (2017) 130 (Supplement 1): 3930.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.3930.3930
Published: 2017
Journal Articles

Coexisting Oncogenic Signaling Pathway Mutations in Cnl/Acml/CMML/MPN-U

Haijiao Zhang, Daniel Bottomly, Libbey K. White, Beth Wilmot, PhD, Shannon Mcweeney, PhD, Jeffrey W. Tyner, PhD
Blood (2017) 130 (Supplement 1): 4213.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.4213.4213
Published: 2017
Journal Articles

High-Throughput Validation of Mutations Identified in Primary Leukemia Cells

Michelle Degnin, BASc, Cristina E. Tognon, Christopher A. Eide, Beth Wilmot, Shannon K. McWeeney, Daniel Bottomly, Rebecca Smith, BASc, Brian J. Druker
Blood (2016) 128 (22): 4725.
DOI: https://doi.org/10.1182/blood.V128.22.4725.4725
Published: 2016
Journal Articles

Characterization of the Genomic Landscape of BCR-ABL1 Kinase-Independent Mechanisms of Resistance to ABL1 Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia

Christopher A. Eide, Daniel Bottomly, Samantha L. Savage, Libbey White, Beth Wilmot, Anna M. Reister Schultz, Kimberly A. Uchida, Anupriya Agarwal, Elie Traer, MD, Lan Beppu, Olga Sala-Torra, Jerald P. Radich, Garrett Eickelberg, Richard D. Press, Marc M. Loriaux, Srinivas K. Tantravahi, MD, Anthony D. Pomicter, MS, Matthew S. Zabriskie, Michael W. Deininger, MD PhD, Thomas O'Hare, PhD, Jeffrey W. Tyner, Shannon K. McWeeney, Cristina E. Tognon, Brian J. Druker
Blood (2016) 128 (22): 1119.
DOI: https://doi.org/10.1182/blood.V128.22.1119.1119
Published: 2016
Journal Articles

Recurrent Pathogenic Cyclin D2 Mutations in Myeloid Malignancies

Vishesh Khanna, BS, Christopher A. Eide, Cristina E. Tognon, Julia E. Maxson, PhD, Beth Wilmot, Daniel Bottomly, Shannon K. McWeeney, Brian J. Druker, MD, Jeffrey W. Tyner
Blood (2016) 128 (22): 2734.
DOI: https://doi.org/10.1182/blood.V128.22.2734.2734
Published: 2016
Journal Articles

Definition of the Minimal Truncated Elements Necessary for CSF3R Leukemogenic Potential

Haijiao Zhang, MD, Anna Reister Schultz, B.S., Samuel B Luty, BS, Sophie Means, B.S., Larry David, PhD, John Klimek, B.S., Daniel Bottomly, Beth Wilmot, Shannon McWeeney, PhD, Yulong Su, B.S., Jeffrey W. Tyner
Blood (2016) 128 (22): 2735.
DOI: https://doi.org/10.1182/blood.V128.22.2735.2735
Published: 2016
Journal Articles

Broad Activity of Apto-253 in AML and Other Hematologic Malignancies Correlates with KLF4 Expression Level

Stephen E. Kurtz, PhD, Daniel Bottomly, MS, Beth Wilmot, PhD, Shannon K. McWeeney, PhD, William Rice, PhD, Stephen B Howell, MD, Avanish Vellanki, Brian J. Druker, MD, Jeffrey W. Tyner, PhD
Blood (2015) 126 (23): 1358.
DOI: https://doi.org/10.1182/blood.V126.23.1358.1358
Published: 2015
Journal Articles

Activating Mutations of Insulin Receptor Substrate 2 (IRS2) in Patients with Tyrosine Kinase Inhibitor-Refractory Chronic Myeloid Leukemia

Samantha L Savage, Christopher A. Eide, Kyle F Concannon, Daniel Bottomly, MS, Beth Wilmot, PhD, Shannon K. McWeeney, PhD, Julia Elizabeth Maxson, PhD, Jeffrey W. Tyner, PhD, Cristina E. Tognon, PhD, Brian J. Druker, MD
Blood (2015) 126 (23): 2461.
DOI: https://doi.org/10.1182/blood.V126.23.2461.2461
Published: 2015
Journal Articles

Exome Sequencing Informs Mechanisms of Clinical Resistance to the FLT3-D835 Inhibitor Crenolanib

Haijiao Zhang, MD, Kevin Matthew Watanabe-Smith, BS, Daniel Bottomly, MS, Beth Wilmot, PhD, Shannon K. McWeeney, PhD, Hagop M. Kantarjian, MD, Judy Ho, Jeremy Davis, Blake Pond, MS, Gautam Borthakur, MD, Abhijit Ramachandran, MS, Jorge E. Cortes, Robert Collins, MD, Jeffrey W. Tyner, PhD
Blood (2015) 126 (23): 2468.
DOI: https://doi.org/10.1182/blood.V126.23.2468.2468
Published: 2015
Journal Articles

Activating Mutations Observed in De Novo Acute Myeloid Leukemia Are Also Present in a Subset of Philadelphia Chromosome (Ph)-Positive Leukemia Patients with BCR-ABL1-Independent Resistance to ABL1 Kinase Inhibitors

Christopher A. Eide, Samantha L. Savage, Anupriya Agarwal, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Stephen E. Kurtz, Thomas O'Hare, Michael W. Deininger, Marc M. Loriaux, Cristina E. Tognon, Jeffrey W. Tyner, Brian J. Druker
Blood (2014) 124 (21): 4514.
DOI: https://doi.org/10.1182/blood.V124.21.4514.4514
Published: 2014
Journal Articles

Philadelphia Chromosome (Ph)-Positive Leukemia Patients Who Fail ABL1 Tyrosine Kinase Inhibitors Without BCR-ABL1 Kinase Domain Point Mutations Demonstrate Sensitivity To PI3-K/AKT Inhibitors

Christopher A. Eide, Samantha L. Savage, Jade Bryant, Anupriya Agarwal, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Thomas O'Hare, Michael W. Deininger, Marc M. Loriaux, Cristina E. Tognon, Jeffrey W. Tyner, Brian J. Druker
Blood (2013) 122 (21): 3994.
DOI: https://doi.org/10.1182/blood.V122.21.3994.3994
Published: 2013
Journal Articles

The CSF3R T618I Mutation Found In Chronic Neutrophilic Leukemia Removes An O-Linked Glycosylation Site and Increases Receptor Dimerization

Julia E. Maxson, PhD, Jason Gotlib, MD, MS, Daniel A. Pollyea, MD, MS, Angela G. Fleischman, MD, PhD, Anupriya Agarwal, Samuel B. Luty, BS, Melissa Abel, Christopher A. Eide, Daniel Bottomly, Beth Wilmot, Shannon K. McWeeney, Cristina E. Tognon, Robert H. Collins, Jr., MD, J. Blake Pond, M.S, Basem Goueli, M.D., Stephen T. Oh, MD, PhD, Michael W. Deininger, MD, PhD, Bill H. Chang, MD, PhD, Marc M. Loriaux, Brian J. Druker, Jeffrey W. Tyner
Blood (2013) 122 (21): 270.
DOI: https://doi.org/10.1182/blood.V122.21.270.270
Published: 2013
Journal Articles

A Truncation Mutant of CSF3R, Identified As a Novel Driver in De Novo Myeloid Leukemia, Signals Through TNK2, and Is Responsive to Dasatinib.

Julia E Maxson, PhD, Jason Gotlib, Angela G. Fleischman, MD, PhD, Christopher A. Eide, Daniel Bottomly, MS, Beth Wilmot, PhD, MS, Shannon McWeeney, PhD, Cristina Tognon, PhD, Marc M Loriaux, MD, PhD, Brian J. Druker, Jeffrey W Tyner, PhD
Blood (2012) 120 (21): 2412.
DOI: https://doi.org/10.1182/blood.V120.21.2412.2412
Published: 2012