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Journal Articles

Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration

So Gun Hong, Noriko Sato, Fanny Legrand, Manasi Gadkari, Michelle Makiya, Kindra Stokes, Katherine N. Howe, Shiqin Judy Yu, Nathaniel Seth Linde, Randall R. Clevenger, Timothy Hunt, Zonghui Hu, Peter L. Choyke, Cynthia E. Dunbar, Amy D. Klion, Luis M. Franco

Blood (2020) 136 (23): 2667–2678.

DOI: https://doi.org/10.1182/blood.2020005161

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Macaque CRISPR/Cas9 Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Mutated Clones and Applicability for Testing Mitigation Approaches

Taehoon Shin, Shirley Chen, BS, Stefan Cordes, MD PhD, Yifan Zhou, MS, Byung-Chul Lee, PhD, Aisha Aljanahi, BS, So Gun Hong, PhD, Robert E. Donahue, VMD, Kyung-Rok Yu, PhD, Cynthia E. Dunbar, MD

Blood (2020) 136 (Supplement 1): 27–28.

DOI: https://doi.org/10.1182/blood-2020-140770

Published: 2020

Journal Articles

Long-Term Eltrombopag for Bone Marrow Failure Depletes Total Body Iron

David J Young, MDPhD, Xing Fan, MD, Emma Groarke, MD, Bhavisha A Patel, MD, Ronan Desmond, MD, Thomas Winkler, MD, Andre Larochelle, MD PhD, Katherine R. Calvo, MD PhD, Neal S. Young, MD, Cynthia E. Dunbar, MD

Blood (2020) 136 (Supplement 1): 39–40.

DOI: https://doi.org/10.1182/blood-2020-141375

Published: 2020

Journal Articles

A Diamond-Blackfan Anemia Patient's Response to Eltrombopag and Genomic Analysis in Different Lineages

Xing Fan, MD, David Young, MD, Thomas Winkler, MD, Zahra Pakbaz, MD, Stephanie Sellers, Ma Evette Barranta, Cynthia E. Dunbar, MD

Blood (2020) 136 (Supplement 1): 16–17.

DOI: https://doi.org/10.1182/blood-2020-138577

Published: 2020

Journal Articles

An All Antibody Approach for Conditioning Bone Marrow for Hematopoietic Stem Cell Transplantation with Anti-cKIT and Anti-CD47 in Non-Human Primates

Kristopher D Marjon, PhD, James Y Chen, MD PhD, Jiaqi Duan, MS, Timothy S Choi, BS, Kavitha Sompalli, MS, Dongdong Feng, PhD, Ofelia Mata, Sharline Chen, B.S., Leslie Kean, MD PhD, Mwe Mwe Chao, MD, Mark Chao, MD PhD, Chris H Takimoto, MD PhD, Balaji Agoram, PhD, Cynthia E. Dunbar, MD, Ravi Majeti, MD PhD, Irving L Weissman, MD, Jie Liu, PhD MD, Jens-Peter Volkmer, MD

Blood (2019) 134 (Supplement_1): 4428.

DOI: https://doi.org/10.1182/blood-2019-131490

Published: 2019

Journal Articles

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag

Clinical Trials & Observations

Thomas Winkler, Xing Fan, James Cooper, Ronan Desmond, David J. Young, Danielle M. Townsley, Phillip Scheinberg, Sophia Grasmeder, Andre Larochelle, Marie Desierto, Janet Valdez, Jennifer Lotter, Colin Wu, Ruba N. Shalhoub, Katherine R. Calvo, Neal S. Young, Cynthia E. Dunbar

Blood (2019) 133 (24): 2575–2585.

DOI: https://doi.org/10.1182/blood.2019000478

Published: 2019

Journal Articles

CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs

Tae-Hoon Shin, Eun Jung Baek, Marcus A. F. Corat, Shirley Chen, Jean-Yves Metais, Aisha A. AlJanahi, Yifan Zhou, Robert E. Donahue, Kyung-Rok Yu, Cynthia E. Dunbar

Blood (2019) 133 (23): 2542–2545.

DOI: https://doi.org/10.1182/blood.2019000800

Published: 2019

Includes: Supplemental data

Journal Articles

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ

Luigi J. Alvarado, Heather D. Huntsman, Hai Cheng, Danielle M. Townsley, Thomas Winkler, Xingmin Feng, Cynthia E. Dunbar, Neal S. Young, Andre Larochelle

Blood (2019) 133 (19): 2043–2055.

DOI: https://doi.org/10.1182/blood-2018-11-884486

Published: 2019

Includes: Supplemental data

Journal Articles

Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome (MDS)

Alana Vicente, MD, Fernanda Gutierrez-Rodrigues, PhD, Valentina Giudice, MD, Zhijie Wu, MD PhD, Sachiko Kajigaya, PhD, Maria del Pilar Fernandez Ibanez, Maher Albitar, MD, Barbara Weinstein, RN, Katherine R. Calvo, MD PhD, Danielle M. Townsley, MDMSc, Phillip Scheinberg, MD, Cynthia E. Dunbar, MD, Neal S. Young, MD, Thomas Winkler, MD

Blood (2018) 132 (Supplement 1): 229.

DOI: https://doi.org/10.1182/blood-2018-99-119780

Published: 2018

Journal Articles

Eltrombopag for Moderate Aplastic Anemia and Unilineage Cytopenias: Dosing, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Xing Fan, MD, Thomas Winkler, MD, Ronan Desmond, MD, Bogdan Dumitriu, MD, Danielle M. Townsley, MD MSc, Maria del Pilar Fernandez Ibanez, Fernanda Gutierrez-Rodrigues, PhD, Sophia Grasmeder, RN, Ma Evette Barranta, Diane Madey, Jennifer Lotter, Janet Valdez, Katherine R. Calvo, MD PhD, Colin Wu, PhD, Neal S. Young, MD, Cynthia E. Dunbar, MD

Blood (2018) 132 (Supplement 1): 538.

DOI: https://doi.org/10.1182/blood-2018-99-112994

Published: 2018

Journal Articles

Single Cell Transcriptome Analysis of GATA2 Deficiency in Hematopoiesis Modeled with Induced Pluripotent Stem Cells

Francis Guitart, BA, Moonjung Jung, MD, Stefan Cordes, MD PhD, Shiqin Yu, Jizhong Zou, So Gun Hong, PhD, Vinh Dang, Diego A Espinoza, BA, Amy Hsu, Steven M. Holland, MD, Danielle M. Townsley, MD MSc, Cynthia E. Dunbar, MD, Thomas Winkler, MD

Blood (2018) 132 (Supplement 1): 5087.

DOI: https://doi.org/10.1182/blood-2018-99-118410

Published: 2018

Journal Articles

Intrabone Delivery of CD34+ Cells Using an Optimized Delivery System Does Not Enhance Engraftment in a Rhesus Macaque Model of Hematopoietic Stem Cell Transplantation

Blood (2018) 132 (Supplement 1): 5677.

DOI: https://doi.org/10.1182/blood-2018-99-114730

Published: 2018

Journal Articles

Towards Improved Decision-Making Based on Genomics in Bone Marrow Failure

Fernanda Gutierrez-Rodrigues, PhD, Carrie Diamond, MD, Ruba Shalhoub, André Pinto, Flávia S Donaires, PhD, Diego V Clé, MD PhD, Luiz Guilherme Darrigo, PhD, Luiz Fernando Catto, MD, Xing Fan, MD, Maria del Pilar Fernandez Ibanez, Sachiko Kajigaya, PhD, Cynthia E. Dunbar, MD, Carmem M. S. Bonfim, MD, Danielle M. Townsley, MD MSc, Rodrigo T. Calado, MD PhD, Neal S. Young, MD

Blood (2018) 132 (Supplement 1): 2587.

DOI: https://doi.org/10.1182/blood-2018-99-115026

Published: 2018

Journal Articles

Modeling Human Paroxysmal Nocturnal Hemoglobinuria Via CRISPR/Cas9 HSPC Gene Editing in Non-Human Primate

Taehoon Shin, PhD, Eun Jung Baek, MD, Marcus A.F. Corat, PhD, Shirley Chen, BS, Robert E. Donahue, VMD, Kyung-Rok Yu, PhD, Cynthia E. Dunbar, MD

Blood (2018) 132 (Supplement 1): 1309.

DOI: https://doi.org/10.1182/blood-2018-99-111984

Published: 2018

Journal Articles

Long-Term, Clonal Tracking Comparing Autologous Transplantation of G-CSF/SCF-Primed Bone Marrow CD34+ Cells with G-CSF/SCF-Mobilized Peripheral Blood CD34+ Cells in Rhesus Macaques

Sanggu Kim, PhD, Robert E. Donahue, VMD, Aylin Bonifacino, MS, Mark Metzger, Cynthia E. Dunbar, MD, Irvin Chen, PhD

Blood (2018) 132 (Supplement 1): 4524.

DOI: https://doi.org/10.1182/blood-2018-99-117047

Published: 2018

Journal Articles

Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes

Clinical Trials & Observations

Sandhya R. Panch, Michael E. Bozik, Thomas Brown, Michelle Makiya, Calman Prussin, Donald G. Archibald, Gregory T. Hebrank, Mary Sullivan, Xiaoping Sun, Lauren Wetzler, JeanAnne Ware, Michael P. Fay, Cynthia E. Dunbar, Steven I. Dworetzky, Paneez Khoury, Irina Maric, Amy D. Klion

Blood (2018) 132 (5): 501–509.

DOI: https://doi.org/10.1182/blood-2018-02-835330

Published: 2018

Includes: Supplemental data

Journal Articles

Eltrombopag mobilizes iron in patients with aplastic anemia

Clinical Trials & Observations

Zhen Zhao, Qian Sun, Lori J. Sokoll, Michael Streiff, Zhe Cheng, Sophie Grasmeder, Danielle M. Townsley, Neal S. Young, Cynthia E. Dunbar, Thomas Winkler

Blood (2018) 131 (21): 2399–2402.

DOI: https://doi.org/10.1182/blood-2018-01-826784

Published: 2018

Includes: Supplemental data

Journal Articles

The impact of aging on primate hematopoiesis as interrogated by clonal tracking

Kyung-Rok Yu, Diego A. Espinoza, Chuanfeng Wu, Lauren Truitt, Tae-Hoon Shin, Shirley Chen, Xing Fan, Idalia M. Yabe, Sandhya Panch, So Gun Hong, Samson Koelle, Rong Lu, Aylin Bonifacino, Allen Krouse, Mark Metzger, Robert E. Donahue, Cynthia E. Dunbar

Blood (2018) 131 (11): 1195–1205.

DOI: https://doi.org/10.1182/blood-2017-08-802033

Published: 2018

Includes: Supplemental data

Journal Articles

Aberrant Clonal Hematopoiesis of the Erythroid and Myeloid Lineages in a Lentivirally Barcoded Rhesus Macaque

Diego A Espinoza, BA, Chuanfeng Wu, MD, Xing Fan, MD, Di Yang, MD, Idalia Montano Yabe, MS, Selami Demirci, PhD, So Gun Hong, PhD, Aylin Bonifacino, MS, Allen Krouse, Mark Metzger, Rong Lu, PhD, Katherine R Calvo, MD PhD, John F Tisdale, MD, Xiaolin Wu, PhD, Suk See De Ravin, MD PhD, Harry L Malech, MD, Robert E Donahue, VMD, Cynthia E Dunbar, MD

Blood (2017) 130 (Supplement 1): 606.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.606.606

Published: 2017

Journal Articles

A Non-Human Primate CRISPR/Cas9 Model of Clonal Hematopoiesis of Indeterminate Potential Demonstrates Expansion of TET2-Disrupted Clones

Kyung-Rok Yu, PhD, Cynthia E Dunbar, MD, Marcus Corat, Shirley Chen, Aisha Aljanahi, Eun Jung Baek, Jean-Yves Metais, Hannah Natanson, Thomas Winkler, MD, Robert E Donahue, VMD

Blood (2017) 130 (Supplement 1): 117.

DOI: https://doi.org/10.1182/blood.V130.Suppl_1.117.117

Published: 2017

2 3 4 5

NARROW

Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration

Macaque CRISPR/Cas9 Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Mutated Clones and Applicability for Testing Mitigation Approaches

Long-Term Eltrombopag for Bone Marrow Failure Depletes Total Body Iron

A Diamond-Blackfan Anemia Patient's Response to Eltrombopag and Genomic Analysis in Different Lineages

An All Antibody Approach for Conditioning Bone Marrow for Hematopoietic Stem Cell Transplantation with Anti-cKIT and Anti-CD47 in Non-Human Primates

Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag

CRISPR/Cas9 PIG -A gene editing in nonhuman primate model demonstrates no intrinsic clonal expansion of PNH HSPCs

Eltrombopag maintains human hematopoietic stem and progenitor cells under inflammatory conditions mediated by IFN-γ

Eltrombopag Improves Hematopoiesis in Patients with Low to Intermediate-2 Risk Myelodysplastic Syndrome (MDS)

Eltrombopag for Moderate Aplastic Anemia and Unilineage Cytopenias: Dosing, Long-Term Follow-up, Clonal Evolution and Somatic Mutation Profiling

Single Cell Transcriptome Analysis of GATA2 Deficiency in Hematopoiesis Modeled with Induced Pluripotent Stem Cells

Intrabone Delivery of CD34+ Cells Using an Optimized Delivery System Does Not Enhance Engraftment in a Rhesus Macaque Model of Hematopoietic Stem Cell Transplantation

Towards Improved Decision-Making Based on Genomics in Bone Marrow Failure

Modeling Human Paroxysmal Nocturnal Hemoglobinuria Via CRISPR/Cas9 HSPC Gene Editing in Non-Human Primate

Long-Term, Clonal Tracking Comparing Autologous Transplantation of G-CSF/SCF-Primed Bone Marrow CD34+ Cells with G-CSF/SCF-Mobilized Peripheral Blood CD34+ Cells in Rhesus Macaques

Dexpramipexole as an oral steroid-sparing agent in hypereosinophilic syndromes

Eltrombopag mobilizes iron in patients with aplastic anemia

The impact of aging on primate hematopoiesis as interrogated by clonal tracking

Aberrant Clonal Hematopoiesis of the Erythroid and Myeloid Lineages in a Lentivirally Barcoded Rhesus Macaque

A Non-Human Primate CRISPR/Cas9 Model of Clonal Hematopoiesis of Indeterminate Potential Demonstrates Expansion of TET2-Disrupted Clones

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American Society of Hematology

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