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Cynthia E. Dunbar
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Journal Articles

Arginine metabolism regulates human erythroid differentiation through hypusination of eIF5A

Pedro Gonzalez-Menendez, Ira Phadke, Meagan E. Olive, Axel Joly, Julien Papoin, Hongxia Yan, Jérémy Galtier, Jessica Platon, Sun Woo Sophie Kang, Kathy L. McGraw, Marie Daumur, Marie Pouzolles, Taisuke Kondo, Stéphanie Boireau, Franciane Paul, David J. Young, Sylvain Lamure, Raghavendra G. Mirmira, Anupama Narla, Guillaume Cartron, Cynthia E. Dunbar, Myriam Boyer-Clavel, Natalie Porat-Shliom, Valérie Dardalhon, Valérie S. Zimmermann, Marc Sitbon, Thomas E. Dever, Narla Mohandas, Lydie Da Costa, Namrata D. Udeshi, Lionel Blanc, Sandrina Kinet, Naomi Taylor
Journal: Blood
Blood (2023) 141 (20): 2520–2536.
DOI: https://doi.org/10.1182/blood.2022017584
Published: 2023
Includes: Supplemental data
Journal Articles

Differential diagnosis of bone marrow failure syndromes guided by machine learning

Fernanda Gutierrez-Rodrigues, Eric Munger, Xiaoyang Ma, Emma M. Groarke, Youbao Tang, Bhavisha A. Patel, Luiz Fernando B. Catto, Diego V. Clé, Marena R. Niewisch, Raquel M. Alves-Paiva, Flávia S. Donaires, André Luiz Pinto, Gustavo Borges, Barbara A. Santana, Lisa J. McReynolds, Neelam Giri, Burak Altintas, Xing Fan, Ruba Shalhoub, Christopher M. Siwy, Carrie Diamond, Diego Quinones Raffo, Kathleen Craft, Sachiko Kajigaya, Ronald M. Summers, Paul Liu, Lea Cunningham, Dennis D. Hickstein, Cynthia E. Dunbar, Ricardo Pasquini, Michel Michels De Oliveira, Elvira D. R. P. Velloso, Blanche P. Alter, Sharon A. Savage, Carmem Bonfim, Colin O. Wu, Rodrigo T. Calado, Neal S. Young
Journal: Blood
Blood (2023) 141 (17): 2100–2113.
DOI: https://doi.org/10.1182/blood.2022017518
Published: 2023
Includes: Supplemental data
Journal Articles

A RUNX1 -FPDMM rhesus macaque model reproduces the human phenotype and predicts challenges to curative gene therapies

Brief Report
Byung-Chul Lee, Yifan Zhou, Erica Bresciani, Neval Ozkaya, Alina Dulau-Florea, Blake Carrington, Tae-Hoon Shin, Valentina Baena, Zulfeqhar A. Syed, So Gun Hong, Tao Zhen, Katherine R. Calvo, Paul Liu, Cynthia E. Dunbar
Journal: Blood
Blood (2023) 141 (3): 231–237.
DOI: https://doi.org/10.1182/blood.2022018193
Published: 2023
Includes: Supplemental data
Journal Articles

Ongoing Production of Tissue-Resident Macrophages from Hematopoietic Stem Cells in Healthy Adult Macaques

Chuanfeng Wu, Andrew R. Rahmberg, Taehoon Shin, So Gun Hong, Luxin Pei, Heather D. Hickman, Jason M. Brenchley, Cynthia E. Dunbar
Journal: Blood
Blood (2022) 140 (Supplement 1): 38–39.
DOI: https://doi.org/10.1182/blood-2022-158576
Published: 2022
Journal Articles

Granulocyte Transfusions As an Adjunctive Therapy in Severe Aplastic Anemia

Roma V. Rajput, Vaani Shah, Ruba Shalhoub, Kamille West-Mitchell, Cathy Conry-Cantilena, David J. Young, Cynthia E. Dunbar, Bhavisha A. Patel, Richard W. Childs, Neal S. Young, Colin O. Wu, Emma M. Groarke, Shelley S. Kalsi
Journal: Blood
Blood (2022) 140 (Supplement 1): 8556–8557.
DOI: https://doi.org/10.1182/blood-2022-162595
Published: 2022
Journal Articles

Treatment of Refractory Diamond-Blackfan Anemia with Eltrombopag

Brynn B Duncan, Jennifer Lotter, Jeanine Superata, Ma Evette Barranta, Ivana Darden, Sanjay Venugopal, Colin O. Wu, Cynthia E. Dunbar, David J. Young
Journal: Blood
Blood (2022) 140 (Supplement 1): 5824–5825.
DOI: https://doi.org/10.1182/blood-2022-160297
Published: 2022
Journal Articles

Clonal Dynamics of HDR-Edited HSPCs Targeting the CD33 Locus in Rhesus Macaques

Byung-Chul Lee, Max Grice, Chuanfeng Wu, Ryland D Mortlock, Taehoon Shin, Yifan Zhou, Uimook Choi, Suk See De Ravin, So Gun Hong, Cynthia E. Dunbar
Journal: Blood
Blood (2022) 140 (Supplement 1): 309–310.
DOI: https://doi.org/10.1182/blood-2022-166504
Published: 2022
Journal Articles

Comparing the Impact of NHEJ-CRISPR/Cas9 and Base Gene Editing on Rhesus Macaque Hematopoietic Stem Cell Clonal Behavior and Integrity

Diana M. Abraham, Yifan Zhou, Richard Lozano, Gregory A. Newby, David R. Liu, Chuanfeng Wu, Cynthia E. Dunbar
Journal: Blood
Blood (2022) 140 (Supplement 1): 4926–4927.
DOI: https://doi.org/10.1182/blood-2022-167373
Published: 2022
Journal Articles

A macaque clonal hematopoiesis model demonstrates expansion of TET2-disrupted clones and utility for testing interventions

Tae-Hoon Shin, Yifan Zhou, Shirley Chen, Stefan Cordes, Max Z. Grice, Xing Fan, Byung-Chul Lee, Aisha A. Aljanahi, So Gun Hong, Kelli L. Vaughan, Julie A. Mattison, Steven G. Kohama, Margarete A. Fabre, Naoya Uchida, Selami Demirci, Marcus A. F. Corat, Jean-Yves Métais, Katherine R. Calvo, Manuel Buscarlet, Hannah Natanson, Kathy L. McGraw, Alan F. List, Lambert Busque, John F. Tisdale, George S. Vassiliou, Kyung-Rok Yu, Cynthia E. Dunbar
Journal: Blood
Blood (2022) 140 (16): 1774–1789.
DOI: https://doi.org/10.1182/blood.2021014875
Published: 2022
Includes: Supplemental data
Journal Articles

Clonal hematopoiesis is not significantly associated with COVID-19 disease severity

Clinical Trials & Observations
Yifan Zhou, Ruba Shalhoub, Stephanie N. Rogers, Shiqin Yu, Muxin Gu, Margarete A. Fabre, Pedro M. Quiros, Tae-Hoon Shin, Arch Diangson, Wenhan Deng, Shubha Anand, Wenhua Lu, Matthew Cullen, Anna L. Godfrey, Jacobus Preller, Jerome Hadjadj, Emmanuelle Jouanguy, Aurélie Cobat, Laurent Abel, Frederic Rieux-Laucat, Benjamin Terrier, Alain Fischer, Lara Novik, Ingelise J. Gordon, Larisa Strom, Martin R. Gaudinski, Andrea Lisco, Irini Sereti, Thomas J. Gniadek, Andrea Biondi, Paolo Bonfanti, Luisa Imberti, Clifton L. Dalgard, Yu Zhang, Kerry Dobbs, Helen C. Su, Luigi D. Notarangelo, Colin O. Wu, Peter J. M. Openshaw, Malcolm G. Semple, Ziad Mallat, Kenneth Baillie, Cynthia E. Dunbar, George S. Vassiliou
Journal: Blood
Blood (2022) 140 (14): 1650–1655.
DOI: https://doi.org/10.1182/blood.2022015721
Published: 2022
Includes: Supplemental data
Journal Articles

Studies of a mosaic patient with DBA and chimeric mice reveal erythroid cell–extrinsic contributions to erythropoiesis

Raymond T. Doty, Xing Fan, David J. Young, Jialiu Liang, Komudi Singh, Zahra Pakbaz, Ronan Desmond, Sara K. Young-Baird, Settara C. Chandrasekharappa, Frank X. Donovan, Susan R. Phelps, Thomas Winkler, Cynthia E. Dunbar, Janis L. Abkowitz
Journal: Blood
Blood (2022) 139 (23): 3439–3449.
DOI: https://doi.org/10.1182/blood.2021013507
Published: 2022
Includes: Supplemental data
Journal Articles

Evaluation of the Relationship between Clonal Hematopoiesis and Severe COVID-19 Disease in Rhesus Macaques

Taehoon Shin, Yifan Zhou, So Gun Hong, John-Paul Todd, Shayne Andrew, Barbara Flynn, Matthew Gagne, Ian Moore, Anthony Cook, Mark Lewis, Kathryn Foulds, Robert Seder, Daniel Douek, Mario Roederer, Cynthia E. Dunbar
Journal: Blood
Blood (2021) 138 (Supplement 1): 3279.
DOI: https://doi.org/10.1182/blood-2021-152628
Published: 2021
Journal Articles

Strong Predictors of Chromosomal Aberrations and Myeloid Neoplasia Following Immunosuppression Therapy for Severe Aplastic Anemia: A Retrospective Cohort Study

Emma M. Groarke, Bhavisha A. Patel, Ruba Shalhoub, Fernanda Gutierrez-Rodrigues, Parth Desai, Harshraj Leuva, Casey Paton, Nina Spitofsky, Jennifer Lotter, Olga Rios, Richard W. Childs, David J. Young, Alina Dulau-Florea, Cynthia E. Dunbar, Katherine R. Calvo, Colin O. Wu, Neal S. Young
Journal: Blood
Blood (2021) 138 (Supplement 1): 601.
DOI: https://doi.org/10.1182/blood-2021-146070
Published: 2021
Journal Articles

Rhesus Macaques As a Preclinical Model Organism for RUNX1-FPD

Byung-Chul Lee, Yifan Zhou, Erica Bresciani, Neval Ozkaya, Taehoon Shin, So Gun Hong, Paul P. Liu, Cynthia E. Dunbar
Journal: Blood
Blood (2021) 138 (Supplement 1): 2185.
DOI: https://doi.org/10.1182/blood-2021-152863
Published: 2021
Journal Articles

Genomic-Based Machine Learning Towards Prediction of the Etiology of Bone Marrow Failure Syndromes

Fernanda Gutierrez-Rodrigues, Eric Munger, Xiaoyang Ma, Youbao Tang, Emma M Groarke, Bhavisha A. Patel, Luiz Fernando Bazzo Catto, Diego V Clé, Marena R. Niewisch, Flávia S Donaires, Sachiko Kajigaya, Cynthia E. Dunbar, Neelam Giri, Michel Michels De Oliveira, Lisa J. McReynolds, Blanche P. Alter, Sharon A. Savage, Carmem M. S. Bonfim, Colin O. Wu, Rodrigo T. Calado, Neal S. Young
Journal: Blood
Blood (2021) 138 (Supplement 1): 2182.
DOI: https://doi.org/10.1182/blood-2021-151258
Published: 2021
Journal Articles

Tissue-Resident Clonal Expansions of Rhesus Macaque NK Cells

Chuanfeng Wu, Ryland D Mortlock, Taehoon Shin, Stefan Cordes, Xing Fan, Jason Brenchley, David A Allan, So Gun Hong, Cynthia E. Dunbar
Journal: Blood
Blood (2021) 138 (Supplement 1): 998.
DOI: https://doi.org/10.1182/blood-2021-146220
Published: 2021
Journal Articles

Single Cell RNA-Seq Characterization of an Adaptive Population of NK Cells after Primary CMV Infection in Rhesus Macaques

Stefan Cordes, Ryland D Mortlock, Lauren Truitt, Di Yang, Diego A Espinoza, Xing Fan, Daniel Ram, Matilda Mostrom, Dollnovan Tran, Lesli Sprehe, R. Keith Reeves, Robert E. Donahue, Michael Kelly, Jinguo Chen, So Gun Hong, Amitinder Kaur, Chuanfeng Wu, Cynthia E. Dunbar
Journal: Blood
Blood (2021) 138 (Supplement 1): 193.
DOI: https://doi.org/10.1182/blood-2021-153667
Published: 2021
Journal Articles

Glucocorticoid-induced eosinopenia results from CXCR4-dependent bone marrow migration

So Gun Hong, Noriko Sato, Fanny Legrand, Manasi Gadkari, Michelle Makiya, Kindra Stokes, Katherine N. Howe, Shiqin Judy Yu, Nathaniel Seth Linde, Randall R. Clevenger, Timothy Hunt, Zonghui Hu, Peter L. Choyke, Cynthia E. Dunbar, Amy D. Klion, Luis M. Franco
Journal: Blood
Blood (2020) 136 (23): 2667–2678.
DOI: https://doi.org/10.1182/blood.2020005161
Published: 2020
Includes: Multimedia, Supplemental data
Journal Articles

Long-Term Eltrombopag for Bone Marrow Failure Depletes Total Body Iron

David J Young, MDPhD, Xing Fan, MD, Emma Groarke, MD, Bhavisha A Patel, MD, Ronan Desmond, MD, Thomas Winkler, MD, Andre Larochelle, MD PhD, Katherine R. Calvo, MD PhD, Neal S. Young, MD, Cynthia E. Dunbar, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
DOI: https://doi.org/10.1182/blood-2020-141375
Published: 2020
Journal Articles

Macaque CRISPR/Cas9 Age-Related Clonal Hematopoiesis Model Demonstrates Expansion of TET2-Mutated Clones and Applicability for Testing Mitigation Approaches

Taehoon Shin, Shirley Chen, BS, Stefan Cordes, MD PhD, Yifan Zhou, MS, Byung-Chul Lee, PhD, Aisha Aljanahi, BS, So Gun Hong, PhD, Robert E. Donahue, VMD, Kyung-Rok Yu, PhD, Cynthia E. Dunbar, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
DOI: https://doi.org/10.1182/blood-2020-140770
Published: 2020