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Craig T. Jordan
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Journal Articles

The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation

Maria L. Amaya, Anagha Inguva, Shanshan Pei, Courtney Jones, Anna Krug, Haobin Ye, Mohammad Minhajuddin, Amanda Winters, Steffanie L. Furtek, Fabia Gamboni, Brett Stevens, Angelo D’Alessandro, Daniel A. Pollyea, Philip Reigan, Craig T. Jordan
Journal: Blood
Blood (2022) 139 (4): 584–596.
DOI: https://doi.org/10.1182/blood.2021013201
Published: 2022
Includes: Supplemental data
Journal Articles

IL-1 Via IRAK1/4 Sustains Acute Myeloid Leukemia Stem Cells Following Treatment and Relapse

Tzu-Chieh Ho, Hiroki Kawano, Mark W. LaMere, Naxin Guo, Yu-Chiao Chiu, Jian Wang, Craig T. Jordan, Nikolay V. Dokholyan, Laura M. Calvi, Rakesh Kumar Singh, Michael W. Becker
Journal: Blood
Blood (2021) 138 (Supplement 1): 1175.
DOI: https://doi.org/10.1182/blood-2021-149903
Published: 2021
Journal Articles

Outcomes Are Similar Following Allogeneic Hematopoietic Stem Cell Transplant for Newly Diagnosed Patients Who Received Venetoclax + Azacitidine Versus Intensive Chemotherapy

Amanda C. Winters, Grace Bosma, Diana Abbott, Mohd Minhajuddin, Craig T Jordan, Daniel A. Pollyea, Jonathan A. Gutman
Journal: Blood
Blood (2021) 138 (Supplement 1): 3957.
DOI: https://doi.org/10.1182/blood-2021-154392
Published: 2021
Journal Articles

Unique Metabolic Vulnerabilities of Myelodysplastic Syndrome Stem Cells

Brett M. Stevens, Krysta L. Engel, Austin E. Gillen, Rachel Culp-Hill, Angelo Dalessandro, Scott Alper, Daniel A. Pollyea, Craig T. Jordan
Journal: Blood
Blood (2021) 138 (Supplement 1): 1511.
DOI: https://doi.org/10.1182/blood-2021-150749
Published: 2021
Journal Articles

Lysosomal Acid Lipase a (LIPA) Modulates Leukemia Stem Cell (LSC) Response to Venetoclax/TKI Combination Therapy in Blast Phase Chronic Myeloid Leukemia

Mohd Minhajuddin, Haobin Ye, Amanda C. Winters, Shanshan Pei, Nabilah Khan, Brett M. Stevens, Biniam Adane, Maria L. Amaya, Anagha Inguva, Anna Krug, Maura Gasparetto, Daniel W. Sherbenou, Daniel A. Pollyea, Clayton Smith, Craig T. Jordan
Journal: Blood
Blood (2021) 138 (Supplement 1): 630.
DOI: https://doi.org/10.1182/blood-2021-151400
Published: 2021
Journal Articles

Targeting MDS Stem Cells with Omacetaxine and Azacitidine for Newly Diagnosed High Grade Patients: Phase 1 Trial Results and Preliminary Mechanistic Studies

Brett M. Stevens, Amanda C. Winters, Mohammad Minhajuddin, Maria L. Amaya, Christine M. McMahon, Jonathan A. Gutman, Clayton Smith, Deng Wang, Connor Adkins, Olivia Ondracek, Craig T. Jordan, Daniel A. Pollyea
Journal: Blood
Blood (2021) 138 (Supplement 1): 2612.
DOI: https://doi.org/10.1182/blood-2021-150824
Published: 2021
Journal Articles

Allogeneic Transplant Improves AML Outcomes Compared to Maintenance Venetoclax and Azacitidine Following Response to Initial Venetoclax and Azacitidine Therapy

Daniel A. Pollyea, Amanda Winters, MDPhD, Craig T. Jordan, PhD, Clayton Smith, MD, Jonathan A. Gutman, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24.
DOI: https://doi.org/10.1182/blood-2020-138821
Published: 2020
Journal Articles

Venetoclax Is Safe and Tolerable As Post-Transplant Maintenance Therapy for AML Patients at High Risk for Relapse

Andrew Kent, MD PhD, Daniel A. Pollyea, Amanda Winters, MDPhD, Craig T. Jordan, PhD, Clayton Smith, MD, Jonathan A. Gutman, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
DOI: https://doi.org/10.1182/blood-2020-138832
Published: 2020
Journal Articles

Venetoclax and Azacitidine for Newly Diagnosed Non-Elderly Adult Patients with Acute Myeloid Leukemia and Adverse Risk Features

Jonathan A. Gutman, MD, Amanda Winters, MDPhD, Maria L Amaya, MD PhD, Christine M. McMahon, MD, Jeffrey Schowinsky, MD, Diana Abbott, PhD, Andrew Hammes, MS, Shanshan Pei, PhD, Brett M. Stevens, PhD, Craig T. Jordan, PhD, Clayton Smith, MD, Daniel A. Pollyea
Journal: Blood
Blood (2020) 136 (Supplement 1): 9.
DOI: https://doi.org/10.1182/blood-2020-136120
Published: 2020
Journal Articles

Inhibition of Fatty Acid Metabolism Re-Sensitizes Resistant Leukemia Stem Cells to Venetoclax with Azacitidine

Courtney L Jones, PhD, Brett M. Stevens, PhD, Rachel Culp-Hill, BS, Angelo Dalessandro, PhD, Anna Krug, BS, Madeline Goosman, Shanshan Pei, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1272.
DOI: https://doi.org/10.1182/blood-2019-125773
Published: 2019
Journal Articles

STAT3 Plays a Critical Role in Mitochondrial Function and Survival of Primary AML Cells

Maria L Amaya, MD PhD, Anagha Inguva, BSc, Courtney L Jones, PhD, Anna Krug, BS, Shanshan Pei, PhD, Phillip Reigan, PhD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1275.
DOI: https://doi.org/10.1182/blood-2019-127669
Published: 2019
Journal Articles

PU.1 Enforces Hematopoietic Stem Cell Quiescence during Chronic Inflammation

James Chavez, BS, Jennifer L Rabe, BS, BA, Kelly Higa, MS, Dirk Loeffler, Ahmed Nouraiz, PhD, Taylor Mills, BA, Beau M Idler, Brett M. Stevens, PhD, Courtney Fleenor, PhD, Claus Nerlov, PhD, Hideaki Nakajima, MD, James Hagman, Timm Schroeder, PhD, Hyun Min Kim, PhD, Craig T Jordan, PhD, James DeGregori, Eric Pietras, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 822.
DOI: https://doi.org/10.1182/blood-2019-129300
Published: 2019
Journal Articles

Developmental Plasticity of Acute Myeloid Leukemia Mediates Resistance to Venetoclax-Based Therapy

Shanshan Pei, PhD, Daniel A Pollyea, MD, Annika Gustafson, Mohammad Minhajuddin, PhD, Brett M. Stevens, PhD, Haobin Ye, PhD, Anagha Inguva, BSc, Maria L Amaya, MD PhD, Anna Krug, BS, Courtney L Jones, PhD, Biniam Adane, PhD, Amanda Winters, MD PhD, Nabilah Khan, Jessica Ponder, PhD, Jeffrey Schowinsky, Andrew Hammes, MS, Diana Abbott, PhD, Jason R Myers, MS, John M Ashton, PhD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Haley E. Ramsey, PhDMSc, Michael R. Savona, MD, Stephen W. Fesik, PhD, Clayton Smith, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 185.
DOI: https://doi.org/10.1182/blood-2019-131390
Published: 2019
Journal Articles

Broad Efficacy of the Translation Inhibitor Omacetaxine in Relapsed/Refractory Multiple Myeloma Samples

Zachary J Walker, BS, MS, Beau M Idler, BA, Michael J VanWyngarden, BS, Brett M. Stevens, PhD, Shelby C Bearrows, BS, Lorraine N Davis, BS, Andrew Hammes, MS, Clayton Smith, MD, Craig T Jordan, PhD, Tomer M Mark, MD MS, Peter A Forsberg, MD, Daniel W Sherbenou, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4404.
DOI: https://doi.org/10.1182/blood-2019-121937
Published: 2019
Journal Articles

PTPN11 Mutated Acute Myeloid Leukemia (AML) Features an Abundant Epichaperome Network and Is Sensitive to the Epichaperome Inhibitor PU-H71

Justin D. Kaner, MD, Montreh Tavakkoli, MA,MD, Lisa Toudic, Brett M. Stevens, PhD, Craig T Jordan, PhD, Tony Taldone, PhD, Gabriela Chiosis, PhD, Ellen K. Ritchie, MD, Pinkal Desai, MDMPH, Michael B. Samuel, MD, Sangmin Lee, MD, Gail J. Roboz, MD, Monica L. Guzman, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3935.
DOI: https://doi.org/10.1182/blood-2019-128276
Published: 2019
Journal Articles

Venetoclax and Azacitidine for Older Newly Diagnosed Patients with Acute Myeloid Leukemia: A Single-Institution Pilot Study Using Measurable Residual Disease to Guide Therapy

Amanda Winters, MD PhD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Brett M. Stevens, PhD, Shanshan Pei, PhD, Jeffrey Schowinsky, Diana Abbott, PhD, Andrew Hammes, MS, Molly Nakic, Lindsey Lyle, Keri Halsema, Dwight Macero, PA-C, Alex Hirose, Chelsey Boggs, Angie Falco, Natalie Monson, Shirstine Rahkola, Sarah Wright, Tyler D'Ovidio, Clayton Smith, MD, Craig T Jordan, PhD, Daniel A Pollyea, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2638.
DOI: https://doi.org/10.1182/blood-2019-122120
Published: 2019
Journal Articles

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

Brief Report
Courtney L. Jones, Brett M. Stevens, Angelo D’Alessandro, Rachel Culp-Hill, Julie A. Reisz, Shanshan Pei, Annika Gustafson, Nabilah Khan, James DeGregori, Daniel A. Pollyea, Craig T. Jordan
Journal: Blood
Blood (2019) 134 (4): 389–394.
DOI: https://doi.org/10.1182/blood.2019898114
Published: 2019
Includes: Supplemental data
Journal Articles

Tracking of AML-Associated Mutations Via Droplet Digital PCR Is Predictive of Outcomes Post-Transplant

Amanda Winters, MD PhD, Madeline Goosman, Brett M Stevens, PhD, Enkhtsetseg Purev, MD PhD, Clayton Smith, MD, Daniel A Pollyea, MD, Craig T Jordan, PhD, Jonathan A Gutman, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2138.
DOI: https://doi.org/10.1182/blood-2018-99-110834
Published: 2018
Journal Articles

Rheumatoid Arthritis Causes Hematopoietic Stem Cell Reprogramming to Maintain Functionality

Taylor Mills, BA, Giovanny Hernandez, BS, Jennifer L Rabe, BS, BA, Susan Kuldanek, MD, James Chavez, BA, Greg Kirkpatrick, PhD, Leila Noetzli, PhD, Widian Jubair, MD, Michelle Zanche, MS, Jason R Myers, MS, Brett M. Stevens, PhD BS, Courtney Fleenor, PhD, Biniam Adane, PhD, John M Ashton, PhD, Craig T Jordan, PhD, James Hagman, Jorge Di Paola, MD, Michael Holers, MD, Kristine Kuhn, Eric Pietras, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2573.
DOI: https://doi.org/10.1182/blood-2018-99-120272
Published: 2018
Journal Articles

A Rapid Functional Screen for Small Molecule and Monoclonal Antibody Drug Sensitivity in Multiple Myeloma Patients

Zachary J Walker, MS, Michael J VanWyngarden, BS, Brett M Stevens, PhD, Christophe Langouët-Astrie, MS, Clayton Smith, MD, Brent E Palmer, PhD, Peter A Forsberg, MD, Tomer M Mark, MD MS, Craig T Jordan, PhD, Daniel W Sherbenou, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3203.
DOI: https://doi.org/10.1182/blood-2018-99-111394
Published: 2018