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Christopher A. Eide
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Journal Articles

A CEBPB/IL-1β/TNF-α Feedback Loop Drives Drug Resistance to Venetoclax and MDM2 Inhibitors in Monocytic Leukemia

Basil Allen, Daniel Bottomly, Thomas Köhnke, Anthony Wang, Hsin-Yun Lin, Kara Johnson, Isabel Kenna, Anastatia Streltsova, Emma Martin, Reid Chen, Lindsey Savoy, Nicola Long, Peter Ryabinin, Stephen E Kurtz, Christopher A Eide, Amy Carlos, Andy Kaempf, Tingting Liu, Cristina E. Tognon, Robert Searles, Paul D. Piehowski, Sara J.C. Gosline, Anupriya Agarwal, Bill H Chang, Michelle Barton, Brian J Druker, Shannon K. McWeeney, Ravindra Majeti, Jeffrey W. Tyner, Haijiao Zhang
Journal: Blood
Blood blood.2024028239.
https://doi.org/10.1182/blood.2024028239
Published: 2025
Includes: Supplemental data
Journal Articles

Mapping the Drug Combination Landscape for AML: An Integrative Ex Vivo Functional and Computational Approach

Xiao Xian Lin, Christopher A. Eide, Stephen E. Kurtz, Vedant Sandhu, Noor Rashidha Binte Meera Sahib, Disha Malani, Melissa Gaik-Ming Ooi, Edward Chow, Sanjukta Das, Jeffrey W. Tyner, Shruti Bhatt
Journal: Blood
Blood (2024) 144 (Supplement 1): 271.
https://doi.org/10.1182/blood-2024-202802
Published: 2024
Journal Articles

Influence of AML Differentiation State in Risk Stratification of Frontline Therapy with Hypomethylating Agents + Venetoclax in AML

Curtis A Lachowiez, Joshua F Zeidner, Ashley M. Eckel, Daniel T Peters, Jacob Fang, Amenech Ashango, Andy Kaempf, Fangyan Dai, Christopher A. Eide, Stephen E. Kurtz, Theodore P Braun, Ronan T. Swords, Jennifer N. Saultz, Jeffrey W. Tyner, Daniel A Pollyea
Journal: Blood
Blood (2024) 144 (Supplement 1): 62.
https://doi.org/10.1182/blood-2024-201532
Published: 2024
Journal Articles

Combination with Palbociclib Overcomes Venetoclax Resistance Mechanisms and Outperforms Single Agent Efficacy in Acute Myeloid Leukemia

Melissa L Stewart, Jessica Gibbs, Daniel Bottomly, Andy Kaempf, Stephen E. Kurtz, Christopher A. Eide, Ariane Huang, Luca Sax, Nicola Long, Shannon K McWeeney, Bill H Chang, Jeffrey W. Tyner
Journal: Blood
Blood (2024) 144 (Supplement 1): 1566.
https://doi.org/10.1182/blood-2024-198516
Published: 2024
Journal Articles

Phase 1 Trial Testing the Novel Combination Therapy of Entrectinib and ASTX727 in TP53 Mutated Relapsed/Refractory Acute Myeloid Leukemia Patients

Cristina Tognon, Shikha Mishra, Andy Kaempf, Byung Park, Sunil K Joshi, Ariane Huang, Stephen E. Kurtz, Luca Sax, Christopher A. Eide, Kara Johnson, Rachel Mahoney, Michael James Lue, Nicole Tong, Lisa Guiducci, Tara Lundberg Willians, Emma Indira Solanki, Rachel J. Cook, Jessica T. Leonard, Curtis A Lachowiez, Gabrielle Meyers, Jennifer N. Saultz, Elie Traer, Jeffrey W. Tyner, Uma Borate, Ronan T. Swords
Journal: Blood
Blood (2024) 144 (Supplement 1): 1498.
https://doi.org/10.1182/blood-2024-208505
Published: 2024
Journal Articles

Results of a Phase 1 Trial Testing the Novel Combination Therapy of Venetoclax and Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia Patients

Uma M. Borate, Yazan F. Madanat, Cristina Tognon, Shikha Mishra, Andy Kaempf, Prapti A. Patel, Stephen E. Kurtz, Kara Johnson, Sumithira Vasu, Sharyn D. Baker, Bridget A Robinson, Tania Q Vu, Christopher A. Eide, Jessica Minnier, Yiqing Zhang, Peter Clement, Sammantha Avaylon, Thomas Jacob, Rachel Cook, Arpita Gandhi, Jessica T. Leonard, Brandon Hayes-Lattin, Laura F. Newell, Richard T Maziarz, Elie Traer, Ronan T. Swords, Jeffrey W Tyner, Brian J. Druker, Jennifer N. Saultz
Journal: Blood
Blood (2023) 142 (Supplement 1): 1515.
https://doi.org/10.1182/blood-2023-191166
Published: 2023
Journal Articles

Acute Myeloid Leukemia Differentiation State and Genotype Influence Anti-Apoptotic Protein Expression, Venetoclax Sensitivity, and Survival in AML

Curtis A. Lachowiez, Christopher A. Eide, Stephen E. Kurtz, Nicola Long, Manoj Rai, Wei Xie, Andy Kaempf, Daniel Bottomly, Rachel Cook, Gabrielle Meyers, Arpita Gandhi, Jessica T. Leonard, Brandon Hayes-Lattin, Laura F. Newell, Richard T Maziarz, Jennifer N. Saultz, Elie Traer, Theodore P Braun, Ronan T. Swords, Shannon K McWeeney, Jeffrey W Tyner
Journal: Blood
Blood (2023) 142 (Supplement 1): 978.
https://doi.org/10.1182/blood-2023-179527
Published: 2023
Journal Articles

Computational Approach Based on Independent Drug Action Identifies Clinically Relevant Combinations for Acute Myeloid Leukemia

Xiao Xian Lin, Vedant Sandhu, Christopher A. Eide, Stephen E. Kurtz, Disha Malani, Tom Erkers, Olli Kallioniemi, Jeffrey W Tyner, Shruti Bhatt
Journal: Blood
Blood (2023) 142 (Supplement 1): 5015.
https://doi.org/10.1182/blood-2023-188731
Published: 2023
Journal Articles

A Rapid Test to Evaluate the Tumor Differentiation State of Acute Myeloid Leukemias

Stephen E. Kurtz, Christopher A. Eide, Nicola Long, Daniel Bottomly, Shannon K McWeeney, Akosha Taylor, Brian J. Druker, Sudarshan Anand, Curtis A. Lachowiez, Jeffrey W Tyner
Journal: Blood
Blood (2023) 142 (Supplement 1): 3643.
https://doi.org/10.1182/blood-2023-180105
Published: 2023
Journal Articles

A Phase I/II Study to Investigate the Addition of Venetoclax to Dasatinib and Steroids in Patients with Newly Diagnosed or Relapsed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL): The Venda Trial, in Progress

Jessica T. Leonard, Rachel Cook, Laura F. Newell, Arpita Gandhi, Ronan T. Swords, Christopher A. Eide, Brandon Hayes-Lattin, Kara Johnson, Elie Traer, Stephen E. Kurtz, Jennifer N. Saultz, Cristina Tognon, Jeffrey W Tyner, Curtis A. Lachowiez
Journal: Blood
Blood (2023) 142 (Supplement 1): 1512.
https://doi.org/10.1182/blood-2023-188313
Published: 2023
Journal Articles

Defining Clinical and Molecular Biomarkers for Venetoclax-Based Drug Combinations to Augment AML Therapy

Christopher A. Eide, Stephen E. Kurtz, Andy Kaempf, Nicola Long, Sunil K Joshi, Tamilla Nechiporuk, Ariane Huang, Charles Dibb, Daniel Bottomly, Shannon K. McWeeney, Bill H. Chang, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood
Blood (2022) 140 (Supplement 1): 1025–1027.
https://doi.org/10.1182/blood-2022-159264
Published: 2022
Journal Articles

Elvn-001, a Next Generation ATP-Competitive ABL1 Tyrosine Kinase Inhibitor for the Treatment of Chronic Myeloid Leukemia

Stefan D Gross, Christopher A. Eide, Michael R Burkard, Anna Reister Schultz, Monette A Aujay, Samuel Kintz, Brian J. Druker, Joseph P Lyssikatos
Journal: Blood
Blood (2022) 140 (Supplement 1): 3095–3096.
https://doi.org/10.1182/blood-2022-162700
Published: 2022
Journal Articles

Associating Ex Vivo Drug Sensitivity with Differentiation Status Identifies Effective Drug Combinations for Acute Myeloid Leukemia

Christopher A. Eide, Stephen E. Kurtz, Andy Kaempf, Nicola Long, Daniel Bottomly, Olga Nikolova, Brian J. Druker, Shannon K. McWeeney, Jeffrey W. Tyner, Anupriya Agarwal
Journal: Blood
Blood (2021) 138 (Supplement 1): 1301.
https://doi.org/10.1182/blood-2021-152043
Published: 2021
Journal Articles

Novel Combination Therapy of Venetoclax and Ruxolitinib in the Treatment of Patients with Relapsed/Refractory Acute Myeloid Leukemia

Uma Borate, Jennifer N. Saultz, Andy Kaempf, Jessica Minnier, Cristina E. Tognon, Stephen E. Kurtz, Christopher A. Eide, Prapti A. Patel, Yazan F. Madanat, Peter Clement, Sammantha Avaylon, Shikha Misra, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood
Blood (2021) 138 (Supplement 1): 2333.
https://doi.org/10.1182/blood-2021-152903
Published: 2021
Journal Articles

A Role for Lipid Metabolism in Tyrosine Kinase Inhibitor (TKI) Resistance of Chronic Myeloid Leukemia (CML)

Mayra A. Gonzalez, Jose L. Lopez, Katherine Schenkel, Kelaiah Reffell, Christopher A. Eide, Sudip Bajpeyi, Anna M. Eiring
Journal: Blood
Blood (2021) 138 (Supplement 1): 2542.
https://doi.org/10.1182/blood-2021-148507
Published: 2021
Journal Articles

A Functional Profiling of Microenvironmental Factors and Small Molecules Reveals Monocyte Chemoattractant Protein-1 Mediates Drug Resistance in Acute Myeloid Leukemia

Rucha V Modak, PhD, Sara J Gosline, Alisa Damnernsawad, PhD, Tamilla Nechiporuk, PhD, Ted Laderas, PhD, Guanming Wu, PhD, Paul Piehowski, [email protected], Stephen E Kurtz, PhD, Christopher A. Eide, Jeffrey W. Tyner, PhD, Karin Rodland, [email protected], Shannon K. McWeeney, PhD, Anupriya Agarwal, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-141686
Published: 2020
Journal Articles

Patterns of Venetoclax Sensitivity in Chronic Lymphocytic Leukemia

James T Dibb, DO, Nicola Long, Christopher A. Eide, Stephen E Kurtz, PhD, Cristina E. Tognon, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–14.
https://doi.org/10.1182/blood-2020-137674
Published: 2020
Journal Articles

Patterns of Sensitivity Exhibited By Venetoclax-Inclusive Drug Combinations in Acute Myeloid Leukemia

Stephen E Kurtz, PhD, Christopher A. Eide, Andy Kaempf, MS, Nicola Long, Anupriya Agarwal, PhD, Cristina E. Tognon, Motomi Mori, PhD, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood
Blood (2019) 134 (Supplement_1): 878.
https://doi.org/10.1182/blood-2019-126020
Published: 2019
Journal Articles

Mathematical and Experimental Evidence That Differentiation of Leukemic Blasts in Acute Myeloid Leukemia Is Not Completely Blocked

William Bolosky, PhD, David B Wilson, PhD, Christopher A. Eide, Susan B Olson, Guang Fan, MD PhD, Brian J. Druker, Anupriya Agarwal, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1435.
https://doi.org/10.1182/blood-2019-131007
Published: 2019
Journal Articles

Genome-Wide CRISPR Screening Identifies MAPK and Mtorc Pathways As Regulators of Sorafenib Resistance in Acute Myeloid Leukemia

Alisa Damnernsawad, PhD, Tamilla Nechiporuk, PhD, Daniel Bottomly, MS, Stephen E Kurtz, PhD, Christopher A. Eide, Shannon K. McWeeney, PhD, Jeffrey W. Tyner
Journal: Blood
Blood (2019) 134 (Supplement_1): 2557.
https://doi.org/10.1182/blood-2019-128877
Published: 2019