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Christian Klein
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Journal Articles

RG6333 (CD19-CD28), a CD19-Targeted Affinity-Optimized CD28 Bispecific Antibody, Enhances and Prolongs the Anti-Tumor Activity of Glofitamab (CD20-TCB) in Preclinical Models

Johannes Sam, Thomas Hofer, Christine Kuettel, Christina Claus, Sylvia Herter, Guy Georges, Jenny Tosca Thom, Leo Kunz, Samuel Gebhardt, Florian Limani, Stefanie Briner, Silvia Jenni, Anne Schönle, Marine Le Clech, Ahmet Varol, Esther Bommer, Birte Appelt, Sara Colombetti, Stephan Gasser, Marina Bacac, Christian Klein, Pablo Umana
Journal: Blood
Blood (2022) 140 (Supplement 1): 3142–3143.
DOI: https://doi.org/10.1182/blood-2022-159941
Published: 2022
Journal Articles

RG6234: A Novel 2:1 GPRC5D T Cell Bispecific Antibody Exhibits Best in Class Potential for the Treatment of Multiple Myeloma As a Monotherapy and in Combination

Jan Eckmann, Tanja Fauti, Aintzane Zabaleta, Laura Blanco, Sahar Kassem, Nadege Carrié, Stefan Lorenz, Alejandro Carpy, Tony Christopeit, Georg Fertig, Luise Bernasconi, Marlene Biehl, Sarah Diggelmann, Melanie Knobloch, Maud Mayoux, Charles Dumontet, Bruno Paiva, Ludovic Martinet, Stéphane Leclair, Wei Xu, Christian Klein, Pablo Umaña
Journal: Blood
Blood (2022) 140 (Supplement 1): 2091–2092.
DOI: https://doi.org/10.1182/blood-2022-157485
Published: 2022
Journal Articles

Pharmacologic Inhibitors of STAT3 or BCL6 Transcriptional Function Sensitize Lymphoma Cells to the Novel PD-1 Cis-Targeted PD1-IL2v Immunocytokine in a Murine Model

Weiyuan Wang, Foster Burton, Sylvia Herter, Laura Codarri Deak, Christian Klein, David Frank
Journal: Blood
Blood (2022) 140 (Supplement 1): 8835–8836.
DOI: https://doi.org/10.1182/blood-2022-167853
Published: 2022
Journal Articles

CD25 Targeting Eliminates Regulatory T Cells and CD25+ Blasts in Acute Myeloid Leukemia

Laurene Pousse, Bruno C. Medeiros, Koorosh Korfi, Marco Berrera, Nadine Kumpesa, Vera Griesser, Jan Eckmann, Vaios Karanikas, Christian Klein, Maria Amann
Journal: Blood
Blood (2022) 140 (Supplement 1): 6291–6292.
DOI: https://doi.org/10.1182/blood-2022-158189
Published: 2022
Journal Articles

Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody

Christian Augsberger, Gerulf Hänel, Wei Xu, Vesna Pulko, Lydia Jasmin Hanisch, Angelique Augustin, John Challier, Katharina Hunt, Binje Vick, Pier Eduardo Rovatti, Christina Krupka, Maurine Rothe, Anne Schönle, Johannes Sam, Emmanuelle Lezan, Axel Ducret, Daniela Ortiz-Franyuti, Antje-Christine Walz, Jörg Benz, Alexander Bujotzek, Felix S. Lichtenegger, Christian Gassner, Alejandro Carpy, Victor Lyamichev, Jigar Patel, Nikola Konstandin, Antje Tunger, Marc Schmitz, Michael von Bergwelt-Baildon, Karsten Spiekermann, Luca Vago, Irmela Jeremias, Estelle Marrer-Berger, Pablo Umaña, Christian Klein, Marion Subklewe
Journal: Blood
Blood (2021) 138 (25): 2655–2669.
DOI: https://doi.org/10.1182/blood.2020010477
Published: 2021
Includes: Supplemental data
Journal Articles

Augmenting Efficacy of T-Cell Bispecific Antibodies in AML through a Tumor Stroma-Targeted 4-1BB Agonist

Gerulf Hänel, Anne-Sophie Neumann, Vesna Pulko, Christina Claus, Alexandra Leutbecher, Anetta Marcinek, Nora Zieger, Veit L Buecklein, Pablo Umana, Christian Klein, Marion Subklewe
Journal: Blood
Blood (2021) 138 (Supplement 1): 1178.
DOI: https://doi.org/10.1182/blood-2021-146762
Published: 2021
Journal Articles

Long-Term Results from a Phase 1b Study of Avadomide in Combination with Obinutuzumab in Patients with Relapsed and/or Refractory B-Cell Non-Hodgkin Lymphoma

Jean-Marie Michot, MD, Reda Bouabdallah, MD, Jeanette K. Doorduijn, MD PhD, Carola Boccomini, MD, Marie José Kersten, MD PhD, Annalisa Chiappella, Pier Luigi Zinzani, MD, Gilles Salles, MD PhD, Fontanet Bijou, MD, Mei Hentrup, BSN, BS, So Hyun Rhee, PharmD, Patrick Hagner, PhD, Christian Klein, PhD, Michael Pourdehnad, Kristen Hege, MD, Juergen Dobmeyer, MD, Zariana Nikolova, MD PhD, Vincent Ribrag, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
DOI: https://doi.org/10.1182/blood-2020-134949
Published: 2020
Journal Articles

Lymphoma Microenvironment Deconvolution Links M1 Macrophage Infiltration to Clinical Outcome in Diffuse Large B-Cell Lymphoma

Mark Yan, Yi Meng Chang, Vibha Raghavan, Estella Dong, Christian Klein, PhD, Tina G Nielsen, Joseph N Paulson, Katerina Hatzi
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
DOI: https://doi.org/10.1182/blood-2020-134867
Published: 2020
Journal Articles

Optimizing Ex-Vivo Expanded NK Cell- Mediated Antibody-Dependent Cellular Cytotoxicity (ADCC) Combined with NKTR-255 in Chronic Lymphocytic Leukemia (CLL), Follicular Lymphoma (FL), and Burkitt Lymphoma (BL)

Yaya Chu, PhD, Susiyan Jiang, MS, Jian Jiang, MD, Meijuan Tian, PhD, Dean Anthony Lee, MD PhD, Loui Madakamutil, Mario Q. Marcondes, MDPhD, Christian Klein, PhD, Mitchell S Cairo, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 23–24.
DOI: https://doi.org/10.1182/blood-2020-139822
Published: 2020
Journal Articles

RG6076 (CD19-4-1BBL): CD19-Targeted 4-1BB Ligand Combination with Glofitamab As an Off-the-Shelf, Enhanced T-Cell Redirection Therapy for B-Cell Malignancies

Sylvia Herter, PhD, Johannes Sam, PhD, Claudia Ferrara Koller, PhD, Sarah Diggelmann, Esther Bommer, Anne Schönle, Christina Claus, PhD, Marina Bacac, PhD, Christian Klein, PhD, Pablo Umana, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40.
DOI: https://doi.org/10.1182/blood-2020-134782
Published: 2020
Journal Articles

Targeting Intracellular WT1 in AML Utilizing a T Cell Bispecific Antibody Construct: Augmenting Efficacy through Combination with Lenalidomide

Christian Klein, PhD, Christian Augsberger, Wei Xu, MD PhD, Christina Heitmüller, PhD, Lydia Hanisch, PhD, Johannes Sam, PhD, Vesna Pulko, PhD, Anne Schönle, John Challier, PhD, Alejandro Carpy, PhD, Nikola Konstandin, PhD, Maurine Rothe, Gerulf Hänel, Veit Bücklein, MD, Felix S. Lichtenegger, MD, Antje Tunger, PhD, Marc Schmitz, MD, Michael von Bergwelt, Karsten Spiekermann, MD, Pablo Umana, PhD, Marion Subklewe, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4450.
DOI: https://doi.org/10.1182/blood-2019-130121
Published: 2019
Journal Articles

Polatuzumab Vedotin, an Antibody-Drug Conjugate Targeting CD79b, Is a Highly Active Agent Against Burkitt Lymphoma and Primary Mediastinal B-Cell Lymphoma

Anthony N. Audino, MD, Matthew J. Barth, MD, Aradhana Tiwari, PhD, Dina Edani, MS, Janet Ayello, MS, MT(ASCP), Lauren Harrison, RN, MSN, Erin Morris, RN, BSN, Jessica C. Hochberg, MD, Stanton Goldman, MD, Christian Klein, PhD, Mitchell S Cairo, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3963.
DOI: https://doi.org/10.1182/blood-2019-128580
Published: 2019
Journal Articles

Phase 1b study of venetoclax-obinutuzumab in previously untreated and relapsed/refractory chronic lymphocytic leukemia

Clinical Trials & Observations
Ian W. Flinn, John G. Gribben, Martin J. S. Dyer, William Wierda, Michael B. Maris, Richard R. Furman, Peter Hillmen, Kerry A. Rogers, Swaminathan Padmanabhan Iyer, Anne Quillet-Mary, Loic Ysebaert, Harriet S. Walter, Maria Verdugo, Christian Klein, Huang Huang, Yanwen Jiang, Gerard Lozanski, Daniela Soriano Pignataro, Kathryn Humphrey, Mehrdad Mobasher, Thomas J. Kipps
Journal: Blood
Blood (2019) 133 (26): 2765–2775.
DOI: https://doi.org/10.1182/blood-2019-01-896290
Published: 2019
Includes: Supplemental data
Journal Articles

Venetoclax plus R- or G-CHOP in non-Hodgkin lymphoma: results from the CAVALLI phase 1b trial

Clinical Trials & Observations
Andrew D. Zelenetz, Gilles Salles, Kylie D. Mason, Carla Casulo, Steven Le Gouill, Laurie H. Sehn, Herve Tilly, Guillaume Cartron, Martine E. D. Chamuleau, Andre Goy, Constantine S. Tam, Pieternella J. Lugtenburg, Adam M. Petrich, Arijit Sinha, Divya Samineni, Sylvia Herter, Ellen Ingalla, Edith Szafer-Glusman, Christian Klein, Deepak Sampath, Martin Kornacker, Mehrdad Mobasher, Franck Morschhauser
Journal: Blood
Blood (2019) 133 (18): 1964–1976.
DOI: https://doi.org/10.1182/blood-2018-11-880526
Published: 2019
Includes: Supplemental data
Journal Articles

Boosting Gamma Delta T Cells-Mediated ADCC By PD-1 Blockade in Follicular Lymphoma

Christine Bezombes, PhD, Cédric Rossi, MD, Pauline Gravelle, Julie Bordenave, Emilie Decaup, Mary Poupot, Marie Tosolini, Don-Marc Franchini, Camille Laurent, MD PhD, Renaud Morin, Jean-Michel Lagarde, Loic Ysebaert, MD PhD, Ariel Savina, Christian Klein, PhD, Patricia Perez-Galan, Jean-Jacques Fournié
Journal: Blood
Blood (2018) 132 (Supplement 1): 5381.
DOI: https://doi.org/10.1182/blood-2018-99-112404
Published: 2018
Journal Articles

Polatuzumab Vedotin Alone or in Combination with Obinutuzumab Synergistically Enhances I n-Vitro Cytotoxicity and Cytokine Release Against CD20+/ CD79b+ Burkitt Lymphoma (BL) /Primary Mediastinal Large B Cell Lymphoma (PMBL)

Aradhana Tiwari, PhD, Dina Edani, MS, Janet Ayello, MS, MT(ASCP), Christian Klein, PhD, Dean Anthony Lee, MD PhD, Mitchell S. Cairo, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1540.
DOI: https://doi.org/10.1182/blood.V130.Suppl_1.1540.1540
Published: 2017
Journal Articles

Human neutrophils mediate trogocytosis rather than phagocytosis of CLL B cells opsonized with anti-CD20 antibodies

Rut Valgardsdottir, Irene Cattaneo, Christian Klein, Martino Introna, Marina Figliuzzi, Josée Golay
Journal: Blood
Blood (2017) 129 (19): 2636–2644.
DOI: https://doi.org/10.1182/blood-2016-08-735605
Published: 2017
Includes: Multimedia, Supplemental data
Journal Articles

CD20 Tcb (RG6026), a Novel "2:1" T Cell Bispecific Antibody for the Treatment of B Cell Malignancies

Marina Bacac, PhD, Pablo Umaña, PhD, Sylvia Herter, PhD, Sara Colombetti, PhD, Johannes Sam, PhD, Marine Le Clech, Anne Freimoser-Grundschober, PhD, Marine Richard, Valeria Nicolini, PhD, Christian Gerdes, PhD, Laurent Lariviere, PhD, Christiane Neumann, PhD, Christian Klein, PhD
Journal: Blood
Blood (2016) 128 (22): 1836.
DOI: https://doi.org/10.1182/blood.V128.22.1836.1836
Published: 2016
Journal Articles

The Triple Combination of the CD20 Antibody Obinutuzumab with the Bcl-2 Inhibitor Venetoclax (GDC-199) and the MDM2 Inhibitor Idasanutlin Results in Superior Efficacy and Long Term Response in Wildtype p53 NHL Tumor Models

Frank Herting, PhD, Thomas Friess, PhD, Pablo Umaña, PhD, Middleton Steven, PhD, Christian Klein, PhD
Journal: Blood
Blood (2016) 128 (22): 4178.
DOI: https://doi.org/10.1182/blood.V128.22.4178.4178
Published: 2016
Journal Articles

CLL Cells from Ibrutinib-Induced Lymphocytosis of Relapsed/Refractory Chronic Lymphocytic Leukemia Patients Are Responsive to Obinutuzumab, but Not Rituximab, Ex Vivo

Loïc Ysebaert, MD PhD, Christian Klein, PhD, Anne Quillet-Mary, PhD
Journal: Blood
Blood (2015) 126 (23): 4157.
DOI: https://doi.org/10.1182/blood.V126.23.4157.4157
Published: 2015