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Journal Articles

The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Qingsong Gao, Sarra L Ryan, Ilaria Iacobucci, Pankaj S Ghate, Ph.D., Ruth E Cranston, Claire J Schwab, Abdelrahman H. Elsayed, Lei Shi, Stanley B Pounds, Shaohua Lei, Pradyumna Baviskar, Deqing Pei, Cheng Cheng, Matthew Bashton, Paul B Sinclair, David R Bentley, Mark Ross, Zoya Kingsbury, Terena James, Kathryn G Roberts, Meenakshi Devidas, Yiping Fan, Wenan Chen, Ti-Cheng Chang, Gang Wu, Andrew J. Carroll, Nyla A. Heerema, Virginia Valentine, Marcus B Valentine, Wenjian Yang, Jun J. Yang, Anthony V Moorman, Christine J Harrison, Charles G. Mullighan
Journal: Blood
Blood blood.2022019094.
DOI: https://doi.org/10.1182/blood.2022019094
Published: 2023
Includes: Supplemental data
Journal Articles

Pharmacotypes across the Genomic Landscape of Pediatric Acute Lymphoblastic Leukemia and Impact on Treatment Response

Shawn Lee, Wenjian Yang, Yoshihiro Gocho, August John, Lauren Rowland, Brandon Smart, Hannah Williams, Dylan Maxwell, Jeremy Hunt, Wentao Yang, Kristine R. Crews, Kathryn G Roberts, Sima Jeha, Cheng Cheng, Seth E. Karol, Mary V. Relling, Gary Rosner, Hiroto Inaba, Charles G. Mullighan, Ching-Hon Pui, William E. Evans, Jun J. Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 1730–1731.
DOI: https://doi.org/10.1182/blood-2022-156699
Published: 2022
Journal Articles

IKZF1 plus Confers a Strong Adverse Prognostic Effect in Total Therapy Studies (XV/XVI)

Ruth Wangondu, Emily Ashcraft, Kathryn G Roberts, Cheng Cheng, Hiroto Inaba, Charles G. Mullighan
Journal: Blood
Blood (2022) 140 (Supplement 1): 118–120.
DOI: https://doi.org/10.1182/blood-2022-158319
Published: 2022
Journal Articles

Epigenetic Fine Mapping and Functional Dissection of Inherited Non-Coding Variation Impacting the Pharmacogenomics of Acute Lymphoblastic Leukemia Treatment

Kashi Raj Bhattarai, Kelly R. Barnett, Robert J. Mobley, Daniel C. Ferguson, Jonathan D. Diedrich, Brennan P. Bergeron, Wenjian Yang, Kristine R. Crews, Wendy Stock, Elisabeth Paietta, Steven M. Kornblau, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Cheng Cheng, Mary V. Relling, William E. Evans, Jun J.J. Yang, Daniel Savic
Journal: Blood
Blood (2022) 140 (Supplement 1): 3027–3028.
DOI: https://doi.org/10.1182/blood-2022-167419
Published: 2022
Journal Articles

Impact of T-cell immunity on chemotherapy response in childhood acute lymphoblastic leukemia

Yizhen Li, Xu Yang, Yu Sun, Zhenhua Li, Wenjian Yang, Bensheng Ju, John Easton, Deqing Pei, Cheng Cheng, Shawn Lee, Ching-Hon Pui, Jiyang Yu, Hongbo Chi, Jun J. Yang
Journal: Blood
Blood (2022) 140 (13): 1507–1521.
DOI: https://doi.org/10.1182/blood.2021014495
Published: 2022
Includes: Supplemental data
Journal Articles

Clofarabine-Based Chemotherapy for KMT2A r Infantile Acute Lymphoblastic Leukemia

Tanja Andrea Gruber, Deqing Pei, John Kim Choi, Cheng Cheng, Elaine Coustan-Smith, Dario Campana, Hope Swanson, Jennifer L Pauley, Hiroto Inaba, Monika Metzger, Jeffrey E. Rubnitz, Raul C Ribeiro, Susana C. Raimondi, William E. Evans, Mary V. Relling, Ching-Hon Pui, Sima Jeha
Journal: Blood
Blood (2021) 138 (Supplement 1): 3406.
DOI: https://doi.org/10.1182/blood-2021-148936
Published: 2021
Journal Articles

The Impact of Genetic Ancestry on the Biology and Prognosis of Childhood Acute Lymphoblastic Leukemia

Shawn Lee, Federico Antillón, Deqing Pei, Wenjian Yang, Kathryn G Roberts, Zhenhua Li, Meenakshi Devidas, Wentao Yang, Cesar Najera, Hai Peng Lin, Ah Moy Tan, Hany Ariffin, Cheng Cheng, William E. Evans, Stephen P Hunger, Sima Jeha, Charles G. Mullighan, Mignon L. Loh, Allen Eng Juh Yeoh, Ching-Hon Pui, Jun J. Yang
Journal: Blood
Blood (2021) 138 (Supplement 1): 3476.
DOI: https://doi.org/10.1182/blood-2021-145655
Published: 2021
Journal Articles

Exposure to Anti-Anaerobic Antimicrobials Around Hematopoietic Cell Transplant (HCT) Is Associated with Poor Outcomes in Pediatric Patients

Jamie Truscott, Gabriela Maron, Diego Hijano, Dinesh Keerthi, Sujuan Huang, Cheng Cheng, Akshay Sharma
Journal: Blood
Blood (2021) 138 (Supplement 1): 2854.
DOI: https://doi.org/10.1182/blood-2021-153147
Published: 2021
Journal Articles

Molecular classification improves risk assessment in adult BCR-ABL1– negative B-ALL

Elisabeth Paietta, Kathryn G. Roberts, Victoria Wang, Zhaohui Gu, Georgina A. N. Buck, Deqing Pei, Cheng Cheng, Ross L. Levine, Omar Abdel-Wahab, Zhongshan Cheng, Gang Wu, Chunxu Qu, Lei Shi, Stanley Pounds, Cheryl L. Willman, Richard Harvey, Janis Racevskis, Jan Barinka, Yanming Zhang, Gordon W. Dewald, Rhett P. Ketterling, David Alejos, Hillard M. Lazarus, Selina M. Luger, Letizia Foroni, Bela Patel, Adele K. Fielding, Ari Melnick, David I. Marks, Anthony V. Moorman, Peter H. Wiernik, Jacob M. Rowe, Martin S. Tallman, Anthony H. Goldstone, Charles G. Mullighan, Mark R. Litzow
Journal: Blood
Blood (2021) 138 (11): 948–958.
DOI: https://doi.org/10.1182/blood.2020010144
Published: 2021
Includes: Supplemental data
Journal Articles

Prognostic factors for CNS control in children with acute lymphoblastic leukemia treated without cranial irradiation

Clinical Trials & Observations
Jingyan Tang, Jie Yu, Jiaoyang Cai, Li Zhang, Shaoyan Hu, Ju Gao, Hua Jiang, Yongjun Fang, Changda Liang, Xiuli Ju, Runming Jin, Xiaowen Zhai, Xuedong Wu, Xin Tian, Qun Hu, Ningling Wang, Hui Jiang, Lirong Sun, Alex W. K. Leung, Minghua Yang, Kaili Pan, Cheng Cheng, Yiping Zhu, Hui Zhang, Chunfu Li, Jun J. Yang, Chi-kong Li, Xiaofan Zhu, Shuhong Shen, Ching-Hon Pui
Journal: Blood
Blood (2021) 138 (4): 331–343.
DOI: https://doi.org/10.1182/blood.2020010438
Published: 2021
Includes: Supplemental data
Journal Articles

Dosing-related saturation of toxicity and accelerated drug clearance with pegaspargase treatment

Clinical Trials & Observations
Yiwei Liu, John C. Panetta, Wenjian Yang, Seth E. Karol, Cheng Cheng, Jun J. Yang, William E. Evans, Hiroto Inaba, Ching-Hon Pui, Sima Jeha, Mary V. Relling
Journal: Blood
Blood (2020) 136 (25): 2955–2958.
DOI: https://doi.org/10.1182/blood.2020006214
Published: 2020
Includes: Supplemental data
Journal Articles

GRP78 Is Expressed on the Cell Surface of Pediatric AML Blasts and Can be Targeted with GRP78-CAR T Cells without Toxicity to Hematopoietic Progenitor Cells

Nikhil Hebbar, PhD, Rebecca Epperly, MD, Abishek Vaidya, MS, Sujuan Huang, Cheng Cheng, PhD, Stephen Gottschalk, MD, Mireya Paulina Velasquez, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12.
DOI: https://doi.org/10.1182/blood-2020-141671
Published: 2020
Journal Articles

Allogeneic Hematopoietic Cell Transplantation Is Critical to Maintain Remissions after CD19-CAR T-Cell Therapy for Pediatric ALL: A Single Center Experience

Aimee C Talleur, MD, Renee M. Madden, MS, MD, Amr Qudeimat, MD, Ewelina Mamcarz, MD, Akshay Sharma, MBBS, Ashok Srinivasan, MD, Ali Y Suliman, MD, Mireya Paulina Velasquez, MD, Timothy Lockey, PhD, Alisha Gaboriault, Seth E. Karol, MD, Hiroto Inaba, MD PhD, Ying Li, MD PhD, Pam Young, Guolian Kang, PhD, Cheng Cheng, PhD, Wenting Zheng, PhD, Sheng Zhou, PhD, Salem M. Akel, PhD, Terrence L Geiger, MD PhD, Michael M Meagher, PhD, Ching-Hon Pui, MD, Brandon M Triplett, MD, Stephen Gottschalk, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
DOI: https://doi.org/10.1182/blood-2020-138528
Published: 2020
Journal Articles

Reduced–dose intensity therapy for pediatric lymphoblastic leukemia: long-term results of the Recife RELLA05 pilot study

Clinical Trials & Observations
Francisco Pedrosa, Elaine Coustan-Smith, Yinmei Zhou, Cheng Cheng, Arli Pedrosa, Mecneide Mendes Lins, Marcia Pedrosa, Norma Lucena-Silva, Alessandra Maria de Luna Ramos, Ester Vinhas, Gaston K. Rivera, Dario Campana, Raul C. Ribeiro
Journal: Blood
Blood (2020) 135 (17): 1458–1466.
DOI: https://doi.org/10.1182/blood.2019004215
Published: 2020
Includes: Supplemental data
Journal Articles

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Benshang Li, Samuel W. Brady, Xiaotu Ma, Shuhong Shen, Yingchi Zhang, Yongjin Li, Karol Szlachta, Li Dong, Yu Liu, Fan Yang, Ningling Wang, Diane A. Flasch, Matthew A. Myers, Heather L. Mulder, Lixia Ding, Yanling Liu, Liqing Tian, Kohei Hagiwara, Ke Xu, Xin Zhou, Edgar Sioson, Tianyi Wang, Liu Yang, Jie Zhao, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, Jiaoyang Cai, Hui-Ying Sun, Ting-Nien Lin, Lijuan Du, Hui Li, Michael Rusch, Michael N. Edmonson, John Easton, Xiaofan Zhu, Jingliao Zhang, Cheng Cheng, Benjamin J. Raphael, Jingyan Tang, James R. Downing, Ludmil B. Alexandrov, Bin-Bing S. Zhou, Ching-Hon Pui, Jun J. Yang, Jinghui Zhang
Journal: Blood
Blood (2020) 135 (1): 41–55.
DOI: https://doi.org/10.1182/blood.2019002220
Published: 2020
Includes: Supplemental data
Journal Articles

Sequential CD19- and Bcma-Specific Chimeric Antigen Receptor T Cell Treatment for RRMM: Report from a Single Center Study

Lingzhi Yan, Zhi Yan, Jingjing Shang, Xiaolan Shi, Song Jin, Liqing Kang, Su Qu, Jin Zhou, Huizhu Kang, Ruju Wang, Ying Yao, Jing Wang, Weiqin Yao, Guanghua Chen, Lei Yu, Depei Wu, MD PhD, Fu Cheng Cheng, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 578.
DOI: https://doi.org/10.1182/blood-2019-129740
Published: 2019
Journal Articles

Initial Safety and Efficacy of Dose-Escalating HDACs Inhibitor Chidamide with VRD (Chi-VRD) Treatment for Newly-Diagnosed High-Risk Transplant Eligible Multiple Myeloma Patients

Jingjing Shang, Weiqin Yao, Lingzhi Yan, Xiaolan Shi, Ruju Wang, Shuang Yan, Yong Liu, Depei Wu, MD PhD, Fu Cheng Cheng, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1855.
DOI: https://doi.org/10.1182/blood-2019-129434
Published: 2019
Journal Articles

Combined Infusion of Anti-CD19 and Anti-Bcma CART Cells after Early or Later Transplantation in the Front Line Was Superior to Salvage Therapy for High Risk MM

Xiaolan Shi, Lingzhi Yan, Jingjing Shang, Liqing Kang, Song Jin, Huizhu Kang, Ruju Wang, Zhu Mingqing, Jiazi Zhou, Feiran Gong, Guanghua Chen, Jin Zhou, Huirong Chang, Weiqin Yao, Ying Yao, Yong Liu, Zhi Yan, Juanjuan Su, Depei Wu, MD PhD, Lei Yu, Fu Cheng Cheng, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1949.
DOI: https://doi.org/10.1182/blood-2019-131546
Published: 2019
Journal Articles

shRNA-Interleukin-6 Modified CD19-Specific Chimeric Antigen Receptor T Cell Significantly Improves the Safety in Acute Lymphoblastic Leukemia

Liqing Kang, Xiaowen Tang, Nan Xu, Minghao Li, Jingwen Tan, Wei Qi, Zhou Yu, Xiaoyan Lou, Shengli Xue, Xin Li, MD, Jian Zhang, MD, Jia Chen, MD, Zhenkun Wang, PhD, Caixia Li, Fu Cheng Cheng, MD PhD, Depei Wu, MD PhD, Lei Yu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2621.
DOI: https://doi.org/10.1182/blood-2019-132067
Published: 2019
Journal Articles

Lack of Benefit of Extended Vincristine and Dexamethasone Pulses during Maintenance Treatment of Childhood Acute Lymphoblastic Leukemia: A Multicenter Randomized Controlled Study of Chinese Children Cancer Group (CCCG)-ALL-2015

Xiaofan Zhu, Shuhong Shen, MD PhD, Jiaoyang Cai, PhD, Shaoyan Hu, MD PhD, Ju Gao, PhD, Hui Zhang, MD PhD, Yongjun Fang, PhD, Xiuli Ju, Xiaowen Zhai, MD PhD, Xuedong Wu, MD PhD, Changda Liang, MD PhD, Xin Tian, PhD, Qun Hu, MD PhD, Ningling Wang, PhD, Runming Jin, MD, Hui Jiang, PhD, Lirong SUN, PhD, Minghua Yang, MD, Kaili Pan, PhD, Chi Kong Li, MBBS,MD, Jun J. Yang, PhD, Cheng Cheng, PhD, JingYan Tang, MD, Ching-Hon Pui, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2576.
DOI: https://doi.org/10.1182/blood-2019-128523
Published: 2019